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| 1 | 30 GHz GeSn photodetector on SOI substrate for 2 µm wavelength application显示文摘We report the demonstration of a normal-incidence p-i-n germanium-tin(Ge_(0.951)Sn_(0.049))photodetector on silicon-on-insulator substrate for 2μm wavelength application.The DC and RF characteristics of the devices have been characterized.A dark current density under−1 V bias of approximately 125 mA/cm^(2) is achieved at room temperature,and the optical responsivity of 14 mA/W is realized for illumination wavelength of 2μm under−1 V reverse bias.In addition,a 3 dB bandwidth(f_(3dB))of around 30 GHz is achieved at−3 V,which is the highest reported value among all group III–V and group IV photodetectors working in the 2μm wavelength range.This work illustrates that a GeSn photodetector has great prospects in 2μm wavelength optical communication. | Xiuli Li Linzhi Peng Zhi Liu Zhiqi Zhou Jun Zheng Chunlai Xue Yuhua Zuo Baile Chen Buwen Cheng | 2021 | Photonics Research2021，9，4： | 6 |
| 2 | Electroluminescence and photoluminescence of dioctylfluorene and 4,7-dithien-2-yl-2,1,3-benzothiadiazole copolymers显示文摘Dioctylfluorene (DOF) and 4,7-dithien-2-yl-2,1,3-benzothiadiazole (DBT) copolymers synthesized in our lab with different compositions of DBT (1%, 5%, 15% and 25%) were utilized to fabricate bilayered light emitting diodes. External quantum efficiency (QE) of the diode fabricated from the copolymer with 15% DBT content reaches 1.4% (ph/el), over 1.0 cd/A in luminance efficiency at the driving voltage of 4.2 V. The highest luminance can reach 3780 cd/m2 at 8.2 V. Devices emit a saturated red light centered at 675 nm with chromaticity coordinate changed from x=0.66, y=0.32 for PDOF-DBT1 (1% DBT) to x=0.70, y= 0.28 for PDOF-DBT25 (25% DBT). | PENG Junbiao, XU Yishe, HOU Qiong, NIU Yuhua, RUAN Wenying & CAO YongInstitute of Polymer Optoelectronic Materials & Devices, South China University of Technology, Guangzhou 510640, China Department of Applied Physics, South China University of Technology | 2002 | Chinese Science Bulletin2002，47，20： | 5 |
| 3 | Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models显示文摘 | Meng Yu Yuhua Fu Yijian Liang Haikun Song Yao Yao Peng Wu Yuwei Yao Yuyin Pan Xue Wen Lixiang Ma Saiyin Hexige Yu Ding Shouqing Luo Boxun Lu | 2017 | Cell Research2017，27，12： | 5 |
| 4 | Chinese expert consensus on the management of chimeric antigen receptor T cell therapy-associated coagulopathy显示文摘Chimeric antigen receptor T-cell(CAR-T)therapy has greatly improved the disease remission rate and long-term survival rate of patients with relapsed/refractory hematological malignancies.[1-3]Currently,several commercial CAR-T products are available in the market and numerous CAR-T clinical trials have been conducted.Attention should be paid to the safety of CAR-T therapy.The main adverse effects of CAR-T therapy are cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS).[4] | Heng Mei Fangping Chen Yue Han Ming Hou He Huang Xiaojun Huang Yuhua Li Aibin Liang Qifa Liu Ting Niu Jun Peng Wenbin Qian Yongping Song Jianxiang Wang Ying Wang Depei Wu Kailin Xu Linhua Yang Renchi Yang Lei Zhang Liansheng Zhang Xi Zhang Xiaohui Zhang Weili Zhao Weidong Han Yu Hu | 2022 | Chinese Medical Journal2022，，14： | 4 |
| 5 | Therapeutic siRNA:state of the art显示文摘RNA interference(RNAi)is an ancient biological mechanism used to defend against external invasion.It theoretically can silence any disease-related genes in a sequence-specific manner,making small interfering RNA(siRNA)a promising therapeutic modality.After a two-decade journey from its discovery,two approvals of siRNA therapeutics,ONPATTRO®(patisiran)and GIVLAARI™(givosiran),have been achieved by Alnylam Pharmaceuticals.Reviewing the long-term pharmaceutical history of human beings,siRNA therapy currently has set up an extraordinary milestone,as it has already changed and will continue to change the treatment and management of human diseases.It can be administered quarterly,even twice-yearly,to achieve therapeutic effects,which is not the case for small molecules and antibodies.The drug development process was extremely hard,aiming to surmount complex obstacles,such as how to efficiently and safely deliver siRNAs to desired tissues and cells and how to enhance the performance of siRNAs with respect to their activity,stability,specificity and potential off-target effects.In this review,the evolution of siRNA chemical modifications and their biomedical performance are comprehensively reviewed.All clinically explored and commercialized siRNA delivery platforms,including the GalNAc(N-acetylgalactosamine)–siRNA conjugate,and their fundamental design principles are thoroughly discussed.The latest progress in siRNA therapeutic development is also summarized.This review provides a comprehensive view and roadmap for general readers working in the field. | Bo Hu Liping Zhong Yuhua Weng Ling Peng Yuanyu Huang Yongxiang Zhao Xing-Jie Liang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 6 | “All‐In‐One” integrated ultrathin SnS2@3D multichannel carbon matrix power high‐areal–capacity lithium battery anode显示文摘Construction of a thickness‐independent electrode with high active material mass loading is crucial for the development of high energy rechargeable lithium battery.Herein,we fabricate an all‐in‐one integrated SnS2@3D multichannel carbon matrix(SnS2@3DMCM)electrode with in‐situ growth of ultrathin SnS2 nanosheets inside the inner walls of three dimensional(3D)multichannels.The interconnected conductive carbon matrix derived from natural wood acts as an integrated porous current collector to avail the electrons transport and accommodate massive SnS2 nanosheets,while plenty of 3D aligned multichannels facilitate fast ions transport with electrode thickness‐independent even under high mass loading.As expected,the integrated SnS2@3DMCM electrode exhibits remarkable electrochemical lithium storage performance,such as exceptional high‐areal‐capacity of 6.4 mAh cm−2,high rate capability of 3 mAh cm−2 under current of 6.8 mAcm−2(10 C),and stable cycling performance of 6.8 mAcm−2 with a high mass loading of 7mg cm−2.The 3D integrated porous electrode constructing conveniently with the natural source paves new avenues towards future high‐performance lithium batteries. | Hongyi Xu Chengxin Peng Yuhua Yan Fei Dong Hao Sun Junhe Yang Shiyou Zheng | 2019 | Carbon Energy2019，1，2： | 4 |
| 7 | Wear Resistance of Austenitic Steel Fe–17Mn–6Si–0.3C with High Silicon and High Manganese显示文摘To solve the problem of poor wear resistance in conventional Hadfield steels under medium and low stress,a new kind of steel with high silicon and high manganese Fe–17Mn–6Si–0.3C was designed and its wear resistance was studied.The results showed that it exhibited better wear resistance than conventional Hadfield steel in both dry friction and abrasive friction.The better wear resistance of the new steel with high silicon and high manganese resulted from the stressinduced γ→ε martensitic transformation. | Haitao Si Renlong Xiong Fan Song Yuhua Wen Huabei Peng | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，2： | 4 |
| 8 | Preferential CTL targeting of Gag is associated with relative viral control in long-term surviving HIV-1 infected former plasma donors from China显示文摘它通常被相信细胞毒素的 T 淋巴细胞(CTL ) 玩的那 CD8 + 在限制人的免疫不全病毒类型 1 的复制(HIV-1 ) 并且在决定感染的结果,和这效果可以部分优先地取决于产品是哪个 HIV 的一个关键角色指向了。在以前的血浆施主(FPD ) 的一个队探讨在 HIV-1-specific CTL 回答和病毒复制之间的关联,天真的 FPD 与 HIV-1 clade B' 紧张感染了的 143 antiretroviral 治疗与 IFN-γ 为 HIV-1-specific CTL 回答被估计;在由使用盖住整个一致 clade B proteome 的重叠的肽(OLP ) 的单个肽水平的 Elispot 试金。由使用一个枪兵的等级关联分析,当是断然相关到 CD4 计数时,我们发现在全部的病毒特定的 CTL 活动之中的作呕特定的 CTL 回答的比例相反地与病毒的负担被相关,与与增加的病毒的负担被联系并且减少的Pol特定、Env特定的回答对比, CD4 数。另外, Vpr-specifc CTL 回答显示出类似的保护的效果与作呕回答,但是与识别的低得多的频率。显著地,我们也观察了在 HLA 之间的一个协会 --*30/B*13/Cw*06 haplotype 和可能由于的更低的病毒的负担限制了作呕特定的 CTL 回答。因此,我们的数据在疾病控制表明作呕特定的 CTL 回答的突出的角色。HLA 的优点 -- 在病毒的控制的 *30/B*13/Cw*06 haplotype 可以在学习个人与作呕特定的 CTL 回答的贡献被联系。 | Mingming Jia Kunxue Hong Jianping Chen Yuhua Ruan Zhe Wang Bing Su Guoliang Ren Xiaoqing Zhang Zhen Liu Quanbi Zhao Dan Li Hong Peng Marcus Altfeld Bruce D Walker Xu G Yu Yiming Shao | 2012 | Cell Research2012，22，5： | 3 |
| 9 | Horizontal GeSn/Ge multi-quantum-well ridge waveguide LEDs on silicon substrates显示文摘A horizontal p-i-n ridge waveguide emitter on a slion(100)substrate with a Gen,g1Sno.c9/Ge multi quantum-well(MQW)active layer was fabricated by molecular beam epitaxy.The device structure was designed to reduce light absorption of metal electrodes and improve injection efficiency.Electroluminescence(EL)at a wavelength of 2160 nm was observed at room temperature.Theoretical calculations indicate that the emission peak corresponds well to the direct bandgap transition(nr-mHr).The light output power was about 2.0μW with an injection current density of 200 kA/cm^2.These results show that the horizontal GeSn/Ge MQW ridge waveguide emiters have great pros-pects for group-IV light sources. | LINZHI PENG Xu LI ZHI LIU XIANGQUAN LIU JUN ZHENG CHUNLAI XUE YUHUA ZUO BUWEN CHENG | 2020 | Photonics Research2020，8，6： | 3 |
| 10 | The structure differences of Japanese encephalitis virus SA14 and SA14-14-2 E proteins elucidate the virulence attenuation mechanism显示文摘Dear Editor,Japanese encephalitis(JE)is a mosquito-borne acute neurological infectious disease caused by the Japanese encephalitis virus(JEV).Globally,68,000 cases of the disease are estimated each year,with a fatality rate of as high as 30%and with approximately 30%-50%of survivors suffering from severe neurological sequelae(WHO,2015). | Xinyu Liu Xin Zhao Rui Na Lili Li Eberhard Warkentin Jennifer Witt Xu Lu Yongxin Yu Yuquan Wei Guohong Peng Yuhua Li Junzhi Wang | 2019 | Protein & Cell2019，10，2： | 3 |
| 11 | A core-shell structured COYID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity显示文摘Although inoculation of COVID-19 vaccines has rolled out globally,there is still a critical need for safe and effective vaccines to ensure fair and equitable supply for all countries.Here,we report on the development of a highly efficacious mRNA vaccine,SW0123 that is composed of sequence-modified mRNA encoding the full-length SARS-CoV-2 Spike protein packaged in core-shell structured lipopolyplex(LPP)nanoparticles.SWOT 23 is easy to produce using a large-scale microfluidics-based apparatus.The unique core-shell structured nanoparticle facilitates vaccine uptake and demonstrates a high colloidal stability,and a desirable biodistribution pattern with low liver targeting effect upon intramuscular administration.Extensive evaluations in mice and nonhuman primates revealed strong immunogenicity of SW0123,represented by induction of Th1-polarized T cell responses and high levels of antibodies that were capable of neutralizing not only the wild-type SARS-CoV-2,but also a panel of variants including D614G and N501Y variants.In addition,SW0123 conferred effective protection in both mice and non-human primates upon SARS-CoV-2 challenge.Taken together,SW0123 is a promising vaccine candidate that holds prospects for further evaluation in humans. | Ren Yang Yao Deng Baoying Huang Lei Huang Ang Lin Yuhua Li Wenling Wang Jingjing Liu Shuaiyao Lu Zhenzhen Zhan Yufei Wang Ruhan A Wen Wang Peihua Niu Li Zhao Shiqiang Li Xiaopin Ma Luyao Zhang Yujian Zhang Weiguo Yao Xingjie Liang Jincun Zhao Zhongmin Liu Xiaozhong Peng Hangwen Li Wenjie Tan | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 3 |
| 12 | A two-grade approach to ranking interval data显示文摘 | Peng Song Jiye Liang Yuhua Qian | 2011 | Knowledge-Based Systems2011，，： | 2 |
| 13 | Myosin Specific-T Lymphocytes Mediated Myocardial Inflammation in Adoptive Transferred Rats显示文摘Myosin specific-T lymphocytes might mediate myocardial inflammation and remodeling after AMI. Myosin- activated or unactivated T lymphocytes in vitro were transferred into na?ve syngeneic rats, respectively. T lymphocyte infiltration and myocyte apoptosis were explored by the H&E and TUNNEL. Proteins and mRNA levels of cytokines (IL-1β, IL-6 and TNF-α) in myocardium were determined by RT-PCR and immunohisto- chemistry. T lymphocyte infiltration was evidently observed after one week of activated T cell transfer. The expressions of cytokines were elevated markedly one week later. The myocyte apoptosis occurred after T lymphocyte infiltration in myocardium. Our findings suggest that cardiac myosin activated-T lymphocytes may mediate myocardial inflammation and remodeling. | Jin Zhang Yuhua Liao Xiang Cheng Jing Chen Peng Chen Xiang Gao Zhengjenny Zhang | 2006 | Cellular & Molecular Immunology2006，3，6： | 2 |
| 14 | Comprehensive Multi-Level Exploration of Buried Active Faults:an Example of the Yinchuan Buried Active Fault显示文摘The paper introduces the steps and methods of multi-approach,multi-level exploration of buried faults in thick Quaternary sediment regions by taking the test exploration of the Yinchuan active fault as example.Based on the comprehensive analyses of previous data,we choose the Xinqushao Village of Xingqing District of Yinchuan City as the test site for the comprehensive exploration.Firstly,we adopted shallow seismic investigation with group intervals of 10m,5m and 1m to gradually trace layer by layer the master fault of the Yinchuan buried fault from a deep depth to a shallow depth where drilling could be used.Then,with composite geological profile drilling,we determined the precise location and dip angle of the fault.The drilling show the buried depth of the upper offset point is 8.3m.Finally,large-scale trenching revealed that the actual buried depth of the upper offset point of the fault is 1.5m from the ground surface and there are paleoearthquake events of 5 stages.Combined with the preliminary result of corresponding sample age,we conclude the Yinchuan buried fault is a mid to late Holocene active fault. | Chai Chizhang Meng Guangkui Du Peng Wang Yin Liu Baojin Shen Weihua LeiQiyun Liao Yuhua Zhao Chengbin Feng Shaoying Zhang Xuehui Xie Xiaofeng | 2007 | Earthquake Research in China2007，21，3： | 1 |
| 15 | Interleukin 6 protects H<sub>2</sub>O<sub>2</sub>‐induced cardiomyocytes injury through upregulation of prohibitin via STAT3 phosphorylation显示文摘 | Yuhua Jia Fenghua Zhou Peng Deng Qin Fan Chunhua Li Yawei Liu Xiuqiong Fu Yingchun Zhou Xin Xu Xuegang Sun | 2012 | Cell Biochem Funct2012，，5： | 1 |
| 16 | Energy-based adaptive orthogonal FRIT and its application in image denoising显示文摘Efficient representation of linear singularities is discussed in this paper. We analyzed the relationship between the “wrap around” effect and the distribution of FRAT (Finite Radon Transform) coefficients first, and then based on study of some properties of the columnwisely FRAT reconstruction procedure, we proposed an energy-based adaptive orthogonal FRIT scheme (EFRIT). Experiments using nonlinear approximation show its superiority in energy concentration over both Discrete Wavelet Transform (DWT) and Finite Ridgelet Transform (FRIT). Furthermore, we have modeled the denoising problem and proposed a novel threshold selecting method. Experiments carried out on images containing strong linear singularities and texture components with varying levels of addictive white Gaussian noise show that our method achieves prominent improvement in terms of both SNR and visual quality as compared with that of DWT and FRIT. | LIU YunXia PENG YuHua QU HuaiJing YIN Yong | 2007 | Science in China(Series F)2007，50，2： | 1 |
| 17 | Energy-based adaptive trans-form scheme in the DPRT domain and its application to image denoising显示文摘 | Liu Yunxia Peng Yuhua Siu Wan-Chi | 2009 | Signal Processing2009，89，1： | 1 |
| 18 | A Fast Algorithm for YCbCr to RGB Conversion显示文摘 | Yang Yang Peng Yuhua Liu Zhaoguang | | 0，，04： | 1 |
| 19 | A fast algorithm for YCbCr to RGB conversion显示文摘 | Yang Yang Peng Yuhua Liu Zhaoguang | 2007 | IEEE Transactions on Consumer Electronics2007，53，4： | 1 |
| 20 | Unascertained measurement classifying model of goaf collapse prediction显示文摘 | DONG Longjun PENG Gangjian FU Yuhua | 2008 | Journal of Coal Science & Engineering2008，14，2： | 1 |
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