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| 1 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 2 | 血脂、脂蛋白和载脂蛋白作为心肌梗死风险标志物(INTER-HEART研究):在52个国家进行的一项病例对照研究显示文摘背景载脂蛋白作为冠心痛的标志物是否优于血脂和脂蛋白,目前存在广泛争议。本研究旨在对载脂蛋白和胆固醇作为急性心肌梗死风险指标进行比较.
方法在52个国家的12461例急性心肌梗死患者和14637例年龄(±5岁)、性别匹配的对照者中进行了一项有关急性心肌梗死的大型、标准化病例对照研究。获得了9345例急性心肌梗死患者和12120例对照者的非空腹血液样本。测定了血脂、脂蛋白和载脂蛋白浓度,并计算了胆固醇和栽脂蛋白比值通过比较五分位数的上四位与最低位,计算每一总体测值和每一种族组的优势比(0R)及其95%CI以及人群归因危险度(PAR)。
结果载脂蛋白B100(ApoB)/载脂蛋白A1(ApoA1)比值的PAR最高(54%),其每一标准差差别的OR最高(1.59,95%CI1.53~1.64)。LDL胆固醇/HDL-胆固醇比值的PAR为37%;总胆固醇/HDL-胆固醇的PAR为32%,其显著低于ApoB/A1比值的PAR(P〈0.0001)。这些结果在所有种族组、男女两性组及所有年龄组均一致。
结论在所有种族组、男女两性组及所有年龄组,非空腹ApoB/A1比值在评估急性心肌梗死风险方面优于任何胆固醇比值,其应当被引入全世界的临床实践中。 | Matthew J McQueen Steven Hawken Xingyu Wang Stephanie Ounpuu Allan Sniderman Jeffrey Probstfield Krisela Steyn John E Sanderson Mahammad Hasani Emilia Volkova Khawar Kazmi Salim Yusuf 郭战宏(译) | 2008 | 世界临床医学2008，2，6： | 3 |
| 3 | High density lipoprotein cholesterol and cardiovascular disease:four prospective American studies显示文摘 | Gordon D J Probstfield J L Garrison R J | 1989 | Circulation1989，29，： | 1 |
| 4 | High density lipoprotein cholesterol and cardiovascular disease:four prospective American studies显示文摘 | Gordon D J Probstfield J L Garrison R J | 1989 | Circulation1989，29，： | 1 |
| 5 | High density lipoprotein cholesterol and cardiovascular disease: four prospective American studies 显示文摘 | Gordon D J Probstfield JL Garrison RJ | 1989 | Circulation1989，79，： | 1 |
| 6 | Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study显示文摘 | Matthew J McQueen Steven Hawken Xingyu Wang Stephanie Ounpuu Allan Sniderman Jeffrey Probstfield Krisela Steyn John E Sanderson Mohammad Hasani Emilia Volkova Khawar Kazmi Salim Yusuf | 2008 | The Lancet2008，，9634： | 1 |
| 7 | Progression of cardiovascular damage: the role of renin-angiotensin system blockade 显示文摘 | Probstfield J L O'Brien K D | 2010 | Am J Cardiol2010，105，1： | 1 |
| 8 | 2型糖尿病患者收缩压的控制:3种干预措施的有效性比较显示文摘该研究在超重和肥胖的成人2型糖尿病患者中评估易于实施的3种控制血压的方式[着重于减肥的强化生活方式干预(intensive life style intervention,ILI);以目标为基础的血压监测与药物治疗;健康教育和帮助]的相对效能。 | espeland ma probstfield j hire d redmon jb evans gw coday m lewis ce johnson kc wilmoth s bahnson j dulin mf green jb knowler wc kitabchi a murillo al osei k rehman su cushman wc 无 陈云(编译) 叶鹏(审校) | 2016 | 中华高血压杂志2016，24，1： | 1 |
| 9 | High-density lipoprotein cholesterol and cardio-vascular disease: fore prospective American studies显示文摘 | GORDON D J PROBSTFIELD J L GARRISON R | 1989 | Circulation1989，79，： | 1 |
| 10 | High- density lipoprotein cholesterol and cardiovascular disease: four prospective American studies 显示文摘 | GORDON D J PROBSTFIELD J L GARRISON R J | 1989 | Circulation1989，79，1： | 1 |
| 11 | Surrogate endpoints in clinical trials: cardiovascular diseases 显示文摘 | WITrES J LAKATOS E PROBSTFIELD J | 1989 | Statistics in Medicine1989，8，4： | 1 |
| 12 | Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy 显示文摘 | Boden W E Probstfield J L Anderson T | 2011 | N Engl J Med2011，365，24： | 1 |
| 13 | High- density lipoprotein cholesterol and coronary heart dis- ease in hypereholesterolemic men: the lipid research clinics coronary primary prevention trial显示文摘 | Gordon D J Knoke J Probstfield JL | 1986 | Circula- tion1986，74，6： | 1 |
| 14 | High-density lipoprotein cholesterol and cardiovascular disease:fore prospective American studies 显示文摘 | GORDON D J PROBSTFIELD J L GARRISON R | 1989 | Circulation1989，79，： | 1 |
| 15 | Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy显示文摘 | AIM-HIGH INVESTIGATORS BODEN W E PROBSTFIELD J L | 2011 | N Engl J Med2011，365，： | 1 |
| 16 | High-density lipoprotein cholesterol and cardiovascular disease:four prospective American studies显示文摘 | Gordon DJ Probstfield JL Garrison R J | | 0，，： | 1 |
| 17 | High-density Lipo protein Cholesterol and Coronary Heart Disease in Hyperchol esterolemic Men: The Lipid Research Clinics Coronary Prima ry Prevention Trial显示文摘 | Gordon DJ Knoke J Probstfield JL | 1986 | Circulation ( S0009 -- 7322)1986，74，： | 1 |
| 18 | High-density lipoprotein cholesterol and coronary heart disease in hypercholesterolemic men: The Lipid Research Clinics Coronary Primary Prevention TriM显示文摘 | Gordon DJ Knoke J Probstfield JL | 1986 | Circulation1986，74，6： | 1 |
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