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| 1 | Isolation and Identification of Cancer Stem-Like Cells from Murine Melanoma Cell Lines显示文摘In current study,cancer stem-like cells in the murine melanoma B16F10 cells were investigated.CD phenotypes of the B16F10 cells were analyzed by flow cytometry,and the specific CD phenotype cells from the B16F10 cells were isolated by MACS.Then we used colony formation assay in soft agar media,the cell growth assay in serum-free culture media as well as the tumorigenicity investigation of the specific CD phenotype cells in C57BL/6 mice, respectively,to identify cancer stem-like cells in the B16F10 cells.The results showed that the B16F10 cells could form spherical clones in serum-free culture media,and the rate of clonegenesis of CD133 + ,CD44 + and CD44 + CD133 + cells was higher than that of CD133 - ,CD44 - and CD44 + CD133 - cells in soft agar media,respectively. The tumorigenic potential of CD133 + ,CD44 + ,CD44 + CD133 + cells and CD44 + CD133 + CD24 + cells was stronger than that of CD133 - ,CD44 - ,CD44 + CD133 - cells and CD44 + CD133 + CD24 - cells in mice,respectively.In conclusion,the CD44 + CD133 + CD24 + cells have some biological properties of cancer stem-like cells or are highly similar to the characteristics of cancer stem cells(CSC).These results provide an important method for identifying cancer stem-like cells in B16F10 cells and for further cancer target therapy. | Jun Dou Meng Pan Ping Wen Yating Li Quan Tang Lili Chu Fengshu Zhao Chuilian Jiang Weihua Hu Kai Hu Ning Gu | 2007 | Cellular & Molecular Immunology2007，4，6： | 25 |
| 2 | Cropland redistribution to marginal lands undermines environmental sustainability显示文摘Cropland redistribution to marginal land has been reported worldwide;however,the resulting impacts on environmental sustainability have not been investigated sufficiently.Here we investigated the environmental impacts of cropland redistribution in China.As a result of urbanization-induced loss of high-quality croplands in south China(~8.5 t ha^(-1)),croplands expanded to marginal lands in northeast(~4.5 t ha^(-1)) and northwest China(~2.9 t ha^(-1)) during 1990-2015 to pursue food security.However,the reclamation in these low-yield and ecologically vulnerable zones considerably undermined local environmental sustainability,for example increasing wind erosion(+3.47%),irrigation water consumption(+34.42%),fertilizer use(+20.02%) and decreasing natural habitats(-3.11%).Forecasts show that further reclamation in marginal lands per current policies would exacerbate environmental costs by 2050.The future cropland security risk will be remarkably intensified because of the conflict between food production and environmental sustainability.Our research suggests that globally emerging reclamation of marginal lands should be restricted and crop yield boost should be encouraged for both food security and environmental benefits. | Wenhui Kuang Jiyuan Liu Hanqin Tian Hao Shi Jinwei Dong Changqing Song Xiaoyong Li Guoming Du Yali Hou Dengsheng Lu Wenfeng Chi Tao Pan Shuwen Zhang Rafiq Hamdi Zherui Yin Huimin Yan Changzhen Yan Shixin Wu Rendong Li Jiuchun Yang Yinyin Dou Wenbin Wu Liqiao Liang Bao Xiang Shiqi Yang | 2022 | National Science Review2022，9，1： | 13 |
| 3 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 4 | A Local Cluster of Omicron Variant COVID-19 Likely Caused by Internationally Mailed Document——Beijing Municipality,China,January 2022显示文摘On January 15,2022,a 26 years old female(Case A)went to a sampling site for coronavirus disease 2019(COVID-19)testing due to excessive fatigue and fever for two days.This patient preliminarily tested positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)using a quantitative real-time reverse transcription polymerase chain reaction(qRT-PCR)method. | Daitao Zhang Shuangsheng Wu Zhenyong Ren Ying Sun Xiangfeng Dou Zhaomin Feng Fu Li Yi Tian Shujuan Cui Baiwei Liu Bing Lyu Xiaoli Wang Feng Liu Lina Jin Chu Jiang Lina Tian Zhenjiang Xin Zhichao Liang Lei Jia Quanyi Wang Yang Pan Peng Yang | 2022 | China CDC weekly2022，4，14： | 6 |
| 5 | Spontaneous remission of acromegaly or gigantism due to subclinical apoplexy of pituitary growth hormone adenoma显示文摘功能的腺瘤能引起荷尔蒙 hypersecretion.The 的自发的宽恕的垂体的背景无临床症状的卒中垂体生长的典型存在荷尔蒙( GH )腺瘤是巨大畸形症或 acromegaly.We 由于 GH adenoma.Methods 的无临床症状的卒中与先端肥大症或巨大畸形症的自发的部分宽恕调查病人的临床的特征有先端肥大症的自发的宽恕的六个病人或巨大畸形症是 enrolled.The 临床的特征, | WANG Xian-ling DOU Jing-tao LU Zhao-hui ZHONG Wen-wen BA Jian-ming JIN Du LU Ju-ming PAN Chang-yu MU Yi-ming | 2011 | Chinese Medical Journal2011，，22： | 4 |
| 6 | Estimating the Health and Economic Outcomes of the Prevention of Mother-to-child Transmission of HIV Using a Decision Tree Model显示文摘In 2016, there were 17.8 million (15.4-20.3 million) women living with HIV/AIDS across the world and the prevalence of reproductive desire among this group was 26%-49%[1]. If pregnant women living with HIV/AIDS are left untreated, the rates of HIV transmission from mother-to-child would range from 14% to 48%, depending on the presence and duration of breastfeeding[2]. | QU Shui Ling WANG Ai Ling PAN Xiao Ping WANG Qian DOU Li Xia ZHANG Tong | 2019 | Biomedical and Environmental Sciences2019，32，1： | 4 |
| 7 | Functional membrane separators for next-generation high-energy rechargeable batteries显示文摘The membrane separator is a key component in a liquid-electrolyte battery for electrically separating the cathode and the anode, meanwhile ensuring ionic transport between them. Besides these basic requirements, endowing the separator with specific beneficial functions is now being paid great attention because it provides an important alternative approach for the development of batteries, particularly next-generation high-energy rechargeable batteries. Herein, functional separators are overviewed based on four key criteria of next-generation high-energy rechargeable batteries: stable,safe, smart and sustainable(4 S). That is, the applied membrane materials and the corresponding functioning mechanisms of the 4 S separators are reviewed. Functional separators with selective permeability have been applied to retard unwanted migration of the specific species(e.g. polysulfide anions in Li-S batteries) from one electrode to the other in order to achieve stable cycling operation. The covered battery types are Li-S, room-temperature Na-S, Li-organic, organic redox-flow(RF) and Li-air batteries. Safe, smart and sustainable separators are then described in sequence following the first criterion of stable cycling. In the final section, key challenges and potential opportunities in the development of 4 S separators are discussed. | Yuede Pan Shulei Chou Hua Kun Liu Shi Xue Dou | 2017 | National Science Review2017，4，6： | 4 |
| 8 | mTOR regulates NLRP3 inflammasome activation via reactive oxygen species in murine lupus显示文摘 | Xiaojing Li Xuefang Zhang Yuchen Pan Guoping Shi Jing Ren Hongye Fan Huan Dou Yayi Hou | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 4 |
| 9 | Microstructure and mechanical properties of large-scale Mg-Gd-Y-Zn-Mn alloys prepared through semi-continuous casting显示文摘Large-scale Mg-8Gd-4Y-1Zn-Mn(wt.%)alloy ingot with a diameter of 315 mm and a length of 2410 mm was prepared through semi-continuous casting.Chemical composition,microstructure and mechanical properties at different locations of the samples with as-cast,T4 and T6 heat-treated states,respectively,were investigated.No obvious macro segregation has been detected in the high-quality alloy ingot.The main eutectic structures at all different locations are composed ofα-Mg,Mg3RE-type,Mg5RE-type and LPSO phases.At the edge of ingot,the unusual casting twins including 10-12 extension twins and 10-11 compression twins were observed due to the intensive internal stress.In T4 heat-treated alloy,the micro segregation was eliminated.The remained phases wereα-Mg and LPSO phase.Combined with the remarkable age-hardening response,T6 samples exhibits improved mechanical properties at ambient temperature,which derives from the dense prismaticβ'precipitates and profuse basalγ'precipitates. | Kui Wang Jingfeng Wang Xiaoxu Dou Yuanding Huang Norbert Hort Sarkis Gavras Shijie Liu Yanwu Cai Jinxing Wang Fusheng Pan | 2020 | Journal of Materials Science & Technology2020，52，17： | 4 |
| 10 | Enhanced pressor response to acute Ang II infusion in mice lacking membrane-associated prostaglandin E2 synthase-1显示文摘 | Dong-juan ZHANG Li-hong CHEN Ya-hua ZHANG Guang-rui YANG Dou DOU Yuan-sheng GAO Xiao-yan ZHANG Xiao-mu KONG Pan ZHAO Dan PU Ming-fen WEI Matthew-D BREYER You-fei GUAN | 2010 | Acta Pharmacologica Sinica2010，31，10： | 3 |
| 11 | Substituent Effects of Pyridyl-methylene Cyclopentadienyl Rare-earth Metal Complexes on Styrene Polymerization显示文摘Salt metathesis reactions between pyridyl-methylene-cyclopentadienyl lithium salt and LnCl_3 followed by the addition of two equivalents of LiCH_2SiMe_3 afforded a series of constrained-geometry-configuration rare-earth metal bis(alkyl) complexes(Cp′CH_2-Py)Ln(CH_2SiMe_3)_2(THF)_n(Py = C_5H_4N, Cp′ = C_5H_4(Cp), Ln = Sc, n = 0(1); Cp′ = C_9H_6(Ind), Ln = Sc, n = 0(2); Cp′ = 3-Me_3Si-C_9H_5(3-Me_3Si-Ind), Ln = Sc, n = 0(3a), Ln = Lu(3b), Y(3c), n = 1; Cp′ = 2,7-(~tBu)_2C_(13)H_8(2,7-(~tBu)_2-Flu), Ln = Sc(4 a), n = 0, Ln = Lu(4b),Y(4c), n = 1) in moderate to good yields, which were characterized by NMR spectroscopy and single-crystal X-ray diffraction(for complex 3a). In the presence of [Ph_3C][B(C_6F_5)_4] and Al^iBu_3, these complexes displayed different performances towards styrene polymerization. Rare-earth metal bis(alkyl) precursors bearing Cp, Ind, and 3-Me_3Si-Ind segments exhibited very low catalytic activity to afford syndiotactic polystyrene. All electron-donating t Bu substituted complexes 4 a, 4 b, and 4 c showed very high activity and perfect syndiotactivity(rrrr > 99%), producing high molecular weight polystyrene(up to 54.1 × 10~4) with relatively narrow molecular distribution(PDI = 1.28-2.49). | Zhen Zhang Zhong-Yi Cai Yu-Peng Pan Yan-Li Dou Shi-Hui Li Dong-Mei Cui | 2019 | Chinese Journal of Polymer Science2019，37，6： | 3 |
| 12 | Non-concomitant cortical structural and functional alterations in sensorimotor areas following incomplete spinal cord injury显示文摘Brain plasticity, including anatomical changes and functional reorganization, is the physiological basis of functional recovery after spinal cord injury(SCI). The correlation between brain anatomical changes and functional reorganization after SCI is unclear. This study aimed to explore whether alterations of cortical structure and network function are concomitant in sensorimotor areas after incomplete SCI. Eighteen patients with incomplete SCI(mean age 40.94 ± 14.10 years old; male:female, 7:11) and 18 healthy subjects(37.33 ± 11.79 years old; male:female, 7:11) were studied by resting state functional magnetic resonance imaging. Gray matter volume(GMV) and functional connectivity were used to evaluate cortical structure and network function, respectively. There was no significant alteration of GMV in sensorimotor areas in patients with incomplete SCI compared with healthy subjects. Intra-hemispheric functional connectivity between left primary somatosensory cortex(BA1) and left primary motor cortex(BA4), and left BA1 and left somatosensory association cortex(BA5) was decreased, as well as inter-hemispheric functional connectivity between left BA1 and right BA4, left BA1 and right BA5, and left BA4 and right BA5 in patients with SCI. Functional connectivity between both BA4 areas was also decreased. The decreased functional connectivity between the left BA1 and the right BA4 positively correlated with American Spinal Injury Association sensory score in SCI patients. The results indicate that alterations of cortical anatomical structure and network functional connectivity in sensorimotor areas were non-concomitant in patients with incomplete SCI, indicating the network functional changes in sensorimotor areas may not be dependent on anatomic structure. The strength of functional connectivity within sensorimotor areas could serve as a potential imaging biomarker for assessment and prediction of sensory function in patients with incomplete SCI. This trial was registered with the Chinese Clinical Trial Registry(registration number: Chi CTR-ROC-17013566). | Yu Pan Wei-bei Dou Yue-heng Wang Hui-wen Luo Yun-xiang Ge Shu-yu Yan Quan Xu Yuan-yuan Tu Yan-qing Xiao Qiong Wu Zhuo-zhao Zheng Hong-liang Zhao | 2017 | Neural Regeneration Research2017，12，12： | 2 |
| 13 | Direct electrodeposition of ZnO nanotube arrays in anodic alumina membranes显示文摘 | L Li S Pan X Dou | 2007 | J Phys Chem C2007，111，： | 1 |
| 14 | Preparation and application of zeolite beta with super-low SiO2/Al2O3 ratio显示文摘 | KANG S DOU T LI Q DUAN A ZHENG Y PAN H | 2008 | J Porous Materials2008，15，2： | 1 |
| 15 | Removal of Tar Component over Cracking Catalysts from High Temperature Fuel Gas显示文摘 | DOU Bin-lin PAN Wei-guo REN Jian-xing | | 0，，8： | 1 |
| 16 | Prediction of SO2 removal efficiency for wet flue gas desulfurization 显示文摘 | Dou B Pan W Jin Q | 2009 | Energy Convers Manage2009，50，10： | 1 |
| 17 | Prediction of SO2 removal efficiency for wet flue gas desulfurization显示文摘 | Dou B L Pan W G Jin Q | 2009 | Energy Conversion and Management2009，50，10： | 1 |
| 18 | Superconducting properties of Al - stabilized MgB2 wires 显示文摘 | Shcherbakov A V Pan A V Dou S X | 2007 | Physica C2007，，： | 1 |
| 19 | Direct electrodeposition of ZnO nanotube arrays in anodic alumina membranes显示文摘 | Li L Pan S H Dou X C | 2007 | J Phys Chem C2007，111，： | 1 |
| 20 | Prediction of SO2 Removal Efficiency for Wet Flue Gas Desulfurization显示文摘 | Dou B L Pan W G Jin Q | 2009 | Energy Conversion and Management2009，，50： | 1 |
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