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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | A comparativestudy of dexmedetomidine with midazolam and midazolam alone forsedation during elective awake fiberoptic intubation显示文摘 | Berges S D Patrick Bender S McSweeney T D | 2010 | J Clin Anesth2010，22，1： | 1 |
| 3 | Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex显示文摘 | Shingo K Patrick S Takuya T | | 0，，： | 1 |
| 4 | Desulfurization of Fuel Oil by Oxidation and Extraction 显示文摘 | Patrick S T James R K John W E | 1990 | Industrial & Engineering Chemist Research1990，29，3： | 1 |
| 5 | 5-Nitro-2-thiophene-aldehyde显示文摘 | Patrick T M Emerson W S | 1952 | J Am Chem Soc1952，74，： | 1 |
| 6 | Low Back Pain: Movement Considerations for Exercise and Training 显示文摘 | William J Hanney Patrick S Pabian Matthew T Smith | 2013 | Strength and conditioning journal2013，35，4： | 1 |
| 7 | A Method for Calibrating Deterministic Forecasts of Rare Events显示文摘 | Marsh Patrick T Kain John S Lakshmanan Valliappa Clark Adam J Hitchens Nathan M Hardy Jill | 2012 | EN2012，，2： | 1 |
| 8 | A comparative study of dexmedetomidine with midazolam and midazolam alone for sedation during elective awake fiberoptic intubation显示文摘 | Bergese S D Patrick B S McSweeney T D | 2010 | J Clin Anesth2010，22，1： | 1 |
| 9 | The Swift Ultra-Violet/Optical Telescope显示文摘 | Peter W. A. Roming Thomas E. Kennedy Keith O. Mason John A. Nousek Lindy Ahr Richard E. Bingham Patrick S. Broos Mary J. Carter Barry K. Hancock Howard E. Huckle S D. Hunsberger Hajime Kawakami Ronnie Killough T Scott Koch Michael K. Mclelland Kelly Smith | 2005 | Space Science Reviews (-)2005，，3： | 1 |
| 10 | Desulfurization of fuel oil by oxidation and extraction显示文摘 | Patrick S T James R K John W E | 1990 | Industrial & engineering chemistry research1990，29，3： | 1 |
| 11 | Anti-oxidant effects of the extracts from the leaves of Chronmlaena odorata on human dermal fibroblasts and epidermal keratinocytes against hydrogen peroxide and hypoxanthine-xanthine oxidase induced damage显示文摘 | THANG P T PATRICK S TEIK L S | 2001 | Burns2001，27，4： | 1 |
| 12 | A comparative study of dexmedetomidine with midazolam and midazolam alon for sedation during elective awake fiberoptic inthbation显示文摘 | Bergese S D Patrick Bender S McSweeney T D | 2010 | J Clin Anesth2010，22，1： | 1 |
| 13 | Species-specific PCR-based assays for the detection of Fusarium species and acomparison with the whole seed agar plate method and trichothecene analysis显示文摘 | Derneke T Clear R M Patrick S K | 2005 | International Journal of Food Microbiology2005，103，： | 1 |
| 14 | Long period fiber gratings for structural bend sensing显示文摘 | Patrick H J Chang C C Vohra S T | 1998 | Electron Lett1998，34，18： | 1 |
| 15 | A A comparative study of dexmedetomidine with midazo- lam and midazolam alone forsedation during elective a- wake fiberoptic intubation 显示文摘 | Bergese S D Patrick Bender S Mc Sweeney T D | 2010 | J Clin Anesth2010，22，1： | 1 |
| 16 | Functional genomics and the biosynthesis of artemisinin显示文摘 | PATRICK S C KEAT H T DEVIN R P | 2007 | Phytochemistry2007，，68： | 1 |
| 17 | A com- parative study of dexmedetomidine with midazolam and mida- zolam alone for sedation during elective awake fiberoptic intu- bation显示文摘 | Bergese S D Patrick Bender S McSweeney T D | 2010 | J Clin Anesth2010，22，1： | 1 |
| 18 | Titania formation by TIC14 gas phase oxidation, surface growth and coagula- tion 显示文摘 | Patrick T S Olivier C Stavros T | 2002 | Aerosol Sci2002，33，： | 1 |
| 19 | The origin, mecbanisms, incidence and clinical Consequences of chromosomal mosaicism in humans 显示文摘 | TAYLOR T H GITLIN S A PATRICK J L | 2014 | Human Reproduction Update2014，20，4： | 1 |
| 20 | Desulfurization of fuel oil by oxidation and extraction显示文摘 | Patrick S T James R K John W E | 1990 | Industrial & engineering chemistry research1990，29，3： | 1 |
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