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48篇 您的检索式:作者名="Pierre Stephan"
    题名 作者 年代 出处 被引量
1口服非洲刺李后人的血清对不同良性前列腺细胞的生物效应显示文摘非洲刺李(太得恩。)是一种普遍用于治疗有症状良性前列腺增生的草药。该药物的活性物质还没有被鉴定出来,因此,确定其血药浓度是不可能的。对该药的疗效目前存在一些争议,因而我们决定用摄入和未摄入非洲刺李的人的血清在体外处理前列腺细胞,观察其对前列腺细胞生长的作用。我们使用的是原代培养和器官培养的良性成纤维(WPMY)前列腺细胞和上皮(PNT2)前列腺细胞。我们也使用了新鲜的良性前列腺组织。研究发现,摄入非洲刺李的人血清可以减少原代培养细胞、器官培养细胞以及WPMY细胞的增殖,但不影响PNT2细胞的增殖。我们还利用AffymetrixHG.U1332.0PLUS芯片分析了处理血清对WPMY细胞基因表达的影响。转录子分析结果显示参与肿瘤抑制通路的多个基因的表达发生了上调,而一些参与炎症及氧化应激通路的基因表达发生了下调。口服非洲刺李可使药物的活性物质达到足够的血清水平,从而抑制成纤维前列腺细胞的增殖。此抑制作用与转录子的改变有关。Stephane Larre Philippe Camparo Eva Comperat Delphine Boulbes Mohammed Haddoum Sylvain Baulande Pascal Soularue Pierre Costa Olivier Cussenot 2012Asian Journal of Andrology2012,14,3:2
2Increased arterial stiffness in inflammatory bowel diseases is dependent upon inflammation and reduced by immunomodulatory drugs显示文摘Luca Zanoli Stefania Rastelli Gaetano Inserra Paolo Lentini Enrico Valvo Emanuela Calcagno Pierre Boutouyrie Stephane Laurent Pietro Castellino 2014Atherosclerosis2014,,2:2
3Trends in Chemical Composition of Wet-only Precipitation at Rural French Monitoring Stations Over the 1990-2003 Period显示文摘Pierre Sicard Patrice Coddeville Stephane Sauvage 2007Water Air Soil Pollut: Focus2007,7,:1
4Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients显示文摘Fran?ois Ghiringhelli Cedric Menard Pierre Emmanuel Puig Sylvain Ladoire Stephan Roux Fran?ois Martin Eric Solary Axel Le Cesne Laurence Zitvogel Bruno Chauffert 2007Cancer Immunology Immunotherapy2007,,5:1
5Infrared characterization of thermal gradients on disc brakes显示文摘Stephane Panier Philippe Dufrenoy Pierre Bremond 2003Proc of SPIE2003,5073,:1
6Electrokinetic Characterization of Polyethersulfone UF Membranes显示文摘Ricq Laurence Pierre Andre Bayle Stephane 1997Desalination1997,109,3:1
7Serum androgen lev- els in elite female athletes 显示文摘Stephane B Pierre YG Angelica LH 2014J C En M2014,99,11:1
8Echocardiographic parameters of ventricu-lar dyssynchrony validation in patients with heart failure using sequential biventri-cular pacing 显示文摘Pierre B stephane L Sylvain R 2004J Am Coll Cardiol2004,44,11:1
9Usefulness of biventricular pacing in patients with congestive heart failure and right bundle branch block显示文摘Stephane Garrigue Sylvain Reuter Jean-Noel Labeque Pierre Jais Meleze Hocini Dipen C Shah Michel Haissaguerre Jacques Clementy 2001The American Journal of Cardiology2001,,12:1
10Laparoscopy-Assisted Left Ovarian Vein Transposition to Treat One Case of Posterior Nutcracker Syndrome显示文摘Olivier Hartung Pierre Barthelemy Stephane V. Berdah Yves S. Alimi 2009Annals of Vascular Surgery2009,,3:1
11Pancreatic involvement in von Hippel-Lindau disease显示文摘Pascal R. Hammel Valerie Vilgrain Benoit Terris Alfred Penfornis Alain Sauvanet Jean-Michel Correas Dominique Chauveau Axel Balian Catherine Beigelman Dermot O'Toole Pierre Bernades Philippe Ruszniewski Stephane Richard 2000Gastroenterology2000,,4:1
12Pacemaker endocarditis: clinical features and management of 60 consecutive cases 显示文摘Pierre M Sylvain R Stephane L 2007Pa- cing Clin Electrophysio12007,30,1:1
13Equivalent Axial Stiffness of Various Components in Bolted Joints Subjected to Ax- ial Loading显示文摘Feras Alkatan Pierre Stephan Alain Daidie 2007Finite Elements in Analysis and Design2007,43,:1
14Human Serum Albumin in the Clinical Syndrome of Heart Failure显示文摘Stephane Arques Pierre Ambrosi 2011Journal of Cardiac Failure2011,,6:1
15Pacemaker endocarditis:clinical features and management of 60 consecutive cases显示文摘Pierre M Sylvain R Stephane L 2007Pacing Clin Electrophysiol2007,30,1:1
16Human serum albumininthe clinical syndrome of heart failure 显示文摘STEPHANE A PIERRE A 2011J Cardiac Fail2011,17,6:1
17Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients显示文摘Fran?ois Ghiringhelli Cedric Menard Pierre Emmanuel Puig Sylvain Ladoire Stephan Roux Fran?ois Martin Eric Solary Axel Le Cesne Laurence Zitvogel Bruno Chauffert 2007Cancer Immunology Immunotherapy2007,,5:1
18Pre-Hospital Triage for Primary Angioplasty显示文摘Hendrik-Jan Dieker Stephan S.B. Liem Hamza El Aidi Pierre van Grunsven Wim R.M. Aengevaeren Marc A. Brouwer Freek W.A. Verheugt 2010JACC: Cardiovascular Interventions2010,,7:1
19Aortic stiffness is an independent predictor of all-cause mortality in hypertensive patients 显示文摘Stephane Laurent Pierre Boutouyrie Roland Asmar 2001Hypertension2001,37,:1
20Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients显示文摘Stephane L Pierre B Roland A 0,,05:1
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