|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 2 | Impact of the addition of resistant starch from modified pea starch on dough and bread performance显示文摘 | PENELLA J M S WRONKOWSKA M SMIETANA M S | 2010 | European Food Research and Technology2010，231，4： | 1 |
| 3 | Budd-Chiari syndrome: the results of duplex and color Doppler imaging 显示文摘 | Grant EG Penella R Tessler FN | 1989 | AJR Am J Roentgenol1989，152，2： | 1 |
| 4 | Experience of off-label use of eltrombopag in the treatment of thrombocytopenia associated with solid tumors显示文摘 | García Lagunar MH Cerezuela Fuentes P Martínez Penella M | 2015 | Farm Hosp2015，39，3： | 1 |
| 5 | Anti-angiogenic therapy using thalidomide combined With chemotherapy in small cell lung cancer:A randomized,double-blind,placebo-controlled trial显示文摘 | Siow Ming Lee Penella J Woll Bobin Rudd | 2009 | J Natl Cancer Inst2009，101，： | 1 |
| 6 | Randomized double - blind placebo- controlled trial of thalidomide in combination with gemcitabine and carboplatin in advanced non - small - cell lung cancer 显示文摘 | Slow ML Robin R Penella JW | 2009 | J Clin Oncol2009，27，31： | 1 |
| 7 | Anti - angiogenic therapy u- sing thalidomide combined with chemotherapy in small cell lung cancer: a randomized, double- blind, placebo- controlled trial 显示文摘 | Siow ML Penella JW Robin R | 2009 | JNCI2009，101，15： | 1 |
| 8 | A new mppt method for low-power solar energy harvesting显示文摘 | Lopez-Lapena O Penella M Gasulla M | 2010 | IEEE Transactions on Industrial Electronics2010，57，9： | 1 |
| 9 | Frequently asked questions about in vivo chlorophyll fluorescence: practical issues显示文摘 | Kalaji H M Schansker G Ladle R J Goltsev V Bosa K Allakhverdiev S I Brestic M Bussotti F Calatayud A Dabrowski P Elsheery N I Ferroni L Guidi L Hogewoning S W Jajoo A Misra A M Nebauer S G Pancaldi S Penella C Poli D Pollastrini M Romanowska-Duda Z B Rutkowska B Ser6dio J Suresh K Szulc W Tambussi E Yanniccari M Zivcak M | 2014 | Photosynthesis Research2014，122，2： | 1 |
| 10 | Hysteroscopic incision of the septate uterus: scissors versus resectoscope 显示文摘 | Cararach M Penella J Ubeda A | 1994 | Hum Roprod1994，9，1： | 1 |
| 11 | Randomized double-blind placebo-co-Lled trial of thalidomide in combination with gemcitabine and carboplatin in advanced non small cell lung cancer显示文摘 | Lee SM Rudd R Penella J | 2009 | Clinical Oncology2009，27，31： | 1 |
| 12 | Effect of whe- at bran and enzyme addition on dough functional performan- ce and phytic acid levels in bread 显示文摘 | SANZ PENELLA J M COLLA C HAROS M | 2008 | Journal of Cereal Science2008，48，3： | 1 |
| 13 | Wholemeal wheat bread: A comparison of different bread making processes and fungal phytase addition 显示文摘 | ROSELL C M SANTOS E SANZ PENELLA J M | 2009 | Journal of Cereal Science2009，50，2： | 1 |
| 14 | A new MPPT method for low-power solar energy harvesting显示文摘 | Lopez-Lapena O Penella M T Gasulla M | 2010 | IEEE Transactions on Industrial Electronics2010，57，9： | 1 |
| 15 | A new MPPT method for low-power solar energy harvesting显示文摘 | Oscar Lopez Lapena Teresa Penella Maria Manel Gasulla | 2010 | IEEE Transactions on Industrial Electronics2010，57，9： | 1 |
| 16 | 盐胁迫下耐盐砧木通过保持光合能力和库强提高嫁接辣椒的产量显示文摘本研究通过两个试验评价了耐盐辣椒A25(Capsicum annuum L.)作为砧木的表现。第一个试验是在普通土壤条件下进行的田间试验,与商业辣椒品种Adige自根植株(A)相比,以A25为砧木的嫁接组合(A/A25)果实产量大大提高(75%),而脐腐病的发病率明显降低(31%)。为深入研究该现象的作用机制,第二个试验于温室中80 mM NaCl处理14 d后,分别检测A和A/A25的长势、矿质成分分布、气体交换、叶绿素荧光参数、抗氧化系统和脯氨酸含量。与对照相比,盐胁迫显著抑制A的植株生长(叶片干质量下降40.6%),而对A/A25没有影响。A/A25与A的叶片及根的离子(Na^+和Cl^-)积累量相似。虽然超氧化物岐化酶、过氧化氢酶和抗坏血酸过氧化物酶的活性增强,非光化学淬灭增加,保护机制被激活,但A植株光合碳同化明显减少(45.6%),且丙二醛(MDA)大量积累表明植株受到了盐胁迫的伤害。相反,A/A25具有发达的根系,能通过保持光合性能来保证接穗和根系在盐胁迫条件下的生长。在盐胁迫下,A/A25的过氧化氢酶和抗坏血酸过氧化物酶活性未发生改变,MDA水平未显著升高,表明A/A25的氧化应激反应没有被激活。在该研究中,脯氨酸水平升高有利于保护由盐胁迫引起的酶稳定性伤害,保证植物的光合性能。以上结果表明,嫁接缓解了盐胁迫对光合作用的负面影响,维持了嫁接植株的长势,提高了商品产量。 | Consuelo Penella Marco Landi Lucia Guidi Sergio G.Nebauer Elisa Pellegrini Alberto San Bautista Damiano Remorini Cristina Nali Salvador López-Galarza Angeles Calatayud 刘越(译) 孔秋生(译) | 2016 | 辣椒杂志2016，，2： | 1 |
| 17 | A new MPPT method for low- power solar energy harvesting显示文摘 | L6pez-Lapefia O Penella M T | 2010 | IEEE Trans on Industrial Electronics2010，57，9： | 1 |
| 18 | A close-loop maximum power point tracker for sub-watt photovohaie panels 显示文摘 | L6pez-Lapefia O Penella M T Gasulla M | 2012 | IEEE Trans on Industrial Electronics2012，59，3： | 1 |
| 19 | Adjuvant chemotherapy with doxorubicin, ifosfamide, and lenograstim for resected soft-tissue sarcoma (EORTC 62931): a multicentre randomised controlled trial显示文摘 | Penella J Woll Peter Reichardt Axel Le Cesne Sylvie Bonvalot Alberto Azzarelli Harald J Hoekstra Michael Leahy Frits Van Coevorden Jaap Verweij Pancras CW Hogendoorn Monia Ouali Sandrine Marreaud Vivien HC Bramwell Peter Hohenberger | 2012 | Lancet Oncology2012，，10： | 1 |
| 20 | Overall Survival Improvement in Patients with Lung Cancer and Bone Metastases Treated with Denosumab Versus Zoledronic Acid: Subgroup Analysis from a Randomized Phase 3 Study显示文摘 | Giorgio Vittorio Scagliotti Vera Hirsh Salvatore Siena David H. Henry Penella J. Woll Christian Manegold Philippe Solal-Celigny Gladys Rodriguez Maciej Krzakowski Nilesh D. Mehta Lara Lipton José Angel García-Sáenz José Rodrigues Pereira Kumar Prabhash Tu | 2012 | Journal of Thoracic Oncology2012，，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员