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| 1 | 代谢型谷氨酸受体可作为一种新型恶性胶质瘤治疗靶点(英文)显示文摘Objective Metabotropic glutamate receptors(mG luR)are predominantly involved in maintenance of cellular homeostasis of central nervous system.However,evidences have suggested other roles of mG luR in human tumors.Aberrant mG luR signaling has been shown to participate in transformation and maintenance of various cancer types,including malignant brain tumors.This review intends to summarize recent findings regarding the involvement of mG luR-mediated intracellular signaling pathways in progression,aggressiveness,and recurrence of malignant gliomas,mainly glioblastomas(GBM),highlighting the potential therapeutic applications of mG luR ligands.In addition to the growing number of studies reporting mG luR gene or protein expression in glioma samples(resections,lineages,and primary cultures),pharmacological blockade in vitro of mG luR1 and mG luR3 by selective ligands has been shown to be anti-proliferative and anti-migratory,decreasing activation of MAPK and PI3K pathways.In addition,mG luR3 antagonists promoted astroglial differentiation of GBM cells and also enabled cytotoxic action of temozolomide(TMZ).mG luR3-dependent TMZ toxicity was supported by increasing levels of MGMT transcripts through an intracellular signaling pathway that sequentially involves PI3K and NF-κB.Further,continuous pharmacological blockade of mG luR1 and mG luR3 have been shown to reduced growth of GBM tumor in two independent in vivo xenograft models.In parallel,low levels of mG luR3 mRNA in GBM resections may be a predictor for long survival rate of patients.Since several Phase I,II and III clinical trials are being performed using group I and II mG luR modulators,there is a strong scientifically-based rationale for testing mG luR antagonists as an adjuvant therapy for malignant brain tumors. | Pereira MS Klamt F Thomé CC Worm PV de Oliveira DL | 2017 | 中华神经外科疾病研究杂志2017，16，1： | 3 |
| 2 | Beta 2 adrenoceptor functional gene variants,obesity,and blood pressure level interactions in the general population显示文摘 | Floriano MS Mota GF | 2003 | Hypertension2003，42，： | 1 |
| 3 | Aortic valve replacement in patients with mild or moderate aortic stenosis and coronary bypass surgery显示文摘 | Pereira JJ Balaban K Lauer MS | 2005 | Am J Med2005，118，7： | 1 |
| 4 | Brachyury and related Tbx proteins interact with the Mixll homeodomain protein and negatively regulate Mixll transcriptional activity 显示文摘 | Pereira LA Wong MS Lim SM | 2011 | PLoS One2011，6，28： | 1 |
| 5 | Beta2 adrenoceptor functional gene variants,obesity,and blood pressure level interactions in the general population显示文摘 | Pereira AC Floriano MS Mota GF | 2003 | Hypertension2003，42，4： | 1 |
| 6 | Relationship between gap size and dentine secondary caries formation assessed in a micro- cosm biofilm model 显示文摘 | Cenci MS Pereira - Cenci T Cury JA | 2009 | Caries Research2009，43，2： | 1 |
| 7 | The pattern recognition receptors Nodl and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila显示文摘 | Frutuoso MS Hori JI Pereira MS | 2010 | Microbes Infect2010，12，11： | 1 |
| 8 | Impact dynamics of multi-body systems with frictional contact using joint coordinates and canonical equations of motion显示文摘 | Nikravesh PE Pereira MS | 1996 | Non-linear Dynamic (S0924-090X)1996，9，1： | 1 |
| 9 | Antithrombin-mediated anticoagulant activity of sulfated polysaccharides显示文摘 | Melo FR Pereira MS Fogue | 2004 | Journal of Biological Chemistry2004，279，20： | 1 |
| 10 | Walled-off pancreatic necrosis and other current concepts in the radiological assessment of acute pancreatitis显示文摘 | Cunha EF Rocha MS Pereira FP | 2014 | Radiologia brasileira2014，47，3： | 1 |
| 11 | The prognostic value of cyclin D1 in renal cell carcinoma显示文摘 | Lima MS Pereira RA Costa RS | 2014 | Int Urol Nephrol2014，46，5： | 1 |
| 12 | Evaluation of unlicensed and offlabel antiepileptic drugs prescribed to children:Brazil-ian Regulatory Agency versus FDA显示文摘 | Borges AP Campos MS Pereira LR | 2013 | Int J Clin Pharm2013，35，3： | 1 |
| 13 | Asymmetrical hippocampal connectivity in mesial temporal lobe epilepsy: evidence from resting state fMRI显示文摘 | Pereira FR Alessio A Sercheli MS | 2010 | BMC Neurosci2010，11，： | 1 |
| 14 | The imaging and pathological features of a mucinous tubular and spindle cell carcinoma of the kidney:a case report显示文摘 | Lima MS Barros-Silva GE Pereira RA | | 0，，： | 1 |
| 15 | Teleconsultations to provide support for primary care practitioners and improve quality of care-the experience of a large scale telehealth service in brazil 显示文摘 | Marcolino MS Pereira Afonso dos Santos J Santos Neves D | 2015 | Stud Health Technol Inform2015，216，： | 1 |
| 16 | Structure and anticoagulant activity of sulfated fucans: Comparison between the regular repetitive and linear fucans from echinoderms with the more heterogeneous and branched polymers from brown algae显示文摘 | Pereira MS Mulloy B Mourao PA | 1999 | J Biol Chem1999，274，： | 1 |
| 17 | Meiotic segrega- tion and interchromosomal effect in the sperm of adouble translocation carrier : a case report 显示文摘 | Juchniuk de Vozzi MS Santos SA Pereira CS | 2009 | Mol Cytogenet2009，1，2： | 1 |
| 18 | The imaging and pathological features of a mueinous tubular and spindle cell carcinoma of the kidney: a ease report 显示文摘 | Lima MS Barros-Silva GE Pereira RA | 2013 | World J Surg Oncol2013，11，1： | 1 |
| 19 | The medicinal plant Porana volubilis contains polysaccharides with anticoagulant activity mediated by heparin cofactor Ⅱ显示文摘 | YOON SJ PEREIRA MS PAVAO MSG | 2002 | Thromb Res2002，106，1： | 1 |
| 20 | structure and anticoagulant activity of a fucosylated chondroitin sulfate from echinoderm显示文摘 | Mourao PAS Pereira MS Pavao MSG | 1996 | J Bio Chem1996，271，23： | 1 |
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