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| 1 | Improved corrosion resistance and thermal stability of sintered Nd-Fe-B magnets with holmium substitution显示文摘The effects of Ho substitution for Nd on the microstructure, corrosion resistance and thermal stability of the Nd-Fe-B magnets were investigated. The(Nd,Ho)-O phase was formed with increasing Ho substitution. The results of potentiodynamic polarization and highly accelerated stress test show improved corrosion resistance with increasing Ho substitution. The optimum mass loss 0.29 mg/cm^2 is achieved.Moreover, the average temperature coefficients for remanence and coercivity in the range of 25-150℃are both closer to zero, indicating improved thermal stability. The mechanisms for the improved corrosion resistance and thermal stability are discussed in relation to the microstructure featuring the(Nd,Ho)-O phase. | Jinghui Di Shuai Guo Ling Chen Pengpeng Yi Guangfei Ding Kan Chen Ming Li Don Lee Aru Yan | 2018 | Journal of Rare Earths2018，36，8： | 11 |
| 2 | Outcomes in refractory diffuse large B-cell lymphoma:results fromamulticenter real-world study in China显示文摘Background:Diffuse large B-cell lymphoma(DLBCL)patients refractory to rituximab-based immunochemotherapy have a dismal prognosis.However,the definition of refractory DLBCL remains inconsistent and no large cohort study data is available from Asian countries.To validate the definition and outcomes of refractory DLBCL in China,we conducted a multicenter,retrospective cohort study.Methods:The REtrospective AnaLysis of Treatment REspoNse of refractory DLBCL(REAL-TREND)study was performed using real-world data from 8 centers in China.DLBCL patients with curative intent were included in the REAL-TREND dataset.Overall survival(OS)was estimated using the Kaplan-Meier method and compared by the log-rank test.Due to heterogeneity in response rates among different centers,the response rates of refractory patients were pooled using random-effect models.Multivariate survival analysis was performed using the Cox regression model.Results:A total of 2778 DLBCL patients diagnosed between January,2010 and December,2015 were enrolled to this study.After validating previous definitions,the SCHOLAR-1 study was most suitable to define refractory DLBCL.The estimated 5-year cumulative incidence of refractory patients was 20%(95% confidence Interval[CI]=18%-22%).After the determination of refractory disease,overall response rate and complete remission rate were 30%(95%CI=22%-38%)and 9%(95%CI=4%-15%),respectively.Patients with either no response to immunochemotherapy or relapse within 12 months after stem-cell transplantation had inferior survival with a median OS of 5.9 months(95%CI=5.5-7.1 months)and 2-year OS rate of 16%(95%CI=12%-20%).International prognostic index score 4-5(hazard ratio[HR]=2.22;95%CI=1.47-3.35),central nervous systemrelapse(HR=1.43;95%CI=1.04-1.97),and best response status(HR=2.68;95%CI=1.42-5.03 for partial remission.HR=5.97,95%CI=3.21-11.11 for stable disease/progressive disease)were independent unfavorable prognostic factors.Conclusions:This is the first large-scale Asian cohort study focusing on outcomes of refractory DLBCL.The definition of the SCHOLAR-1 study identifies patients with homogenously inferior survival,thus is appropriate to select refractory DLBCL.Due to poor clinical outcomes in the rituximab era,patients with refractory DLBCL may be potential candidates for novel treatment modalities. | Shuo Wang Li Wang Jianda Hu Wenbin Qian Xi Zhang Yu Hu Qi Zhu Bobin Chen Depei Wu Chung-Chou H.Chang Pengpeng Xu Xiaoyun Zheng Juying Wei Yao Liu Guohui Cui Yong Tang Yan Ma Haiwen Huang Hongmei Yi Weili Zhao | 2021 | Cancer Communications2021，41，3： | 10 |
| 3 | Low dose bisphenol A impairs spermatogenesis by suppressing reproductive hormone production and promoting germ cell apoptosis in adult rats显示文摘Bisphenol A (BPA), an estrogenic chemical, has been shown to reduce sperm count; however, the underlyingmechanisms remain unknown. Herein, we show that oral administration of BPA (2 μg/kg) for consecutive 14 daysin adult rats (BPA rats) significantly reduced the sperm count and the number of germ cells compared to controls.The serum levels of testosterone and follicle-stimulating hormone (FSH), as well as the level of GnRH mRNA inBPA rats were lower than those of control rats. Testosterone treatment could partially rescue the reduction of germcells in BPA rats. Notably, the number of apoptotic germ cells was significantly increased in BPA rats, which wasinsensitive to testosterone. Furthermore, the levels of Fas, FasL and caspase-3 mRNA in the testicle of BPA ratswere increased in comparison with controls. These results indicate that exposure to a low dose of BPA impairsspermatogenesis through decreasing reproductive hormones and activating the Fas/FasL signaling pathway. | Pengpeng Jin Xiaoli Wang Fei Chang Yinyang Bai Yingchun Li Rong Zhou Ling Chen | 2013 | The Journal of Biomedical Research2013，27，2： | 5 |
| 4 | Time-Variant Reliability-Based Multi-Objective Fuzzy Design Optimization for Anti-Roll Torsion Bar of EMU显示文摘Although various types of anti-roll torsion bars have been developed to inhibit excessive roll angle of the electric multiple unit(EMU)car body,it is critical to ensure the reliability of structural design due to the complexity of the problems involving time and uncertainties.To address this issue,amulti-objective fuzzy design optimization model is constructed considering time-variant stiffness and strength reliability constraints for the anti-roll torsion bar.A hybrid optimization strategy combining the design of experiment(DoE)sampling and non-linear programming by quadratic lagrangian(NLPQL)is presented to deal with the design optimization model.To characterize the effect of time on the structural performance of the torsion bar,the continuous-time model combined with Ito lemma is proposed to establish the time-variant stiffness and strength reliability constraints.Fuzzy mathematics is employed to conduct uncertainty quantification for the design parameters of the torsion bar.A physical programming approach is used to improve the designer’s preference and to make the optimization results more consistent with engineering practices.Moreover,the effectiveness of the proposed method has been validated by comparing with current methods in a practical engineering case. | Pengpeng Zhi Zhonglai Wang Bingzhi Chen Ziqiang Sheng | 2022 | Computer Modeling in Engineering & Sciences2022，，5： | 5 |
| 5 | Controllable synthesis of highly crystallized mesoporous TiO2/WO3 heterojunctions for acetone gas sensing显示文摘Mesoporous semiconducting metal oxides(SMOs)heterojunctions are appealing sensors for gas detecting.However,due to the different hydrolysis and condensation mechanism of every metal precursor and the contradiction between high crystallinity and high surface area,the synthesis of mesoporous SMOs heterojunctions with highly o rdered mesostructures,highly crystallized frameworks,and high surface area remains a huge challenge.In this work,we develop a novel'acid-base pair'adjusted solvent evaporation induced self-assembly(EISA)strategy to prepare highly crystallized ordered mesoporous TiO2/WO3(OM-TiO2/WO3)heterojunctions.The WCl6 and titanium isopropoxide(TIPO)are used as the precursors,respectively,which function as the'acid-base pair',enabling the coassembly with the structure directing agent(PEO-b-PS)into highly ordered meso structures.In addition,PEO-b-PS can be converted to rigid carbon which can protect the meso structures from collapse during the crystallization process.The resultant OM-TiO2/WO3 heterojunctions possess primitive cubic mesostructures,large pore size(~21.1 nm),highly crystalline frameworks and surface area(~98 m2/g).As a sensor for acetone,the obtained OM-TiO2/WO3 show excellent re sponse/recovery perfo rmance(3 s/5 s),good linear dependence,repeatability,selectivity,and long-term stability(35 days). | Changyao Wang Yuhui Li Pengpeng Qiu Linlin Duan Wei Bi Yan Chen Dingyi Guo Yupu Liu Wei Luo Yonghui Deng | 2020 | Chinese Chemical Letters2020，31，5： | 4 |
| 6 | Urinary donor-derived cell-free DNA as a non-invasive biomarker for BK polyomavirus-associated nephropathy显示文摘BK polyomavirus-associated nephropathy(BKPyVAN)is a common cause of allograft failure.However,differentiation between BKPyVAN and type I T cell-mediated rejection(TCMR)is challenging when simian virus 40(SV40)staining is negative,because of the similarities in histopathology.This study investigated whether donor-derived cell-free DNA(ddcfDNA)can be used to differentiate BKPyVAN.Target region capture sequencing was applied to detect the ddcfDNAs of 12 recipients with stable graft function,22 with type I TCMR,21 with proven BKPy VAN,and 5 with possible Py VAN.We found that urinary ddcfDNA levels were upregulated in recipients with graft injury,whereas plasma ddcfDNA levels were comparable for all groups.The median urinary concentrations and fractions of ddcfDNA in proven BKPyVAN recipients were significantly higher than those in type I TCMR recipients(10.4 vs.6.1 ng/mL,P<0.001 and 68.4%vs.55.3%,P=0.013,respectively).Urinary ddcfDNA fractions(not concentrations)were higher in the BKPyVAN-pure subgroup than in the BKPyVAN-rejection-like subgroup(81.30%vs.56.64%,P=0.025).With a cut-off value of 7.81 ng/m L,urinary ddcf DNA concentrations distinguished proven BKPyVAN from type I TCMR(area under the curve(AUC)=0.848,95%confidence interval(95%CI):0.734 to 0.963).These findings suggest that urinary ddcf DNA is a non-invasive biomarker which can reliably differentiate BKPy VAN from type I TCMR. | Jia SHEN Luying GUO Wenhua LEI Shuaihui LIU Pengpeng YAN Haitao LIU Jingyi ZHOU Qin ZHOU Feng LIU Tingya JIANG Huiping WANG Jianyong WU Jianghua CHEN Rending WANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，11： | 4 |
| 7 | High-performance fiber-integrated multifunctional graphene-optoelectronic device with photoelectric detection and optic-phase modulation显示文摘In graphene-based optoelectronic devices,the ultraweak interaction between a light and monolayer graphene leads to low optical absorption and low responsivity for the photodetectors and relative high half-wave voltage for the phase modulator.Here,an integration of the monolayer graphene onto the side-polished optical fiber is demonstrated,which is capable of providing a cost-effective strategy to enhance the light–graphene interaction,allowing us to obtain a highly efficient optical absorption in graphene and achieve multifunctions:photodetection and optical phase modulation.As a photodetector,the device has ultrahigh responsivity(1.5×10^(7) A/W)and high external quantum efficiency(>1.2×10^(9)%).Additionally,the polybutadiene/polymethyl methacrylate(PMMA)film on the graphene can render the device an optical phase modulator through the large thermo-optic effect of the PMMA.As a phase modulator,the device has a relatively low half-wave voltage of 3 V with a 16 dB extinction ratio in Mach–Zehnder interferometer configuration. | LINQING ZHUO PENGPENG FAN SHUANG ZHANG YUANSONG ZHAN YANMEI LINYU ZHANG DONGQUAN LI ZHEN CHE WENGUO ZHU HUADAN ZHENG JIEYUAN TANG JUN ZHANG YONGCHUN ZHONG WENXIAO FANG GUOGUANG LU JIANHUI YU ZHE CHEN | 2020 | Photonics Research2020，8，12： | 3 |
| 8 | Hepatitis B virus-associated follicular lymphoma presents T-cell inflamed phenotype and response to lenalidomide显示文摘Dear Editor,Follicular lymphoma(FL)represents the most common subtype of indolent non-Hodgkin's lymphoma(NHL)with distinct pathological,cytogenetic,and molecular features,accounting for 9.7%of NHLs in China[1].FL maintains a differentiation stage similar to germinal center(GC)B cells and is divided into grades 1,2,3A,and 3B[2].Up to 90%of FLs harbor the t(14;18)(q32;q21)/BCL2 apoptosis regula-tor(BCL2)-immunoglobulin heavy locus(IGH)transloca-tion and epigenetic modifier mutations,particularly lysine methyltransferase 2D(KMT2D)and CREB-binding pro-tein(CREBBP)[2]. | Nan Wang Wei Qin Zhong Zheng Ming Zhao Jie Xiong Hai Fang Rui Sun Yichao Wang Chen Li Lei DongXiaojian Sun Li Wang Pengpeng Xu Shu Cheng Haimin Xu Fan Zhang Weili Zhao | 2022 | Cancer Communications2022，42，2： | 2 |
| 9 | Chemotherapy initiation with single-course methotrexate alone or combined with dactinomycin versus multi-course methotrexate for low-risk gestational trophoblastic neoplasia: a multi-centric randomized clinical trial显示文摘We aimed to evaluate the effectiveness and safety of single-course initial regimens in patients with low-risk gestational trophoblastic neoplasia(GTN).In this trial (NCT01823315),276 patients were analyzed.Patients were allocated to three initiated regimens:single-course methotrexate(MTX),single-course MTX+dactinomycin(ACTD),and multi-course MTX(control arm).The primary endpoint was the complete remission(CR)rate by initial drug(s).The primary CR rate was 64.4%with multi-course MTX in the control arm.For the single-course MTX arm,the CR rate was 35.8%by one course;it increased to 59.3%after subsequent multi-course MTX,with non-inferiority to the control(difference-5.1%,95%confidence interval(CI)-19.4%to 9.2%,P=0.014).After further treatment with multi-course ACTD,the CR rate(93.3%)was similar to that of the control(95.2%,P=0.577).For the single-course MTX+ACTD arm,the CR rate was 46.7%by one course,which increased to 89.1%after subsequent multi-course,with non-inferiority(difference 24.7%,95%CI 12.8%-36.6%,P<0.001)to the control.It was similar to the CR rate by MTX and further ACTD in the control arm(89.1%vs.95.2%,P=0.135).Four patients experienced recurrence,with no death,during the 2-year follow-up.We demonstrated that chemotherapy initiation with single-course MTX may be an alternative regimen for patients with low-risk GTN. | Lili Chen Ling Xi Jie Jiang Rutie Yin Pengpeng Qu Xiuqin Li Xiaoyun Wan Yaxia Chen Dongxiao Hu Yuyan Mao Zimin Pan Xiaodong Cheng Xinyu Wang Qingli Li Danhui Weng Xi Zhang Hong Zhang Quanhong Ping Xiaomei Liu Xing Xie Beihua Kong Ding Ma Weiguo Lu | 2022 | Frontiers of Medicine2022，16，2： | 2 |
| 10 | A novel microRNA miR-MTCO3P38 inhibits malignant progression via STAT3/PTTG1/MYC in hepatocellular carcinoma显示文摘To the Editor,Hepatocellular carcinoma(HCC)is a malignant tumor with the fourth highest incidence and the third highest mortality among all tumor sites in China.1 Finding new diagnostic markers and therapeutic molecules may be of great value in the treatment of HCC and the improvement of prognosis. | Deliang Guo Yang Gu Dong Ma Pengpeng Liu Baiyang Chen Zhisu Liu Ping Wu Quanyan Liu | 2022 | Genes & Diseases2022，9，4： | 1 |
| 11 | Rapid magnetic removal of aqueous heavy metals and their relevant mechanisms using nanoscale zero valent iron (nZVI) particles显示文摘 | Pengpeng Huang Zhengfang Ye Wuming Xie Qi Chen Jing Li Zhencheng Xu Maosheng Yao | 2013 | Water Research2013，，12： | 1 |
| 12 | 多西紫杉醇和卡铂联合治疗上皮性卵巢癌、原发性腹膜癌和输卵管癌的荟萃分析(英文)显示文摘Objective:The aim of this study was to compare the efficacies and safeties of the combination of docetaxelcarboplatin with the combination of non docetaxel-carboplatin as first-line chemotherapy for advanced epithelial ovarian,primary peritoneal or fallopian tube cancers.Methods:Relevant articles were identified from MEDLINE(1993-2010),EMBASE(1980-2010),MEDION,the Cochrane library,Science Citation Index Expanded databases,hand searching of reference lists from primary articles and reviews,conference abstracts and contact with experts in the field.The review included 5 relevant primary studies(1430 women).Data was extracted for study characteristics and quality.Bivariate random-effect model metaanalysis was used to estimate diagnostic accuracy of the various index tests.A quantitative meta-analysis was carried out by two reviewers based on the inclusion criteria from all available studies.Results:The frequency of the subgroup analysis of toxicity showed that toxicity action of combination of docetaxel-carboplatin was more severe than that of non docetaxelcarboplatin group(OR = 1.33,95% CI = 1.13-1.56,P = 0.0005),whereas that of clinical responses was equivalent in comparison combination of docetaxel-carboplatin with combination of paclitaxel-carboplatin or docetaxel-cisplatin(OR = 1.0,95% CI = 0.87-1.16,P = 0.95).There were heterogeneity(χ2 = 79.36,P < 0.00001) and inconsistency(83.6%) in toxicity analysis among the trials,while neither heterogeneity(χ2 = 3.21,P = 0.99) nor inconsistency(I2 = 0%) in clinical responses among the trials.Conclusion:The safety of combination of docetaxel-carboplatin is less than that of combination of paclitaxelcarboplatin or docetaxel-cisplatin.However,the clinical responses of combination of docetaxel-carboplatin are comparable with combination of paclitaxel-carboplatin or docetaxel-cisplatin. | Hongxiao Chen Yang Rao Pengpeng Qu | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，8： | 1 |
| 13 | Efficiency enhancement in DIBSQ:PC71BM organic photovoltaic cells by using Liq-doped Bphen as a cathode buffer layer显示文摘 | Guo CHEN Changfeng SI Pengpeng ZHANG Kunping GUO Saihu PAN Wenqing ZHU Bin WEI | 2017 | Frontiers of Materials Science2017，11，3： | 1 |
| 14 | Transformation of microstructure and phase of disodium guanosine 5′-monophosphate: Thermodynamic perspectives显示文摘Microstructure and phase transformation of disodium guanosine 5′-monophosphate(5′-GMPNa_2) are extremely important for controlling the process and understanding the mechanism of crystallization. In this work, the thermodynamic properties of polymorphous 5′-GMPNa_2 especially the solubility were studied, the solubility results show that 5′-GMPNa_2 is more soluble in ethanol–water(E–W) than in isopropanol–water(I–W). The amorphous form of 5′-GMPNa_2 is more soluble than the crystalline form at the same mole fraction and temperature. Meanwhile, the crystalline forms and morphologies of the residual solids were characterized by PXRD and SEM. The results indicate that solid forms of 5′-GMPNa_2 transformed spontaneously from amorphous to crystalline when the ethanol proportion is ≥20%. In addition, increasing the pH facilitates the dissolution of 5′-GMPNa_2 and helps to maintain the crystalline form. The associated Gibbs free energy values were calculated to verify the trend of transformation from amorphous to crystalline 5′-GMPNa_2. These results should help to guide the industrial crystallization process and to obtain the crystalline form of 5′-GMPNa_2. | Qiao Chen Fengxia Zou Pengpeng Yang Jingwei Zhou Jinglan Wu Wei Zhuang Hanjie Ying | 2018 | Chinese Journal of Chemical Engineering2018，26，10： | 1 |
| 15 | Soil microbial communities as potential regulators of N2O sources in highly acidic soils显示文摘●Soil pH was a key driver of N2O emission and sources in acidic soils.●N2O emission was significantly positively associated with the ratio of ITS to 16S.●N2O was significantly correlated with bacterial and fungal community composition.●Fungi contributed to N2O in highly acidic tea plantations and vegetable fields.Acidic soil is a main source of global nitrous oxide(N2O)emissions.However,the mechanism behind the high N2O emissions from acidic soils remains a knowledge gap.The objective of this microcosm incubation study was to pin-point the microbial mechanisms involved in N2O production processes in acidic soils.For that purpose,the isotopic signatures and microbial community structure and composition of four soil samples were examined.The results showed that highly acid soils(pH=3.51)emitted 89 times more N2O than alkaline soils(pH=7.95)under the same nitrogen(N)inputs.Fungal denitrification caused high N2O emissions in acidic soils.ITS to 16S abundance ratio was positively correlated with cumulative N2O emissions from the tested soils.The highly acid soils(pH<4.5)showed greater fungal nirK gene abundance and lower abundance of AOA-amoA,AOB-amoA,nirK,nosZ I and nosZ II genes.The unclassified Aspergillaceae fungi(63.65%)dominated the highly acidic soils and was the most strongly correlated genus with N2O emissions.These findings highlight that soil microbial community structures,denitrifying fungi in particular,shaped by low pH(pH<4.5)lead to high N2O emissions from acidic soils. | Junhui Yin Huaihai Chen Pengpeng Duan Kun Zhu Naihui Li Yan Ma Yumeng Xu Jingheng Guo Rui Liu Qing Chen | 2023 | Soil Ecology Letters2023，5，4： | 1 |
| 16 | Distance-controllable and direction-steerable opto-conveyor for targeting delivery显示文摘Opto-conveyors have attracted widespread interest in various fields because of their non-invasive and non-contact delivery of micro/nanoparticles.However,the flexible control of the delivery distance and the dynamic steering of the delivery direction,although very desirable in all-optical manipulation,have not yet been achieved by optoconveyors.Here,using a simple and cost-effective scheme of an elliptically focused laser beam obliquely irradiated on a substrate,a direction-steerable and distance-controllable opto-conveyor for the targeting delivery of microparticles is implemented.Theoretically,in the proposed scheme of the opto-conveyor,the transverse and longitudinal resultant forces of the optical gradient force and the optical scattering force result in the transverse confinement and the longitudinal transportation of microparticles,respectively.In this study,it is experimentally shown that the proposed opto-conveyor is capable of realizing the targeting delivery for microparticles.Additionally,the delivery distance of microparticles can be flexibly and precisely controlled by simply adjusting the irradiation time.By simply rotating the cylindrical lens,the proposed opto-conveyor is capable of steering the delivery direction flexibly within a large range of azimuthal angles,from-75°to 75°.This study also successfully demonstrated the real-time dynamic steering of the delivery direction from-45°to 45°with the dynamical rotation of the cylindrical lens.Owing to its simplicity,flexibility,and controllability,the proposed method is capable of creating new opportunities in bioassays as well as in drug delivery. | Zhen Che Wenguo Zhu Yaoming Huang Yu Zhang Linqing Zhuo Pengpeng Fan Zhibin Li Huadan Zheng Wenjin Long Wentao Qiu Yunhan Luo Jun Zhang Jinghua Ge Jianhui Yu Zhe Chen | 2020 | Photonics Research2020，8，7： | 1 |
| 17 | Detection of Spotted Fever Group Rickettsia in Haemaphysalis longicornis From Hebei Province, China显示文摘 | Zou Yaxue Wang Qiuyue Fu Zhixin Liu Pengpeng Jin Hongtao Yang Huanhuan Gao Hongwei Xi Zhang Liu Quan Chen Lifeng | 2011 | EN2011，，5： | 1 |
| 18 | Interactive software development platform for household appliance testing in dustry 显示文摘 | Zhongwen Guo Pengpeng Chen Yuan Feng | 2010 | IEEE transaclions on instrumentation and measure mere2010，59，5： | 1 |
| 19 | Influence of thermal annealing-induced molecular aggregation on film properties and photovoltaic performance of bulk heterojunction solar cells based on a squaraine dye显示文摘 | Pengpeng ZHANG Zhitian LING Guo CHEN Bin WEI | 2018 | Frontiers of Materials Science2018，12，2： | 1 |
| 20 | Synergistic lubricating effect of graphene/ionic liquid composite material used as an additive显示文摘We prepared a graphene/ionic liquid(G/IL)composite material by the hybridization of G and an IL for use as a lubricating oil additive.The friction coefficient and wear volume of a base oil containing 0.04 wt%of the G/IL composite was reduced by 45%and 90%,respectively.Furthermore,the base oil containing the G/IL composite exhibited better lubricating properties than the base oil containing G,IL,or a mixture of IL and G at the same mass fraction.A synergistic lubrication mechanism was also revealed.The G/IL composite was adsorbed and deposited on the wear surface,forming a more ordered protective film and a unique tribochemical reaction film during rubbing.Therefore,the G/IL composite exhibited the synergistic lubricating effects of G and IL,which significantly improved the lubricating performance of the base oil.This study also suggested a way to limit the out-of-plane puckering of G at the macroscale. | Lincong LIU Ming ZHOU Youtang MO Pengpeng BAI Qilin WEI Long JIN Shengli YOU Mingyue WANG Liangchuan LI Xin CHEN Xiao LI Yu TIAN | 2021 | Friction2021，9，6： | 1 |
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