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| 1 | Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing显示文摘Targeting immune checkpoints such as programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for treating melanoma,gastric cancer(GC)and bladder cancer with clinical benefit.Nevertheless,many patients failed to respond to anti-PD-1/PD-L1 treatment,so it is necessary to seek an alternative strategy for traditional PD-1/PD-L1 targeting immunotherapy.Here with the data from The Cancer Genome Atlas(TCGA)and our in-house tissue library,PD-L1 expression was found to be positively correlated with the expression of ubiquitin-specific processing protease 7(USP7)in GC.Furthermore,USP7 directly interacted with PD-L1 in order to stabilize it,Gastric cancer;Immunosuppression;Cancer biologywhile abrogation of USP7 attenuated PD-L1/PD-1 interaction and sensitized cancer cells to T cell killing in vitro and in vivo.Besides,USP7 inhibitor suppressed GC cells proliferation by stabilizing P53 in vitro and in vivo.Collectively,our findings indicate that in addition to inhibiting cancer cells proliferation,USP7 inhibitor can also downregulate PD-L1 expression to enhance anti-tumor immune response simultaneously.Hence,these data posit USP7 inhibitor as an anti-proliferation agent as well as a novel therapeutic agent in PD-L1/PD-1 blockade strategy that can promote the immune response of the tumor. | Zhiru Wang Wenting Kang Ouwen Li Fengyu Qi Junwei Wang Yinghua You Pengxing He Zhenhe Suo Yichao Zheng Hong-Min Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 5 |
| 2 | Involvement of a cell wall-associated kinase,WAKL4,in Arabidopsis mineral responses显示文摘 | Hou X Tong H SeIby J Dewitt J PengX He ZH | 2005 | Plant Physiol2005，139，4： | 1 |
| 3 | Design of dual-core connected mesh topology and fine-grained fault-tolerant mechanism for 3D optical network-on-chip显示文摘This paper proposes a fault-tolerant mechanism including a reliable three-dimensional(3D)topology structure named 3D DCMesh(3D dual-core connected mesh)and a fault-tolerant routing algorithm for 3D optical network-on-chip(3D ONoC).In 3D DCMesh,each intellectual property(IP)core connects two optical routers(ORs)with perpendicular physical locations.Thus,every IP core has an additional path selection to play a certain role in redundant protection since it breaks the traditional thinking that each IP core connects only one OR.On the other hand,the previous fault-tolerant algorithm rudely treats the faulty ORs as invalid,resulting in low utilization of resources inside ORs.Hence,this paper proposes a fine-grained fault-tolerant algorithm based on microring resonator faults(FTM-MR),where some ORs along the transmission path can still work normally even if their internal MRs lose efficiency.The simulation results show that the solution in this study outperforms the previous related work by 10.86%-19.97%,6.75%-8.83%,and 13.08%-18.8% for average insertion loss,crosstalk noise,and signal-to-noise ratio(SNR),respectively,under different topology sizes without OR-fault.It can improve the insertion loss performance,crosstalk noise,and the SNR by a maximum of 67.41%,14.2%,and 187.63%,respectively,when the node failure rates are in the range of 50%. | Pengxing GUO Xiangyu HE Yufei YANG Kun LIU Sijing YU Weigang HOU Lei GUO | 2023 | Science China(Information Sciences)2023，66，11： | 0 |
| 4 | Inhibition of lysine-specific demethylase 1(LSD1)prevented tumor growth and metastasis by downregulating PD-L1 expression in lung adenocarcinoma显示文摘Lysine-specific demethylase 1(LSD1),as a histone lysine demethylase,demethylates monomethyl and dimethyl of histone H3 on lysine 4(H3K4)and lysine 9(H3K9).Studies have reported that high LSD1 expression promotes cell proliferation,migration,and invasion by regulating chromatin morphology and gene expression,and is closely related to the development of non-small cell lung cancer(NSCLC).1 However,the underlying mechanism of LSD1 on cell proliferation and migration remains unclear. | Pengxing He Linna Du Pan Hao Han Yang Yufei Ren Huiqin Kang Yanli Ding Wen Zhao Yichao Xu Hongmin Liu | 2023 | Genes & Diseases2023，10，5： | 0 |
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