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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Smallest detectabledifference in outcome variables related to painful restriction ofthe temporomandibular joint显示文摘 | Kropmans TJ Dijkstra PU Stegenga B | 1999 | J Dent Res1999，78，3： | 1 |
| 3 | A new disease in rabbits显示文摘 | Liu S J Xue H P Pu B Q | 1984 | Anima Husb Vet Med1984，16，： | 1 |
| 4 | Tailoring the structure and property of silicon-doped diamond-like carbon films by controlling the silicon content 显示文摘 | Wang J J Pu J B Zhang G A | 2013 | Surface & Coatings Technology2013，59，： | 1 |
| 5 | Effects of Different Bismuth-based Compounds Additives on the Positive Temperature Coefficient Effect of BaTiO3 Ceramics 显示文摘 | Yuan Q B Pu Y P | 2012 | Materials Letters2012，6，： | 1 |
| 6 | Electrical signals control wound healing through phosphati-dylinositol-3-OH kinase-gamma and PTEN 显示文摘 | ZHA0 M SONG B PU J | 2006 | Nature2006，442，7101： | 1 |
| 7 | Isolstion and characterization of methicillin-resistant Staphylococcus aureus strains from Louisiana retail meats显示文摘 | Pu S Han F Ge B | | 0，，01： | 1 |
| 8 | Influence of sintering at- mosphere on dielectric properties and microstructure of CaCu3Ti4012 ceramics 显示文摘 | Wang B Pu Y P Wu H D | 2013 | Ceramics International2013，39，： | 1 |
| 9 | Selective Neutralization of Acid Sites on the External Surface of H-ZSM5Crystallites by a Mechanochemical Method for Methylation of Methylnaphthalene 显示文摘 | Tomoyuki I Pu S B Jun-ichiro K | 1996 | Appl Catal A:General1996，146，： | 1 |
| 10 | Characterization of toxin genes and antimicrobial susceptibility of Staphylococcus aureus isolates from Louisiana retail meats显示文摘 | Pu S Wang F Ge B | 2011 | Foodborne Pathog Dis2011，8，2： | 1 |
| 11 | A new viral disease in rabbit显示文摘 | LIU S J XUE H P PU B Q | 1984 | AnimHusb Vet Med1984，16，： | 1 |
| 12 | Affibody-attached hyperbranched conjugated polyelectrolyte for targeted fluorescence imaging of HER2-positive cancer cell显示文摘 | Pu K Y Shi J B Liping Cai L P | 2011 | Biomacromolecules2011，12，： | 1 |
| 13 | Isolation and characterization of AaWRKY1, an Artemisia annua transcription factor that regulates the amorpha-4, 11-diene synthase gene, a key gene of artemisinin biosynthesis 显示文摘 | Ma D M Pu G B Lei C Y | 2009 | Plant CellPhysiol2009，50，12： | 1 |
| 14 | Phosphorylation of H4 Ser 47 promotes HIRA-mediated nucleosome assembly显示文摘 | Kang B Pu M Hu G | | 0，，13： | 1 |
| 15 | Optimization of culture medium for yellow pigments production with Monascus anka mutant using response surface methodology显示文摘 | ZHOU B WANG J F PU Y W | 2009 | Eur Food Res Technol2009，228，6： | 1 |
| 16 | Conifer Species Recognition: an Rxploratory Analysis of in Situ Hyperspectral Data 显示文摘 | Pu R L Yu B | 1997 | Remote Sensing of Environment1997，62，： | 1 |
| 17 | Theory of fractional covariance matrix and its applications in PCA and 2DPCA显示文摘 | Gao C B Zhou J L Pu Q | | 0，，： | 1 |
| 18 | Tissue quanlity is an important determinant of telomerase activity as measured by TRAP assay显示文摘 | Pu Yan Fred TB Jean B | 1998 | Biotechniques1998，25，： | 1 |
| 19 | Adsorption and separation of β, β-dimethylnaphthalene isomers on various large-pore zeolites having 12-oxygen-member-ring structure 显示文摘 | Pu S B Tanaka Y Inui T | 1996 | Separations Technology1996，6，： | 1 |
| 20 | Frequency of thrombolytic therapy in patients with acute ischemie stroke and the risk of inhospital mortality: the german stroke registers study group显示文摘 | Heuschmann PU Berger K Misselwltz B | 2003 | Stroke2003，34，： | 1 |
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