|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Homoharringtonine is a safe and effective substitute for anthracyclines in children younger than 2 years old with acute myeloid leukemia显示文摘Homoharringtonine (HHT),a plant alkaloid from Cephalotaxus harringtonia,exhibits a unique anticancer mechanism and has been widely used in China to treat patients with acute myeloid leukemia (AML) since the 1970s.Trial SCMC-AML-2009 presented herein was a randomized clinical study designed based on our previous findings that pediatric AML patients younger than two years old may benefit from HHT-containing chemotherapy regimens.Patients randomized to arm A were treated with a standard chemotherapy regimen comprising mainly of anthracyclines and cytarabine (Ara-C),whereas patients in arm B were treated with HHTcontaining regimens in which anthracyclines in all but the initial induction therapy were replaced by HHT.From February 2009 to November 2015,59 patients less than 2 years old with de novo AML (other than acute promyelocytic leukemia) were recruited.A total of 42 patients achieved a morphologic complete remission (CR) after the first course,with similar rates in both arms (70.6% vs.72.0%).At the end of the follow-up period,40 patients remained in CR and 5 patients underwent hematopoietic stem cell transplantation in CR,which could not be considered as events but censors.The 5-year event-free survival (EFS) was 60.2%± 9.6% for arm A and 88.0%± 6.5% for arm B (P=0.024).Patients in arm B experienced shorter durations of leukopenia,neutropenia,and thrombocytopenia and had a lower risk of infection during consolidation chemotherapy with high-dosage Ara-C.Consequently,the homoharringtonine-based regimen achieved excellent EFS and alleviated hematologic toxicity for children aged younger than 2 years with de novo AML compared with the anthracycline-based regimen. | Xiaoxiao Chen Yanjing Tang Jing Chen Ru Chen Longjun Gu Huiliang Xue Ci Pan Jingyan Tang Shuhong Shen | 2019 | Frontiers of Medicine2019，13，3： | 3 |
| 2 | Early T-cell precursor leukemia:a subtype of high risk childhood acute lymphoblastic leukemia显示文摘Acute lymphoblastic leukemia includes T-cell acute lymphoblastic leukemia(T-ALL)and B-cell acute lymphoblastic leukemia(B-ALL).In children,T-ALL usually has a worse prognosis than B-ALL,although childhood T-ALL prognoses have improved remarkably.The varying outcomes among T-ALL cases suggest that an unrecognized biological heterogeneity may contribute to chemo-resistance.Deep exploration of T-lymphocyte development in recent years has found a subgroup of patients with a phenotype that resembles early T-cell precursor,which confers a much poorer prognosis than any other form of T-ALL.This novel subtype of T-ALL was called early T-cell precursor acute lymphoblastic leukemia(ETP-ALL).Flow cytometry data from T-ALL patients enrolled in Shanghai Children’s Medical Center between July 2002 and October 2010 were assessed according to Dr.Campana’s protocol.Among total 89 T-ALL cases,74 cases had enough immunophenotype data available to differentiate between ETP(CD1a^(-),CD8^(-),CD5^(dim),at least one marker of stem cell or myeloid lineage)and non-ETP.From these 74 subjects,12 ETP-ALL cases(16.2%)were identified.The event-free survival(EFS)rate at 66.8 months was 11.1%±10.1% for ETP-ALL and 57.6%±5.6% for non-ETP-ALL(P=0.003).The overall survival rates were 13.3%±11.0% for ETP-ALL and 64.7%±6.3% for non-ETP-ALL(P=0.002).Our findings demonstrate that early T-cell precursor leukemia is a very high-risk subtype of acute lymphoblastic leukemia with poor prognosis. | Meilin Ma Xiang Wang Jingyan Tang Huiliang Xue Jing Chen Ci Pan Hua Jiang Shuhong Shen | 2012 | Frontiers of Medicine2012，6，4： | 2 |
| 3 | Significant loss of soil inorganic carbon at the continental scale显示文摘Widespread soil acidification due to atmospheric acid deposition and agricultural fertilization may greatly accelerate soil carbonate dissolution and CO_(2) release.However,to date,few studies have addressed these processes.Here,we use meta-analysis and nationwide-survey datasets to investigate changes in soil inorganic carbon(SIC)stocks in China.We observe an overall decrease in SIC stocks in topsoil(0-30 cm)(11.33 g C m^(-2)yr^(-1))from the 1980s to the 2010s.Total SIC stocks have decreased by∼8.99±2.24%(1.37±0.37 Pg C).The average SIC losses across China(0.046 Pg C yr^(-1))and in cropland(0.016 Pg C yr^(-1))account for∼17.6%-24.0%of the terrestrial C sink and 57.1%of the soil organic carbon sink in cropland,respectively.Nitrogen deposition and climate change have profound influences on SIC cycling.We estimate that∼19.12%-19.47%of SIC stocks will be further lost by 2100.The consumption of SIC may offset a large portion of global efforts aimed at ecosystem carbon sequestration,which emphasizes the importance of achieving a better understanding of the indirect coupling mechanisms of nitrogen and carbon cycling and of effective countermeasures to minimize SIC loss. | Xiao-Dong Song Fei Yang Hua-Yong Wu Jing Zhang De-Cheng Li Feng Liu Yu-Guo Zhao Jin-Ling Yang Bing Ju Chong-Fa Cai Biao Huang Huai-Yu Long Ying Lu Yue-Yu Sui Qiu-Bing Wang Ke-Ning Wu Feng-Rong Zhang Ming-Kui Zhang Zhou Shi Wan-Zhu Ma Gang Xin Zhi-Ping Qi Qing-Rui Chang En Ci Da-Gang Yuan Yang-Zhu Zhang Jun-Ping Bai Jia-Ying Chen Jie Chen Yin-Jun Chen Yun-Zhong Dong Chun-Lan Han Ling Li Li-Ming Liu Jian-Jun Pan Fu-Peng Song Fu-Jun Sun Deng-Feng Wang Tian-Wei Wang Xiang-Hua Wei Hong-Qi Wu Xia Zhao Qing Zhou Gan-Lin Zhang | 2022 | National Science Review2022，9，2： | 2 |
| 4 | The role of ferulic acid removal during bleaching of wheat straw mechanical pulp with peroxygenreagents显示文摘 | PAN G X THOMSON CI LEARY G J | 2003 | Holzforsehung2003，57，3： | 1 |
| 5 | Associations between carotid atherosclerosis and high factor VI activity, dyslipidemia, and hypertension显示文摘 | Pan WH Bai CI Chen JR | 1997 | Stroke1997，28，： | 1 |
| 6 | A genome-wide scanforloci linked to plasma levels of glucose and HbAlc in a community-based sample of caucasian pedigrees:The Framitlsham offspring Study显示文摘 | Meigs JB Pan huysen CI Myers RH | 2002 | Diabetes Care2002，25，10： | 1 |
| 7 | Trace elements in hair of patients with blackfoot disease 显示文摘 | Pan TC Lin TH Tseng CI | 1993 | Biol Trace Elem Res1993，39，： | 1 |
| 8 | Effect of Selenium source and level in hen's diet on tissue Selenium deposition and egg Selenium concentrations显示文摘 | PAN CI HUANG KH ZHAO YX | 2007 | Journal of Agricultural and Food Chemistry2007，55，3： | 1 |
| 9 | Pooled analysis of the performance of liquid‐based cytology in population‐based cervical cancer screening studies in China显示文摘 | Qin‐Jing Pan Shang‐ying Hu Xun Zhang Pu‐wa Ci Wen‐hua Zhang Hui‐qin Guo Jian Cao Fang‐hui Zhao Alice Lytwyn You‐lin Qiao | 2013 | Cancer Cytopathology2013，，9： | 1 |
| 10 | A genome - wide scan for loci linked to plasma levels of glucose and HbAlc in a community - based sample of Caucasian pedigrees: The Framingham Offspring Study 显示文摘 | Meigs JB Pan huysen CI Myers RH | 2002 | Diabetes Care2002，25，10： | 1 |
| 11 | Influences of pulse frequency on formation and properties of composite anodic oxide films on Ti-10V-2Fe-3Al alloy显示文摘A thick composite anodic oxide film was fabricated in an environmentally friendly malic acid electrolyte containing Poly Tetra Fluoro Ethylene(PTFE)nanoparticles on Ti-10V-2Fe-3Al alloys.The influence of pulse frequency on the morphology,microstructure and composition of composite anodic oxide films containing PTFE nanoparticles was investigated using Field Emission Scanning Electron Microscopy(FE-SEM)equipped with Energy Dispersive Spectroscopy(EDS),Atomic Force Microscopy(AFM)and Raman spectroscopy.The tribological properties in terms of the friction coefficient,wear loss and morphology of worn surfaces were measured by ball-ondisc tests.The electrochemical property was evaluated by potentiodynamic polarization.The results indicated that the titanium dioxide of composite anodic oxide films transformed from anatase to rutile with the change of pulse frequency,which could result from the electrochemical dynamic equilibrium.The combination of PTFE nanoparticles and malic acid electrolyte molecules can influence the energy fluctuation of electrochemical equilibrium and formation of composite anodic oxide films.Moreover,composite anodic oxide films fabricated under the condition of 1.0–2.0 Hz exhibited the best wear resistance and corrosion property.The schematic diagram of the film formation and PTFE nanoparticles spreading process under different frequencies was elucidated. | Xu DAI Chen WEN Liang WU Lei LIU Yulong WU Xingxing DING Jiahao WU Wenjun CI Aitao TANG Fusheng PAN | 2021 | Chinese Journal of Aeronautics2021，34，11： | 0 |
| 12 | 中国台湾地区汉族青少年高血压3阶段结合多位点测试和基因表达分析的全基因组关联研究显示文摘虽然已经进行了多次大规模的全基因组关联研究(genome—wide association studies,GWAs),但是仅少数研究成功地鉴定出能重复的、重要的高血压基因位点,而且在中国人中进行的相关研究更少。与迟发性高血压相比,青少年高血压(young—onset hypertension,YOH)被认为是更有希望治疗的疾病,因为其受到遗传因素的影响更大。 | Chiang KM Yang HC Liang YJ Chen JW Hwang SM Ho HY Ting CT Lin TH Sheu SH Tsai WC Chen JH Leu HB Yin WH Chiu TY Chen CI Lin SJ Thomas GN Tomlinson B Guo Y Gui HS Sham PC Lam TH Pan WH 练桂丽 叶鹏 | 2014 | 中华高血压杂志2014，22，12： | 0 |
| 13 | Effect of Zn on mechanical and corrosion properties of Mg-Sc-Zn alloys显示文摘The effect of different Zn concentrations(0 wt.%,1 wt.%,3 wt.%,and 6 wt.%)on the microstructure,cor-rosion property,and mechanical property of Mg-0.3Sc-x Zn(x=0 wt.%,1 wt.%,3 wt.%,and 6 wt.%)alloys was investigated.Here,MSZ1 alloy exhibits the highest corrosion resistance(0.194 mm/y)and appropriate mechanical properties with an ultimate tensile strength of 228 MPa and elongation of 19%.The superior corrosion resistance of Mg-0.3Sc-1Zn alloys is attributed to the homogeneous volta-potential distribution and the dense corrosion product film.With the increase in zinc content,the strength and plasticity of Mg-0.3Sc-x Zn alloys(x=0 wt.%,1 wt.%,3 wt.%,6 wt.%)improved to some extent.The precipitated ScZn phase plays the role of the second phase strengthening,which enables MSZ6 to obtain the maximum tensile strength.However,the ScZn phase with low volta potential intensifies the galvanic corrosion,re-sulting in the decline of the corrosion performance. | Wenjun Ci Xianhua Chen Yue Sun Xu Dai Guanzheng Zhu Di Zhao Fusheng Pan | 2023 | Journal of Materials Science & Technology2023，，27： | 0 |
| 14 | Mating system and progeny genetic diversity of Camellia oleifera ‘Ruan Zhi’显示文摘Camellia oleifera Abel.is an important economic tree species of southern China.In this study,we evaluated the mating system and genetic diversity of a series of cultivars of C.oleifera‘Ruan Zhi’.A total of 159 individuals from the progenies of four cultivars were tested by simple sequence repeat molecular markers.Results reveal that 11 pairs of primers showed polymorphism and their polymorphism information content value was greater than 0.73,suggesting that these primers could be used to identify the genetic diversity of open-pollinated populations.The average number of effective alleles(Ne=4.88)was significantly different from the average number of alleles(Na=12.18),and their distribution in the sample population was not uniform.The average observed heterozygosity(Ho=0.96)was greater than the average expected heterozygosity(He=0.79),and the population heterozygote was excessive.Shannon index was 1.84 and populations showed high genetic diversity.As regards to the mating system,the multilocus outcrossing rate was 0.996,and the single locus 0.866.These results indicate a high degree of outcrossing by C.oleifera‘Ruan Zhi’.We recommend selecting individuals for high genetic gain from the progenies of cultivars because of outcrossing characteristics and genetic diversity for application to germplasm conservation and promotion. | Zijie Zhang Jingxiang Meng Daofeng Pan Ci Yang Yue Li | 2019 | Journal of Forestry Research2019，30，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员