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| 1 | The Patatin-Containing Phospholipase A pPLAIIα Modulates Oxylipin Formation and Water Loss in Arabidopsis thaliana显示文摘patatin 相关的 phospholipase A (pPLA ) 水解膜 glycerolipids 将生产 monoacyl 混合物和免费的丰满的酸。Phospholipids 被 pPLAII 在 sn-1 和 sn-2 劈开包括那些包含的 oxophytodienoic 酸,位置,和 galactolipids 能也用作底层。pPLAII 的脱离减少了 lysophosphatidylcholine 和 lysophosphatidylethanolamine 层次,而是增加的免费的亚麻酸的酸。pPLAII 缺乏的植物显示了 jasmonic 酸和甲基的高水平 jasmonate,以及 oxylipin-biosynthetic 中介 13-hydroperoxylinolenic 酸和比酸的 12-oxophytodienoic 野类型(WT ) 植物。涉及 oxylipin 生产的基因的表示比在 WT 植物在 pPLAII 缺乏的异种也是更高的。变异的植物比 WT 植物更快速失去了水。WT 和变异的植物的 stomata 对 abscisic 酸同样作出回应。响应干燥,异种和 WT 叶子以一样的率生产了 abscisic 酸,,但是,在干燥的 4h 以后, jasmonic 酸水平比 WT 离开的在异种是高得多的。这些结果显示 pPLAII 否定地调整 oxylipin 生产并且从膜在氧化地修改的丰满的酸的移动建议一个角色。 | Wen-Yu Yang Yong Zheng Sung Chul Bahn Xiang-Qing Pan Mao-Yin Li Hieu Sy Vu Mary R.Roth Brad Scheu Ruth Welt Yue-Yun Hong Xue-Min Wang | 2012 | Molecular Plant2012，5，2： | 5 |
| 2 | 社区人群血压和颈动脉血流速度与脑容量和脑小血管病的关系显示文摘做脑磁共振成像(magnetic resonance imaging,MRI)经常发现脑小血管病(cerebral small vessel disease,CSVD)。研究已证明高血压和低颈动脉血流速度与脑血管病存在关联。但是,这种关联与脑容量和CSVD的相关性仍有待研究。本文纳入基于社区的I-Lan纵向衰老研究(I-Lan longitudinal aging study)中年龄≥50岁的成年人721例进行分析,采用多普勒超声测量颈总动脉和颈内动脉血流速度,包括收缩期峰值血流速度(peak systolic velocity,PSV)和舒张终末期血流速度(end-diastolic velocity,EDV)。 | 袁源(摘译) 郑武洪(审校) Chuang SY Wang PN Chen LK Chou KH Chung CP Chen CH Mitchell GF Pan WH Cheng HM | 2021 | 中华高血压杂志2021，29，9： | 4 |
| 3 | Structural Comparison and Drug Screening of Spike Proteins of Ten SARS-CoV-2 Variants显示文摘SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)has evolved many variants with stronger infectivity and immune evasion than the original strain,including Alpha,Beta,Gamma,Delta,Epsilon,Kappa,lota,Lambda,and 21H strains.Amino acid mutations are enriched in the spike protein of SARS CoV-2.which plays a crucial role in cell infetion.However,the impact of these mutations on protein structure and function is unclear.Understanding the pathophysiology and pandemic feaures of these SARS-CoV-2 variants requires knowledge of the spike protein structures.Here,we obtained the spike protein structures of 10 main globally endemic SARS CoV-2 strains using AlphaFold2.The clustering analysis based on structural similarity revealed the unique features of the mainly pandemic SARS CoV-2 Delta variants.indicating that structural clusters can reflect the current characteristics of the epidemic more accurately than those based on the protein sequence.The analysis of the binding afinities of ACE2-RBD,antibody-NTD,and antibody-RBD complexes in the different variants revealed that the recognition of antibodies against SI NTD and RBD was decreased in the variants,especally the Delta variant compared with the original strain,which may induce the immune evasion of SARS-CoV-2 variants.Furthermore,by virtual screening the ZINC database against a high-accuracy predicted structure of Delta spike protein and experimental validation,we identified multiple compounds that target S1 NTD and RBD,which might contribute towards the development of clinical anti-SARS-CoV-2 medicines.Our findings provided a basic foundation for future in vitro and in vivo investigations that might speed up the development of potential therapies for the SARS-CoV-2 va riants. | Qiangzhen Yang Xuemin Jian Ali Alamdar Shah Syed Aamir Fahira Chenxiang Zheng zijia Zhu Ke Wang Jinmai Zhang Yangin Wen Zhiqiang Li Dun Pan Tingting Lu Zhuo Wang Yongyong Shi | 2022 | Research2022，，2： | 2 |
| 4 | Association of obesity and cancer risk in Canada显示文摘 | Pan SY Johnson KC Ugnat AM | 2004 | Am J Epidemiol2004，159，3： | 1 |
| 5 | Beneficial effect of docosahexaenoic acid on cholestatic liver injury in rats显示文摘 | Chen WY Lin SY Pan HC | 2012 | J Nutr Biochem2012，23，3： | 1 |
| 6 | Pool Analysis of the Performance of Liquid-Based Cytology in Population-based Cervical Cancer Screening Studies in China 显示文摘 | Pan QJ Hu SY Zhang X | 2013 | Cancer Cytopathol2013，121，9： | 1 |
| 7 | Implementation of multiple strat- egies for improved door - to - balloon time in patients with ST - seg- ment elevation myocardial infarction 显示文摘 | Pan MW Chen SY Chen CC | 2014 | Heart Vessels2014，29，2： | 1 |
| 8 | Overexpression of osteopontin is associated with intrahepatic metastasis, early recurrence, and poorer prognosis of surgically resected hepatocellular carcinoma显示文摘 | Pan HW Ou YH Peng SY | 2003 | Cancer2003，98，1： | 1 |
| 9 | Polymorphisms in XRCC1 and glutathioneS-transfcrase genes and hepatitis 13 related hepatocellular carcinoma显示文摘 | Yu MW Yang SY Pan IJ | 2003 | J Natl Cancer Inst2003，95，19： | 1 |
| 10 | A new technology of extraction and purification of proanthocyanidins derived from sea buckthorn bark显示文摘 | Xu XY Xie BJ Pan SY | 2006 | J Sci Food Agric2006，86，： | 1 |
| 11 | Overexpression of osteopontin is associated with intrahepatic metastasis,early recurrence,and poorer prognosis of surgically reseeted hepato cellular carcinoma显示文摘 | Pan HW Ou YH Peng SY | 2003 | Cancer2003，98，1： | 1 |
| 12 | Comparison studies of tacrine and bis7-tacrine on the suppression of scopolamine-induced behavioral changes and inhibition of acetylcholinesterase in mice 显示文摘 | Pan SY Yu ZL Xiang C J | 2009 | Pharma- cology2009，83，： | 1 |
| 13 | Induction of apoptosis by the oolong tea polyphenol theasinensin A through cytochrome c release and activation of caspase-9 and caspase-3 in human U937cells显示文摘 | Pan MH Ling YC Lin-Shian SY | 2000 | J Agric Food Chem2000，48，12： | 1 |
| 14 | Drug therapy for ulcerative colitis显示文摘 | Xu CT Meng SY Pan BR | 2004 | World J Gastroenterol2004，10，16： | 1 |
| 15 | Endothelin- 1 is a potent regulator in vivo in vascular calcification and in vitro in cal- cification of vascular smooth muscle cells 显示文摘 | Wu SY Zhang BH Pan CS | 2003 | Peptides2003，24，8： | 1 |
| 16 | Overexpression of osteopotin is associated with intrahepatic matastasis,early recurrence,and poorer prognosis of surgically resected hepatocellular careinoma显示文摘 | Pan HW Qu YH Peng SY | 2003 | Cancer2003，98，1： | 1 |
| 17 | Structure-function study ofthe glucose-6-phosphate transporter,an eukaryotic antiporterdeficient in glycogen storage disease type Ib显示文摘 | Pan CJ Chen SY Lee S Chou JY | 2009 | Mol Genet Metab2009，96，1： | 1 |
| 18 | Schisandrin B from Schisandra chinensis reduces hepatic lipid contents in hypercholesterolaemic mice 显示文摘 | Pan SY Dong H Zhao XY | 2008 | Pharm Pharmacol2008，60，3： | 1 |
| 19 | Asian dust storm and pulmonary function of school children in Seoul显示文摘 | Hong YC Pan XC Kim SY | 2010 | Sci Total Environ2010，408，： | 1 |
| 20 | Drug therapy for ulcerative colitis显示文摘 | XU CT MENG SY PAN BR | 2004 | World J Gatroenterol2004，10，16： | 1 |
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