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| 1 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 2 | Folasade ekulona and barbara smith, an improved genetic system for bioengi- neering buoyant gas vesicle nanoparticles from haloar- chaea显示文摘 | Dassarma S Karan R Priya D el al | 2013 | BMC Biotechnol2013，196，13： | 1 |
| 3 | LbL Fabricated Poly(styrene sulfonate)/TiO2 Multilayer Thin Films for Environmental Applications显示文摘 | D Neela Priya Jayant M Modak Ashok M Raichur | 2009 | ACS Appl Mater Interfaces2009，1，11： | 1 |
| 4 | Surface plasmon resonance based on fiber optic ammonia sensor utilizing Bromocresol purple显示文摘 | PRIYA B BANSHI D G | 2013 | Plasmonics2013，8，： | 1 |
| 5 | Multimodal system for harvesting magnetic and mechanical energy显示文摘 | Dong S X Zhai J Y Li J F Viehland D Priya S | 2008 | Applied Physics Letters2008，93，10： | 1 |
| 6 | Insulin inhibitors intranuclear nuclear factor K and stimulates IoB in mononuclear cells in obese subjects:evidence for an anti-inflammatory effect 显示文摘 | Paresh D Ahmad A Priya M | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 7 | Solvent extraction of Zr(Ⅳ) from acidic chloride solution using 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester (PC-88A) 显示文摘 | Reddy B R Kumar J R Reddy A V Priya D N | 2004 | Hydrometallurgy2004，72，： | 1 |
| 8 | Person independent facial expression detection using MBWM and multiclass SVM显示文摘 | PRIYA G N BANU R S D W | 2012 | International Journal of Computer Applications2012，55，17： | 1 |
| 9 | Solvent extraction of zireonium(Ⅳ) from acidic chloride solutions using 2- ethyl hexyl phosphonie acid mono-2-ethyl hexyl ester ( PC-88A ) 显示文摘 | Reddy B R Kumar J R Reddy A V Priya D N | 2004 | Hydrometallurgy2004，72，： | 1 |
| 10 | Inactivation of aflatoxin B1 by using the synergistic effect of hydrogen peroxide and gamma radiation 显示文摘 | Umesh D Patel Priya Goviffdarajan Prafulla J Dave | 1989 | Applied and Environmental Microbiology1989，55，2： | 1 |
| 11 | Preoperative chemotherapy: updates of national surgical adjuvant breast and bowel pro- ject protocols 13-18 and B-27显示文摘 | Priya R Stewart J A Harry D B | 2008 | J Clin Oncol2008，26，5： | 1 |
| 12 | A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children 显示文摘 | Priya D Xiaoti G Rashidul H | 2011 | JClinInvest2011，121，3： | 1 |
| 13 | Process development for theseparation of copper(lI), nickel(11) and zinc(11) from sulphatesolutions by solvent extraction using LIX 84 I显示文摘 | REDDY B R PRIYA D N | 2005 | Hydrometallurgy2005，45，2： | 1 |
| 14 | Increased optical damage resistance in Sc2O3-doped LiNbO3显示文摘 | PRIYA S UCHINO K VIEHLAND D | 2001 | Jpn Appl Phys2001，78，9： | 1 |
| 15 | The core and unique proteins of haloarchaea显示文摘 | Mclinda D Capes Priya DasSarma Shiladitya DasSarma | 2012 | BMC Genomics2012，39，13： | 1 |
| 16 | Solvent extraction of cadmi-um from sulphate solutions using TOPS99,PC88A,Cyanex 272 and their mixtures显示文摘 | Reddy B R Priya D N Kumar J R | 2004 | Hydrometallurgy2004，74，： | 1 |
| 17 | 查看详情显示文摘 | Dong S X Zhai J Y Priya S Li J F Viehland D | | 0，，： | 1 |
| 18 | Piezoelectric windmill : a novel so- lution to remote sensing显示文摘 | Priya S Chen C T Fye D | 2005 | Japanese Journal of Applied Physics2005，44，1： | 1 |
| 19 | Solar transmittance of honeycomb and parallel slat arrays 显示文摘 | Kaushika N D Priya R P | 1991 | Energy Covers Mgmt1991，32，4： | 1 |
| 20 | Energy Harvesting Technologies显示文摘 | Priya S Inman D J | | 0，，06： | 1 |
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