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| 1 | The PI3K/AKT Pathway and Renal Cell Carcinoma显示文摘The phosphatidylinositol 3 kinase(PI3K)/AKT pathway is genetically targeted in more pathway components and in more tumor types than any other growth factor signaling pathway,and thus is frequently activated as a cancer driver.More importantly,the PI3K/AKT pathway is composed of multiple bifurcating and converging kinase cascades,providing many potential targets for cancer therapy.Renal cell carcinoma(RCC) is a high-risk and high-mortality cancer that is notoriously resistant to traditional chemotherapies or radiotherapies.The PI3K/AKT pathway is modestly mutated but highly activated in RCC,representing a promising drug target.Indeed,PI3 K pathway inhibitors of the rapalog family are approved for use in RCC.Recent large-scale integrated analyses of a large number of patients have provided a molecular basis for RCC,reiterating the critical role of the PI3K/AKT pathway in this cancer.In this review,we summarize the genetic alterations of the PI3K/AKT pathway in RCC as indicated in the latest large-scale genome sequencing data,as well as treatments for RCC that target the aberrant activated PI3K/AKT pathway. | Huifang Guo Peter German Shanshan Bai Sean Barnes Wei Guo Xiangjie Qi Hongxiang Lou Jiyong Liang Eric Jonasch Gordon B.Mills Zhiyong Ding | 2015 | Journal of Genetics and Genomics2015，42，7： | 39 |
| 2 | Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR显示文摘 | Noelia A-Gonzalez Steven J. Bensinger Cynthia Hong Susana Beceiro Michelle N. Bradley Noam Zelcer Jose Deniz Cristina Ramirez Mercedes Díaz German Gallardo Carlos Ruiz de Galarreta Jon Salazar Felix Lopez Peter Edwards John Parks Miguel Andujar Peter Tont | 2009 | Immunity2009，，2： | 1 |
| 3 | Common reflecting element (CRE) method revisited显示文摘 | Hubral Peter Tygel martin Schleicher Jorg Hocht German | 2000 | Geophysics2000，65，3： | 1 |
| 4 | Knee Su:gery and Ar throscopy European Society of Sports Traumatology, Knee Surgery and Arthroseopy显示文摘 | Peter M German A Marulanda M | 2010 | Arthroscopy2010，18，2： | 1 |
| 5 | Mechanical properties and water vapor permeability of edible films from whey protein isolate and sodium dodecyl sulfate显示文摘 | PETER FAIRLEY FRANK J MONAHAN J BRUCE GERMAN | 1996 | Agric Food Chem1996，44，2： | 1 |
| 6 | Phospholipase A2 and small, dense low-density lipoprotein显示文摘 | EVA HURT-CAME JO GERMAN CAME JO PETER SARTIPY | 2000 | Current opinion in lipidology2000，11，： | 1 |
| 7 | 低场诱导液-气界面纳米颗粒组装体自旋玻璃行为和可控各向异性显示文摘利用纳米尺度结构单元堆积成具有丰富物理性能的一维(1D)组装体,是材料设计的研究前沿.然而,弱磁场诱导1D阵列的制备及其磁性能机制的揭示仍然具有挑战性.本文采用强度不同的组装场(0/1/3/5/30/50 mT),在二甘醇-空气界面上制备了由无序四氧化三铁纳米立方体组成的低维组装体.随着组装场从0增长到50 mT,环形组装体先变为细长多孔网状,再逐步变为细丝阵列,其中细丝阵列的合成条件为组装场≥3 mT且施加组装场时间t>14 min.通过调控组装场强度可得到自旋玻璃特性和静(动)各向异性~2(3).在弱组装场下磁偶极和无序排列易磁化轴之间相互作用导致自旋玻璃特性,进一步增大组装场将加强磁偶极作用和易磁化轴排列,导致自旋玻璃特性消失和强各向异性.本研究不仅提出了一种制备自旋玻璃和可控各向异性组装体的策略,还为理解低维组装磁相互作用提供了新思路. | 廖晓奇 Seda Ulusoy 黄锐 Erik Wetterskog Klas Gunnarsson 王宇 梁华伟 曾昱嘉 German Salazar-Alvarez Peter Svedlindh | 2022 | Science China Materials2022，65，1： | 0 |
| 8 | Genesis of H-ZSM-11 Acidity under Hydrogen and Water Vapor Treatment显示文摘 | Peter Eugenovich Strizhak Vlasenko Nina Vasilievna Kochkin Yuriy Nickolaevich Kalishyn Yevhen Yurievieh Tel'biz German Michailovich | 2010 | Journal of Chemistry and Chemical Engineering2010，4，7： | 0 |
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