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| 1 | BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis显示文摘Leukotriene B4(LTB4)synthesis is enhanced in the colonic mucosa in patients with inflammatory bowel disease(IBD).BLT1,a highaffinity receptor for LTB4,exhibits no effect on the progression of dextran sodium sulfate(DSS)-induced colitis,which mostly relies on innate immunity.Here,we reported that BLT1 regulates trinitrobenzene sulfonic acid(TNBS)-induced colitis,which reflects CD4+T-cell-dependent adaptive immune mechanisms of IBD.We found that BLT1 signaling enhanced the progression of colitis through controlling the production of proinflammatory cytokines by dendritic cells(DCs)and modulating the differentiation of Th1 and Th17.BLT1−/−mice displayed an alleviated severity of TNBS-induced colitis with reduced body weight loss and infiltrating cells in the lamina propria.BLT1 deficiency in DCs led to reduced production of proinflammatory cytokines,including IL-6,TNF-α,and IL-12,and these results were further confirmed via treatment with a BLT1 antagonist.The impaired cytokine production by BLT1−/−DCs subsequently led to reduced Th1 and Th17 differentiation both in vitro and in vivo.We further performed a conditional DC reconstitution experiment to assess whether BLT1 in DCs plays a major role in regulating the pathogenesis of TNBS-induced colitis,and the results indicate that BLT1 deficiency in DCs also significantly reduces disease severity.The mechanistic study demonstrated that BLT1-regulated proinflammatory cytokine production through the Gαiβγsubunit-phospholipase Cβ(PLCβ)-PKC pathway.Notably,we found that treatment with the BLT1 antagonist also reduced the production of proinflammatory cytokines by human peripheral blood DCs.Our findings reveal the critical role of BLT1 in regulating adaptive immunity and TNBS-induced colitis,which further supports BLT1 as a potential drug target for adaptive immunity-mediated IBD. | Jinfeng Zhou Weiming Lai Wanjie Yang Juping Pan Hu Shen Yingying Cai Cuixia Yang Ningjia Ma Yue Zhang Ru Zhang Xin Xie Zhongjun Dong Yuan Gao Changsheng Du | 2018 | Cellular & Molecular Immunology2018，15，12： | 9 |
| 2 | The Optimal Cross-section Design of the “Trapezoid-V” Shaped Drainage Canal of Viscous Debris Flow显示文摘Debris flow drainage canal is one of the most widely used engineering measures to prevent and manage debris flow hazards.The shape and the sizes of the cross-section are important parameters when design debris flow drainage canal.Therefore,how to design the appropriate shape and sizes of the cross-section so that the drainage canal can have the optimal drainage capacity is very important and few researched at home and abroad.This study was conducted to analyze the hydraulic condition of a Trapezoid-V shaped drainage canal and optimize its cross-section.By assuming characteristic sizes of the cross-section,the paper deduced the configuration parameter of the cross-section of a Trapezoid-V shaped debris flow drainage canal.By theory analysis,it indicates that the optimal configuration parameter is only related to the side slope coefficient and the bottom transverse slope coefficient.For this study,the Heishui Gully,a first-order tributary of the lower Jinsha River,was used as an example to design the optimal cross-section of the drainage canal of debris flow. | YOU Yong | 2011 | Journal of Mountain Science2011，8，1： | 8 |
| 3 | Performances of improved Tent chaos-based FM radar signal显示文摘A novel algorithm is proposed to solve the poor performance problem of the Tent chaos-based frequency modulation(FM) signal for range-Doppler imaging,which takes it into complex multi-segment system by increasing its segments.The simulation results show that the effectiveness of the proposed algorithm,as well as the performance of the improved Tent FM signal is obvious in a multipath or noise propagation environment. | Shaobin Xie Zishu He Jinfeng Hu Lidong Liu Jichun Pan | 2012 | Journal of Systems Engineering and Electronics2012，23，3： | 6 |
| 4 | Highly Textured N-Type SnSe Polycrystals with Enhanced Thermoelectric Performance显示文摘Thermoelectric materials,which directly convert heat into electricity based on the Seebeck effects,have long been investigated for use in semiconductor refrigeration or waste heat recovery.Among them,SnSe has attracted significant attention due to its promising performance in both p-type and n-type crystals;in particular,a higher out-of-plane ZT value could be achieved in ntype SnSe due to its 3D charge and 2D phonon transports.In this work,the thermoelectric transport properties of n-type polycrystalline SnSe were investigated with an emphasis on the out-of-plane transport through producing textural microstructure.The textures were fabricated using mechanical alloying and repeated spark plasma sintering(SPS),as a kind of hot pressing,aimed at producing strong anisotropic transports in n-type polycrystalline SnSe as that in crystalline SnSe.Results show that the lowest thermal conductivity of 0.36 Wm^(-1) K^(-1) was obtained at 783 K in perpendicular to texture direction.Interestingly,the electrical transport properties are less anisotropic and even nearly isotropic,and the power factors reach 681.3μWm^(-1) K^(-2) at 783 K along both parallel and perpendicular directions.The combination of large isotropic power factor and low anisotropic thermal conductivity leads to a maximum ZT of 1.5 at 783 K.The high performance elucidates the outstanding electrical and thermal transport behaviors in n-type polycrystalline SnSe,and a higher thermoelectric performance can be expected with future optimizing texture in n-type polycrystalline SnSe. | Peng-Peng Shang Jinfeng Dong Jun Pei Fu-Hua Sun Yu Pan Huaichao Tang Bo-Ping Zhang Li-Dong Zhao Jing-Feng Li | 2019 | Research2019，，1： | 5 |
| 5 | Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model显示文摘Sepsis is a complex syndrome caused by multiple pathogens and involves multiple organ failure,particularly spleen dysfunction.In 2017,the worldwide incidence was 48.9 million sepsis cases and 1l million sepsis-related deaths were reported(Rudd et al.,2020).Inflammation,oxidative stress,and apoptosis are the most common pathologies seen in sepsis.Liensinine(LIE)is a bisbenzylisoquinoline-type alkaloid extracted from the seed embryo of Nelumbo nucifera.Lotus seed hearts have high content of LIE which mainly has antihypertensive and antiarrhythmic pharmacological effects.It can exert anti-carcinogenicactivityby regulating cell. | HANYU WANG YUANHAO YANG XIAO ZHANG YAN WANG HUI FAN JINFENG SHI XUELIAN TAN BAOSHI XU JINGCHAO QIANG ENZHUANG PAN MINGYI CHU ZIBO DONG JINGQUAN DONG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 4 |
| 6 | Materials Experiment on Tiangong-2 Space Laboratory显示文摘During the China's Tiangong-2(TG-2) flight mission, the experiments of 18 kinds of material samples were conducted in space by using a Multiple Materials Processing Furnace(MMPF) mounted in the orbital module of the TG-2 space laboratory. After the experiments of 12 kinds of samples of the first and second batches were completed successfully, astronauts packed and brought them back to the ground by ShenzhouII spacecraft. By studying processing and formation on semiconductor and optoelectronics materials, metal alloys and metastable materials, functional single-crystal, micro-and nano-composite materials encapsulated in sample ampoules both in space and on Earth, we expect to explore some physical and chemical processes and mechanism of the materials formation that are normally obscured and therefore are difficult to study quantitatively on the ground due to the gravity-induced convection, to obtain the processing and synthesis technology for preparing high quality materials, and lead to the improvement and development of materials processing techniques on Earth, and also develop the experiment device and comprehensive ability for materials experiment in microgravity environment. This report briefly introduces the main points of each research work and preliminary comparative analysis results of 12 samples carried out by scientists undertaking research task. | LI Xiangyang LU Ye MENG Xiangjian WANG Jianlu WANG Reng CHEN Lidong HUA Zile LI Xiaoya SHI Jianlin LIU Jinfeng XU Guisheng WEI Bingbo XIE Wenjun YIN Zhigang ZHANG Xingwang JIANG Hongxiang LI Hong LUO Xinghong ZHANG Haifeng ZHAO Jiuzhou WANG Binbin PAN Mingxiang | 2018 | 空间科学学报2018，38，5： | 4 |
| 7 | Investigation of hrDNA targeting vector-mediated tumor-specific suicide gene therapy for hepatocellular carcinoma显示文摘Human ribosomal DNA (hrDNA) target- ing vector (pHrn) is one of the human derived vectors, which was devised by our lab and has got patent authority. To investigate its effect on gene therapy for hepatocellular carcinoma, a double suicide fusion gene expression cassette, CDUPRT/GFP controlled by a synthetic CMV enhancer-enhanced hTERT promoter (CeTp) which was determined by luciferase assays was constructed in pHrn backbone, creating an expression vector pHr-CeTpCDUPRT/GFP. After transfer of plasmid to hepatocellular carcinoma cell line Bel7402 in vitro, the transfection efficiency reached 30%―50% by using flow cytometer. The expression of CDUPRT/GFP was detected by RT-PCR and Western Blotting. After the administra- tion of 5-FC, high performance liquid chromatography (HPLC) was applied to examine the level of 5-FU in supernatant, resulting in a concentration of 60.15 μg/mL. The Methylthiazolyl tetrazolium (MTT) assay was then utilized to investigate the antitumor effect of pHr-CeTpCDUPRT/GFP in Bel7402 cells, and rela- tive cell survival of 60%-35% was observed after 5-FC treatment. In vivo experiments, the nude mouse model of hepatocellular carcinoma was constructed and in situ gene therapy was performed. The results indicated the tumor growth of treatment group was obviously suppressed, and some even shrank, whenthe vectors and prodrugs were injected continuously. The expression of CDUPRT in tumor tissues was also identified by RT-PCR, and the concentration of 5-FU was 7.694 μg/mL in blood serum using HPLC detection. Then the pathological section of tumor tissues revealed significant tumor cell necrosis. All of these results provide important experiment evidences of the gene therapy for hepatocellular carcinoma with the utilization of our vectors. | WANG Lina XUE Zhigang LI Zhuo XUE Jinfeng LIU Xionghao PAN Qian LONG Zhigao CAI Fang WU Lingqian DAI Heping XIA Kun LIANG Desheng XIA Jiahui | 2006 | Chinese Science Bulletin2006，51，19： | 3 |
| 8 | Molecularly tagged genes and quantitative trait loci in cucumber with recommendations for QTL nomenclature显示文摘Cucumber,Cucumis sativus L.(2n=2x=14),is an important vegetable crop worldwide.It was the first specialty crop with a publicly available draft genome.Its relatively small,diploid genome,short life cycle,and selfcompatible mating system offers advantages for genetic studies.In recent years,significant progress has been made in molecular mapping,and identification of genes and QTL responsible for key phenotypic traits,but a systematic review of the work is lacking.Here,we conducted an extensive literature review on mutants,genes and QTL that have been molecularly mapped or characterized in cucumber.We documented 81 simply inherited trait genes or major-effect QTL that have been cloned or fine mapped.For each gene,detailed information was compiled including chromosome locations,allelic variants and associated polymorphisms,predicted functions,and diagnostic markers that could be used for marker-assisted selection in cucumber breeding.We also documented 322 QTL for 42 quantitative traits,including 109 for disease resistances against seven pathogens.By alignment of these QTL on the latest version of cucumber draft genomes,consensus QTL across multiple studies were inferred,which provided insights into heritable correlations among different traits.Through collaborative efforts among public and private cucumber researchers,we identified 130 quantitative traits and developed a set of recommendations for QTL nomenclature in cucumber.This is the first attempt to systematically summarize,analyze and inventory cucumber mutants,cloned or mapped genes and QTL,which should be a useful resource for the cucurbit research community. | Yuhui Wang Kailiang Bo Xingfang Gu Junsong Pan Yuhong Li Jinfeng Chen Changlong Wen Zhonghai Ren Huazhong Ren Xuehao Chen Rebecca Grumet Yiqun Weng | 2020 | Horticulture Research2020，7，1： | 2 |
| 9 | Influences of dissolved and colloidal organic carbon on the uptake of Ag, Cd and Cr by the marine mussel Peraa virdis 显示文摘 | Pan Jinfeng Wang Wenxiong | 2004 | Environmental Pollution2004，129，： | 1 |
| 10 | Mixed Aleatory-epistemic Uncertainty Modeling of Wind Power Forecast Errors in Operation Reliability Evaluation of Power Systems显示文摘As the share of wind power in power systems continues to increase, the limited predictability of wind power generation brings serious potential risks to power system reliability. Previous research works have generally described the uncertainty of wind power forecast errors(WPFEs) based on normal distribution or other standard distribution models, which only characterize the aleatory uncertainty. In fact, epistemic uncertainty in WPFE modeling due to limited data and knowledge should also be addressed. This paper proposes a multi-source information fusion method(MSIFM) to quantify WPFEs when considering both aleatory and epistemic uncertainties. An extended focal element(EFE) selection method based on the adequacy of historical data is developed to consider the characteristics of WPFEs. Two supplementary expert information sources are modeled to improve the accuracy in the case of insufficient historical data. An operation reliability evaluation technique is also developed considering the proposed WPFE model. Finally,a double-layer Monte Carlo simulation method is introduced to generate a time-series output of the wind power. The effectiveness and accuracy of the proposed MSIFM are demonstrated through simulation results. | Jinfeng Ding Kaigui Xie Bo Hu Changzheng Shao Tao Niu Chunyan Li Congcong Pan | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，5： | 1 |
| 11 | Rheological Behavior and Thermal Properties of Poly(butyl acrylate-co-2-ethylhexyl acrylate) grafted Vinyl Chloride Resin显示文摘 | Pan Mingwang Zhang Liucheng Yuan Jinfeng | 2005 | Journal of Applied Polymer Science2005，95，2： | 1 |
| 12 | Cryprotec- tire effects of trehalose on grass carp ( cteopharyngodon idellus) surimi during frozen storage显示文摘 | Pan Jinfeng Shen Huixiong Luo Yongkang | 2010 | Journal of Food Processing and Preservation2010，34，4： | 1 |
| 13 | Changes in physiochemical properties of myofibrillar protein from silver carp (Hypophthalmichthys mollitrix) during heat treatment 显示文摘 | Pan Jinfeng Shen Huixing You Juan | 2011 | J Food Biochem2011，35，3： | 1 |
| 14 | The Simulation of Temperature and Hu- midity Control System Based on PROTEUS 显示文摘 | Xu Xiumei Pan Jinfeng | 2011 | Electric Engineering and Computer2011，，： | 1 |
| 15 | Research on the nonisocyanate polyurethane显示文摘 | Zhou Qingfeng Pan Mingwang Yuan Jinfeng | 2006 | The Chemistry Bulletin2006，69，2： | 1 |
| 16 | Rheological behavior and thermal properties of Poly (butyl acrylate- co - 2 - ethylhexyl acrylate) - grafted Vinyl Chloride resin显示文摘 | Mingwang Pan Liucheng Zhang Jinfeng Yuan | 2005 | Journal of Applied Polymer Science2005，95，2： | 1 |
| 17 | Formation of bulk magnetic ternary Fe 80 P 13 C 7 glassy alloy显示文摘 | Qiang Li Jinfeng Li Pan Gong Kefu Yao Jingen Gao Hongxiang Li | 2012 | Intermetallics2012，，： | 1 |
| 18 | Pollutant emissions from biomass burning:A review on emission characteristics,environmental impacts,and research perspectives显示文摘Biomass is one most abundant resource on the earth providing important energies in support of so-cioeconomic development in many areas.Burning of biomass fuels comprises to nearly 10%of the total energy from anthropogenic combustion processes:however,as the burning is usually incomplete,this process yields products of incomplete combustion posing consequently significant impacts on air quality,human health,and climate change.Here,we analyzed spatiotemporal characteristics in intentional and unintentional biomass burning from different sectors,discussed impacts of biomass burning emissions on indoor and outdoor air quality,and consequent influences on human health.The global total con-sumption amount of biomass including both natural and anthropogenic sources was approximately 7900 Tg in 2019,with significantly large regional and sectorial discrepancies among regions.Globally,anthropogenic biomass burning amounts increased gradually,but notably in some developing countries like China residential consumption of biomass fuels,as one large sector of biomass use,decreased over time.Uncommercial biomass consumption needs to be accurately quantified.There are relatively rich datasets of pollutant emission factors from biomass burning,including laboratory and field tests,but still large variations exit and contribute substantially to the uncertainty in emission inventory.Global pri-mary PM2.5,black carbon and organic carbon emissions from biomass burning were about 51,4.6,and 29 Tg,respectively,contributing to nearly 70%,55%,and 90%of the total emission from all sources,and emissions from the residential sector and open fires are major sources.Brown carbon emissions from biomass burning attracts growing interests but available studies adopted different methodologies challenging the comparability of those results.Biomass burning emissions polluted not only ambient air but more severely indoor air quality,adversely affecting human health.Future studies that should be emphasized and promoted are suggested. | Ke Jiang Ran Xing Zhihan Luo Wenxuan Huang Fan Yi Yatai Men Nan Zhao Zhaofeng Chang jinfeng Zhao Bo Pan Guofeng shen | 2024 | Particuology2024，85，2： | 0 |
| 19 | Integrated Use of Alternative Methods for Evaluating the Skin Sensitization Potencies of Five Frequently Used Preservatives in Cosmetics显示文摘In vitro skin sensitization testing methods based on the adverse outcome pathway(AOP)were used to evaluate the skin sensitization potencies of 5 commonly used preservatives.According to the“2 out of 3”principle of the integrated approaches to testing and assessment(IATA)the direct peptide reactivity assay(DPRA)and the human cell line activation test(h-CLAT)were used to detect the preservatives commonly used in cosmetics,including phenoxyethanol.methyl paraben,propyl paraben,imidazolidinyl urea and DMDM hydantoin.The DPRA and the h-CLA were carried out according to the OEC442C and 442E guidelines,respectively.The results show that.phenoxyethanol and methyl paraben are both negative in DPRA and h-CLAT while imidazolidinyl urea and DMDM hydantoin are both positive in these two tests.Propyl paraben has negative result in DPRA but positive result in h-CLAT.Therefore,imidazolidiny urea and DMDM hydantoin are sensitizers,while phenoxyethanol and methylparaben are non-sensitizers.Taken animal and human data into consideration,it is predicted that propyl paraben should be a non-sensitizer.The combination of DPRA and h-CLAT can make up for the limitations of using a single method,and it is suitable for the preliminary screening of cosmetic raw materials according to skin sensitization. | Wang Rui Wang Huan Han Yu-qing Zhao Jinfeng Yan Shiyu Pan Yao | 2023 | China Detergent & Cosmetics2023，8，2： | 0 |
| 20 | Rainbow guiding of the lowest-order antisymmetric Lamb mode in phononic crystal plate显示文摘The modern acoustic circuits have experienced significant progress with the development of artificial structures, including phononic crystals, metamaterials or metasurfaces. Among the most intensive topics, the reconfigurable acoustic guides are achieved through several mechanisms. In this work, we report on the rainbow guiding for the lowest-order antisymmetric Lamb(A_0) mode in a phononic crystal plate, where the linear waveguides are constituted by erecting aligned pillars either solid or hollow. We show both numerically and experimentally that the whispering gallery modes(WGMs) in the hollow pillars can be generated by the defect mode that propagates in the waveguide. Then, the reemission of A_0 mode by the WGMs to the outer lateral areas can lead to spatial control of frequency selective wave guidance called 'rainbow guiding'. Our approach allows for an accurate control of the wave guiding and facilitates the integration of waveguides within other devices in the acoustic circuits. | ZHAO JinFeng YUAN WeiTao BONELLO Bernard DJAFARI-ROUHANI Bahram PAN YongDong ZHONG Zheng | 2019 | Science China(Technological Sciences)2019，62，3： | 0 |
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