|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Viral hepatitis update: Progress and perspectives显示文摘Viral hepatitis,secondary to infection with hepatitis A,B,C,D,and E viruses,are a major public health problem and an important cause of morbidity and mortality.Despite the huge medical advances achieved in recent years,there are still points of conflict concerning the pathogenesis,immune response,development of new and more effective vaccines,therapies,and treatment.This review focuses on the most important research topics that deal with issues that are currently being solved,those that remain to be solved,and future research directions.For hepatitis A virus we will address epidemiology,molecular surveillance,new susceptible populations as well as environmental and food detections.In the case of hepatitis B virus,we will discuss host factors related to disease,diagnosis,therapy,and vaccine improvement.On hepatitis C virus,we will focus on pathogenesis,immune response,direct action antivirals treatment in the context of solid organ transplantation,issues related to hepatocellular carcinoma development,direct action antivirals resistance due to selection of resistanceassociated variants,and vaccination.Regarding hepatitis D virus,we describe diagnostic methodology,pathogenesis,and therapy.Finally,for hepatitis E virus,we will address epidemiology(including new emerging species),diagnosis,clinical aspects,treatment,the development of a vaccine,and environmental surveillance. | María B Pisano Cecilia G Giadans Diego M Flichman Viviana E Ré María V Preciado Pamela Valva | 2021 | World Journal of Gastroenterology2021，27，26： | 8 |
| 2 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 3 | Illustrating the coupled human-environment system for vulnerability analysis three case studies显示文摘 | Turner II BL Roger E K Pamela A M | 2003 | The Proceedings of the National Academy of Sciences2003，14，： | 1 |
| 4 | Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes显示文摘 | Gong A Y Pamela S T Melissa A M | 2003 | Am J Cell Physiol2003，25，6： | 1 |
| 5 | Membrane concentrate management options:a comprehensive critical review 显示文摘 | PAMELA C A SMITH D W GAMAL E-D M | 2009 | Canadian Journal of Civil Engineering2009，36，6： | 1 |
| 6 | Epithelial invasion and cell lysis by virulent strains of Streptococcus suis is enhanced by the presence of suilysin显示文摘 | Pamela M Norton Charlotte Rolph Philip N Ward Robert W Bentley James A Leigh | 1999 | FEMS Immunology and Medical Microbiology1999，，1： | 1 |
| 7 | Emotion regulation as a scientific construct: metho-dological challenges and directions for child development research显示文摘 | Pamela M Sarah E Martin T A | 2004 | Child Development2004，75，2： | 1 |
| 8 | On the release of ^nH from cathodically polarized Pd electrodes 显示文摘 | Szpak S Pamela A M | 1998 | Fusion Technology1998，11，34： | 1 |
| 9 | The storm cell identi- fication and tracking algorithm: an enhanced WSR-88D algorithm 显示文摘 | JOHNSON J T PAMELA M WITT A | 1998 | Weather and Forecasting1998，13，2： | 1 |
| 10 | A Qualitative Study of Potential Suicide Risk Factors in Returning Combat Veterans显示文摘 | Brenner Lisa A Gutierrez Peter M Cornette Michelle M Betthauser Lisa M Bahraini Nazanin Staves Pamela J | 2008 | Journal of Mental Health Counseling2008，，： | 1 |
| 11 | Dispositional antecedents and consequences of emotional labor at work显示文摘 | LIU Y M PAMELA L PERREWE W A | 2004 | Journal of Leadership and Organizational Studies2004，10，4： | 1 |
| 12 | Epithelial invasion and cell lysis by virulent strains of Streptococcus suis is enhanced by the presence of suilysin显示文摘 | Pamela M Norton Charlotte Rolph Philip N Ward Robert W Bentley James A Leigh | 1999 | FEMS Immunology and Medical Microbiology1999，，1： | 1 |
| 13 | Why do fiver otters scent - mark an experimental test of several hypotheses 显示文摘 | Rostain R R Ben-David M Pamela Groves & Jan A Randall | 2004 | Animal Behaviour2004，68，： | 1 |
| 14 | Efficient persistence of extrachromosomal KSHV DNA mediated by latency - associated nuclear antigen显示文摘 | Mary E B Pamela A C Kenneth M K | 1999 | Science1999，284，： | 1 |
| 15 | A framework for vulnerability analysis in sustainability science 显示文摘 | TURNER B L ROGER E K PAMELA A M | 2003 | Proceedings of the National Academy of Sciences of the United States of America2003，100，14： | 1 |
| 16 | Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone显示文摘 | PAMELA A W JOSE C DIJANA M V | 2004 | Science2004，305，5684： | 1 |
| 17 | The storm cell identification and tracking algorithm:An enhanced WSR288D algorithm显示文摘 | Johnson J T M Pamela A Witt | 1998 | Wea Forecasting1998，13，： | 1 |
| 18 | Beneficial effects of traditional Chinese medicine on the treatment of osteoporosis on ovariectomised rat models显示文摘 | Pamela R Norazlina M Shuid A N | 2013 | Curr Drug Targets2013，14，16： | 1 |
| 19 | Net primary productivity and nutrient cycling across a mesic to wet precipitation gradient in Hawaiian montane forest显示文摘 | Edward A G Pamela A M | 2001 | Oecologia2001，128，： | 1 |
| 20 | Genome - wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization 显示文摘 | JASON M CASOLARI CHRISTOPHER R BROWN PAMELA A SILVER | 2004 | Cell2004，117，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员