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| 1 | Is transient elastography a useful tool for screening liver disease?显示文摘Transient elastography(TE)is a new non invasive tool for measuring liver stiffness,which is correlated to the histologic stage of liver fibrosis.Several studies in chronic liver disease(CLD)have determined a good accuracy of TE in predicting significant fibrosis and an optimal accuracy in predicting cirrhosis.Normal liver stiffness ranges between 3.3-7.8 KPa and using a cut off of 7.1 KPa,significant fibrosis and cirrhosis can be excluded with a very high negative predictive value(NPV).Positive predictive value(PPV)for the diagnosis of cirrhosis is lower using just a single scan but increases to 90% if high stiffness values are confirmed by a second independent scan.However the presence of fatty liver and metabolic syndrome slightly increases the readings and may reduce the accuracy of the test.It is uncertain if this increase is related to the presence of steatofibrosis or ifit is caused by steatosis itself.TE can be used in screening patients attending the liver clinics to identify those with signifi cant fi brosis or cirrhosis and may be particularly useful in discriminating HBV inactive carriers from chronic hepatitis B patients.TE,however,is not reliable in predicting the presence of esophageal varices in cirrhotics.Another potential indication for TE is the systematic screening of populations at high risk for CLD,such as intravenous drug users and alcoholics,but further studies are needed to determine its diagnostic accuracy in these settings. | Paolo Del Poggio Silvia Colombo | 2009 | World Journal of Gastroenterology2009，15，12： | 5 |
| 2 | Peptide aptamers:The versatile role of specific protein function inhibitors in plant biotechnology显示文摘In recent years,peptide aptamers have emerged as novel molecular tools that have attracted the attention of researchers in various fields of basic and applied science,ranging from medicine to analytical chemistry.These artificial short peptides are able to specifically bind,track,and inhibit a given target molecule with high affinity,even molecules with poor immunogenicity or high toxicity,and represent a remarkable alternative to antibodies in many different applications.Their use is on the rise,driven mainly by the medical and pharmaceutical sector.Here we discuss the enormous potential of peptide aptamers in both basic and applied aspects of plant biotechnology and food safety.The different peptide aptamer selection methods available both in vivo and in vitro are introduced,and the most important possible applications in plant biotechnology are illustrated.In particular,we discuss the generation of broadbased virus resistance in crops, 'reverse genetics' and aptasensors in bioassays for detecting contaminations in food and feed.Furthermore,we suggest an alternative to the transfer of peptide aptamers into plant cells via genetic transformation,based on the use of cell-penetrating peptides that overcome the limits imposed by both crop transformation and Genetically Modified Organism commercialization. | Monica Colombo Chiara Mizzotti Simona Masiero Martin M.Kater Paolo Pesaresi | 2015 | Journal of Integrative Plant Biology2015，57，11： | 4 |
| 3 | Macro- and micro-cellular porous ceramics from preceramic polymers显示文摘 | Paolo Colombo Enrico Bernardo | 2003 | Composites Science and Technology2003，，16： | 3 |
| 4 | Low-dose tenofovir is more potent than adefovir and is effective in controlling HBV viremia in chronic HBeAg-negative hepatitis B显示文摘AIM: To study the efficacy of tenofovir disoproxil fumarate (TDF) at low dose in a small open trial of chronic hepatitis B patients with advanced stage disease. METHODS: Eleven patients were treated with TDF 75 mg for a median period of 80 (range, 24-576) wk and then 7 cases were shifted to an adefovir 10 mg treatment group. All patients had been pre-treated with lamivudine: 5 had YMDD resistant mutants and 6 wild- type virus. When TDF was started, 4 patients had low- level viremia and 6 were PCR-negative. RESULTS: During TDF treatment, PCR remained negative in 10 patients, transaminase levels were normal and no significant viral breakthrough was observed. The drug was well tolerated in all cases. When TDF 75 mg was substituted with adefovir 10 mg, 3 out of 7 patients had a persistent viral rebound (2700-130 000 copies/mL), in whom lamivudine had to be reintroduced. CONCLUSION: Low-dose TDF monotherapy can control HBV viremia for an extended period of time without the emergence of resistance and is more potent than adefovir at the standard dosage. The use of a reduced dose of TDF could diminish the cost of therapy in low-income countries, but further studies in a larger population and in HBeAg-positive subjects are needed. | Paolo Del Poggio Maurizio Zaccanelli Maria Oggionni Silvia Colombo Carlo Jamoletti Vesna Puhalo | 2007 | World Journal of Gastroenterology2007，13，30： | 3 |
| 5 | PGR5-PGRL1-Dependent Cyclic Electron Transport Modulates Linear Electron Transport Rate in Arabidopsis thaliana显示文摘植物在环境、新陈代谢的条件下面为幸存和生长需要光合的电子运输的紧密的规定。为这个目的,线性电子运输(让) 小径被很多条其他的电子转移小径和阀门补充。在 Arabidopsis,在 photosystem 附近的周期的电子运输(CET ) 我(希腊语的第二十三个字母) ,它从 ferrodoxinto plastoquinone 再循环电子,大多数被调查其他的线路。然而,互相依赖让, CET 和 CET 的相对重要性仍然保持不清楚,主要由于在对 CET 的贡献的精确评价的困难面对让,它在生理的条件下面统治电子流动。我们因此与一项最小的切开水的活动产生了 Arabidopsis 异种,并且这样低率让由在 PsbO1 联合猛烈变化, PsbP2, PsbQ1, PsbQ2,和 PsbR loci。结果 5 异种是可行的,尽管成熟叶子包含仅仅 ∼20% 野类型自然地不太丰富的 PsbO2 蛋白质。5plants 补偿减小在由增加 CET 的率,并且导致让一强壮的非光化学的熄灭(NPQ ) 反应在 dark-to-light 转变期间。识别如此的高能力的 CET 的分子的起源,我们构造了缺乏 qE 部件的三六倍的异种 NPQ (5npq4-1 ) ,调停 NDH 的 CET (5 crr4-3 ) ,或 PGR5-PGRL1-mediated CET (5 pgr5 ) 。他们的分析表明 PGR5-PGRL1-mediated CET 在 C3plants 在 pH 形成和 NPQ 的正式就职起一个主要作用。而且当 pgr5 在波动下面在幼苗舞台死时,光调节, 5 家 pgr5 工厂能幸存,它在 modulating 加重 PGR5 的重要性 intersystem 电子转移。 | Marjaana Suorsa Fabio Rossi Luca Tadini Mathias Labs Monica Colombo Peter Jahns Martin M. Kater Dario Leister Giovanni Finazzi Eva-Mari Aro Roberto Barbato Paolo Pesaresi | 2016 | Molecular Plant2016，9，2： | 3 |
| 6 | Head-to-head comparison of transient elastography (TE), real-time tissue elastography (RTE), and acoustic radiation force impulse (ARFI) imaging in the diagnosis of liver fibrosis显示文摘 | Silvia Colombo Marco Buonocore Anna Poggio Carlo Jamoletti Stefano Elia Mario Mattiello Davide Zabbialini Paolo Poggio | 2012 | Journal of Gastroenterology2012，，4： | 2 |
| 7 | Head-to-head comparison of transient elastography (TE), real-time tissue elastography (RTE), and acoustic radiation force impulse (ARFI) imaging in the diagnosis of liver fibrosis显示文摘 | Silvia Colombo Marco Buonocore Anna Poggio Carlo Jamoletti Stefano Elia Mario Mattiello Davide Zabbialini Paolo Poggio | 2012 | Journal of Gastroenterology2012，，4： | 1 |
| 8 | Macro- and micro-cellular porous ceramics from preceramic polymers 显示文摘 | Paolo Colombo Enrico Bernardo | 2003 | Composites Science and Technology:20032003，63，16： | 1 |
| 9 | Polymer-derived ceramics: 40 years of research and innovation in advanced ceramics 显示文摘 | Paolo Colombo | 2010 | J Am Ce- ram Soc2010，93，7： | 1 |
| 10 | Ceramic foams from preceramic polymers显示文摘 | Paolo Colombo John R. Hellmann | 2002 | 2002 (5-6)2002，，5： | 1 |
| 11 | Ceramic foams from preceramic polymers显示文摘 | Paolo Colombo John R. Hellmann | 2002 | Materials Research Innovations (-)2002，，5： | 1 |
| 12 | Mechanical Properties of Silicon Oxycarbide Ceramic Foams 显示文摘 | Paolo Colombo | 2001 | Ultrahigh-Temperature Ceramics2001，84，10： | 1 |
| 13 | Micro-/Macroporous Ceramics from Preceramic Precursors显示文摘 | Paolo Colombo | 2001 | Ultrahigh-Temperature Ceramics2001，84，10： | 1 |
| 14 | Spray dried amikacin powder for inhalation in cystic fibrosis patients: A quality by design approach for product construction显示文摘 | Silvia Belotti Alessandra Rossi Paolo Colombo Ruggero Bettini Dimitrios Rekkas Stavros Politis Gaia Colombo Anna Giulia Balducci Francesca Buttini | 2014 | International Journal of Pharmaceutics2014，，： | 1 |
| 15 | Antioxidant drugs combined with alpha-interferon in chronic hepatitis C not responsive to alpha-interferon alone: a randomized, multicentre study显示文摘 | Gaetano Idéo Antonio Bellobuono Silvana Tempini Luca Mondazzi Aido Airoldi Gianpiero Benetti Franco Bissoli Cristina Cestari Enrico Colombo Paolo Del Poggio Osvaldo Fracassetti Sergio Lazzaroni Achille Marelli Bruno Paris Alberto Prada Enrico Rainer Luigi | 1999 | European Journal of Gastroenterology & Hepatology1999，，11： | 1 |
| 16 | Vascular Inflammation in Obesity and Sleep Apnea显示文摘 | Sanja Jelic David J. Lederer Tessa Adams Margherita Padeletti Paolo C. Colombo Phillip H. Factor Thierry H. Le Jemtel | 2010 | Circulation2010，，8： | 1 |
| 17 | Elective versus provisional intra-aortic balloon pumping in high-risk percutaneous transluminal coronary angioplasty显示文摘 | Carlo Briguori Cristiano Sarais Paolo Pagnotta Flavio Airoldi Francesco Liistro Fabio Sgura Vassilis Spanos Mauro Carlino Matteo Montorfano Carlo Di Mario Antonio Colombo | 2003 | American Heart Journal2003，，4： | 1 |
| 18 | Inflammatory activation: cardiac, renal, and cardio-renal interactions in patients with the cardiorenal syndrome显示文摘 | Paolo Colombo Anjali Ganda Jeffrey Lin Duygu Onat Ante Harxhi Julia Iyasere Nir Uriel Gad Cotter | 2012 | Heart Failure Reviews2012，，2： | 1 |
| 19 | Refining sorafenib therapy: lessons from clinical practice显示文摘 | Luigi Bolondi Antonio Craxi Franco Trevisani Bruno Daniele Giovan Giuseppe Di Costanzo Stefano Fagiuoli Calogero Cammà Paolo Bruzzi Romano Danesi Federico Spandonaro Corrado Boni Armando Santoro Massimo Colombo | 2015 | Future Oncol2015，，3： | 1 |
| 20 | Endoscopic ultrasound-guided fine-needle aspiration for suspected malignancies adjacent to the gastrointestinal tract显示文摘AIM:To investigate the impact of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA)in association with a multidisciplinary team evaluation for the detection of gastrointestinal malignancies.METHODS:A cohort of 1019 patients with suspected malignant lesions adjacent to the gastrointestinal tract received EUS-FNA after a standardized multidisciplinary team evaluation(MTE)and were divided into 4 groups according to their specific malignant risk score(MRS).Patients with a MRS of 0(without detectable risk of malignancy)received only EUS without FNA.For patients with a MRS score ranging from 1(low risk)-through 2(intermediate risk)-to 3(high risk),EUS-FNA cytology of the lesion was planned for a different time and was prioritized for those patients at higher risk for cancer.The accuracy,efficiency and quality assessment for the early detection of patients with potentially curable malignant lesions were evaluated for the whole cohort and in the different classes of MRSs.The time to definitive cytological diagnosis(TDCD),accuracy,sensitivity,specificity,positive and negative predictive values,and the rate of inconclusive tests were calculated for all patients and for each MRS group.RESULTS:A total of 1019 patients with suspected malignant lesions were evaluated by EUS-FNA.In 515patients of 616 with true malignant lesions the tumor was diagnosed by EUS-FNA;421 patients with resectable lesions received early surgical treatment,and 94patients received chemo-radiotherapy.The overall diagnostic accuracy for the 1019 lesions in which a final diagnosis was obtained by EUS-FNA was 0.95.When patients were stratified by MTE into 4 classes of MRSs,a higher rate of patients in the group with higher cancer risk(MRS-3)received early treatment and EUSFNA showed the highest level of accuracy(1.0).TDCD was also shorter in the MRS-3 group.The number of patients who received surgical treatment or chemo-radiotherapy was significantly higher in the MRS-3 patient group(36.3%in MRS-3,10.7%in MRS-2,and 3.5%in MRS-1).CONCLUSION:EUS-FNA can effectively detect a curable malignant lesions at an earlier time and at a higher rate in patients with a higher cancer risk that were evaluated using MTE. | Pietro Gambitta Antonio Armellino Edoardo Forti Maurizio Vertemati Paola Enrica Colombo Paolo Aseni | 2014 | World Journal of Gastroenterology2014，20，26： | 1 |
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