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| 1 | Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors显示文摘Long non-coding RNAs(lncRNAs)are members of the non-protein coding RNA family longer than 200 nucleotides.They participate in the regulation of gene and protein expression influencing apoptosis,cell proliferation and immune responses,thereby playing a critical role in the development and progression of various cancers,including colorectal cancer(CRC).As CRC is one of the most frequently diagnosed malignancies worldwide with high mortality,its screening and early detection are crucial,so the identification of disease-specific biomarkers is necessary.LncRNAs are promising candidates as they are involved in carcinogenesis,and certain lncRNAs(e.g.,CCAT1,CRNDE,CRCAL1-4)show altered expression in adenomas,making them potential early diagnostic markers.In addition to being useful as tissue-specific markers,analysis of circulating lncRNAs(e.g.,CCAT1,CCAT2,BLACAT1,CRNDE,NEAT1,UCA1)in peripheral blood offers the possibility to establish minimally invasive,liquid biopsy-based diagnostic tests.This review article aims to describe the origin,structure,and functions of lncRNAs and to discuss their contribution to CRC development.Moreover,our purpose is to summarise lncRNAs showing altered expression levels during tumor formation in both colon tissue and plasma/serum samples and to demonstrate their clinical implications as diagnostic or prognostic biomarkers for CRC. | Orsolya Galamb Barbara K Barták Alexandra Kalmár Zsófia B Nagy Krisztina A Szigeti Zsolt Tulassay Peter Igaz Béla Molnár | 2019 | World Journal of Gastroenterology2019，25，34： | 18 |
| 2 | Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicentre, randomised, tandem colonoscopy trial显示文摘 | Ian M Gralnek Peter D Siersema Zamir Halpern Ori Segol Alaa Melhem Alain Suissa Erwin Santo Alan Sloyer Jay Fenster Leon M G Moons Vincent K Dik Ralph B D’Agostino Douglas K Rex | 2014 | Lancet Oncology2014，，3： | 6 |
| 3 | A systematic review and meta-analysis of laparoscopic versus open distal pancreatectomy for benign and malignant lesions of the pancreas: It’s time to randomize显示文摘 | Arianeb Mehrabi Mohammadreza Hafezi Jalal Arvin Majid Esmaeilzadeh Camelia Garoussi Golnaz Emami Julia K?ssler-Ebs Beat Peter Müller-Stich Markus W. Büchler Thilo Hackert Markus K. Diener | 2014 | Surgery2014，，： | 4 |
| 4 | Disagreement between symptom-reflux association analysis parameters in pediatric gastroesophageal reflux disease investigation显示文摘AIM: To assess the agreement within 3 commonly used symptom-reflux association analysis (SAA) parameters investigating gastroesophageal reflux disease (GERD) in infants. METHODS: Twenty three infants with suspected GERD were included in this study. Symptom index (SI), Symptom sensitivity index (SSI) and symptom association probability (SAP) related to cough and irritability were calculated after 24 h combined pH/multiple intraluminal impedance (MII) monitoring. Through defined cutoff values, SI, SSI and SAP values are differentiated in normal and abnormal, whereas abnormal values point towards gastroesophageal reflux (GER) as the origin of symptoms. We analyzed the correlation and the concordance of the diagnostic classification of these 3 SAA parameters.RESULTS: Evaluating the GER-irritability association, SI, SSI and SAP showed non-identical classification of normal and abnormal cases in 39.2% of the infants. When irritability was taken as a symptom, there was only a poor inter-parameter association between SI and SSI, and between SI and SAP (Kendall’s tau b = 0.37, P < 0.05; Kendall’s tau b = 0.36, P < 0.05, respectively). Evaluating the GER-cough association, SI, SSI and SAP showed non-identical classification of normal and abnormal cases in 52.2% of the patients. When cough was taken as a symptom, only SI and SSI showed a poor inter-parameter association (Kendall’s tau b = 0.33, P < 0.05). CONCLUSION: In infants investigated for suspected GERD with pH/MII-monitoring, SI, SSI and SAP showed a poor inter-parameter association and important dis-agreements in diagnostic classification. These limitations must be taken into consideration when interpreting the results of SAA in infants. | Samuel C Lüthold Mascha K Rochat Peter Bhler | 2010 | World Journal of Gastroenterology2010，16，19： | 3 |
| 5 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 6 | Chemical and pharmacological evaluation of Hypericum perforation extracts显示文摘KEY WORDS Hypericum perforation; High pressure liquid chromatography; serotonin uptake inhibitors; tree radicals; antioxidants; hyperforin; hypericin; quercetin; rutinABSTRACTAIM: To determine the concentrations of chemical characteristic to extracts of leaves and flowers of Hypericum perforatnm (St John’s wort) in a number of selected samples and, following chemical characterization, to investigate the effects of these extracts on several pharmacological properties including effects of the extracts on inhibition of 5-hydroxytryptamine (5-HT) uptake and on an-tioxidant properties. METHODS: The samples were analyzed for the presence of characteristic chemicals by high performance liquid chromatography (HPLC) directly coupled to ultraviolet wavelength absorbance and positive or negative mode electrospray mass spectrometric detection. The effects of extracts on 5-HT uptake were determined by quantifying 3H-5-HT incorporation into rat hip-pocampal prisms. Estimates of effects of extracts on free radical | B Duff SLOLEY Liana J URICHUK LING Lei GU Lie-Dong Ronald T COUTTS Peter K T PANG Jacqueline J SHAN | 2000 | Acta Pharmacologica Sinica2000，21，12： | 2 |
| 7 | Invasion and meteatasis in chronic cancer 显示文摘 | Shereen K Peter B Roman I | 2003 | Mol Cancer2003，2，1： | 1 |
| 8 | Sol-gel template synthesis of semiconductor nanostructures 显示文摘 | Lakshmi Peter K | 1997 | Chem Mater1997，9，： | 1 |
| 9 | On the production of radioisotopes in the atmosphere by cosmic radiation and their application to meteorology 显示文摘 | Lal D Malhorta P K Peters B | 1958 | J Atmos Terr Phys1958，12，： | 1 |
| 10 | ES显示文摘 | Alexander J Gretel B Peter K | 2005 | European Journal of Trauma2005，1，： | 1 |
| 11 | Applications for T-cell epitope queries and tools in the Immune Epitope Database and Analysis Resource显示文摘 | Yohan K Alessandro S Peters B | 2011 | Journal of Immunological Methods2011，374，30： | 1 |
| 12 | Nonlinear modeling and adaptive monitoring with fuzzy and multivariate statistical methods in biological wastewater treatment plants显示文摘 | Chang K Y Peter A V Lee I B 2003 | 2003 | Biotechnology2003，105，12： | 1 |
| 13 | Earliest gestational age for fetal sexing in cell-free maternal plasma显示文摘 | Rijnders R J van der Luijt R B Peters E D Goeree J K Van Der Schoot C E Ploos Van Amstel J K | 2003 | Prenat Diagn2003，23，： | 1 |
| 14 | Metabolic profiles of three fiber types of skeletal muscle in guinea pigs and rabbits 显示文摘 | Peter J B Barnard R J Edgerton V R Gillespie C A Stemple K E | 1972 | Biochemistry1972，11，： | 1 |
| 15 | Mukiple oil families in the West Siberian Basin 显示文摘 | PETERS K E KONTOROVICH A E HUIZINGA B J | 1994 | AAPG Bulletin1994，78，6： | 1 |
| 16 | Phytoplanktonbloom status:Chlorophylla biomass as an indicator of water qualitycondition in the southern estuaries of Florida,USA显示文摘 | Joseph N B Christopher R K Peter B O | 2009 | EcologicalIndicator2009，，9： | 1 |
| 17 | Colloid and heavy metal transport at landfill sites in direct contact with groundwater显示文摘 | Thomas B Peter F Thorsten K | 2006 | Water Research2006，40，14： | 1 |
| 18 | Random attractors for stochastic reaction -diffusion equations on unbounded domains显示文摘 | Peter W B Lu K N Wang B X | 2009 | J Diff Eqns2009，246，2： | 1 |
| 19 | Motivat ing the Client/Employee System as a Service Production Strat egy显示文摘 | Mills Peter K Richard B Chase Newton Margulies | 1983 | The Academy of Management Review1983，8，2： | 1 |
| 20 | Parametric sensitivity in first order reliability theory显示文摘 | Peter B Steen K | 1989 | Journal of Engineering Mechanics1989，115，7： | 1 |
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