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| 1 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 2 | Association of ADAM33 gene polymorphisms with adult - onset asthma and its severity in an Indi- an aduh population 显示文摘 | Priya T Shally A Rajendra P | 2011 | Journal of Genetics2011，90，： | 1 |
| 3 | Association of AD- AM33 gene polymorphisms with asthma in Indian children 显示文摘 | Shally A Priya T Subramaniam anesh | 2011 | Jour- nal of Human Genetics2011，56，： | 1 |
| 4 | A thermodynamic study of liquid Cu-Cr alloys and metastable liquid immiscibility显示文摘 | Jacob K T Priya S Waseda Y | 2000 | Z Metal2000，，91： | 1 |
| 5 | Relationship between plasmid occurrence and antibiotic resistance in Myroides odo- ratimimus SKS05-GRD isolated from raw chicken meat显示文摘 | Suganthi R Priya T S Saranya A | 2013 | World J Microbiol Biotechnol2013，29，6： | 1 |
| 6 | Model based analysis of piezoelectric transformers 显示文摘 | HEMSEL T PRIYA S | 2006 | Ultrasonics2006，44，1： | 1 |
| 7 | Sinapic acid prevents hypertension and cardiovascular remodeling in pharmacological model of nitric oxide inhibited rats显示文摘 | Silambarasan T Manivannan J Krishna Priya M | 2014 | PLoS One2014，9，11： | 1 |
| 8 | Sinapic acid protects heart against ischemia/reperfusion injury and H9c2 cardiomyoblast cells against oxidative stress显示文摘 | Silambarasan T Manivannan J Priya MK | 2015 | Biochem Biophys Res Commun2015，456，4： | 1 |
| 9 | A rare case of term viable secondary abbominal pregnancy following rupture of a rudimentary horm:a case report显示文摘 | Amritha B Sumangali T Priya B | 2009 | J Medical Case Reports2009，29，3： | 1 |
| 10 | The design of a hardware accelerator for real-time complete visibility graph construction and efficient FPGA implementation 显示文摘 | Sridharan K Priya T K | 2005 | IEEE Trans on Industrial Electronics2005，52，4： | 1 |
| 11 | Diethylamine phosphate as VPI for steel components显示文摘 | Subramania A Sathiya Priya A R Vasudevan T | 2006 | Materials Chemistry and Physics2006，100，1： | 1 |
| 12 | FPGA- based fuzzy logic controller for electric vehicle 显示文摘 | Poorani S Urmila Priya T V S Kumar K U | 2005 | The Institution of En- gineers2005，45，5： | 1 |
| 13 | Molecular characterization and effect of RNA interference of retinoid X receptor (RXR) on E75 and chitinase gene expression in Chinese shrimp Fenneropenaeus chinensis 显示文摘 | Priya T A Li F Zhang J | 2009 | Comp Biochem Physiol B Biochem Mol Biol2009，153，1： | 1 |
| 14 | A database of bacterial lipoproteins(DOLOP)with functional assignments to predicted lipoproteins显示文摘 | BABU M M PRIYA M L SELVAN A T | 2006 | Journal of bacteriology2006，188，8： | 1 |
| 15 | A Database of Bacterial Lipoproteins (DOLOP) With Functional Assignments to Predicted Lipoproteins显示文摘 | Babu M M Priya M L Selvan A T | 2006 | Journal of Bacteriology2006，188，： | 1 |
| 16 | SARS: Epidemiology, Clinical Presentation, Management, ant Infection Control Measures显示文摘 | Priya SA Zelalem T qhomas F | 2003 | Mayo Clin Proc2003，78，： | 1 |
| 17 | Piezoelectric windmill : a novel so- lution to remote sensing显示文摘 | Priya S Chen C T Fye D | 2005 | Japanese Journal of Applied Physics2005，44，1： | 1 |
| 18 | The design of a hardware accelerator forreal-time complete visibility graph construction and efficient FPGAimplementation显示文摘 | Sridharan K Priya T K | 2005 | IEEE Transactions on Industrial Electronics2005，52，4： | 1 |
| 19 | Sinapic acid prevents hypertension and cardiovascular remodeling in pharmacological model of nitric oxide inhib- ited rats 显示文摘 | SILAMBARASAN T MANIVANNAN J PRIYA N K et al | 2014 | PLoS One2014，9，12： | 1 |
| 20 | Effect of temperature on shape&optical properties of MgO/ZnO nanocomposites显示文摘 | SELVI K T RATHNAKUMARI M PRIYA M | 2014 | Asian Journal of Chemistry2014，26，18： | 1 |
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