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| 1 | Genetic testing vs microforceps biopsy in pancreatic cysts:Systematic review and meta-analysis显示文摘BACKGROUND Carcinoembryonic antigen(CEA)and cytology in pancreatic cystic fluid are suboptimal for evaluation of pancreatic cystic neoplasms.Genetic testing and microforceps biopsy are promising tools for pre-operative diagnostic improvement but comparative performance of both methods is unknown.AIM To compare the accuracy of genetic testing and microforceps biopsy in pancreatic cysts referred for surgery.METHODS We performed a literature search in Medline,Scopus,and Web of Science for studies evaluating genetic testing of cystic fluid and microforceps biopsy of pancreatic cysts,with endoscopic ultrasound with fine-needle aspiration(EUSFNA)prior to surgery and surgical pathology as reference standard for diagnosis.We evaluated the diagnostic accuracy for:1-benign cysts;2-mucinous low-risk cysts;3-high-risk cysts,and the diagnostic yield and rate of correctly identified cysts with microforceps biopsy and molecular analysis.We also assessed publication bias,heterogeneity,and study quality.RESULTS Eight studies,including 1206 patients,of which 203(17%)referred for surgery who met the inclusion criteria were analyzed in the systematic review,and seven studies were included in the meta-analysis.Genetic testing and microforceps biopsies were identical for diagnosis of benign cysts.Molecular analysis was superior for diagnosis of both low and high-risk mucinous cysts,with sensitivities of 0.89(95%CI:0.79-0.95)and 0.57(95%CI:0.42-0.71),specificities of 0.88(95%CI:0.75-0.95)and 0.88(95%CI:0.80-0.93)and AUC of 0.9555 and 0.92,respectively.The diagnostic yield was higher in microforceps biopsies than in genetic analysis(0.73 vs 0.54,respectively)but the rates of correctly identified cysts were identical(0.73 with 95%CI:0.62-0.82 vs 0.71 with 95%CI:0.49-0.86,respectively).CONCLUSION Genetic testing and microforceps biopsies are useful second tests,with identical results in benign pancreatic cysts.Genetic analysis performs better for low-and high-risk cysts but has lower diagnostic yield. | Sandra Faias Luisa Pereira Angelo Luis Paula Chaves Marilia Cravo | 2019 | World Journal of Gastroenterology2019，25，26： | 1 |
| 2 | Methodology for Ca- ble Modeling and Simulation for High-frequency Phenomena Studies in PWM Motor Drlves显示文摘 | Paula H D de Andrade D D Chaves M L | 2008 | IEEE Transactions on Pow- er Electronics2008，23，2： | 1 |
| 3 | UV-C effect on ethylene, polyamines and the regulation of tomato fruit ripening 显示文摘 | Tiecher A de Paula L A Chaves F C Rombaldi C V | 2013 | Postharvest Biology and Technology2013，86，： | 1 |
| 4 | Short chain fatty acids are effective in short-term treatment of chronic radiation proctitis显示文摘 | Anabela Pinto M.D. Paulo Fidalgo M.D. Marília Cravo M.D. Ph.D. Jaime Mid?es M.D. Paula Chaves M.D. Joaninha Rosa M.D. Maria dos Anjos Birto M.D. Carlos Nobre Leit?o M.D. Ph.D | 1999 | Diseases of the Colon & Rectum1999，，6： | 1 |
| 5 | Cancer risk in Barrett?s oesophagus显示文摘 | António Dias Pereira Alexandra Suspiro Paula Chaves | 2007 | European Journal of Gastroenterology & Hepatology2007，，11： | 1 |
| 6 | Adenoma incidence decreases u nder the efect of polypectomy显示文摘 | Isadora Rosa Paulo Fidalgo Jose Soares Susana Vinga Carla Oliveira Joao P Silva Susana M Ferro Paula Chaves Antonio G Oliveira Carlos N Leitao | 2012 | World Journal of Gastroenterology2012，18，11： | 1 |
| 7 | Structural characterization of cold extracted fraction of soluble sulfated polysaccharide from red seaweed Gracilaria birdiae显示文摘 | Jeanny S. Maciel Luciano S. Chaves Bartolomeu W.S. Souza Dárlio I.A. Teixeira Ana L.P. Freitas Judith P.A. Feitosa Regina C.M. de Paula | 2007 | Carbohydrate Polymers2007，，4： | 1 |
| 8 | Methylation changes at the GNAS imprinted locus in pancreatic cystic neoplasms are important for the diagnosis of malignant cysts显示文摘BACKGROUND Guanine nucleotide-binding protein,alpha stimulating(GNAS)mutations are characteristic of intraductal papillary mucinous neoplasms(IPMNs).Pancreatic ductal adenocarcinomas(PDACs)harboring GNAS mutations originate in IPMNs.GNAS is a complex imprinted locus that produces five transcripts regulated by differential methylated regions,NESP55,GNASAS,GNASXL,GNAS1A,and GNAS.AIM To evaluate if methylation changes in the differential methylated regions of GNAS locus contributed to malignant progression of pancreatic cysts.METHODS GNAS locus methylation was analyzed in archival pancreatic cyst fluid(PCF)obtained by endoscopic ultrasound with fine-needle aspiration by methylation specific–multiplex ligation dependent probe amplification.Results were normalized and analyzed using Coffalyser.Net software.RESULTS Fifty-two PCF samples obtained by endoscopic ultrasound with fine-needle aspiration and previously characterized for KRAS and GNAS mutations were studied.The final diagnoses were surgical(11)and clinicopathological(41),including 30 benign cysts,14 pre-malignant cyst,and eight malignant cysts.Methylation changes at NESP55,GNASAS,GNAS1A,and especially GNASXL were more frequent in malignant cysts,and NESP55 and GNASAS were useful for diagnosis.A combined variable defined as“GNAS locus methylation changes”was significantly associated with malignancy(6/8 malignant cysts and only 2/20 benign cysts)and improved classification.Hypermethylation in both maternally(NESP55)and paternally(GNASXL)derived promoters was found in 3/3 PDACs.CONCLUSION This is the first study to identify methylation changes in the GNAS locus,improving the diagnosis of malignant pancreatic cysts and suggesting a role in progression to PDAC. | Sandra Faias Marlene Duarte Luísa Pereira Paula Chaves Marília Cravo Antonio Dias Pereira Cristina Albuquerque | 2020 | World Journal of Gastrointestinal Oncology2020，12，9： | 0 |
| 9 | What Is the Impact of Computer Literacy on the Academic Performance of D-learning Students?显示文摘 | Eduardo de Paula e Silva Chaves Celia Regina Andreoli | 2014 | US-China Education Review(A)2014，4，5： | 0 |
| 10 | Comparison of Functional Capability,Flexibility,Strength and Quality of Life in Aged Women Engaged in Resistance Exercise,Weight-Bearing Training or Hydro-Gymnastics显示文摘Although any type or amount of physical exercise may reverse the cellular processes that lead to the aging,regular physical exercise can attenuate the decline in physical and functional abilities observed in elderly.Currently,the most encouraged activities in gyms and clubs are resistance training,functional training,and hydrogymnastics.The main objective of this study was to compare the effects of the aforementioned exercises regarding muscle strength,flexibility,functional capability and quality of life of elderly women.We divided 36 elderly women in four groups:Sedentary(S);Hydro-gymnastics(H);Functional Training(F);or Resistance Training(RT).The results reveal that the groups engaged in physical exercise showed a significant difference(p<0.05)in relation to S in all evaluations.The results also show that between the different exercises evaluated,resistance training practitioners have greater strength and better functional capability. | Otávio Augusto Soares Machado Waldecir Paula Lima Bruna Vieira de Souza Fábio Gianolla Luiz Francisco Killian Giovanna Athanásio Chaves Machado Renata Gorjao | 2019 | Journal of Sports Science2019，7，4： | 0 |
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