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| 1 | Homology-mediated end joining-based targeted integration using CRISPR/Cas9显示文摘 | Yao, Xuan Wang, Xing Hu, Xinde Liu, Zhen Liu, Junlai Zhou, Haibo Shen, Xiaowen Wei, Yu Huang, Zijian Ying, Wenqin Wang, Yan Nie, Yan-Hong Zhang, Chen-Chen Li, Sanlan Cheng, Leping Wang, Qifang Wu, Yan Huang, Pengyu Sun, Qiang Shi, Linyu Yang, Hui | 2017 | Cell Research2017，27，6： | 28 |
| 2 | Management of cytokine release syndrome related to CAR-T cell therapy显示文摘Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. This syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immune cells. This phenomenon causes multisystem damages and sometimes even death. In this study, we reported the management of a patient with recurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRS during CAR-T treatment. The early application of tocilizumab, an anti-IL-6 receptor antibody, according to toxicity grading and clinical manifestation is recommended especially for patients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRS toxicities deteriorated rapidly. Moreover, low doses of dexamethasone (5-10 mg/day) were used for refractory CRS not responding to tocilizumab. The effective management of the toxicities associated with CRS will bring additional survival opportunities and improve the quality of life for patients with cancer. | Hongli Chen Fangxia Wang Pengyu Zhang Yilin Zhang Yinxia Chen Xiaohu Fan Xingmei Cao Jie Liu Yun Yang Baiyan Wang Bo Lei Liufang Gu Ju Bai Lili Wei Ruili Zhang Qiuchuan Zhuang Wanggang Zhang Wanhong Zhao Aili He | 2019 | Frontiers of Medicine2019，13，5： | 21 |
| 3 | Simvastatin suppresses vascular inflammation and atherosclerosis in ApoE-/- mice by downregulating the HMGB1-RAGE axis显示文摘 | Ming LIU Ying Yu Hong JIANG Lei ZHANG Pei-pei ZHANG PengYU Jian-guo JIA Rui-zhen CHEN Yun-zeng ZOU Jun-bo GE | 2013 | Acta Pharmacologica Sinica2013，34，6： | 18 |
| 4 | Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver显示文摘Dear Editor,RNA knockdown in vivo carries significant potential for dis-ease modeling and therapies.Despite the emerging approaches of CRISPR/Cas9-mediated permanent knock out of targeted genes,strategies targeting RNA for disruption are advantageous in the treatment of acquired metabolic disorders when permanent modification of genome DNA is not appropriate,and RNA virus infection diseases when pathogenic DNA is not available(such as SARS-Cov-2 and MERS infections). | Bingbing He Wenbo Peng Jia Huang Hang Zhang Yingsi Zhou Xiali Yang Jing Liu Zhijle Li Chunlong Xu Mingxing Xue Hui Yang Pengyu Huang | 2020 | Protein & Cell2020，11，7： | 7 |
| 5 | An area-based position and attitude estimation for unmanned aerial vehicle navigation显示文摘The paper aims to challenge non-GPS navigation problems by using visual sensors and geo-referenced images. An area-based method is proposed to estimate full navigation parameters(FNPs), including attitude, altitude and horizontal position, for unmanned aerial vehicle(UAV) navigation. Our method is composed of three main modules: geometric transfer function, local normalized sobel energy image(LNSEI) based objective function and simplex-simulated annealing(SSA) based optimization algorithm. The adoption of relatively rich scene information and LNSEI, makes it possible to yield a solution robustly even in the presence of very noisy cases, such as multi-modal and/or multi-temporal images that differ in the type of visual sensor, season, illumination, weather, and so on, and also to handle the sparsely textured regions where features are barely detected or matched. Simulation experiments using many synthetic images clearly support noise resistance and estimation accuracy, and experimental results using 2367 real images show the maximum estimation error of 5.16(meter) for horizontal position, 9.72(meter) for altitude and 0.82(degree) for attitude. | LIU XiaoChun WANG Hou FU Dan YU QiFeng GUO PengYu LEI ZhiHui SHANG Yang | 2015 | Science China(Technological Sciences)2015，58，5： | 7 |
| 6 | A critical review on chemical constituents and pharmacological effects of Lilium显示文摘Genus Lilium is famous for edible and medicinal function which is related to its chemical constituents and pharmacological effects.Chemical researches showed that genus Lilium genus mainly contains steroidal saponins,polysaccharides,alkaloids and flavonoids.Pharmacological effects of Lilium include anti-tumor,hypoglycemic,antibacterial,anti-oxidation,anti-depression and anti-inflammatory.This paper summarized chemical constituents and pharmacological effects of Lilium. | Pengyu Wang Jian Li Fatma Alzahra K.Attia Wenyi Kang Jinfeng Wei Zhenhua Liu Changqin Li | 2019 | Food Science and Human Wellness2019，8，4： | 6 |
| 7 | Ni(OH)_(2) nanoparticles encapsulated in conductive nanowire array for high-performance alkaline seawater oxidation显示文摘Design and development of high-efficiency and durable oxygen evolution reaction(OER)electrocatalysts is crucial for hydrogen production from seawater splitting.Herein,we report the in situ electrochemical conversion of a nanoarray of Ni(TCNQ)2(TCNQ=tetracyanoquinodimethane)on graphite paper into Ni(OH)_(2) nanoparticles confined in a conductive TCNQ nanoarray(Ni(OH)_(2)-TCNQ/GP)by anode oxidation.The Ni(OH)_(2)-TCNQ/GP exhibits high OER performance and demands overpotentials of 340 and 382 mV to deliver 100 mA·cm^(−2) in alkaline freshwater and alkaline seawater,respectively.Meanwhile,the Ni(OH)_(2)-TCNQ/GP also demonstrates steady long-term electrochemical durability for at least 80 h under alkaline seawater. | Longcheng Zhang Jiaqian Wang Pengyu Liu Jie Liang Yongsong Luo Guanwei Cui Bo Tang Qian Liu Xuedong Yan Haigang Hao Meiling Liu Rui Gao Xuping Sun | 2022 | Nano Research2022，15，7： | 5 |
| 8 | Fluvial facies reservoir productivity prediction method based on principal component analysis and artificial neural network显示文摘It is difficult to forecast the well productivity because of the complexity of vertical and horizontal developments in fluvial facies reservoir.This paper proposes a method based on Principal Component Analysis and Artificial Neural Network to predict well productivity of fluvial facies reservoir.The method summarizes the statistical reservoir factors and engineering factors that affect the well productivity,extracts information by applying the principal component analysis method and approximates arbitrary functions of the neural network to realize an accurate and efficient prediction on the fluvial facies reservoir well productivity.This method provides an effective way for forecasting the productivity of fluvial facies reservoir which is affected by multifactors and complex mechanism.The study result shows that this method is a practical,effective,accurate and indirect productivity forecast method and is suitable for field application. | Pengyu Gao Chong Jiang Qin Huang Hui Cai Zhifeng Luo Meijia Liu | 2016 | Petroleum2016，2，1： | 4 |
| 9 | Influence of puerarin,paeoniflorin,and menthol on structure and barrier function of tight junctions in MDCK and MDCK-MDR1 Cells显示文摘Objective:In this study,the influence of puerarin,paeoniflorin,and menthol on the structure and barrier function of tight junctions(TJs)in MadineDarby canine kidney epithelial(MDCK)and MDCK-multi-drug resistance 1(MDR1)cells was evaluated to determine the mechanisms by which the drugs cross the bloodebrain barrier(BBB).Method:Cells were treated with puerarin,paeoniflorin,and menthol followed by immunohistochemical staining with occludin,claudin-1,and F-actin.The cells were then observed using laser-scanning confocal microscopy.Average optical density(AOD)of the immunofluorescence images of the proteins were analyzed using ImageJ software while Transepithelial electrical resistance(TEER)was measured using an epithelial voltohmmeter.Results:Confocal microscopy revealed that puerarin-and paeoniflorin-treated tight junction proteins were conspicuous while menthol suppressed their expression.Correspondingly,AOD values of cells treated with puerarin or paeoniflorin,or both showed no difference compared to the control group(P>.05)while the menthol group value was downregulated.In 3 h,TEER of cells not treated with menthol were similar to the control group,while treatment with menthol significantly decreased TEER value(P<.05).In addition,application of menthol decreased TEER in MDCK cells earlier than in MDCK-MDR1 cells.Conclusion:Menthol but not puerarin and paeoniflorin may enhance paracellular transport and improve drug penetration of the BBB by disrupting the structure and,thereby,weakening the barrier function of TJs. | Lin Zhang Shouying Du Yang Lu Chang Liu Huichao Wu Bing Yang Jie Bai Pengyue Li | 2015 | Journal of Traditional Chinese Medical Sciences2015，2，2： | 4 |
| 10 | Study on magnetization reversal behavior for annealed Nd2Fe14B/α-Fe nancomposite alloys显示文摘在 -Fe/Nd2Fe14B 合金的磁化颠倒行为上的热退火的效果被调查。分别地,直到从 0.66 的 0.87 T 和直到 0.76 的顽磁比率先生 / 女士的从 0.67 的顽磁先生的激烈的增加在 -Fe/Nd2Fe14B 合金被观察在 610 牡楴汣獥琠慨 ? 敳晬愭獳浥汢摥椠瑮 ? 桴 ? 汦睯牥氭歩? 潭灲潨潬祧爠獥汵楴杮椠 ? 退火了 L 湵慤瑮瀠牯獥椠 ? 污?楤敲瑣潩獮郄?郄吗?? | ZHANG Pengyue PAN Minxiang GE Hongliang YUE Ming LIU Weiqiang | 2013 | Journal of Rare Earths2013，31，8： | 2 |
| 11 | PPP-RTK functional models formulated with undiferenced and uncombined GNSS observations显示文摘Technique PPP-RTK combines the advantages of both the Precise Point Positioning(PPP)and the Real-Time Kinematic(RTK)positioning.With the emergence of multi-frequency Global Navigation Satellite System(GNSS)observations,it is preferable to formulate PPP-RTK functional models based on original(undiferenced and uncombined)observations.While there exist many variants of the undiferenced and uncombined PPP–RTK models,a unifed theoretical framework needs developing to link these variants.In this contribution,we formulate a class of undiferenced and uncombined PPP-RTK functional models in a systematic way and cast them in a unifed framework.This framework classifes the models into a code-plus-phase category and a phase-only category.Each category covers a variety of measurement scenarios on the network side,ranging from small-,medium-to large-scale networks.For each scenario,special care has been taken of the distinct ionospheric constraints and the diference between Code Division Multiple Access(CDMA)and Frequency Division Multiple Access(FDMA)signals.The key to systematically formulating these models lies in how to deal with the rank defciency problems encountered.We opt for the Singularity-basis(S-basis)theory,giving rise to the full-rank observation equations in which the estimable parameters turn out to be the functions of original parameters and those selected as the S-basis.In the sequel,it becomes straightforward to derive for each scenario the user model as it,more or less,amounts to the single-receiver network model.Benefting from the presented theoretical framework,the relationships and diferences between various undiferenced and uncombined PPP-RTK models become clear,which can lead to the better use of these models in a specifc situation. | Baocheng Zhang Pengyu Hou Jiuping Zha Teng Liu | 2022 | Satellite Navigation2022，3，1： | 2 |
| 12 | Synthesis and characterization of dendronized hyperbranched polymers through the “A_3+B_2” approach显示文摘Dendronized hyperbranched polymer(DHP) is a new kind of polymer, which combines the advantages of dendrimers and hyperbranched polymers. In this work, two dendronized hyperbranched polymers, DHPG0 and DHPG1, were successfully prepared through the simple 'A_3+B_2' type Sonogashira coupling reaction. The nonlinear optical(NLO) effects of DHPG0 and DHPG1, characterized by the d33 values, were 183 and 220 pm V^(–1) respectively, higher than those of their analogues of dendronized polymers and dendrimers, thanks to the special topological structure. Also, the obtained polymers displayed excellent solubility, good processability, and high thermal stability. | Guangchao Liu Pengyu Chen Runli Tang Zhen Li | 2016 | Science China Chemistry2016，59，12： | 2 |
| 13 | Arabidopsis Synaptotagmin 2 Participates in Pollen Germination and Tube Growth and Is Delivered to Plasma Membrane via Conventional Secretion显示文摘Arabidopsis synaptotagmin (SYT2 ) 2 被报导了在体的房间参予一条异乎寻常的能分泌的小径。我们的结果证明 SYT2 主要在 Arabidopsis thaliana 的花粉被表示。展出的 syt2 T-DNA 和 RNA 干扰异种线的花粉减少了全部的萌芽并且阻碍了花粉试管生长。在 SYT2 对不同、补缀的分隔空间局部性,但是能与 Golgi 标记, BODIPY TR C5 ceramide 和 GmMan1-mCherry 共同本地化的花粉 tubeindicates 的 SYT2-GFP 熔化蛋白质的表示的分析。然而,对在 Arabidopsis 暂停房间的血浆膜局部性的 SYT2-DsRed-E5was,除了 Golgi 仪器。在血浆膜的 SYT2 的本地化被在花粉试管染色的 immunofluorescence 进一步支持。而且, brefeldin Atreatment 禁止了 SYT2 的运输到血浆膜并且引起了 SYT2 聚集并且形成扩大分隔空间。SYT2-C2AB 领域的截断也在 Golgi 仪器导致了 SYT2 的保留。phospholipid 有约束力的试金显示出的 invitro SYT2-C2AB 领域以一种钙依赖者方式绑在 phospholipid 膜。一起拿,我们的结果显示了那 SYT2 为花粉萌芽和花粉试管生长被要求,并且涉及常规 exocytosis。 | Hui Wang Shengcheng Han Wei Siao Chunqing Song Yun Xiang Xiaorong Wu Pengyu Cheng Hongjuan Li JAn Jasik Karol Micieta JAn Turna Boris Voigtt Frantisek Baluska Jin Liu Yingdian Wang Heping Zhao | 2015 | Molecular Plant2015，8，12： | 2 |
| 14 | LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice显示文摘The LIM domain-containing proteins Pinch1/2 regulate integrin activation and cell–extracellular matrix interaction and adhesion.Here,we report that deleting Pinch1 in limb mesenchymal stem cells(MSCs)and Pinch2 globally(double knockout;dKO)in mice causes severe chondrodysplasia,while single mutant mice do not display marked defects.Pinch deletion decreases chondrocyte proliferation,accelerates cell differentiation and disrupts column formation.Pinch loss drastically reduces Smad2/3 protein expression in proliferative zone(PZ)chondrocytes and increases Runx2 and Col10a1 expression in both PZ and hypertrophic zone(HZ)chondrocytes.Pinch loss increases sclerostin and Rankl expression in HZ chondrocytes,reduces bone formation,and increases bone resorption,leading to low bone mass.In vitro studies revealed that Pinch1 and Smad2/3 colocalize in the nuclei of chondrocytes.Through its C-terminal region,Pinch1 interacts with Smad2/3 proteins.Pinch loss increases Smad2/3 ubiquitination and degradation in primary bone marrow stromal cells(BMSCs).Pinch loss reduces TGF-β-induced Smad2/3 phosphorylation and nuclear localization in primary BMSCs.Interestingly,compared to those from single mutant mice,BMSCs from dKO mice express dramatically lower protein levels ofβ-catenin and Yap1/Taz and display reduced osteogenic but increased adipogenic differentiation capacity.Finally,ablating Pinch1 in chondrocytes and Pinch2 globally causes severe osteopenia with subtle limb shortening.Collectively,our findings demonstrate critical roles for Pinch1/2 and a functional redundancy of both factors in the control of chondrogenesis and bone mass through distinct mechanisms. | Yiming Lei Xuekun Fu Pengyu Li Sixiong Lin Qinnan Yan Yumei Lai Xin Liu Yishu Wang Xiaochun Bai Chuanju Liu Di Chen Xuenong Zou Xu Cao Huiling Cao Guozhi Xiao | 2020 | Bone Research2020，8，4： | 2 |
| 15 | Anti-arthritic effects of microneedling with bee venom gel显示文摘Objective:To combine with transdermal drug delivery using microneedle to simulate the bee venom therapy to evaluate the permeation of bee venom gel.Methods:In this study,the sodium urate and LPS were used on rats and mice to construct the model.Bee venom gelemicroneedle combination effect on the model is to determine the role of microneedle gel permeation by observing inflammation factors.Results:Compared with the model group,the bee venom gelemicroneedle combination group can reduce the level of serum nitric oxide of the acute gouty inflammation model caused by sodium urate,and on LPS induced mouse model of acute inflammation effect and the micro.Conclusions:Bee venom can significantly suppress the occurrence of gouty arthritis inflammation in rats and mice LPS inflammatory reaction.Choose the 750 mm microneedle with 10N force on skin about 3 minutes,bee venom can play the optimal role,and the anti-inflammatory effect is obvious.Microneedles can promote the percutaneous absorption of the active macromolecules bee venom gel. | Mengdi Zhao Jie Bai Yang Lu Shouying Du Kexin Shang Pengyue Li Liu Yang Boyu Dong Ning Tan | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，4： | 2 |
| 16 | Susceptibility Assessment of Landslides in Alpine-Canyon Region Using Multiple GIS-Based Models显示文摘This study explores a comparative study of three susceptibility assessment models based on remote sensing(RS) and geographic information system(GIS). The Lenggu region(China) was selected as a case study. At first, a landslide inventory map was compiled using data from existing geology reports, satellite imagery, and coupling with field observations. Subsequently, three models were built to map the landslide susceptibility using analytical hierarchy process(AHP), fuzzy logic(FL) and certainty factors(CF). The resulting models were validated and compared using areas under the curve(AUC). The AUC plot estimation results indicated that the three models are promising methods for landslide susceptibility mapping. Among the three methods, CF model has highest prediction accuracy than the other two models. Similarly, the outcome of this study reveals that streams, faults, slope and elevation are the main conditioning factors of landslides. Especially, the erosion of streams plays a key role of the landslide occurrence. These landslide susceptibility maps, to some extent, reflect spatial distribution characteristics of landslides in alpine-canyon region of southwest China, and can be used for land planning and hazard risk assessment. | HU Man LIU Qiuqiang LIU Pengyu | 2019 | Wuhan University Journal of Natural Sciences2019，24，3： | 2 |
| 17 | Identification of Weather Phenomena Based on Lightweight Convolutional Neural Networks显示文摘Weather phenomenon recognition plays an important role in the field of meteorology.Nowadays,weather radars and weathers sensor have been widely used for weather recognition.However,given the high cost in deploying and maintaining the devices,it is difficult to apply them to intensive weather phenomenon recognition.Moreover,advanced machine learning models such as Convolutional Neural Networks(CNNs)have shown a lot of promise in meteorology,but these models also require intensive computation and large memory,which make it difficult to use them in reality.In practice,lightweight models are often used to solve such problems.However,lightweight models often result in significant performance losses.To this end,after taking a deep dive into a large number of lightweight models and summarizing their shortcomings,we propose a novel lightweight CNNs model which is constructed based on new building blocks.The experimental results show that the model proposed in this paper has comparable performance with the mainstream non-lightweight model while also saving 25 times of memory consumption.Such memory reduction is even better than that of existing lightweight models. | Congcong Wang Pengyu Liu Kebin Jia Xiaowei Jia Yaoyao Li | 2020 | Computers, Materials & Continua2020，，9： | 2 |
| 18 | Molten salt synthesis of mullite whiskers from various alumina precursors显示文摘 | Pengyu Zhang Jiachen Liu Haiyan Du Zhongqiu Li Shun Li Sha Li Rui Xu | 2009 | Journal of Alloys and Compounds2009，，1： | 2 |
| 19 | Influence of silica sources on morphology of mullite whiskers in Na 2 SO 4 flux显示文摘 | Pengyu Zhang Jiachen Liu Haiyan Du Zhongqiu Li Shun Li Chao Chen | 2009 | Journal of Alloys and Compounds2009，，1： | 1 |
| 20 | ICPAES determination of germanium in GdSiGe series alloys as magnetic refrigeration material 显示文摘 | Liu Pengyu Li Na Shao Rongzhen Liu Bing Wu Xing | 2007 | Journal of Rare Earths2007，25，： | 1 |
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