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| 1 | Peripheral Lymphocyte Subsets as a Marker of Parkinson's Disease in a Chinese Population显示文摘In this study, we conducted a clinical analysis of lymphocyte subtypes in 268 patients with Parkinson's disease(PD) to assess their clinical impact as a potential marker of advanced PD in Chinese patients. The participants comprised 268 sporadic PD patients and 268 healthy controls. The numbers of natural killer(NK) cells and CD3+, CD3+CD4+, CD3+CD8+, and CD19+ lymphocytes from peripheral blood were determined by immunostaining and flow cytometric analysis and the percentages of these CD+ T cells were calculated. The ratio of regulatory T(Treg)/helper T 17(Th17) lymphocytes from 64 PD patients and 46 controls was determined by flow cytometric analysis.The results showed that the percentage of NK cells was higher in advanced PD patients than in controls(22.92% ±10.08% versus 19.76% ± 10.09%, P = 0.006), while CD3+ T cells are decreased(62.93% ± 9.27% versus65.75% ± 9.13%, P = 0.005). The percentage of CD19+B cells in male patients was lower(P = 0.021) than in female patients, whereas NK cells were increased(P \ 0.0001). The scores on the Unified Parkinson's Disease Rating Scale(UPDRS) and the Non-Motor Symptoms Scale in late-onset PD patients were significantly higher than those in earlyonset patients(P = 0.024 and P = 0.007, respectively). The percentage of CD19+ B cells in patients with UPDRS scores[24 was lower than in those with scores \24(10.17% ±4.19% versus 12.22% ± 5.39%, P = 0.009). In addition, the Treg/Th17 ratio in female patients was higher than that in female controls(13.88 ± 6.32 versus 9.94 ± 4.06, P =0.042). These results suggest that the percentages of NK cells,CD3+ T cells, and CD19+ B cells along with the Treg/Th17 ratio in peripheral blood may be used to predict the risk of PD in Chinese individuals and provide fresh avenues for novel diagnostic biomarkers and therapeutic designs. | Luan Cen Chaohao Yang Shuxuan Huang Miaomiao Zhou Xiaolu Tang Kaiping Li Wenyuan Guo Zhuohua Wu Mingshu Mo Yousheng Xiao Xiang Chen Xinling Yang Qinhui Huang Chaojun Chen Shaogang Qu Pingyi Xu | 2017 | Neuroscience Bulletin2017，33，5： | 5 |
| 2 | Preparation, characterization and hydrodesulfurization performances of Co-Ni_2P/SBA-15 catalysts显示文摘A series of Co-Ni2P/SBA-15 catalysts with various Co contents, Ni2P contents and P/Ni molar ratios were prepared by impregnating nickel nitrate, diammonium hydrogen phosphate, and then cobalt nitrate into SBA-15 support followed by temperature-programmed reduction in a H2 flow. The catalyst structure was characterized by X-ray diffraction(XRD), high resolution-transmission electron microscopy(HR-TEM)and N2adsorption-desorption techniques and their catalytic performance of the hydrodesulfurization(HDS) of dibenzothiophene(DBT) was evaluated. The effects of Co contents, Ni2 P contents and P/Ni molar ratios on the catalyst structure and HDS of DBT over the Co-Ni2P/SBA-15 catalyst were investigated. The results indicated that the mesoporous structure was mainly maintained and the nickel phosphides were well dispersed in all of the characterized catalysts. The 4Co-25Ni2P/SBA-15(P/Ni = 0.8) catalyst with the Co and Ni2 P contents of 4 wt% and25 wt%, respectively, and the P/Ni molar ratio of 0.8 showed the highest catalytic performance for HDS of DBT. Under the reaction conditions of 380?C and 3.0 MPa, the DBT conversion can reach 99.62%. The HDS of DBT proceeded mainly via the direct desulfurization(DDS)pathway with biphenyl(BP) as the dominant product on all of the catalysts and the BP selectivity was slightly enhanced after the introduction of Co promoters. | Zhou-jun Wang Pingyi Wu Ling Lan Kunhong Liu Yaqiong Hu Shengfu Ji | 2015 | Journal of Energy Chemistry2015，24，2： | 1 |
| 3 | Effective capacity of a correlated Rayleigh fading Channel显示文摘 | Wang Qing Wu Dapeng Fan Pingyi | 2010 | Wireless Communications and Mobile Computing2010，，1： | 1 |
| 4 | Steam reforming of methane to hydrogen ovet Ni - based metal monolith catalysts显示文摘 | Pingyi Wu Xiujin Li Shengfu Ji | 2009 | Catalysis Today2009，146，12： | 1 |
| 5 | Catalytic oxidation of CO over CuxCe1-xO2-x/SBA - 15/FeCrAl monolithic catalysts显示文摘 | Fuzhen Zhao Shengfu Ji Pingyi Wu | 2009 | Catalysis Today2009，1471，： | 1 |
| 6 | Preparation of nickel phosphide/SBA - 15/cordierite monolithic catalysts and catalytic activity for hydrodesulfurization of dibenzothiophene 显示文摘 | Ni Wei Shengfu Ji Pingyi Wu | 2009 | Catalysis Today2009，1471，： | 1 |
| 7 | Deactivation Bebavior of Pd-Based SBA-15 Mesoporous Silica Catalysts for the Catalytic Combustion of Methane显示文摘 | Yin Fengxiang Ji Shengfu Wu Pingyi | 2008 | Journal of Catalysis2008，257，： | 1 |
| 8 | Steam reforming of methane to hydrogen over Ni based metal monolith catalysts 显示文摘 | Wu Pingyi Li Xiuiin Ji Shengfu Lang Ban Fabien Habimana Li Chengyue | 2009 | Catalysis Today2009，146，12： | 1 |
| 9 | Catalytic oxidation of CO over Cux Ce1-xO2- x/ SBA-15/FeCrAl monolithic catalysts显示文摘 | Zhao Fuzhen Ji Shengfu Wu Pingyi Li Zhenfeng Li Chengyue | 2009 | Catalysis Today2009，147，1： | 1 |
| 10 | High Stable and Accurate Vehicle Selection Scheme Based on Federated Edge Learning in Vehicular Networks显示文摘Federated edge learning(FEEL)technology for vehicular networks is considered as a promising technology to reduce the computation workload while keeping the privacy of users.In the FEEL system,vehicles upload data to the edge servers,which train the vehicles’data to update local models and then return the result to vehicles to avoid sharing the original data.However,the cache queue in the edge is limited and the channel between edge server and each vehicle is time-varying.Thus,it is challenging to select a suitable number of vehicles to ensure that the uploaded data can keep a stable cache queue in edge server while maximizing the learning accuracy.Moreover,selecting vehicles with different resource statuses to update data will affect the total amount of data involved in training,which further affects the model accuracy.In this paper,we propose a vehicle selection scheme,which maximizes the learning accuracy while ensuring the stability of the cache queue,where the statuses of all the vehicles in the coverage of edge server are taken into account.The performance of this scheme is evaluated through simulation experiments,which indicates that our proposed scheme can perform better than the known benchmark scheme. | Qiong Wu Xiaobo Wang Qiang Fan Pingyi Fan Cui Zhang Zhengquan Li | 2023 | China Communications2023，20，3： | 0 |
| 11 | Towards V2I Age-Aware Fairness Access:A DQN Based Intelligent Vehicular Node Training and Test Method显示文摘Vehicles on the road exchange data with base station frequently through vehicle to infrastructure(V2I)communications to ensure the normal use of vehicular applications,where the IEEE 802.11 distributed coordination function is employed to allocate a minimum contention window(MCW)for channel access.Each vehicle may change its MCW to achieve more access opportunities at the expense of others,which results in unfair communication performance.Moreover,the key access parameter MCW is privacy information and each vehicle is not willing to share it with other vehicles.In this uncertain setting,age of information(AoI),which measures the freshness of data and is closely related with fairness,has become an important communication metric.On this basis,we design an intelligent vehicular node to learn the dynamic environment and predict the optimal MCW,which can make the intelligent node achieve age fairness.In order to allocate the optimal MCW for the vehicular node,we employ a learning algorithm to make a desirable decision by learning from replay history data.In particular,the algorithm is proposed by extending the traditional deep-Q-learning(DQN)training and testing method.Finally,by comparing with other methods,it is proved that the proposed DQN method can significantly improve the age fairness of the intelligent node. | WU Qiong SHI Shuai WAN Ziyang FAN Qiang FAN Pingyi ZHANG Cui | 2023 | Chinese Journal of Electronics2023，32，6： | 0 |
| 12 | CHCHD2 maintains mitochondrial contact site and cristae organizing system stability and protects against mitochondrial dysfunction in an experimental model of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is the second most common neurodegenerative disease after Alzheimer’s dementia.Mitochondrial dysfunction is involved in the pathology of PD.Coiled-coil-helix-coiled-coil-helix domain-containing 2(CHCHD2)was identified as associated with autosomal dominant PD.However,the mechanism of CHCHD2 in PD remains unclear.Methods:Short hairpin RNA(ShRNA)-mediated CHCHD2 knockdown or lentivirus-mediated CHCHD2 overexpression was performed to investigate the impact of CHCHD2 on mitochondrial morphology and function in neuronal tumor cell lines represented with human neuroblastoma(SHSY5Y)and HeLa cells.Blue-native polyacrylamide gel electrophoresis(PAGE)and two-dimensional sodium dodecyl sulfate-PAGE analysis were used to illustrate the role of CHCHD2 in mitochondrial contact site and cristae organizing system(MICOS).Co-immunoprecipitation and immunoblotting were used to address the interaction between CHCHD2 and Mic10.Serotype injection of adeno-associated vector-mediated CHCHD2 and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)administration were used to examine the influence of CHCHD2 in vivo.Results:We found that the overexpression of CHCHD2 can protect against methyl-4-phenylpyridinium(MPP+)-induced mitochondrial dysfunction and inhibit the loss of dopaminergic neurons in the MPTP-induced mouse model.Furthermore,we identified that CHCHD2 interacted with Mic10,and overexpression of CHCHD2 can protect against MPP+-induced MICOS impairment,while knockdown of CHCHD2 impaired the stability of MICOS.Conclusion:This study indicated that CHCHD2 could interact with Mic10 and maintain the stability of the MICOS complex,which contributes to protecting mitochondrial function in PD. | Lin Lu Hengxu Mao Miaomiao Zhou Yuwan Lin Wei Dai Jiewen Qiu Yousheng Xiao Mingshu Mo Xiaoqin Zhu Zhuohua Wu Zhong Pei Wenyuan Guo Pingyi Xu Xiang Chen | 2022 | Chinese Medical Journal2022，，13： | 0 |
| 13 | CHCHD2 Thr61Ile mutation impairs F1F0-ATPase assembly in in vitro and in vivo models of Parkinson's disease显示文摘Mitochondrial dysfunction is a significant pathological alte ration that occurs in Parkinson's disease(PD),and the Thr61lle(T61I)mutation in coiled-coil helix coiled-coil helix domain containing 2(CHCHD2),a crucial mitochondrial protein,has been reported to cause Parkinson's disease.FIFO-ATPase participates in the synthesis of cellular adenosine triphosphate(ATP)and plays a central role in mitochondrial energy metabolism.However,the specific roles of wild-type(WT)CHCHD2 and T611-mutant CHCHD2 in regulating F1FO-ATPase activity in Parkinson's disease,as well as whether CHCHD2 or CHCHD2 T61I affects mitochondrial function through regulating F1FO-ATPase activity,remain unclea r.Therefore,in this study,we expressed WT CHCHD2 and T61l-mutant CHCHD2 in an MPP^(+)-induced SH-SY5Y cell model of PD.We found that CHCHD2 protected mitochondria from developing MPP^(+)-induced dysfunction.Under normal conditions,ove rexpression of WT CHCHD2 promoted F1FO-ATPase assembly,while T61I-mutant CHCHD2 appeared to have lost the ability to regulate F1FO-ATPase assembly.In addition,mass spectrometry and immunoprecipitation showed that there was an interaction between CHCHD2 and F1FO-ATPase.Three weeks after transfection with AAV-CHCHD2 T61I,we intraperitoneally injected 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into mice to establish an animal model of chronic Parkinson's disease and found that exogenous expression of the mutant protein worsened the behavioral deficits and dopaminergic neurodegeneration seen in this model.These findings suggest that WT CHCHD2 can alleviate mitochondrial dysfunction in PD by maintaining F1F0-ATPase structure and function. | Xiang Chen Yuwan Lin Zhiling Zhang Yuting Tang Panghai Ye Wei Dai Wenlong Zhang Hanqun Liu Guoyou Peng Shuxuan Huang Jiewen Qiu Wenyuan Guo Xiaoqin Zhu Zhuohua Wu Yaoyun Kuang Pingyi Xu Miaomiao Zhou | 2024 | Neural Regeneration Research2024，19，1： | 0 |
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