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| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | Gene expression profiling and endothelin in acute experimental pancreatitis显示文摘AIM:To analyze gene expression profiles in an experimental pancreatitis and provide functional reversal of hypersensitivity with candidate gene endothelin-1 antagonists.METHODS:Dibutyltin dichloride(DBTC) is a chemical used as a polyvinyl carbonate stabilizer/catalyzer,biocide in agriculture,antifouling agent in paint and fabric.DBTC induces an acute pancreatitis flare through generation of reactive oxygen species.Lewis-inbred rats received a single i.v.injection with either DBTC or vehicle.Spinal cord and dorsal root ganglia(DRG) were taken at the peak of inflammation and processed for transcriptional profiling with a cDNA microarray biased for rat brain-specific genes.In a second study,groups of animals with DBTC-induced pancreatitis were treated with endothelin(ET) receptor antagonists [ET-A(BQ123) and ET-B BQ788)].Spontaneous pain related mechanical and thermal hypersensitivity were measured.Immunohistochemical analysis was performed using anti-ET-A and ET-B antibodies on sections from pancreatic tissues and DRG of the T10-12 spinal segments.RESULTS:Animals developed acute pancreatic inflammation persisting 7-10 d as confirmed by pathological studies(edema in parenchyma,loss of pancreatic architecture and islets,infiltration of inflammatory cells,neutrophil and mononuclear cells,degeneration,vacuolization and necrosis of acinar cells) and the painrelated behaviors(cutaneous secondary mechanical and thermal hypersensitivity).Gene expression profile was different in the spinal cord from animals with pancreatitis compared to the vehicle control group.Over 260 up-regulated and 60 down-regulated unique genes could be classified into 8 functional gene families:circulatory/acute phase/immunomodulatory;extracellular matrix;structural;channel/receptor/transporter;signaling transduction;transcription/translation-related;antioxidants/chaperones/heat shock;pancreatic and other enzymes.ET-1 was among the 52 candidate genes upregulated greater than 2-fold in animals with pancreatic inflammation and visceral pain-related behavior.Treatments with the ET-A(BQ123) and ET-B(BQ-788) antagonists revealed significant protection against inflammatory pain related mechanical and thermal hypersensitivity behaviors in animals with pancreatitis(P < 0.05).Open field spontaneous behavioral activity(at baseline,day 6 and 30 min after drug treatments(BQ123,BQ788) showed overall stable activity levels indicating that the drugs produced no undesirable effects on normal exploratory behaviors,except for a trend toward reduction of the active time and increase in resting time at the highest dose(300 μmol/L).Immunocytochemical localization revealed that expression of ET-A and ET-B receptors increased in DRG from animals with pancreatitis.Endothelin receptor localization was combined in dual staining with neuronal marker NeuN,and glia marker,glial fibrillary acidic protein.ET-A was expressed in the cell bodies and occasional nuclei of DRG neurons in na ve animals.However,phenotypic expression of ET-A receptor was greatly increased in neurons of all sizes in animals with pancreatitis.Similarly,ET-B receptor was localized in neurons and in the satellite glia,as well as in the Schwann cell glial myelin sheaths surrounding the axons passing through the DRG.CONCLUSION:Endothelin-receptor antagonists protect against inflammatory pain responses without interfering with normal exploratory behaviors.Candidate genes can serve as future biomarkers for diagnosis and/or targeted gene therapy. | Helieh S Oz Ying Lu Louis P Vera-Portocarrero Pei Ge Ada Silos-Santiago Karin N Westlund | 2012 | World Journal of Gastroenterology2012，18，32： | 6 |
| 3 | A quick evaluating method for automotive fuel cell lifetime 显示文摘 | PEI P C CHANG Q F TANG T | 2008 | International Journal of Hydrogen Energy2008，33，： | 1 |
| 4 | Effects of injection angle on atomization of liquid jets in transverse airflow 显示文摘 | Raymond P F Wu Pei Kuan | 2000 | AIAA J2000，38，1： | 1 |
| 5 | 显示文摘 | Pei S Kleefisch M S Kobylinski T P | 1994 | Catalysis Letters1994，30，14： | 1 |
| 6 | Synthesis and Characterization of V-HMS Employed for Catalytic Hydroxylation of Benzene 显示文摘 | Feng S J Pei S P Yue B | 2009 | Catal Lett2009，131，： | 1 |
| 7 | Triassic volcanism in eastern Heilongjiang and Jilin provinces, NE China: chronology, geochemistry, and tectonic implications显示文摘 | Xu W L Ji w Q Pei F P | 2009 | Journal of Asian Earth Sciences2009，34，： | 1 |
| 8 | Rotary Ultrasonic Machining of Structural Ceramics-A Review显示文摘 | Pei Z J Khanna N Ferreira P M | 1995 | Ceramic Engineering and Science Proceedings1995，，16： | 1 |
| 9 | Plastic flow in rotary ultrasonic machining of ceramics显示文摘 | Pei Z J Ferreira P M Haselkorn M | 1995 | Journal of Materials Processing Technology1995，48，14： | 1 |
| 10 | Rosuvastatin at- tenuates monocrotatine-induced pulmonary hyperten- sion via regulation of Akt/eNOS signaling and asym- metric dimethylarginine metabolism显示文摘 | PEI Y Z MA P WANG X | 2011 | Eur J Phar- macol2011，666，： | 1 |
| 11 | Rosuvastatin attenuates monocrotalineinduced pulmonary hypertension via regulation of Akt/eNOS signaling and asymmetric dimethylarginine metabolism显示文摘 | Pei Y Ma P Wang X | | 0，，： | 1 |
| 12 | On the lattice basis reduction multi-sequence synthesis algorithm显示文摘 | Wang L P Zhu Y F and Pei D Y | | 0，，11： | 1 |
| 13 | Modeling of Ductile-mode Material Re- moval in Rotary Ultrasonic Machining显示文摘 | Pei Z J Ferreira P M | 1998 | Intemational Journal of Machine Tools & Manufacture1998，，38： | 1 |
| 14 | Main factors affecting the lifetime of proton exchange membrane fuel cells in vehicle applications: A review显示文摘 | Pei P C Chen H C | 2014 | Applied Energy2014，125，： | 1 |
| 15 | A novel thermotropic liquid crystalline-benzoylated bacterial cellulos 显示文摘 | Wang Y Luo Q P Pei C H | 2008 | Carbohydr Polym2008，74，： | 1 |
| 16 | The fossil Mammals of locality 13 in Choukoutien 显示文摘 | TEILHARD de Chardin P PEI W C | 1941 | Pal Sin New Ser C1941，10，： | 1 |
| 17 | A new method to evaluate deposit-forming tendency of liquid lubricants by differential scanning calorimetry显示文摘 | Y Zhang Pei P Perez J M | 1992 | Lubrication Engineering1992，48，3： | 1 |
| 18 | Improved Operation of Differential Protection of Power Transformers for Internal Fault显示文摘 | LIU Pei Malik O P CHEN De-shu | 1992 | IEEE Trans on Power Delivery1992，7，4： | 1 |
| 19 | Stealth polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers: pharmacoki- netics and anti-tumor effects 显示文摘 | LI Y P PEI Y Y ZHOU Z H el al | 2001 | Biol Pharm Bull2001，24，6： | 1 |
| 20 | The effect of rapid solidification on the microstructure and hydrogen storage properties of V35Ti25Cr40 hydrogen storage alloy 显示文摘 | PEI P SONG X P LIU J CHEN G L QIN X B WANG B Y | 2009 | Int J Hydrogen Energy2009，34，19： | 1 |
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