|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Three-dimensional printing for heart diseases: clinical application review显示文摘Heart diseases remain the top threat to human health,and the treatment of heart diseases changes with each passing day.Convincing evidence shows that three-dimensional(3D)printing allows for a more precise understanding of the complex anatomy associated with various heart diseases.In addition,3D-printed models of cardiac diseases may serve as effective educational tools and for hands-on simulation of surgical interventions.We introduce examples of the clinical applications of different types of 3D printing based on specific cases and clinical application scenarios of 3D printing in treating heart diseases.We also discuss the limitations and clinically unmet needs of 3D printing in this context. | Yanyan Ma Peng Ding Lanlan Li Yang Liu Ping Jin Jiayou Tang Jian Yang | 2021 | Bio-Design and Manufacturing2021，4，3： | 3 |
| 2 | Accessible chromatin regions and their functional interrelations with gene transcription and epigenetic modifications in sorghum genome显示文摘Accessible chromatin regions(ACRs)provide physical scaffolds to recruit transcriptional co-regulators and displace their nearby nucleosomes in multiple plant species.Characterization of ACRs and investigation of their biological effects in Sorghum bicolor has lagged behind.Regulation of gene expression relies on the transcriptional co-regulators that are recruited to ACRs to affect epigenomic modifications of surrounding nucleosomes.In this study,we employed transposase-accessible chromatin sequencing to identify ACRs and decipher how the presence of ACRs affects gene expression and epigenetic signatures in the Sorghum genome.As a result,21077 ACRs,which are mapped to 22.9%of genes and 2.7%of repeats,were identified.The profiling of ACRs on gene structures reveals a narrow and sharp peak around the transcription start site,with relatively weak and broad signals covering the entire gene body and an explicit but wide peak from the transcription termination site to its downstream regions.We discovered that the correlations between gene expression levels and profiled ACR densities are dependent on the positions of ACRs.The occurrence of genic ACRs cumulatively enhances the transcriptional activity of intergenic ACR-associated genes.In addition,an intricate crosstalk among ACRs,gene expression,and epigenetic marks has been unveiled by integrating multiple-omics analyses of whole-genome bisulfite sequencing,6mA immunoprecipitation followed by sequencing,RNA sequencing,chromatin immunoprecipitation sequencing,and DNase I hypersensitive sites sequencing datasets.Our study provides a genome-wide landscape of ACRs in sorghum,decrypts their interrelations with various epigenetic marks,and sheds new light on their roles in transcriptional regulation. | Chao Zhou Zhu Yuan Xueping Ma Huilan Yang Ping Wang Lanlan Zheng Yonghong Zhang Xiaoyun Liu | 2021 | Plant Communications2021，2，1： | 2 |
| 3 | The Design of UWB Antenna for Mobile Phone and the Antenna Influence on Human Head Model显示文摘In order to improve the performance of the antenna at low frequency,short circuit branch and coupling feed structure are introduced into the folded broadband single antenna in this paper,then resonant frequency is merged into the antenna using method of stagger tuning,finally,a UWB antenna is designed to w ork betw een 800 MHz ~ 2700 MHz. Analysis are conducted to determine the antenna's properties. The short-circuit w ire location,feeding point location and the length of folded strip are discussed in detail. The SAR is calculated by HFSS simulation softw are w hile the antenna is close to a 3D human head model. The research results show that the antenna can cover eight commonly used commercial frequency bands at present,and electromagnetic radiation of the antenna has tiny influence on the human head model. | PING Lanlan WU Dongsheng PENG Jinhua JIN Haihong ZHANG Jing | 2017 | Instrumentation2017，4，2： | 1 |
| 4 | Fabrication, characterization and photocatalytic activity of Gd 3+ -doped titania nanoparticles with mesostructure显示文摘 | De Zhao Tianyou Peng Min Liu Lanlan Lu Ping Cai | 2008 | Microporous and Mesoporous Materials2008，，1： | 1 |
| 5 | Activation of lineage competence in hemogenic endothelium precedes the formation of hematopoietic stem cell heterogeneity显示文摘Hematopoietic stem and progenitor cells (HSPCs) are considered as a heterogeneous population, but precisely when, where and how HSPC heterogeneity arises remain largely unclear. Here, using a combination of single-cell multi-omics, lineage tracing and functional assays, we show that embryonic HSPCs originate from heterogeneous hemogenic endothelial cells (HECs) during zebrafish embryogenesis. Integrated single-cell transcriptome and chromatin accessibility analysis demonstrates transcriptional heterogeneity and regulatory programs that prime lymphoid/myeloid fates at the HEC level. Importantly, spi^(2+) HECs give rise to lymphoid/myeloid-primed HSPCs (L/M-HSPCs) and display a stress-responsive function under acute inflammation. Moreover, we uncover that Spi2 is required for the formation of L/M-HSPCs through tightly controlling the endothelial-to-hematopoietic transition program. Finally, single-cell transcriptional comparison of zebrafish and human HECs and human induced pluripotent stem cell-based hematopoietic differentiation results support the evolutionary conservation of L/M-HECs and a conserved role of SPI1 (spi2 homolog in mammals) in humans. These results unveil the lineage origin, biological function and molecular determinant of HSPC heterogeneity and lay the foundation for new strategies for induction of transplantable lineage-primed HSPCs in vitro. | Jun Xia Mengyao Liu Caiying Zhu Shicheng Liu Lanlan Ai Dongyuan Ma Ping Zhu Lu Wang Feng Liu | 2023 | Cell Research2023，33，6： | 0 |
| 6 | Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition model显示文摘我们评估了 calpain 的角色 integrin 的劈开相关的变化在 integrin IIb3 的 3 细胞质的尾巴用一个 trans 主导的抑制模型的双向发信号。妄想的 Tac-3 蛋白质(即, Tac-3 , Tac-3741 , Tac-3747 , Tac-3754 , Tac-3759 ,并且 Tac-3NITY )由组成细胞外并且人的 IL-2 受体( Tac )和人的 integrin 的 transmembrane 领域 3 细胞质的领域稳定地在怀有人的 glycoprotein Ib-IX 和野类型的 integrin IIb3 的 123 个 CHO 房间被表示。不同房间是为稳定的粘附,并且为在外面在里面代表并且在内外面分别地表明事件的有约束力的可溶的纤维蛋白原的 assayed 并且在使不能调动的纤维蛋白原上传播。禁止的妄想的蛋白质 Tac-3,和 Tac-3NITY 部分稀释了稳定的粘附并且传播。Tac-3, Tac-3759, Tac-3NITY,和 Tac-3754,然而并非 Tac-3747 或 Tac-3741,损害了可溶的纤维蛋白原绑定。结果显示双向发信号被 Tac-3 和 Tac-3NITY 显著地禁止,虽然到更小的程度。而且,仅仅在内外面发信号在 123/Tac-3759 和 123/Tac-3754 房间被损害与相对照一在 123/Tac-3747 和 123/Tac-3741 房间的未经触动的双向发信号。在结论, integrin 的 calpain 劈开 3 在由与细胞质的蛋白质打断它的相互作用而非改变它的符合构造发信号上导致了规章的效果,并且可以因此调整血小板功能。 | Jiansong Huang Yulan Zhou Xiaoyu Su Yuanjing Lyu Lanlan Tao Xiaofeng Shi Ping Liu Zhangbiao Long Zheng Ruan Bing Xiao Wenda Xi Quansheng Zhou Jianhua Mao Xiaodong Xi | 2016 | Frontiers of Medicine2016，10，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员