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| 1 | 代谢型谷氨酸受体可作为一种新型恶性胶质瘤治疗靶点(英文)显示文摘Objective Metabotropic glutamate receptors(mG luR)are predominantly involved in maintenance of cellular homeostasis of central nervous system.However,evidences have suggested other roles of mG luR in human tumors.Aberrant mG luR signaling has been shown to participate in transformation and maintenance of various cancer types,including malignant brain tumors.This review intends to summarize recent findings regarding the involvement of mG luR-mediated intracellular signaling pathways in progression,aggressiveness,and recurrence of malignant gliomas,mainly glioblastomas(GBM),highlighting the potential therapeutic applications of mG luR ligands.In addition to the growing number of studies reporting mG luR gene or protein expression in glioma samples(resections,lineages,and primary cultures),pharmacological blockade in vitro of mG luR1 and mG luR3 by selective ligands has been shown to be anti-proliferative and anti-migratory,decreasing activation of MAPK and PI3K pathways.In addition,mG luR3 antagonists promoted astroglial differentiation of GBM cells and also enabled cytotoxic action of temozolomide(TMZ).mG luR3-dependent TMZ toxicity was supported by increasing levels of MGMT transcripts through an intracellular signaling pathway that sequentially involves PI3K and NF-κB.Further,continuous pharmacological blockade of mG luR1 and mG luR3 have been shown to reduced growth of GBM tumor in two independent in vivo xenograft models.In parallel,low levels of mG luR3 mRNA in GBM resections may be a predictor for long survival rate of patients.Since several Phase I,II and III clinical trials are being performed using group I and II mG luR modulators,there is a strong scientifically-based rationale for testing mG luR antagonists as an adjuvant therapy for malignant brain tumors. | Pereira MS Klamt F Thomé CC Worm PV de Oliveira DL | 2017 | 中华神经外科疾病研究杂志2017，16，1： | 3 |
| 2 | Adeno-associatedvirus and human papillomavirus types in cervical samplesof pregnant and non-pregnant women 显示文摘 | Freitas LB Pereira CC Checon R | 2009 | Eur J Obstet Gy-necol Heprod Biol2009，145，1： | 1 |
| 3 | Duchenne muscular dystrophy: alpha-dystroglycan immunoexpression in skeletal muscle and cognitive performance显示文摘 | Pereira CC Kiyomoto BH Cardoso R | 2005 | Arq Neuropsiquiatr2005，63，4： | 1 |
| 4 | Cancer chemoprevention agent development strategies for genistein显示文摘 | Steele VE Pereira MA sigman CC | 1995 | J Nutr1995，125，： | 1 |
| 5 | Intraoral approach to zygomatic fracture: modified technique for infraorbital rim fixation 显示文摘 | De Souza Carvalho AC Pereira CC Queiroz TP | 2012 | J Craniofac Surg2012，23，2： | 1 |
| 6 | Cassava starch coating and citric acid to preserve quality parameters of fresh-cut'Tommy Atkins”mango显示文摘 | Chiumarelli M Pereira LM Ferrari CC | | 0，，05： | 1 |
| 7 | Intraoral approach to zygomatic fracture : modified technique for infraorbital rim fix- ation 显示文摘 | de Souza CAC Pereira CC Queiroz TP | 2012 | J Craniofac Surg2012，23，2： | 1 |
| 8 | Survival rate and in vitro development of in vivo-produced and cryopreserved dog embryos 显示文摘 | Luz MR Holanda CC Pereira J J | 2009 | Reproduction Fertility and Development2009，22，： | 1 |
| 9 | Effects of inspiratory muscle training on muscular and pulmonary function after bariatric surgery in obese patients显示文摘 | Casali CC Pereira AP Martinez JA | 2011 | Obes Surg2011，21，9： | 1 |
| 10 | Cervical disc calcification in children : a long - term review 显示文摘 | Wong CC Pereira B Pho RW | 1992 | Spine1992，17，： | 1 |
| 11 | Effects of local anes- thetic on the time between analgesic boluses and the duration of la- bor in patient-controlled epidural analgesia: prospective study of two ultra-low dose regimens of ropivaeaine and sufentanil显示文摘 | Costa-Martins JM Dias CC Pereira M | 2015 | Acla Med Port2015，28，： | 1 |
| 12 | Cancer chemoprevention agent development strategies for genistein显示文摘 | Steele VE Pereira MA Sigman CC | 1995 | J Nutr1995，125，3： | 1 |
| 13 | Adeno-associated virus and human papillomavirus types in cervical samples of pregnant and non-pregnant women显示文摘 | Freitas LB Pereira CC Checon R | 2009 | Eur J Obstet Gynecol Reprod Biol2009，145，1： | 1 |
| 14 | Failing factors associated with osseointegrated dental implant loss 显示文摘 | Montes CC Pereira FA Thome G | 2007 | Implant Dent2007，16，4： | 1 |
| 15 | Failing factors associated with osseointegrated dental implant loss显示文摘 | Montes CC Pereira FA Thorne G | 2007 | Im- plant Dent2007，16，4： | 1 |
| 16 | Pervaporative recovery of volatile aroma compounds from fruit juices显示文摘 | Pereira CC Ribeiro CP Nobrega R | 2006 | J Membr Sci2006，274，12： | 1 |
| 17 | Use of titanium mesh for reconstruction of extensive defects in al fracture 显示文摘 | Mario HF Gulinelli JL Pereira CC | 2010 | Journal of craniofacial surgery2010，21，3： | 1 |
| 18 | Adeno-associated virus and human papillomavirus types in cervical samples of pregnant andnon-pregnant women显示文摘 | Freitas LB Pereira CC Checon R | | 0，，01： | 1 |
| 19 | Microbiota benefits after inulin and partially hydrolized guar gum supplementation: a randomized clinical trial in constipated women 显示文摘 | Linetzky Waitzberg D Alves Pereira CC Logullo L | 2012 | Nutr Hosp2012，27，： | 1 |
| 20 | Adeno-associated virus and human papillomavirus types in cervical samples of pregnant and non-pregnant women 显示文摘 | Freitas LB Pereira CC Checon R | 2009 | Eur J Obstet Gynecol Reprod Biol2009，145，1： | 1 |
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