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| 1 | Analysis of blockchain protocol against static adversarial miners corrupted by long delay attackers显示文摘Bitcoin, which was initially introduced by Nakamoto, is the most disruptive and impactive cryptocurrency. The core Bitcoin technology is the so-called blockchain protocol. In recent years, several studies have focused on rigorous analyses of the security of Nakamoto’s blockchain protocol in an asynchronous network where network delay must be considered. Wei, Yuan, and Zheng investigated the effect of a long delay attack against Nakamoto’s blockchain protocol. However, their proof only holds in the honest miner setting. In this study, we improve Wei, Yuan and Zheng’s result using a stronger model where the adversary can perform long delay attacks and corrupt a certain fraction of the miners. We propose a method to analyze the converge event and demonstrate that the properties of chain growth, common prefix, and chain quality still hold with reasonable parameters in our stronger model. | Quan YUAN Puwen WEI Keting JIA Haiyang XUE | 2020 | Science China(Information Sciences)2020，63，3： | 3 |
| 2 | Clay nanosheet-mediated delivery of recombinant plasmids expressing artificial miRNAs via leaf spray to prevent infection by plant DNA viruses显示文摘Whitefly-transmitted begomoviruses are economically important plant pathogens that cause severe problems in many crop plants,such as tomato,papaya,cotton,and tobacco.Tomato yellow leaf curl virus(TYLCV)is a typical monopartite begomovirus that has been extensively studied,but methods that can efficiently control begomoviruses are still scarce.In this study,we combined artificial microRNA(amiRNA)-mediated silencing technology and clay nanosheetmediated delivery by spraying and developed a method for efficiently preventing TYLCV infection in tomato plants.We designed three amiRNAs that target different regions of TYLCV to silence virus-produced transcripts.Three plant expression vectors expressing pre-amiRNAs were constructed,and recombinant plasmid DNAs(pDNAs)were loaded onto nontoxic and degradable layered double hydroxide(LDH)clay nanosheets.LDH nanosheets containing multiple pDNAs were sprayed onto plant leaves.We found that the designed amiRNAs were significantly accumulated in leaves 7 days after spraying,while the pDNAs were sustainably detected for 35 days after the spray,suggesting that the LDH nanosheets released pDNAs in a sustained manner,protected pDNAs from degradation and efficiently delivered pDNAs into plant cells.Importantly,when the LDH nanosheets coated with pDNAs were sprayed onto plants infected by TYLCV,both the disease severity and TYLCV viral concentration in sprayed plants were significantly decreased during the 35 days,while the levels of H_(2)O_(2) were significantly increased in those plants.Taken together,these results indicate that LDH nanosheets loaded with pDNAs expressing amiRNAs can be a sustainable and promising tool for begomovirus control. | Qili Liu Yanpeng Li Kedong Xu Dongxiao Li Haiyan Hu Feng Zhou Puwen Song Yongang Yu Qichao Wei Qian Liu Weipeng Wang Ruifang Bu Haili Sun Xiaohui Wang Jianjun Hao Honglian Li Chengwei Li | 2020 | Horticulture Research2020，7，1： | 1 |
| 3 | Micro RNA ‐133b inhibits the growth of non‐small‐cell lung cancer by targeting the epidermal growth factor receptor显示文摘 | Lingxiang Liu Xiaoyan Shao Wen Gao Zhi Zhang Ping Liu Rongsheng Wang Puwen Huang Yongmei Yin Yongqian Shu | 2012 | FEBS J2012，，： | 1 |
| 4 | High intensity focused ultrasound in combination with chemotherapy by the regime of PFC: a clinical study for advanced gastric carcinoma显示文摘Objective: To evaluate the recent curative efficacy and security of High intensity focused ultrasound (HIFU) in combination with chemotherapy(PFC) in patients with advanced gastric carcinoma. Method: Sixty patients with measurable advanced gastric carcinoma,proved pathologically, were divided into Group A and Group B. Group A: Patients were treated by HIFU(FEP-BY01) in combination with chemotherapy(PFC, paclitaxel, cisplatin and 5-fluorouracil). Group B: Patients were treated with the single regime of PFC. Results: All cases could be evaluated. In group A, 5 patients achieved complete response, 17 patients achieved partial response,and a response rate was 73.3%. The stable disease(SD) and the inefficiency all were 13.3%(4/30) respectively, and msurvival time(MST) was 13.9 months. In group B, 2 patients achieved complete response, 14 patients achieved partial response,and a response rate was53.3%. The stable disease(SD) was 23.3%(7/30). The inefficiency all were 23.3%(7/30) respectively, and median survival time was 9.6 months. There was significant difference between two groups’ MST(P<0.05). Major toxicities included bone marrow depression, nausea, vomiting and alopecia, without significant differences between two groups(P>0.05). Conclusion: This study shows that HIFU in combination with chemotherapy(PFC) was a new efficent and secure therapy for the patients with advanced gastric carcinoma. It was observed that the MST was prolonged. Prospective trials should be warranted to determine the result. | Qingxia Mu Yongqian Shu Puwen Huang Kaihua Lu Rongsheng Wang | 2005 | Journal of Nanjing Medical University2005，19，4： | 0 |
| 5 | How Do Mind-Body Practices Benefit Employees? A Daily Diary Study of Mind–Body Practices after Work and Employees’ Next-Day Proactive Behavior显示文摘Although it is becoming increasingly popular for organizations to offer programs of mind–body practices to their employees to improve their physical and mental health,the effects that after-work sessions of mind–body prac-tices have on employees’work behavior remain unclear.Using the model of proactive motivation and experience sampling,this study explored the relationship between employees’mind–body practices after work and their proactive behavior in the workplace on the following day.A multilevel path analysis of data from 82 employees over seven consecutive workdays showed that employees’mind–body practices after work had a positive effect on their proactive behavior in the workplace on the following day.The relationship was mediated by next-day high-activated positive affect and problem-solving confidence.Furthermore,job control positively moderated the rela-tionship between high-activated positive affect and proactive behavior but not that between problem-solving con-fidence and proactive behavior.We discuss the theoretical and practical implications of thesefindings,and propose future research directions. | Puwen Shang Jinfan Zhou Guanglei Zhang | 2023 | International Journal of Mental Health Promotion2023，25，1： | 0 |
| 6 | Automatic identification of rock discontinuity and stability analysis of tunnel rock blocks using terrestrial laser scanning显示文摘Local geometric information and discontinuity features are key aspects of the analysis of the evolution and failure mechanisms of unstable rock blocks in rock tunnels.This study demonstrates the integration of terrestrial laser scanning(TLS)with distinct element method for rock mass characterization and stability analysis in tunnels.TLS records detailed geometric information of the surrounding rock mass by scanning and collecting the positions of millions of rock surface points without contact.By conducting a fuzzy K-means method,a discontinuity automatic identification algorithm was developed,and a method for obtaining the geometric parameters of discontinuities was proposed.This method permits the user to visually identify each discontinuity and acquire its spatial distribution features(e.g.occurrences,spac-ings,trace lengths)in great detail.Compared with hand mapping in conventional geotechnical surveys,the geometric information of discontinuities obtained by this approach is more accurate and the iden-tification is more efficient.Then,a discrete fracture network with the same statistical characteristics as the actual discontinuities was generated with the distinct element method,and a representative nu-merical model of the jointed surrounding rock mass was established.By means of numerical simulation,potential unstable rock blocks were assessed,and failure mechanisms were analyzed.This method was applied to detection and assessment of unstable rock blocks in the spillway and sand flushing tunnel of the Hongshiyan hydropower project after a collapse.The results show that the noncontact detection of blocks was more labor-saving with lower safety risks compared with manual surveys,and the stability assessment was more reliable since the numerical model built by this method was more consistent with the distribution characteristics of actual joints.This study can provide a reference for geological survey and unstable rock block hazard mitigation in tunnels subjected to complex geology and active rockfalls. | Meng Wang Jiawen Zhou Junlin Chen Nan Jiang Puwen Zhang Haibo Li | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，7： | 0 |
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