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| 1 | Role of neurotrophic factors in enhancing linear axonal growth of ganglionic sensory neurons in vitro显示文摘Neurotrophins play a major role in the regulation of neuronal growth such as neurite sprouting or regeneration in response to nerve injuries. The role of nerve growth factor, neurotrophin-3, and brain-derived neurotrophic factor in maintaining the survival of peripheral neurons remains poorly understood. In regenerative medicine, different modalities have been investigated for the delivery of growth factors to the injured neurons, in search of a suitable system for clinical applications. This study was to investigate the influence of nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factor on the growth of neurites using two in vitro models of dorsal root ganglia explants and dorsal root ganglia-derived primary cell dissociated cultures. Quantitative data showed that the total neurite length and tortuosity were differently influenced by trophic factors. Nerve growth factor and, indirectly, brain-derived neurotrophic factor stimulate the tortuous growth of sensory fibers and the formation of cell clusters. Neurotrophin-3, however, enhances neurite growth in terms of length and linearity allowing for a more organized and directed axonal elongation towards a peripheral target compared to the other growth factors. These findings could be of considerable importance for any clinical application of neurotrophic factors in peripheral nerve regeneration. Ethical approval was obtained from the Regione Piemonte Animal Ethics Committee ASLTO1(file # 864/2016-PR) on September 14, 2016. | Michele Fornaro Alessia Giovannelli Angelica Foggetti Luisa Muratori Stefano Geuna Giorgia Novajra Isabelle Perroteau | 2020 | Neural Regeneration Research2020，15，9： | 3 |
| 2 | Subventricular zone-derived neuroblast migration to the olfactory bulb is modulated by matrix remodelling显示文摘 | Bovetti S Bovolin P Perroteau I | 2007 | Neuroscience2007，25，7： | 1 |
| 3 | Subventricular zone - derived neuroblast migration to the olfactory bulb is modulated by matrix remodeling 显示文摘 | Bovetti S Bovolin P Perroteau I | 2007 | Neuroscience2007，25，7： | 1 |
| 4 | Neuregulin 1 role in Schwann cell regulation and potential applications to promote peripheral nerve regeneration显示文摘 | Gambarotta G Fregnan F Gnavi S Perroteau I | | 0，，： | 1 |
| 5 | Subventricular zone-derived neuroblast migration to the olfactory bulb is modulated by matrix remodelling 显示文摘 | Bovetti S Bovolin P Perroteau I | 2007 | Neuroscience2007，25，7： | 1 |
| 6 | Glutamatergic deaf ferentation of olfactory bulb modulates the expression of mGluR1a mRNA显示文摘 | Ferraris N Perroteau I De Marchis S | 1997 | Neuroreport1997，8，8： | 1 |
| 7 | Expression of alpha2a-2b neuregulin-1 is associated with early periph-eral nerve repair along muscle-enriched tubes显示文摘 | Nicolino S Raimondo S Tos P Battiston B Fornaro M Geuna S Perroteau I | | 0，，： | 1 |
| 8 | Subventricular zone- derived neurohlast migration to the olfactory bulb is modulated by matrix remodelling显示文摘 | Bovetti S Bovolin P Perroteau I | 2007 | Eur J Neurosei2007，25，7： | 1 |
| 9 | Transregulation of erbB expression in the mouse olfactory bulb显示文摘 | PERROTEAU I OBERTO M SONCIN I | 1999 | Cell Mol Biol1999，45，3： | 1 |
| 10 | Glutamatergic deafferentation of olfactory bulb modulates the expression of mGluRla Mrna 显示文摘 | Ferraris N Perroteau I Marchis S | 1997 | Neuroreport1997，8，： | 1 |
| 11 | Subventricular zone- derived neuroblast migration to the olfactory bulb is modula- ted by matrix remodelling显示文摘 | Bovetti S Bovolin P Perroteau I | 2007 | Neuroscience2007，25，7： | 1 |
| 12 | Glutamatergic deafferentation of olfactory bulb modulates the expression of mGluRla mRNA显示文摘 | Ferraris N Perroteau I Marchis S | 1997 | Neuroreport1997，8，8： | 1 |
| 13 | Glutamatergic deafferentation of olfactory bulb modulates the expression of mGlu RlamRNA 显示文摘 | FerrarisN Perroteau I MarchisS | 1997 | Neuroreport1997，8，19： | 1 |
| 14 | Neuregulin 1 isoforms could be an effective therapeutic candidate to promote peripheral nerve regeneration显示文摘Traumatic injuries of peripheral nerves represent common casualties and their social impact is considerably high.Although peripheral nerves retain a good regeneration potential,the clinical outcome after nerve lesion is far from being satisfactory and functional recovery is almost never complete,especially in the case of large nerve defects,that result in loss or diminished sensitivity and/or motor activity of the innervated target organs.Therefore,to improve the outcome | Giovanna Gambarotta Giulia Ronchi Stefano Geuna Isabelle Perroteau | 2014 | Neural Regeneration Research2014，9，12： | 0 |
| 15 | Chitosan conduits enriched with fibrin-collagen hydrogel with or without adipose-derived mesenchymal stem cells for the repair of 15-mm-long sciatic nerve defect显示文摘Hollow conduits of natural or synthetic origins have shown acceptable regeneration results in short nerve gap repair;however,results are still not comparable with the current gold standard technique“autografts”.Hollow conduits do not provide a successful regeneration outcome when it comes to critical nerve gap repair.Enriching the lumen of conduits with different extracellular materials and cells could provide a better biomimicry of the natural nerve regenerating environment and is expected to ameliorate the conduit performance.In this study,we evaluated nerve regeneration in vivo using hollow chitosan conduits or conduits enriched with fibrin-collagen hydrogels alone or with the further addition of adipose-derived mesenchymal stem cells in a 15 mm rat sciatic nerve transection model.Unexpected changes in the hydrogel consistency and structural stability in vivo led to a failure of nerve regeneration after 15 weeks.Nevertheless,the molecular assessment in the early regeneration phase(7,14,and 28 days)has shown an upregulation of useful regenerative genes in hydrogel enriched conduits compared with the hollow ones.Hydrogels composed of fibrin-collagen were able to upregulate the expression of soluble NRG1,a growth factor that plays an important role in Schwann cell transdifferentiation.The further enrichment with adipose-derived mesenchymal stem cells has led to the upregulation of other important genes such as ErbB2,VEGF-A,BDNF,c-Jun,and ATF3. | Marwa El Soury óscar Darío García-García Isabella Tarulli Jesús Chato-Astrain Isabelle Perroteau Stefano Geuna Stefania Raimondo Giovanna Gambarotia Víctor Carriel | 2023 | Neural Regeneration Research2023，18，6： | 0 |
| 16 | Quantitative interactomic of CD40 in primary B cells显示文摘INTRODUCTION Over the past few decades,antibody-based therapies have emerged as an additional tool to treat patients developing cancer and auto-immune diseases.The natural properties of the developed antibodies may lead to agonist or blocking functions for the targeted molecule.Thus,antibodies developed for clinical trials are extensively analyzed in vitro and in vivo for safety and efficacy,yet they are not routinely evaluated for their potential signaling effectiveness. | Jeremy Argenty Emilie Maturin Mylene Camus Valentin Mellado Jeanne Perroteau Benoit Pasquier Guillaume Voisinne Odile Burlet-Schiltz Lih-Ling Lin Anne Gonzalez de Peredo Romain Roncagalli Bernard Malissen | 2024 | hLife2024，2，2： | 0 |
| 17 | Clustering of prostate cancer healthcare pathways in the French National Healthcare database显示文摘Background:Healthcare pathways of patients with prostate cancer are heterogeneous and complex to apprehend using traditional descriptive statistics.Clustering and visualization methods can enhance their characterization.Methods:Patients with prostate cancer in 2014 were identified in the French National Healthcare database(Système National des Données de Santé—SNDS)and their data were extracted with up to 5 years of history and 4 years of follow‐up.Fifty‐one‐specific encounters constitutive of prostate cancer management were synthesized into four macro‐variables using a clustering approach.Their values over patient follow‐ups constituted healthcare pathways.Optimal matching was applied to calculate distances between pathways.Partitioning around medoids was then used to define consistent groups across four exclusive cohorts of incident prostate cancer patients:Hormone‐sensitive(HSPC),metastatic hormone‐sensitive(mHSPC),castration‐resistant(CRPC),and metastatic castration‐resistant(mCRPC).Index plots were used to represent pathways clusters.Results:The repartition of macro‐variables values—surveillance,local treatment,androgenic deprivation,and advanced treatment—appeared to be consistent with prostate cancer status.Two to five clusters of healthcare pathways were observed in each of the different cohorts,corresponding for most of them to relevant clinical patterns,although some heterogeneity remained.For instance,clustering allowed to distinguish patients undergoing active surveillance,or treated according to cancer progression risk in HSPC,and patients receiving treatment for potentially curative or palliative purposes in mHSPC and mCRPC.Conclusion:Visualization methods combined with a clustering approach enabled the identification of clinically relevant patterns of prostate cancer management.Characterization of these care pathways is an essential element for the comprehension and the robust assessment of healthcare technology effectiveness. | Roméo Baulain Jérémy Jové Dunia Sakr Marine Gross‐Goupil Magali Rouyer Marius Puel Patrick Blin Cécile Droz‐Perroteau Régis Lassalle Nicolas H.Thurin | 2023 | Cancer Innovation2023，2，1： | 0 |
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