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| 1 | 基质金属蛋白酶1的组织抑制剂通过介导CD63与整合素β_1的相互作用促进心肌纤维化显示文摘心肌纤维化指细胞外基质纤维胶原蛋白的过度积累。纤维化是各种心肌病的关键特征,会影响心脏收缩和舒张功能。金属蛋白酶1组织抑制剂(tissue inhibitor of metalloproteinase-1,TIMP1)水平在心肌纤维化过程中始终增加,被认为是纤维化的标记物。 | Takawale A Zhang P Patel VB Wang X Oudit G Kassiri Z 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，4： | 13 |
| 2 | 固定低剂量三联抗高血压药物与常规治疗对斯里兰卡轻度至中度高血压患者血压控制的疗效差异:一项随机临床试验显示文摘控制不良的高血压是全球领先的公共卫生问题,需要新的治疗策略。该研究评估低剂量三联抗高血压药物治疗是否能达到比常规治疗更好的血压控制。研究者纳入2016年2月至2017年5月在斯里兰卡11所城市医院诊所就诊的需要开始抗高血压治疗(未治疗的患者)或接受单药治疗的患者,进行低剂量三联降压与常规治疗比较的随机、开放性试验,随访至2017年10月。 | Web-ster R Salam A de Silva HA Selak V Stepien S Rajapakse S Amarasekara S Amarasena N Billot L de Silva AP Fernando M Guggilla R Jan S Jayawardena J Maulik PK Mendis S Munasinghe J Naik N Prabhakaran D Ranasinghe G Thom S Tisserra N Senaratne V Wijekoon S Wijeyasingam S Rodgers A Patel A 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 7 |
| 3 | 中心和外周动脉脉搏波传导速度测量的重复性:社区动脉粥样硬化风险研究显示文摘通过脉搏波传导速度(pulsewavevelocity,PwV)检测动脉硬化程度是当前对高血压和心血管病风险评估和分层所日渐常用的方式。颈股动脉脉搏波传导速度(catroidfemoralarteryPWV,cfPWV)是一项公认的测定中心动脉硬化程度的方式。 | Meyer ML Tanaka H Palta P Patel MD Camplain R Couper D Cheng S Al Qunaibet A Poon AK Heiss G 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，5： | 6 |
| 4 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 5 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 6 | Endourological treatment of ureteral strictures: 2 referral centers 显示文摘 | Fushs G J Patel A Gutierez J | 1996 | J Urol1996，155，： | 1 |
| 7 | Influence of dates ofplanting and nitrogen levels on the smoke constituents ofbidi tobacco cultivars 显示文摘 | Patel J A Patel B K Patel G R | 1989 | Tobacco Research1989，15，1： | 1 |
| 8 | Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice显示文摘 | Lacek K Vercauteren K Grzyb K Naddeo M Verhoye L Slowikowski M P Fafi-Kremer S Patel A H Baumert T F Folgori A Leroux-Roels G Cortese R Meuleman P Nicosia A | 2012 | J Hepatol2012，57，1： | 1 |
| 9 | Combination of the superior and inferior pedicle'continuities'for anastomosis of an SIEA flap to a contralateral DIEP flap in double-pedicled abdominal free flaps:a further modification of the Hamdi classification显示文摘 | Mohan A T Patel N G Malata C M | 2014 | J Plast Reconstr Aesthet Surg2014，67，10： | 1 |
| 10 | Beta-arrestin-mediated signaling in the heart显示文摘 | Patel P A Tilley D G Rockman H A | 2008 | Circ J2008，72，11： | 1 |
| 11 | Expression analyses of Arabidopsis oligopeptide transporters during seed germination, veg etative growth and reproduetion显示文摘 | STACEY M G OSAWA H PATEL A | 2006 | Planta2006，223，： | 1 |
| 12 | Stable carbon isotope ratio analysis of Australian orange juices 显示文摘 | SIMPKINS W A PATEL G HARRISON M | 2000 | Food Chem2000，70，： | 1 |
| 13 | Measurement of gas holdup and mean bubble diameter in bubble column reactors by dynamic gas disengagement method显示文摘 | Daly J G Patel S A Bukur D B | | 0，，13： | 1 |
| 14 | Systematic review of ablation techniques for the treatment of malignant or aggressive benign lesions in children显示文摘 | Gómez F M Patel P A Stuart S | 2014 | Pediatric Radiology2014，44，10： | 1 |
| 15 | Stereoseleetive reduction of fl-keto esters by Geotrichum candidum 显示文摘 | Patel R N Banerjee A Mcnamee C G | 1992 | Enzyme Microb Technol1992，14，9： | 1 |
| 16 | The application of ultrasound to the synthesis of poly(organosilanes) 显示文摘 | Price G J Patel A M | 1996 | Eur Polym1996，32，11： | 1 |
| 17 | TopologyOptimization Using a Hybrid Cellular AutomatonMethod with Local Control Rules显示文摘 | Tovar A Patel N M Niebur G L | 2006 | Journal ofMechanical Design2006，128，11： | 1 |
| 18 | Simultaneous carbon, nitrogen and phosphorous removal from municipal wastewater in a circulating fluidized bed bioreactor 显示文摘 | Patel A Zhu J Nakhla G | 2006 | Chemosphere2006，65，： | 1 |
| 19 | Stable carbon isotope ratio analysis of Australian orange juices显示文摘 | Simpkins W A Patel G Harrison M | 2000 | Food Chemistry2000，70，： | 1 |
| 20 | Body mass index is an independent determinant of left atrial size显示文摘 | Ayer J G Almafragy H S Patel A A | 2008 | Heart Lung Circ2008，17，1： | 1 |
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