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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors显示文摘 | Shuhang Wang Yongping Song Feifei Yan Delong Liu | 2016 | Frontiers of Medicine2016，10，4： | 21 |
| 3 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 4 | Evaluation of solar aided biomass power generation systems with parabolic trough field显示文摘Solar and biomass are both renewable energy resources.Using biomass as fuel is becoming more and more attractive after governments increase the tariff for the electricity from the renewable sources.However the costs of power from a biomass power generation plant depend greatly on the availability and quality of the biomass resource.The commercialization of solar alone thermal power generation is hindered by its high initial investment and low thermal efficiency.In this paper,a concept of integrating solar into a biomass power generation system is put forward.In the system the oil heated by a parabolic trough solar field is used to replace the extraction steam to preheat the feed water(entering a biomass boiler) and the previous extraction steam thus saved can continue to do work in the lower stages of turbine.The performance of the hybrid system with different replacements is analyzed and compared through two typical solar aided biomass generating units.The results show that the integration not only reduces the consumption of biomass fuel(at the same generation capacity) but is also proved to be an efficient way to convert solar thermal energy into power.The results also show that with the same solar aperture area,the higher the grade of the replaced extraction steam,the better the thermal performance and economy. | HOU HongJuan YANG YongPing HU Eric SONG JiFeng DONG ChangQing MAO Jian | 2011 | Science China(Technological Sciences)2011，54，6： | 15 |
| 5 | Arsenic trioxide and microRNA-204 display contrary effects on regulating adipogenic and osteogenic differentiation of mesenchymal stem cells in aplastic anemia显示文摘我们的以前的研究证明了砷三氧化物(ATO ) 在与无形的贫血症(AA ) 对待病人有临床的功效。然而,机制尚待被阐明。骨头髓的重要部件造血的微型环境,骨头髓间充质的干细胞(BMSC ) ,经常在 AA 病人被改变。在这研究, AA BMSC 是容易的被导致进 adipocytes 而非造骨细胞,这被发现。ATO 治疗能部分至少恢复 AA BMSC 的区别不平衡。我们进一步在 AA BMSC 区别作为一个关键管理者识别了 miR-204。酶记者试金证明 miR-204 能直接绑在 Runx2 mRNA 的 3-untranslated 区域,调整成骨的一个关键抄写因素。而且, adipogenic 区别被支持, osteogenic 区别在 miR-204 被禁止过去表示的房间而成骨被提高, adipocyte 形成在房间被禁止,那失去了 miR-204 功能,它建议了它的内长的功能。一起我们证明 ATO 能禁止 adipogenic 区别,但是在 AA BMSC 支持 osteogenic 区别,在 AA 病人为 ATO 临床的功效提供可能的解释。MiR-204 戏在调整 BMSC 区别的一个关键角色,和下面调整的 miR-204 表示可能是新奇策略对待 AA。 | Junmei Zhao Chao Wang Yongping Song Baijun Fang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，10： | 7 |
| 6 | Chinese expert consensus on the management of chimeric antigen receptor T cell therapy-associated coagulopathy显示文摘Chimeric antigen receptor T-cell(CAR-T)therapy has greatly improved the disease remission rate and long-term survival rate of patients with relapsed/refractory hematological malignancies.[1-3]Currently,several commercial CAR-T products are available in the market and numerous CAR-T clinical trials have been conducted.Attention should be paid to the safety of CAR-T therapy.The main adverse effects of CAR-T therapy are cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS).[4] | Heng Mei Fangping Chen Yue Han Ming Hou He Huang Xiaojun Huang Yuhua Li Aibin Liang Qifa Liu Ting Niu Jun Peng Wenbin Qian Yongping Song Jianxiang Wang Ying Wang Depei Wu Kailin Xu Linhua Yang Renchi Yang Lei Zhang Liansheng Zhang Xi Zhang Xiaohui Zhang Weili Zhao Weidong Han Yu Hu | 2022 | Chinese Medical Journal2022，，14： | 4 |
| 7 | Sintilimab for relapsed/refractory extranodal NK/T cell lymphoma: a multicenter, single-arm, phase 2 trial (ORIENT-4)显示文摘This study(ORIENT-4)aimed to assess the efficacy and safety of sintilimab,a humanized anti-PD-1 antibody,in patients with relapsed/refractory extranodal NK/T cell lymphoma(r/r ENKTL).ORIENT-4 is a multicenter,single-arm,phase 2 clinical trial(NCT03228836).Patients with r/r ENKTL who failed to at least one asparaginase-based regimen were enrolled to receive sintilimab 200 mg intravenously every 3 weeks for up to 24 months.The primary endpoint was the objective response rate(ORR)based on Lugano 2014 criteria.Twenty-eight patients with r/r ENKTL were enrolled from August 31,2017 to February 7,2018.Twenty-one patients(75.0%,95%CI:55.1–89.3%)achieved an objective response.With a median follow-up of 30.4 months,the median overall survival(OS)was not reached.The 24-month OS rate was 78.6%(95%CI,58.4–89.8%).Most treatment-related adverse events(TRAEs)were grade 1–2(71.4%),and the most common TRAE was decreased lymphocyte count(42.9%).Serious adverse events(SAEs)occurred in 7(25.0%)patients,and no patient died of adverse events.Sintilimab is effective and well tolerated in patients with r/r ENKTL and could be a novel therapeutic approach for the control of ENKTL in patients. | Rong Tao Lei Fan Yongping Song Yu Hu Wei Zhang Yafei Wang Wei Xu Jianyong Li | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 4 |
| 8 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 9 | Poor outcomes of immunoglobulin D multiple myeloma patients in the era of novel agents:a single-center experience显示文摘Dear Editor, Multiple myeloma (MM) is a disease characterized by the clonal expansion of malignant plasma cells in the marrow, leading to anemia, hypercalcemia, bone lesion, and renal dysfunction [1]. Immunoglobulin D (IgD) myeloma is a rare subtype of MM, accounting for approximately 1% to 2% of all MM patients [2]. It occurs at a young age, often accom-panied with a high disease burden and short median sur-vival (18-21 months) [3, 4]. Several studies have suggested that in patients with IgD subtype, the outcomes of those who have had undergone autologous stem cell transplanta-tion (ASCT) were superior than those treated with chemo-therapy alone [5, 6]. However, these have been debatable as other reports have displayed opposite results [7, 8]. | Qian Zhao Feng Li Ping Song Xiaogang Zhou Zhiming An Jiangang Mei Jingjing Shao Hanqing Li Xuli Wang Xing Guo Yongping Zhai | 2019 | Cancer Communications2019，39，1： | 3 |
| 10 | Reduced intensity conditioning and co-transplantation of unrelated peripheral stem cells combined with umbilical cord mesenchymal stem/stroma cells for young patients with refractory severe aplastic anemia显示文摘 | Yuewen Fu Qian Wang Jian Zhou Shengquan Liu Baijun Fang Xudong Wei Yongping Song | 2013 | International Journal of Hematology2013，，6： | 2 |
| 11 | Venetoclax and low-dose cytarabine induced complete remissionin a patient with high-risk acute myeloid leukemia: a case report显示文摘Conventional combination therapies have not resulted in considerable progress in the treatment ofacute myeloid leukemia (AML). Elderly patients with AML and poor risk factors have grave prognosis.Midostaurin has been recently approved for the treatment of FLT-3-mutated AML. Venetoclax, a BCL-2 inhibitor,has been approved for the treatment of relapsed and/or refractory chronic lymphoid leukemia. Clinical trials onapplying venetoclax in combination with cytarabine and other agents to treat various hematological malignanciesare currently underway. Here, we present a case of a male patient with poor performance status and whodeveloped AML following allogeneic hematopoietic stem cell transplant for high-risk myelodysplasia. The patientwith high risk AML achieved complete response to the combined treatment regimen of low-dose cytarabine andvenetoclax. Furthermore, we reviewed current clinical trials on the use of venetoclax for hematologicalmalignancies. | Bingshan Liu Roshni Narurkar Madhura Hanmantgad Wahib Zafar Yongping Song Delong Liu | 2018 | Frontiers of Medicine2018，12，5： | 2 |
| 12 | Culturing adequate CAR-T cells from less peripheral blood to treat B-cell malignancies显示文摘Objective:Chimeric antigen receptor-modified T(CAR-T)cells have shown impressive results against relapsed/refractory B cell malignancies.However,the traditional manufacture of CAR-T cells requires leukapheresis to isolate large amounts of peripheral blood T cells,thus making some patients ineligible for the procedure.Methods:We developed a simple method for CAR-T cell preparation requiring small volumes of peripheral blood.First,CD3+T cells isolated from 50 mL peripheral blood from patients(B-cell malignancies)were stimulated with immobilized anti-CD3/RetroNectin in 6-well plates and then transduced with CAR-expressing lentiviral vector.After 4 d,the T cells were transferred to culture bags for large-scale CAR-T cell expansion.In vitro and animal experiments were performed to evaluate the activity of the manufactured CAR-T cells.Finally,29 patients with B-cell acute lymphoblastic leukemia(B-ALL)and 9 patients with B-cell lymphoma were treated with the CAR-T cells.Results:The CAR-T cells were expanded to 1–3×10^(8) cells in 8–10 d and successfully killed B cell-derived malignant tumor cells in vitro and in vivo.For patients with B-ALL,the complete remission rate was 93%1 month after CAR-T cell infusion;after 12 months,the overall survival(OS)and leukemia-free survival rates were 69%and 31%,respectively.For patients with lymphoma,the objective response rate(including complete and partial remission)was 78%2 months after CAR-T cell infusion,and after 12 months,the OS and progression-free survival rates were 71%and 43%,respectively.Cytokine-release syndrome(CRS)occurred in 65.51%and 55.56%of patients with B-ALL and B-cell lymphoma,respectively;severe CRS developed in 20.69%of patients with B-ALL and in no patients with lymphoma.Conclusions:Our novel method can generate sufficient numbers of CAR-T cells for clinical use from 50–100 mL peripheral blood,thus providing an alternative means of CAR-T cell generation for patients ineligible for leukapheresis. | Lu Han Jian Zhou Linlin Li Keshu Zhou Lingdi Zhao Xinghu Zhu Qingsong Yin Yufu Li Hongqin You Jishuai Zhang Yongping Song Quanli Gao | 2021 | Cancer Biology & Medicine2021，18，4： | 2 |
| 13 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hp00b90ocp9wk6bvw.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 14 | Effect of sericin on diabetic hippocampal growth hormone/insulin-like growth factor 1 axis显示文摘Previous studies have shown that sericin extracted from silk cocoon significantly reduces blood glucose levels and protects the nervous system against diabetes mellitus. In this study, a rat type 2 diabetes mellitus model was established by intraperitoneal injection of 25 mg/kg streptozotocin for 3 successive days, following which the rats were treated with sericin for 35 days. After treatment, the blood glucose levels of the diabetic rats decreased significantly, the growth hormone level in serum and its expression in the hippocampus decreased significantly, while the insulin-like growth factor-1 level in serum and insulin-like growth factor-1 and growth hormone receptor expression in the hippocampus increased significantly. The experimental findings indicate that sericin improves disorders of the growth hormone/insulin-like growth factor 1 axis to alleviate hippocampal damage in diabetic rats. | Zhihong Chen Songhe Yang Yaqiang He Chengjun Song Yongping Liu | 2013 | Neural Regeneration Research2013，8，19： | 2 |
| 15 | Characterization of a Novel Weak Allele of RGA1/D1 and Its Potential Application in Rice Breeding显示文摘Semi-dwarfing improves the lodging resistance and yield of rice,and the vast majority of modern rice varieties harbor the sd1 allele to decrease plant height,resulting in reduced genetic diversity and negative agronomic traits.Thus,exploring alternative sources of dwarfism is imperative for rice breeding.Here,we identified a novel RGA1 allele,d1-w,from a local indica variety Xiaolixiang(XLX)using a map-based cloning approach.Compared with other rice varieties,RGA1 in XLX contained a unique single nucleotide polymorphism that resulted in an additional transcript and reduced functional RGA1 transcript level.The RGA1 from Nipponbare was introduced into XLX to estimate the value of d1-w in rice breeding.Compared with transgenic XLX plants(XLX^(D1)),XLX exhibited reduced plant height,increased stem strength,lower reactive oxygen species accumulation,delayed senescence,stronger photosynthesis,higher grain yield and quality(including external,milling and nutritional qualities),and enhanced resistance to drought and Rhizoctonia solani.Therefore,we proposed that the d1-w allele has potential as an excellent dwarfism resource for rice breeding. | LIU Yantong LI Ting JIANG Zhishu ZENG Chuihai HE Rong QIU Jiao LIN Xiaoli PENG Limei SONG Yongping ZHOU Dahu CAI Yicong ZHU Changlan FU Junru HE Haohua XU Jie | 2022 | Rice science2022，29，6： | 2 |
| 16 | Single-crystal microplates of two-dimensional organic-inorganic lead halide layered perovskites for optoelectronics显示文摘器官无机的混合 perovskites 在高效率的太阳能电池和轻排放由于他们的应用吸引可观的注意。与三维的 perovskites 相比,二维(2D ) 分层的混合 perovskites 有一个更高的激子绑定精力和潜在地更高的轻排放的效率。因为他们能是为综合光电子的合适的积木,有明确的 nanoscale 形态学的高质量的水晶的 2D perovskites 的生长是合乎需要的并且(nano ) photonics。此处,我们基于 2-phenylethylammonium 报导 2D perovskites 的单个水晶的 microplates 的灵巧的答案生长( C 6 H 5 CH 2 CH 2 NH 3+,豌豆)阳离子,(豌豆) 2 PbX 4( X = Br ,我),与通过一个溶解再结晶过程的明确的矩形的几何学和 nanoscale 厚度。水晶结构(豌豆)2 PbX 4 首先用单个水晶的 X 光检查衍射被证实。一个答案阶段运输生长过程被开发在与与铅醋酸盐先锋电影涂的底层不同的另一干净底层上与几百纳米的十测微计和厚度的一种典型尺寸种 microplates。表面地形学分析建议 2D microplates 的形成被婚礼蛋糕生长机制多半驾驶。通过卤化物 alloying,光致发光排放(豌豆)2 Pb (Br,我) 有狭窄的山峰带宽的 4 perovskites 乐意地被调节从紫(~ 410 nm ) 到绿色(~ 530 nm ) 。 | Dewei Ma Yongping Fu Lianna Dang Jianyuan Zhai Ilia A. Guzei Song Jin | 2017 | Nano Research2017，10，6： | 2 |
| 17 | The Active Sites and Corresponding Stability Challenges of the M-N-C Catalysts for Proton Exchange Membrane Fuel Cell显示文摘Proton exchange membrane fuel cells(PEMFCs)as promising alternatives to traditional internal combustion engines have attracted massive concerns to promote their wide application in society.However,the biggest challenge to the commercialization of PEMFCs remains the high cost due to the adoption of the platinum group metal(PGM)catalysts in the cathode. | Ruolin Peng Zhongkun Zhao Hongmin Sun Yongping Yang Tinglu Song Yao Yang Jiankun Shao Haibo Jin Hongtao Sun Zipeng Zhao | 2023 | Chinese Journal of Chemistry2023，41，6： | 1 |
| 18 | Twelve years' experience and clinical results of using the radial artery for coronary revascularization显示文摘 | Cheng Zhaoyun Zhao Ziniu Quan Xiaoqiang Wang Sheng Zhao Jian Sun Junjie Hu Junlong Gao Chuanyu Song Yongping | 2014 | Chinese Medical Journal2014，，5： | 1 |
| 19 | Association of Myeloid-derived Suppressor Cells and Efficacy of Cytokine-induced Killer Cell Immunotherapy in Metastatic Renal Cell Carcinoma Patients显示文摘 | Zibing Wang Yong Zhang Yuqing Liu Li Wang Lingdi Zhao Tiejun Yang Chaohong He Yongping Song Quanli Gao | 2014 | Journal of Immunotherapy2014，，： | 1 |
| 20 | Effect of homogenization temperature on microstructure and mechanical properties of low-carbon high-boron cast steel显示文摘 | Fu Hanguang Song Xuding Lei Yongping | | 0，，03： | 1 |
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