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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | 显示文摘 | PHELPS T J PALUMBO A V BELIAEV A S | 2002 | Current Opinion in Biotechnology2002，13，1： | 1 |
| 3 | Gas metabolism evidence in support of the juxtaposition of hydrogen-producing and methanogenic bacteria in sewage sludge and lake sediments 显示文摘 | Conrad R Phelps T J Zeikus J G | 1985 | Applied and Environmental Microbiology1985，50，3： | 1 |
| 4 | Production of alpha 1,3-galactosyltransferase-deficient pigs显示文摘 | Phelps C J Koike C Vaught T D | 2003 | Science2003，299，： | 1 |
| 5 | Use of tactile and visual cues in consumer judgments of appleripeness显示文摘 | RICHARDSON N H PHELPS T MCDERMOTT S GUNSON A | 1998 | Journal of Sensory Studies1998，13，2： | 1 |
| 6 | Biogeochemical dynamics in zerovalent iron columns: implications for permeable reactive barriers 显示文摘 | Gu B Phelps T J Liang L | 1999 | Environmental Science and Technology1999，33，13： | 1 |
| 7 | Production of monosex male black crappie, Pornoxis nigromaculatus, populations by multiple androgen immersion显示文摘 | ARALAN T PHELPS R P | 2004 | Aquaculture2004，234，14： | 1 |
| 8 | Positive streamer system intensification and its possible role in lightning initiation显示文摘 | Phelps C T | 1974 | Journal of Atmospheric and Terrestrial Physics1974，36，1： | 1 |
| 9 | Microsatellite repeat variation within the yl gene of maize and teosinte显示文摘 | Phelps T L Hall A E Buckner B | 1996 | The Journal of Heredity1996，87，： | 1 |
| 10 | The effects of air pressure and water vapour content on the propagation of positive corona streamers, and their im- plications to lightning initiation显示文摘 | Griffiths R F Phelps C T | 1976 | Quarterly Journal of the Royal Meteorological Society1976，102，432： | 1 |
| 11 | Lack of skin fibrosis in tight skin(TSK) mice with targeted mutation in the interleukin -4R alpha and transforming growth factor-beta genes显示文摘 | Mcgaha T Saito S Phelps RG | 2001 | Invest Dermatol2001，116，1： | 1 |
| 12 | Production of alpha-l, 3- galactosyltransferase-deficient pigs显示文摘 | Phelps C J Koike C Vaught T D | 2003 | Science2003，299，： | 1 |
| 13 | A model for lightning initiation arising from positive corona streamer development显示文摘 | Griffiths R F Phelps C T | 1976 | Journal of Geophysical Re- search1976，81，21： | 1 |
| 14 | Production of alpha-1, 3- galactosyltransferase-deficient pigs 显示文摘 | Phelps C J Koike C Vaught T D | 2003 | Science2003，299，5605： | 1 |
| 15 | Surfactant protein A, an innate immune factor, is expressed in the vaginal mucosa and is present in vaginal lavage fluid显示文摘 | MacNeill C Umstead T M Phelps D S | 2004 | Immunology2004，111，： | 1 |
| 16 | Production of α1,3-galactosyltransferase-deficient pigs显示文摘 | PHELP C J KOIKE C VAUGHT T D | 2003 | Science2003，299，： | 1 |
| 17 | Dependence of positive streamer propagation on air pressure and water vapour content显示文摘 | Phelps C T Griffiths R F | 1976 | J Appl Phys1976，47，7： | 1 |
| 18 | Survival of subsurface microorganisms exposed to UV radiation and hydrogen peroxide显示文摘 | ARRAGE A A PHELPS T J BENOIT R E | 1993 | Applied and Environmental Microbiology1993，59，11： | 1 |
| 19 | Biogeochemical dynamics in zero-valent iron columns: Implications for permeable reactive barriers 显示文摘 | Gu B Phelps T J Liang L | 1999 | Environ Sci Technol1999，33，13： | 1 |
| 20 | Multi-institutional phase Ⅱ study of selumetinib in patients with metastatic biliary cancers显示文摘 | Bekaii-Saab T Phelps MA Li X | | 0，，17： | 1 |
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