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| 1 | The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation显示文摘Interleukin(IL)17-producing T helper(Th17)cells play critical roles in the clearance of extracellular bacteria and fungi as well as the pathogenesis of various autoimmune diseases,such as multiple sclerosis,psoriasis,and ulcerative colitis.Although a global transcriptional regulatory network of Th17 cell differentiation has been mapped recently,the participation of epigenetic modifications in the differentiation process has yet to be elucidated.We demonstrated here that histone H3 lysine-27(H3K27)demethylation,predominantly mediated by the H3K27 demethylase Jmjd3,crucially regulated Th17 cell differentiation.Activation of naı¨ve CD41 T cells immediately induced high expression of Jmjd3.Genetic depletion of Jmjd3 in CD41 T cells specifically impaired Th17 cell differentiation both in vitro and in vivo.Ectopic expression of Jmjd3 largely rescued the impaired differentiation of Th17 cells in vitro in Jmjd3-deficientCD41 T cells.Importantly,Jmjd3-deficient mice were resistant to the induction of experimental autoimmune encephalomyelitis(EAE).Furthermore,inhibition of the H3K27 demethylase activity with the specific inhibitor GSK-J4 dramatically suppressed Th17 cell differentiation in vitro.At the molecular level,Jmjd3 directly bound to and reduced the level of H3K27 trimethylation(me3)at the genomic sites ofRorc,which encodes the masterTh17 transcription factorRorgt,and Th17 cytokine genes such as Il17,Il17f,and Il22.Therefore,our studies established acritical role of Jmjd3-mediatedH3K27demethylation inTh17 cell differentiation andsuggest that Jmjd3 can be a novel therapeutic target for suppressing autoimmune responses. | Zhi Liu Wei Cao Longxia Xu Xi Chen Yu Zhan Qian Yang Sanhong Liu Pengfei Chen Yuhang Jiang Xiaohua Sun Yu Tao Yiming Hu Cuifeng Li Qi Wang Ying Wang Charlie Degui Chen Yufang Shi Xiaoren Zhang | 2015 | Journal of Molecular Cell Biology2015，7，6： | 6 |
| 2 | Uncertainty analysis of hydrological processes based on ARMA-GARCH model显示文摘Uncertainty analysis and risk analysis are two important areas of modern water resource management,in which accurate variance estimation is required.The traditional runoff model is established under the assumption that the variance is a constant or it changes with the seasons.However,hydrological processes in the real world are often heteroscedastic,which can be tested by McLeod-Li test and Engle Lagrange multiplier test.In such cases,the GARCH model of hydrological processes is established in this article.First,the seasonal factors in the sequence are removed.Second,the traditional ARMA model is established.Then,the GARCH model is used to correct the residual.At last,the daily runoff data in 1949-2001 of Yichang Hydrological Station is taken to be an example.The result shows that compared to the traditional ARMA model,the GARCH model has the ability to predict more accurate confidence intervals under the same confidence level. | WANG HongRui GAO Xiong QIAN LongXia YU Song | 2012 | Science China(Technological Sciences)2012，55，8： | 6 |
| 3 | On the existence of periodic solutions to a fonrth-order p-Laplacian differential equation with a deviating argument 显示文摘 | WANG Zhengxin QIAN Longxia LU Shiping | 2010 | Nonlinear Analysis:Real World Ap- plications2010，11，： | 1 |
| 4 | The existence and uniqueness of periodic solutions for a kind of Duigmg - type equation with two deviating arguments显示文摘 | Wang Zhengxin Qian Longxia Lu Shiping etal | 2010 | Nonlinear Analysis2010，73，： | 1 |
| 5 | The existence and uniqueness of periodic solutions for a kind of Duffing-type equation with two deviating arguments 显示文摘 | Wang Zhengxin Qian Longxia Lu Shiping | 2010 | Nonlinear Anal2010，73，9： | 1 |
| 6 | Ecological compensation mechanism for urban green land and its application in Shanghai, China显示文摘Urban green land compensation plays an impor-tant role in county development,ecological environment management and many other fields.The concept,methods and principles of urban green land are introduced in this paper.According to the pay fee method,the value and ecological function of various types of urban green land were analyzed.The cost-benefit analysis method(CBAM)was used to estimate different external diseconomy benefits caused by green land loss.The authors applied CBAM to estimate such benefits in the case of Shanghai,China,and calculated the actual compensation value for green land.Results indicated that in 2002,the compensation value for the green land of Shanghai was RMB 8.58×10^(5) Yuan/hm^(2). | WANG Yan DING Xiaowen QIAN Longxia WANG Hongrui | 2007 | Frontiers of Environmental Science & Engineering2007，1，3： | 0 |
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