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| 1 | Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial显示文摘 | Florian Lordick Yoon-Koo Kang Hyun-Cheol Chung Pamela Salman Sang Cheul Oh Gy?rgy Bodoky Galina Kurteva Constantin Volovat Vladimir M Moiseyenko Vera Gorbunova Joon Oh Park Akira Sawaki Ilhan Celik Heiko G?tte Helena Melezínková Markus Moehler | 2013 | Lancet Oncology2013，，6： | 14 |
| 2 | Viral hepatitis update: Progress and perspectives显示文摘Viral hepatitis,secondary to infection with hepatitis A,B,C,D,and E viruses,are a major public health problem and an important cause of morbidity and mortality.Despite the huge medical advances achieved in recent years,there are still points of conflict concerning the pathogenesis,immune response,development of new and more effective vaccines,therapies,and treatment.This review focuses on the most important research topics that deal with issues that are currently being solved,those that remain to be solved,and future research directions.For hepatitis A virus we will address epidemiology,molecular surveillance,new susceptible populations as well as environmental and food detections.In the case of hepatitis B virus,we will discuss host factors related to disease,diagnosis,therapy,and vaccine improvement.On hepatitis C virus,we will focus on pathogenesis,immune response,direct action antivirals treatment in the context of solid organ transplantation,issues related to hepatocellular carcinoma development,direct action antivirals resistance due to selection of resistanceassociated variants,and vaccination.Regarding hepatitis D virus,we describe diagnostic methodology,pathogenesis,and therapy.Finally,for hepatitis E virus,we will address epidemiology(including new emerging species),diagnosis,clinical aspects,treatment,the development of a vaccine,and environmental surveillance. | María B Pisano Cecilia G Giadans Diego M Flichman Viviana E Ré María V Preciado Pamela Valva | 2021 | World Journal of Gastroenterology2021，27，26： | 8 |
| 3 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 4 | Prevalence of unsuspected thyroid nodules in adults on contrast enhanced 16-and 64-MDCT of the chest显示文摘AIM: To determine the prevalence of unsuspected thyroid nodules on contrast enhanced 16and 64-modified discrete cosine transform (MDCT) of the chest, in a population of adult outpatients imaged for indications other than thyroid disease. METHODS: This retrospective study involved review of intravascular contrast-enhanced MDCT scans of the chest from 3077 consecutive adult outpatients, to identify unsuspected thyroid nodules. Exclusion criteria included history of thyroid cancer, known thyroid nodules or thyroid disease and risk factors for thyroid cancer, as evidenced by their medical records. One of 9 radiologists recorded number of nodules, location and bidirectional measurement of largest nodule, as well as amount of thyroid visualized on the chest computed tomography (CT). Presence of nodule was correlated with age, gender, race and percentage of thyroid imaged. RESULTS: A total of 2510 (2510/3077 or 81.6%) study subjects were included in the data analysis; among them,one or more nodules were identified in 629 subjects (629/2510 or 25.1%), with 242 (242/629 or 38.5%) having multiple nodules. Patients with nodule(s) were significantly older than those without (64 ± 13 years vs 58 ± 14 years, P < 0.0001), and female gender was associated with presence of nodule(s) (373/1222 or 30.5% vs 256/1288 or 19.9%, P < 0.0001). Women were also more likely having multiple nodules (167/373 or 44.8%) compared to men (75/256 or 29.3%, P < 0.0001). The majority of nodules (427/629 or 67.9%) were less than 1 cm. CONCLUSION: This retrospective review revealed a prevalence of 25.1% for unsuspected thyroid nodules on contrast-enhanced chest CT. | Sameer Ahmed Pamela T Johnson Karen M Horton Atif Zaheer Saline Tsai Elliot K Fishman | 2012 | World Journal of Radiology2012，4，7： | 4 |
| 5 | Illustrating the coupled human-environment system for vulnerability analysis three case studies显示文摘 | Turner II BL Roger E K Pamela A M | 2003 | The Proceedings of the National Academy of Sciences2003，14，： | 1 |
| 6 | Phytoestrogen consumption and breast cancer risk in a multiethnic population, full 显示文摘 | PAMELA L HORN-ROSS JOHN E M | 2001 | Am J Epidemiol2001，154，5： | 1 |
| 7 | Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes显示文摘 | Gong A Y Pamela S T Melissa A M | 2003 | Am J Cell Physiol2003，25，6： | 1 |
| 8 | Employee creativity in taiwan : an application of role identity theory 显示文摘 | Farmer S M Pamela T Kate K - M | 2003 | The Academy of Management Journal2003，46，5： | 1 |
| 9 | Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin显示文摘 | Pamela M | 2009 | Genes Nutr2009，4，4： | 1 |
| 10 | Creative self - efficacy: its potential antecedents and relationship to creative performance显示文摘 | Pamela T Farmer S M | 2002 | The Academy of Management Journal2002，45，6： | 1 |
| 11 | An evaluation of foot care behavionrs in individuals with type 2 diabetes living in Malta 显示文摘 | Pamela B Stephen M Cynthia F | 2013 | J Diabetes Nurs2013，17，2： | 1 |
| 12 | Membrane concentrate management options:a comprehensive critical review 显示文摘 | PAMELA C A SMITH D W GAMAL E-D M | 2009 | Canadian Journal of Civil Engineering2009，36，6： | 1 |
| 13 | Cyclooxygenase-independent chemoprevention with an aspirin derivative in a rat model of colonic adenocarcinoma显示文摘 | Adrian W Webb M Pamela L | 1998 | Life Sci1998，62，23： | 1 |
| 14 | Epithelial invasion and cell lysis by virulent strains of Streptococcus suis is enhanced by the presence of suilysin显示文摘 | Pamela M Norton Charlotte Rolph Philip N Ward Robert W Bentley James A Leigh | 1999 | FEMS Immunology and Medical Microbiology1999，，1： | 1 |
| 15 | Peripheral and intestinal regulatory CD4+ CD25 high T cells in inflammatory Bowel disease显示文摘 | Jochen M Christoph L Pamela M | 2005 | Gastroenterology2005，128，： | 1 |
| 16 | Emotion regulation as a scientific construct: metho-dological challenges and directions for child development research显示文摘 | Pamela M Sarah E Martin T A | 2004 | Child Development2004，75，2： | 1 |
| 17 | Friends or Strangers? Firm-Specific Uncertainty,Market Uncertainty,and Network Partner Selection 显示文摘 | CHRISTINE M B PAMELA R H DAMON J P | 2004 | Organization Science2004，15，3： | 1 |
| 18 | Total knee arthroplasty after open reduction and internal fixation of fractures of the tibial plateau显示文摘 | Khaled J Saleh M Pamela F | 2001 | J Bone Joint Surg Am2001，83，8： | 1 |
| 19 | A real time IMC tuned PID controller for DC motor显示文摘 | SARANYA M PAMELA D | 2012 | International Journal of Recent Technology and Engineering2012，1，1： | 1 |
| 20 | On the release of ^nH from cathodically polarized Pd electrodes 显示文摘 | Szpak S Pamela A M | 1998 | Fusion Technology1998，11，34： | 1 |
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