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| 1 | Long non-coding RNA HOTAIR in carcinogenesis and metastasis显示文摘长非编码的 RNA (lncRNAs ) 作为基因规定的潜在地新、关键的层在最近的年里获得了巨大的注意。LncRNAs 流行地在基因规定在染色体,而是他们的角色被抄录,疾病开发大部分是未知的。HOX antisense intergenic RNA (HOTAIR ) ,位于 HOXC 地点的 lncRNA,被显示了镇压 HOXD 基因表示并且支持乳癌转移。机械学地, HOTAIR 交往与并且招募 polycomb 压抑的建筑群 2 (PRC2 ) 并且由 EZH2 (PRC2 的一个子单元) 调整染色体占有,它导致 HOXD 地点的 histone H3 离氨酸 27 trimethylation。而且, HOTAIR 是弥漫地在很人的癌症的 overexpressed 与 noncancerous 相比邻近的纸巾。这评论在过去的 6 年在 HOTAIR lncRNA 上总结研究。 | Jinsong Zhang Peijing Zhang Li Wang Hai-long Piao Li Ma | 2014 | Acta Biochimica et Biophysica Sinica2014，46，1： | 29 |
| 2 | Cluster analysis for syndromes of real-world coronary heartdisease with angina pectoris显示文摘Syndromes of coronary heart disease with angina pectoris were analyzed to provide guidance forclinical practice and to improve accuracy of traditional Chinese medicine (TCM) diagnoses and efficacy of TCMtreatment. A total of 860 cases with coronary heart disease with angina pectoris were selected from TCM ClinicalResearch Information Sharing System for TCM clinics and research. Syndromes were automatically extractedwith the cluster method and were analyzed to provide objective evidence for clinical studies. Final syndromeclassifications were recognized and confirmed by clinical experts. Popular syndromes included Qi and blooddeficiency, blood stasis and obstruction collaterals, liver depression and spleen deficiency, and Qi stagnation andblood stasis. Syndromes Qi and blood deficiency and blood stasis and obstruction collaterals accounted for 28.61%of total syndromes, whereas liver depression and spleen deficiency and Qi stagnation and blood stasis accountedfor 26.44%. The main syndrome elements comprised Qi deficiency, blood deficiency, blood stasis, and Qistagnation. | Yufeng Zhao Xueyun Yu Xinyu Cao Lin Luo Liyun He Shusong Mao Li Ma Peijing Rong Yuxue Zhao Guozheng Li Baoyan Liu | 2018 | Frontiers of Medicine2018，12，5： | 28 |
| 3 | An alternative therapy for drug-resistant epilepsy: transcutaneous auricular vagus nerve stimulation显示文摘 | Rong Peijing Liu Aihua Zhang Jianguo Wang Yuping Yang Anchao Li Liang Ben Hui Li Liping Liu Rupeng He Wei Liu Huanguang Huang Feng Li Xia Wu Peng Zhu Bing | 2014 | Chinese Medical Journal2014，，2： | 20 |
| 4 | Effect of acupuncture at Neiguan (PC 6) on cardiac function using echocardiography in myocardial ischemia rats induced by isoproterenol显示文摘OBJECTIVE: To investigate the effect of acupuncture at Neiguan(PC 6) on cardiac function using echocardiography in rat models of myocardial ischemia(MI) induced by isoproterenol(ISO).METHODS: Twenty-seven Sprague-Dawley rats were randomly assigned to normal, model, and acupuncture groups. The model and acupuncture groups were given injections of ISO(85 mg/kg) to establish the MI model. After model establishment,the acupuncture group was treated with acupuncture at Neiguan(PC 6) for 30 min. Echocardiography was used to monitor diastolic and systolic function for 30 min starting from the time after the acupuncture needles were removed. Changes in the length of left ventricular internal diameter at end-diastole(LVIDd), length of left ventricular internal diameter at end-systole(LVIDs), the ratio of mitral peak velocity at early diastole and atrial contraction(E/A), ejection fraction(EF), fractional shortening(FS), and stroke volume(SV) were measured.RESULTS: Compared with the model group at 0and 15 min after needles were removed, the means of LVIDd and LVIDs were significantly lower(P <0.01) and E/A, EF, FS, and SV significantly higher(P < 0.01) in the acupuncture group. In the acupuncture group, the means of LVIDd and LVIDs15 min after the needles were removed were significantly higher(P < 0.01) than those at 0 min. The means of E/A, EF, FS, and SV significantly decreased(P < 0.01) from 0 to 15 min in the acupuncture group.CONCLUSION: These findings indicate that acupuncture at Neiguan(PC 6) can affect cardiac function by increasing left ventricular diastolic and systolic function in MI rat models, but the effect only lasts for 15 min. | Wang Songzi Ren Lu Jia Lianqun Gu Zhongyue Fan Xu Chen Wenna Hou Ping Liang Fanrong Rong Peijing Ma Tieming Liu Xulai Chen Yiguo | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 12 |
| 5 | Mechanism of acupuncture regulating visceral sensation and mobility显示文摘Chinese ancient medical scientists have long focused on the internal and external contacts between acupoints on the surface of the body and the viscera.The Miraculous Pivot(it is one of the earliest medical classics in China)stated,“Twelve regular channels belong to the zang-fu organs internally,and connect to the extremities and joints externally.”Traditional Chinese medicine considers acupoints as defined areas where the Qi of viscera and meridians are transfused.These include the reaction points of visceral diseases on the body surface as well as the acupuncture trigger points that promote the flow of Qi and blood,and regulate visceral function.Chinese ancient medical scientists classified the specificity of the main acupoints in the body based on the meridian doctrine,which has been instructing clinical application for about 2000 years.Laws on the domino effect of acupoints have mainly focused on conclusions to clinical experiences.Indications of some acupoints exceed the practical paradigm since the excessive extension occurred during theory derivation.The current research direction on acupuncture focuses on three aspects:the effectiveness of acupuncture and moxibustion;the relevances and associations between meridians and viscera;and the physical and chemical properties and relevant physical basis of acupoints.The relevance between meridians and viscera is the central theory in the meridian doctrine,and acupoints are regarded as an important link in the relationship between meridians and viscera.Specific relationships between acupoints and target organs exist.Stimulating different acupoints on the body surface can help deal with different diseases,especially visceral diseases.In addition,acupoints have a dual function of reflecting and treating visceral diseases.There is no systemic research available on acupoint specificity,despite current knowledge and clinical experiences,which results in a weak foundation for acupuncture theory.This study focuses on the relevance and associations between meridians and viscera.A summary of the mechanisms of acupuncture regulating visceral sensation and mobility and the specific relationships between acupoints and their target organs are presented in this review. | Peijing Rong Bing Zhu Yuqing Li Xinyan Gao Hui Ben Yanhua Li Liang Li Wei He Rupeng Liu Lingling Yu | 2011 | Frontiers of Medicine2011，5，2： | 8 |
| 6 | Impact of microbubble enhanced, pulsed, focused ultrasound on tumor circulation of subcutaneous VX2 cancer显示文摘 | Li Peijing Zhu Mei Xu Yali Zhao Yang Gao Shunji Liu Zheng Gao Yun-hua | 2014 | Chinese Medical Journal2014，，14： | 6 |
| 7 | PK-tailored tertiary prophylaxis in patients with severe hemophilia A at beijing Children’s Hospital显示文摘Importance:Tertiary prophylaxis using a low-dose regimen is usually insufficient to prevent recurrent joint bleeding and deterioration in joint diseases in children with severe hemophilia A.Pharmacokinetic(PK)dosing is a useful approach to increase the precision and efficiency of prophylaxis.Objective:To explore the efficacy of PK-tailored tertiary prophylaxis in children with severe hemophilia A.Methods:We implemented a PK-tailored tertiary prophylaxis program for 15 boys with severe hemophilia A aged 5-16 years at Beijing Children’s Hospital.Following PK testing and a 6-month evaluation period(phase I),15 patients were divided in two groups according to individual PK data and actual bleeding:(1)a PK-tailored group[modified prophylaxis regimen according to PK data for the next 6 months(phase II);n=8]and(2)a maintenance group(continued the original regimen for the next 6 months;n=7).We compared the bleeding rate,infusion frequency,and factor VIII(FVIII)consumption between the two groups.results:In the PK-tailored group,the median annual joint bleeding rate was reduced from 7.8 in phase I to 1.4 in phase II,mean annual total factor consumption increased from 1619.0 IU/kg in phase I to 2401.9 IU/kg in phase II,and median infusion frequency for prophylaxis increased from 104 times/year in phase I to 156 times/year in phase II(P<0.05).Although the FVIII consumption increased,it remained at approximately half of the standard method.Interpretation:PK-tailored prophylaxis may represent a more efficient approach to individual prophylaxis in China,but further studies are required to verify this. | Peijing Li Zhenping Chen Xiaoling Cheng Yan Wang Ningning Zhang Yingzi Zhen Xinyi Wu Runhui Wu | 2019 | Pediatric Investigation2019，3，1： | 3 |
| 8 | Electroacupuncture of Neiguan(PC 6) inhibits enhanced voltage-gated sodium currents in ischemic ventricular myocytes显示文摘OBJECTIVE: To examine the effect of electroacupuncture(EA) at bilateral Neiguan(PC 6) on voltage-gated Na+currents(INa) and channels(Nav) in ischemic ventricular myocytes.METHODS: EA serum was prepared from six male adult Sprague-Dawley rats that had received EA at bilateral Neiguan(PC 6). Eighteen ventricular myocytes were prepared from six SD rats using an enzymolysis approach. Myocardial ischemia was mimicked by perfusion of ischemic solution. Whole-cell patch-clamping was used to record three currents evoked from isolated cells. The first current was the control, and recorded in absence of ischemic solution current. The second was the ischemic current,and recorded after perfusion of ischemic solution for 5 min, while the EA current was last, and recorded after perfusion of EA serum for 5 min. Navkinetic curves were fitted using related formulas.RESULTS: Compared with those in controls, in the presence of ischemic solution, peak amplitudes of INasignificantly increased from ﹣40 m V to +30 m V,and half-maximal inactivation potentials of Navincreased significantly, while half-maximal activation potentials, slope factors and the recovery time from inactivation to activation of Navwere unchanged. Compared with those in the ischemic solution, in the presence of EA serum, peak ischemic current amplitudes significantly reduced from ﹣40m V to + 40 m V, and half-maximal inactivation potentials were restored, while half-maximal activation potentials, slope factors and the recovery time from inactivation to activation of Navwere unchanged.CONCLUSION: EA at bilateral Neiguan(PC 6) can reduce enhanced INavia restoration of delayed Navinactivation in ischemic ventricular myocytes. | Baoqiang Dong Chunri Li Xiaoqing Zhang Shudong Wang Zhedong Cheng Peijing Rong | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 3 |
| 9 | Effect of Nucleating Agents and Heat Treatments on the Crystallization of Magnesium Aluminosilicate Transparent Glass-ceramics显示文摘The crystallization behavior and transparent property of MgO-Al2O3-SiO2 (MAS) glasses with TiO2 and TiO2+ZrO2 as nucleating agents were discussed by differential thermal analysis, X-ray diffraction, field emission-environment scanning electron microscope, energy dispersive spectrum and UV-VIS-NIR scanning spectrophotometer. It was found that the glass crystallized at 950 ℃ with ZrO2 less than 3% could obtain transparent glass ceramic, which presented purple to colorless. With the nucleating agent additives (5% TiO2+3% ZrO2), the colorless transparent glass-ceramics with spinel as the main crystal phase could be prepared, and the transmittance reached about 80% . As the crystallized temperature increase to 1 000 ℃, besides spinel(MgAl2O4), sapphirine (Mg3.5Al9Si1.5O20) and ZrTiO4 precipitated from matrix glass, and the transmitance of glass-ceramic decreased. | 王静 CHENG Jinshu 汤李缨 TIAN Peijing | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，1： | 3 |
| 10 | Microstructure, mechanical properties and tribological behavior of tribofilm generated from natural serpentine mineral powders as lubricant additive显示文摘 | Helong Yu Yi Xu Peijing Shi Hongmei Wang Min Wei Keke Zhao Binshi Xu | 2013 | Wear (-)2013，，1： | 2 |
| 11 | A novel classification method for aid decision of traditional Chinese patent medicines for stroke treatment显示文摘 | Yufeng Zhao Bo Liu Liyun He Wenjing Bai Xueyun Yu Xinyu Cao Lin Luo Peijing Rong Yuxue Zhao Guozheng Li Baoyan Liu | 2017 | Frontiers of Medicine2017，11，3： | 2 |
| 12 | Review of controlled clinical trials on acupuncture versus sham acupuncture in Germany显示文摘OBJECTIVE: To examine German controlled clinical trials on the therapeutic effects of acupuncture vs sham acupuncture, and to find whether there are problems with the conclusion that sham acupuncture has no significant deviation from acupuncture. METHODS: We focused on literature from the last ten years (2002-2011) included in PubMed about controlled clinical trials on acupuncture vs sham acupuncture carried out in Germany. The methods applied in sham acupuncture are summarized, and the difference between the acupuncture and sham groups were analyzed. We measured effects based on the following criteria: acupuncture is effective and superior to sham, acupuncture is effective but similar to sham, both of them have uncertainty regarding treatment effect, or no significant effect. Finally, we reviewed the hypotheses of different scholars on sham acupuncture and analyzed their results.RESULTS: Four types of controlled clinical trials including sham acupuncture on non-Traditional Chinese Medicine acupoints, minimal acupuncture on non-acupoints, placebo needle and sham laser acupuncture had varying results in the 57 articles analyzed. Some showed that acupuncture had a better effect than sham, while some suggest acupuncture and sham had similar effects. In all studies using sham acupuncture on non-therapeutic points, sham electrodes, and sham electro-acupuncture, the therapeutic effect was better than sham. Of the trials, 37 demonstrated that acupuncture had a better effect than sham acupuncture. Only nine trials found no significant difference between acupuncture and sham. Two controlled trials for the same condition (neck pain) conducted by two different German research institutes used the same control method, but reached contradictory conclusions. CONCLUSION: We found problems in conclusions based on results of controlled clinical trials of sham acupuncture in Germany. Therefore, there is still not enough evidence to support the statements that 'acupuncture and sham acupuncture have no difference in treatment effect' and 'acupuncture is just a placebo effect.' The control methods of sham acupuncture used in Germany may not be standardized and may not be suitable for acupuncture clinical trial research. We suggest that research on the methodology of sham acupuncture should be given priority in the design of acupuncture trials in the future. | Wei He Yuanyuan Tong Yingkai Zhao Li Zhang Hui Ben Qingguang Qin Feng Huang Peijing Rong | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 2 |
| 13 | Composites for Recyclability显示文摘 | Peijs T | 2003 | Materials Today2003，6，： | 1 |
| 14 | Review: current in-ternational research into cellulose nanofibers and nanocomposites显示文摘 | Berglund L A Peijs T Eichhom S J | 2010 | Journal of Materials Science2010，45，1： | 1 |
| 15 | Mechanical Properties of Flexible Knitted Composites 显示文摘 | T Peijs | 1996 | Advanced Composites Letters1996，5，1： | 1 |
| 16 | A retrospective analysis of thirty- one cases of plasma cell leukemia from a single center in China 显示文摘 | Peijing Q Yan X Yafei W | 2009 | Acta Haematol2009，121，： | 1 |
| 17 | The effect of light rare earths on the chemical durability and weathering of Na 2 O–CaO–SiO 2 glasses显示文摘 | Mitang Wang Jinshu Cheng Qiming Liu Peijing Tian Mei Li | 2010 | Journal of Nuclear Materials2010，，2： | 1 |
| 18 | Simulation of mould filling in resin transfer moulding显示文摘 | Van Melick H G H Haagh G A A V Van de Vosse F N Peijs T | 1998 | Advanced Composites Letters1998，7，1： | 1 |
| 19 | Fiber-reinforced composites with tailored interphases using PPE/epoxy blends as a matrix system显示文摘 | Benderbosch R W Peijs T Meijer H E H | 1996 | Composites1996，，27： | 1 |
| 20 | High--resolution mapping of am- plifications and deletions in pecliatric osteosarcoma by use of CGH analysis of cDNA microarrays显示文摘 | SquireJA PeiJ Marrano P | 2003 | Genes chromosomes cancer2003，38，3： | 1 |
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