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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 3 | Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study显示文摘 | Hongjie Yu Joseph T Wu Benjamin J Cowling Qiaohong Liao Vicky J Fang Sheng Zhou Peng Wu Hang Zhou Eric H Y Lau Danhuai Guo Michael Y Ni Zhibin Peng Luzhao Feng Hui Jiang Huiming Luo Qun Li Zijian Feng Yu Wang Weizhong Yang Gabriel M Leung | 2013 | The Lancet2013，，： | 2 |
| 4 | Amino functionalized ionic liquid as an efficient and recyclable catalyst for knoevenagel reactions in water 显示文摘 | Cai Y Q Peng Y Q Song G H | 2006 | Catal Lett2006，109，： | 1 |
| 5 | Preparation and photocatalytic activity of dysprosium doped tungsten trioxide nanoparticles 显示文摘 | Liu H J Peng T Y Ke D N | 2007 | Materials Chemistry and Physics2007，104，23： | 1 |
| 6 | Loss of p12CDK2-AP1 expression in human oral squamous cell carcinoma with disrupted transforming growth factor-beta-Smad signaling pathway显示文摘 | PENG H SHINTANI S KIM Y al | 2006 | Neoplasia2006，8，： | 1 |
| 7 | Endothelin-1 increases expression of cyclooxygenase-2 and production of interlukin-8 in hunan pulmonary epithelial cells显示文摘 | Peng H Chen P Cai Y | 2008 | Peptides2008，29，3： | 1 |
| 8 | Reaction of N-methyl-2-pyrrolidinone with carbon disulfide显示文摘 | Zong Z M Peng Y L Qin Z H | 2000 | Energy Fuels2000，14，3： | 1 |
| 9 | Amino functionalized ionic liquid as an efficient and recyclable catalyst for knoevenagel reactions in water显示文摘 | Cai Y Q Peng Y Q Song G H | 2006 | Catalysis Letters2006，109，12： | 1 |
| 10 | Regeneration of high-performance activated carbon from spent catalyst: Optimization using response surface methodology 显示文摘 | ZHANG Z Y PENG J H QU W W | 2009 | Journal of the Taiwan Institute of Chemical Engineers2009，，40： | 1 |
| 11 | Tissue distribution and maternal transfer of poly-and perfluorinated compounds in Chinese sturgeon (Acipenser sinensis) : implications for reproductive risk 显示文摘 | Peng H Wei Q W Wan Y | 2010 | Environ Sci Technol2010，44，5： | 1 |
| 12 | An Optimization Method Inspired by Chaotic Ant Behavior 显示文摘 | LI L X YANG Y X PENG H P | 2006 | Internation- al Journal of Bifurcation Chaos2006，，16： | 1 |
| 13 | Atomic states, potential energies, volumes, stability and brittleness of ordered FCC TiAl2 type alloys显示文摘 | Xie Y Q Tao H J Peng H J | 2005 | Physica B2005，366，： | 1 |
| 14 | Studies on cutting propagation techniques of Spatholobus suberectus 显示文摘 | HUANG X Y LU H Z PENG Y D | 2010 | Medicinal Plant2010，1，3： | 1 |
| 15 | Nuclear contrast angiography: a simple method for morphological characterization of cerebral arte ries 显示文摘 | Meng H Peng Y Hasan R | 2009 | Brain Res2009，1261，： | 1 |
| 16 | Decreased CD4^+ CD25^+ cells and increased dimeric IgA -producing cells in tonsils in IgA nephropathy 显示文摘 | HUANG H PENG Y LIU H | 2010 | Nephrol2010，23，2： | 1 |
| 17 | Field emission properties of diamond- like carbon films annealed at different temperatures 显示文摘 | LI J J GU C Z PENG H Y | 2005 | Applied Surface Science2005，251，14： | 1 |
| 18 | Model selection in linear mixed effect models显示文摘 | Peng H Lu Y | 2012 | Journal of Multivariate Analysis2012，109，： | 1 |
| 19 | Genetic variations in Tibetan populations and high-alti- tude adaptation at the Himalayas显示文摘 | Peng Y Yang Z Zhang H Cui C Qi X Luo X | 2011 | Mol Biol Evol2011，28，： | 1 |
| 20 | Tempol,a nitroxide antioxidant,improves locomotor and histological outcomes after spinal cord contusion in rats显示文摘 | Hillard VH Peng H Zhang Y | | 0，，10： | 1 |
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