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| 1 | Changes in Mean and Extreme Temperature and Precipitation over the Arid Region of Northwestern China: Observation and Projection显示文摘This paper reports a comprehensive study on the observed and projected spatiotemporal changes in mean and extreme climate over the arid region of northwestern China, based on gridded observation data and CMIP5 simulations under the RCP4.5 and RCP8.5 scenarios. The observational results reveal an increase in annual mean temperature since 1961, largely attributable to the increase in minimum temperature. The annual mean precipitation also exhibits a significant increasing tendency. The precipitation amount in the most recent decade was greater than in any preceding decade since 1961. Seasonally,the greatest increase in temperature and precipitation appears in winter and in summer, respectively. Widespread significant changes in temperature-related extremes are consistent with warming, with decreases in cold extremes and increases in warm extremes. The warming of the coldest night is greater than that of the warmest day, and changes in cold and warm nights are more evident than for cold and warm days. Extreme precipitation and wet days exhibit an increasing trend, and the maximum number of consecutive dry days shows a tendency toward shorter duration. Multi-model ensemble mean projections indicate an overall continual increase in temperature and precipitation during the 21 st century. Decreases in cold extremes, increases in warm extremes, intensification of extreme precipitation, increases in wet days, and decreases in consecutive dry days, are expected under both emissions scenarios, with larger changes corresponding to stronger radiative forcing. | Yujie WANG Botao ZHOU Dahe QIN Jia WU Rong GAO Lianchun SONG | 2017 | Advances in Atmospheric Sciences2017，34，3： | 37 |
| 2 | GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity显示文摘Gasdermin B (GSDMB) has been reported to be associated with immune diseases in humans, but the detailed molecular mechanisms remain unsolved. The N-terminus of GSDMB by itself, unlike other gasdermin family proteins, does not induce cell death. Here, we show that GSDMB is highly expressed in the leukocytes of septic shock patients, which is associated with increased release of the gasdermin D (GSDMD) N-terminus. GSDMB expression and the accumulation of the N-terminal fragment of GSDMD are induced by the activation of the non-canonical pyroptosis pathway in a human monocyte cell line. The downregulation of GSDMB alleviates the cleavage of GSDMD and cell death. Consistently, the overexpression of GSDMB promotes GSDMD cleavage, accompanied by increased LDH release. We further found that GSDMB promotes caspase-4 activity, which is required for the cleavage of GSDMD in non-canonical pyroptosis, by directly binding to the CARD domain of caspase-4. Our study reveals a GSDMB-mediated novel regulatory mechanism for non-canonical pyroptosis and suggests a potential new strategy for the treatment of inflammatory diseases. | Qin Chen Peiliang Shi Yufang Wang Dayuan Zou Xiuwen Wu Dingyu Wang Qiongyuan Hu Yujie Zou Zan Huang Jianan Ren Zhaoyu Lin Xiang Gao | 2019 | Journal of Molecular Cell Biology2019，11，6： | 22 |
| 3 | Substance P-modified human serum albumin nanoparticles loaded with paclitaxel for targeted therapy of glioma显示文摘The blood–brain barrier(BBB) and the poor ability of many drugs to cross that barrier greatly limits the efficacy of chemotherapies for glioblastoma multiforme(GBM). The present study exploits albumin as drug delivery vehicle to promote the chemotherapeutic efficacy of paclitaxel(PTX) by improving the stability and targeting efficiency of PTX/albumin nanoparticles(NPs). Here we characterize PTX-loaded human serum albumin(HSA) NPs stabilized with intramolecular disulfide bonds and modified with substance P(SP) peptide as the targeting ligand. The fabricated SP-HSA-PTX NPs exhibited satisfactory drug-loading content(7.89%) and entrapment efficiency(85.7%) with a spherical structure(about 150 nm) and zeta potential of -12.0 mV. The in vitro drug release from SP-HSA-PTX NPs occurred in a redox-responsive manner. Due to the targeting effect of the SP peptide, cellular uptake of SP-HSA-PTX NPs into brain capillary endothelial cells(BCECs) and U87 cells was greatly improved.The low IC_(50), prolonged survival period and the obvious pro-apoptotic effect shown by TUNEL analysis all demonstrated that the fabricated SP-HSA-PTX NPs showed a satisfactory anti-tumor effect and could serve as a novel strategy for GBM treatment. | Chunhui Ruan Lisha Liu Yifei Lu Yu Zhang Xi He Xinli Chen Yujie Zhang Qinjun Chen Qin Guo Tao Sun Chen Jiang | 2018 | Acta Pharmaceutica Sinica B2018，8，1： | 19 |
| 4 | Reponses and sensitivities of maize phenology to climate change from 1981 to 2009 in Henan Province, China显示文摘与全球温暖,响应气候变化的庄稼 phenological 移动成为了一个热研究话题。基于长期的观察 agro 气象学的 phenological 数据(1981-2009 ) 和气象学的数据,我们时间、空间的分析的份量上变在玉米物候学和他们的敏感给因素用气候趋势改变的气候调音率和敏感分析方法。结果显示播种朋友显著地被耽搁,延期趋势率是 9.0 d ?????????????????? ┴吗?? | LIU Yujie QIN Ya GE Quansheng DAI Junhu CHEN Qiaomin | 2017 | Journal of Geographical Sciences2017，27，9： | 14 |
| 5 | Graphene-carbon nanotube hybrid films for high- performance flexible photodetectors显示文摘Graphene 活跃地为灵活、可拉长的设备作为候选人材料正在被探索。然而,基于 graphene 的灵活 photonic 设备的发展,即光电探测器,被碳原子的单个层的低吸收度妨碍。最近,货车 der Waals 结合了碳 nanotube 和 graphene 混血儿电影证明了像静脉的碳 nanotube 网络的优秀 photoresponsivity,和使用导致了显著地更高的机械力量。这里,我们第一次报导,有 51 A/W 和快回答 ~ 预定的 ~ 的高 photoresponsivity 的一个灵活光电探测器在可见范围上的 40 ms,揭示这个新兴的所有碳混血儿的唯一的潜力为灵活设备拍摄。另外,设备对重复弯曲展出好坚韧性,建议它在大区域的矩阵数组的适用性灵活光电探测器。 | Yujie Liu Yuanda Liu Shuchao Qin Yongbing Xu Rong Zhang Fengqiu Wang | 2017 | Nano Research2017，10，6： | 7 |
| 6 | GLUT1-mediated effective anti-miRNA21 pompon for cancer therapy显示文摘Oncogenic microRNAs are essential components in regulating the gene expression of cancer cells. Especially miR21, which is a major player involved of tumor initiation, progression, invasion and metastasis in several cancers. The delivery of anti-miR21 sequences has significant potential for cancer treatment. Nevertheless, since anti-miR21 sequences are extremely unstable and they need to obtain certain concentration to function, it is intensely difficult to build an effective delivery system for them.The purpose of this work is to construct a self-assembled glutathione(GSH)-responsive system with tumor accumulation capacity for effective anti-miR21 delivery and cancer therapy. A novel drug delivery nanosphere carrying millions of anti-miR21 sequences was developed through the rolling circle transcription(RCT) method. GSH-responsive cationic polymer polyethyleneimine(pOEI) was synthesized to protect the nanosphere from degradation by Dicer or other RNase in normal cells and optimize the pompon-like nanoparticle to suitable size. Dehydroascorbic acid(DHA), a targeting molecule, which is a substrate of glucose transporter 1(GLUT 1) and highly expressed on malignant tumor cells, was connected to pOEI through PEG, and then the polymer was used for contracting a RNA nanospheres into nanopompons. The anti-miR21 nanopompons showed its potential for effective cancer therapy. | Qin Guo Chao Li Wenxi Zhou Xinli Chen Yu Zhang Yifei Lu Yujie Zhang Qinjun Chen Donghui Liang Tao Sun Chen Jiang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 5 |
| 7 | Questions about NgAgo显示文摘 | Shawn Burgess Linzhao Cheng Feng Gu Zhiwei Huang Shuo Lin Jinsong Li Wei Li Wei Qin Yujie Sun Zhou Songyang Wensheng Wei Qiang Wu Haoyi Wang Xiaoqun Wang Jing-Wei Xiong Jianzhong Xi Hui Yang Bin Zhou Bo Zhang Junjiu Huang | 2016 | Protein & Cell2016，7，12： | 5 |
| 8 | A central analgesic mechanism of acupuncture for migraine An ongoing functional MRI study显示文摘Shaoyang acupoints are the most frequently used in migraine treatment.However,the central analgesic mechanism remains poorly understood.Studies have demonstrated that single stimulus of the verum acupuncture in healthy subjects can induce significant connectivity or activity changes in painrelated central networks compared with sham acupuncture.However,these findings are not indicative of the central analgesic mechanism of acupuncture at Shaoyang acupoints.Thus,we recruited 100migraine sufferers and randomly assigned them into five groups:Shaoyang uncommon acupoint,Shaoyang common acupoint,Yangming uncommon acupoint,non-acupoint control,and blank control groups.Subjects were subjected to evaluation of curative effects and functional MRI prior to and after10 and 20 acupuncture treatments.All subjects were diagnosed by physicians and enrolled following clinical physical examination.Subjects were observed during 1–4 weeks after inclusion.At the fifth week,the first clinical evaluation and resting functional MRI were conducted.The Shaoyang uncommon acupoint,Shaoyang common acupoint,Yangming uncommon acupoint,and non-acupoint control grousp then were treated with acupuncture,five times per week,20 times in total over 4 weeks.The second and third clinical evaluations and resting functional MRI screenings were conducted following10 and 20 acupuncture treatments.The blank control group was observed during the 5 to 8 week period,followed by clinical evaluation and resting functional MRI.The aim of this study was to examine changes in brain functional activity and central networks in subjects with migraine undergoing acupuncture at Shaoyang uncommon acupoints.This study provides a further explanation of the central analgesic mechanism by which acupuncture at Shaoyang acupoints treats migraine. | Lei Lan Yujie Gao Fang Zeng Wei Qin Mingkai Dong Mailan Liu Taipin Guo Fanrong Liang | 2013 | Neural Regeneration Research2013，8，28： | 3 |
| 9 | Comparison of aerosol characteristics during haze periods over two urban agglomerations in China using CALIPSO observations显示文摘 | Qiong Liu Xiaojun Ma Yanrong Yu Yan Qin Yonghang Chen Yanming Kang Hua Zhang Tiantao Cheng Yan Ling Yujie Tang | 2017 | Particuology2017，15，4： | 2 |
| 10 | Global patterns and changes of carbon emissions from land use during 1992e2015显示文摘Carbon emissions from land use(ELUC)are an important part of anthropogenic CO_(2) emissions,but its size and location remain uncertain,and our knowledge of the relationship between ELUC and GDP remains partial.We showed that the carbon emissions directly caused by land use change(direct ELUC)during 1992-2015 was 26.54 Pg C(1.15 Pg C yr^(-1)),with a decreased trend and a net reduction rate of0.15 Pg C yr^(-1).The areas that exhibited reductions were concentrated in South America,Central Africa,and Southeast Asia,and those with increments were scattered in Northwestern North America,Eastern South America,Central Africa,East Asia,and parts of Southeast Asia.For the indirect carbon emissions from the utilization of built-up land(indirect ELUC),it manifested an upward trend with a total emission of 27.51 Pg C(1.2 Pg C yr^(-1)).The total value resulted by global ELUC was $136.3×10^(9) US,and the value of annual was equivalent to 3.7 times the GDP of the Central African Republic in 2015($5.93×10^(9) US yr^(-1)).Among the 79 countries and regions considered in this study,54 represented the upward GDP with increased emissions,and only 25 experienced GDP growth with emission reductions.These findings highlight the pivotal role of land use change in the carbon cycle and the significance of coordinated development between GDP and carbon emissions. | Shiqi Tian Shijie Wang Xiaoyong Bai Guangjie Luo Qin Li Yujie Yang Zeyin Hu Chaojun Li Yuanhong Deng | 2021 | Environmental Science and Ecotechnology2021，，3： | 2 |
| 11 | Cluster segmentation algorithm based on the Vicsek with static summoning points显示文摘Because of the low convergence efficiency of the typical Vicsek model,a Vicsek with static summoning points(VSSP)algorithm based on the Vicsek model considering static summoning points is proposed.Firstly,the mathematical model of the individual movement total cost on each summoning point is established.Then the individual classification rule is designed according to the initial state of the cluster to obtain the subclusters guided by each summoning point.Finally,the summoning factor is introduced to modify the course angle updating formula of the Vicsek model.To verify the effectiveness of the proposed algorithm and study the effect of the cluster summoning factor on the convergence rate,three groups of simulation experiments under different summoning factors are designed in this paper.To verify the superiority of the VSSP algorithm,the performance of the VSSP algorithm is compared with the classic algorithm by designing the algorithm performance comparison verification experiment.The results show that the algorithm proposed in this paper has good convergence and course angle consistency.The summoning factor is the sensitive factor of cluster convergence.This algorithm can provide a reference for efficient cluster segmentation movement. | MA Yan MAO Zhaoyong QIN Jian MENG Xiangyao XIAO Yujie CHEN Jianhua FENG Wei | 2021 | Journal of Systems Engineering and Electronics2021，32，3： | 1 |
| 12 | Copper-Catalyzed Asymmetric Hydroamination:A Unified Strategy for the Synthesis of Chiralβ-Amino Acid and Its Derivatives显示文摘Catalytic asymmetric aza-Michael represents one of the most convenient and atom-economical approaches for the rapid construction of biologically active chiralβ-amino acid frameworks.However,the direct enantioselective addition of nitrogen-based nucleophiles to intrinsically low reactivity ofα,β-unsaturated carboxylic acid,ester,and amide,as well as simpleα,β-unsaturated nitrile,remains a long-standing challenge. | Ge Zhang Yujie Liang Tao Qin Tao Xiong Shuyu Liu Wei Guan Qian Zhang | 2021 | CCS Chemistry2021，3，7： | 1 |
| 13 | Photoluminescence Mechanism Model for Oxidized Porous Silicon and Nanoscale-silicon-particle-em- bedded Silicon Oxide 显示文摘 | QIN Guogang LI Yujie | 2003 | Phys Rev B2003，68，08： | 1 |
| 14 | Physical and mechanical properties of dental nanocompesites composed of aliphatic epoxy resin and epoxidized aromatic hyperbranched polymers 显示文摘 | Yujie Zhang Daohong Zhang Chuangye Qin | | Polymer Composites in press0，，： | 1 |
| 15 | Acupuncture improves cognitive deficits and regulates the brain cell proliferation of SAMP8 mice显示文摘 | Haiyan Cheng Jianchun Yu Zhiguo Jiang Xuezhu Zhang Cunzhi Liu Yingmei Peng Fuyan Chen You Qu Yujie Jia Qingfei Tian Chuan Xiao Qin Chu Kun Nie Bohong Kan Xiaolin Hu Jingxian Han | 2007 | Neuroscience Letters2007，，2： | 1 |
| 16 | Involvement of reactive oxygen species in indomethacin-induced apoptosis of small intestinal epithelial cells显示文摘 | Tatsushi Omatsu Yuji Naito Osamu Handa Natsuko Hayashi Katsura Mizushima Ying Qin Ikuhiro Hirata Satoko Adachi Tetsuya Okayama Etsuko Kishimoto Tomohisa Takagi Satoshi Kokura Hiroshi Ichikawa Toshikazu Yoshikawa | 2009 | Journal of Gastroenterology2009，，19： | 1 |
| 17 | A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism显示文摘Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven therapy.Here,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified legs.Because of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was approved.Preclinical release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were introduced.We further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude mice.After the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the ulcers.When followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear cells.Skin biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged site.No infusion or local treatment-related adverse events occurred.Thus,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity. | Lianju Qin Jing Zhang Yujie Xiao Kang Liu Yugui Cui Fangyan Xu Wenkai Ren Yanggang Yuan Chunyan Jiang Song Ning Xiaoxue Ye Ming Zeng Hanyang Qian Anning Bian Fan Li Guang Yang Shaowen Tang Zhihong Zhang Juncheng Dai Jing Guo Qiang Wang Bin Sun Yifei Ge Chun Ouyang Xueqiang Xu Jing Wang Yaoyu Huang Hongqing Cui Jing Zhou Meilian Wang Zhonglan Su Yan Lu Di Wu Jingping Shi Wei Liu Li Dong Yinbing Pan Baiqiao Zhao Ying Cui Xueyan Gao Zhanhui Gao Xiang Ma Aiqin Chen Jie Wang Meng Cao Qian Cui Li Chen Feng Chen Youjia Yu Qiang Ji Zhiwei Zhang Mufeng Gu Xiaojun Zhuang Xiaolin Lv Hui Wang Yanyan Pan Ling Wang Xianrong Xu Jing Zhao Xiuqin Wang Cuiping Liu Ningxia Liang Changying Xing Jiayin Liu Ningning Wang | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 18 | Melatonin decreases GSDME mediated mesothelial cell pyroptosis and prevents peritoneal fibrosis and ultrafiltration failure显示文摘Peritoneal fibrosis together with increased capillaries is the primary cause of peritoneal dialysis failure.Mesothelial cell loss is an initiating event for peritoneal fibrosis.We find that the elevated glucose concentrations in peritoneal dialysate drive mesothelial cell pyroptosis in a manner dependent on caspase-3 and Gasdermin E,driving downstream inflammatory responses,including the activation of macrophages.Moreover,pyroptosis is associated with elevated vascular endothelial growth factor A and C,two key factors in vascular angiogenesis and lymphatic vessel formation.GSDME deficiency mice are protected from high glucose induced peritoneal fibrosis and ultrafiltration failure.Application of melatonin abrogates mesothelial cell pyroptosis through a MT1R-mediated action,and successfully reduces peritoneal fibrosis and angiogenesis in an animal model while preserving dialysis efficacy.Mechanistically,melatonin treatment maintains mitochondrial integrity in mesothelial cells,meanwhile activating m TOR signaling through an increase in the glycolysis product dihydroxyacetone phosphate.These effects together with quenching free radicals by melatonin help mesothelial cells maintain a relatively stable internal environment in the face of high-glucose stress.Thus,Melatonin treatment holds some promise in preserving mesothelium integrity and in decreasing angiogenesis to protect peritoneum function in patients undergoing peritoneal dialysis. | Hongxia Ruan Xuejuan Li Lina Zhou Zihan Zheng Rulin Hua Xu Wang Yuan Wang Yujie Fan Shuwen Guo Lihua Wang Shafiq ur Rahman Ziwei Wang Yuyuan Wei Shuangyan Yu Rongzhi Zhang Qian Cheng Jie Sheng Xue Li Xiaoyan Liu Ruqiang Yuan Xiaoyan Zhang Lihong Chen Guowang Xu Youfei Guan Jing Nie Hongqiang Qin Feng Zheng | 2024 | Science China(Life Sciences)2024，67，2： | 0 |
| 19 | Baseline radiologic features as predictors of efficacy in patients with pancreatic neuroendocrine tumors with liver metastases receiving surufatinib显示文摘Objective:Currently,pre-treatment prediction of patients with pancreatic neuroendocrine tumors with liver metastases(PNELM)receiving surufatinib treatment was unsatisfying.Our objective was to examine the association between radiological characteristics and efficacy/prognosis.Methods:We enrolled patients with liver metastases in the phase III,SANET-p trial(NCT02589821)and obtained contrast-enhanced computed tomography(CECT)images.Qualitative and quantitative parameters including hepatic tumor margins,lesion volumes,enhancement pattern,localization types,and enhancement ratios were evaluated.The progression-free survival(PFS)and hazard ratio(HR)were calculated using Cox’s proportional hazard model.Efficacy was analyzed by logistic-regression models.Results:Among 152 patients who had baseline CECT assessments and were included in this analysis,the surufatinib group showed statistically superior efficacy in terms of median PFS compared to placebo across various qualitative and quantitative parameters.In the multivariable analysis of patients receiving surufatinib(N=100),those with higher arterial phase standardized enhancement ratio-peri-lesion(ASER-peri)exhibited longer PFS[HR=0.039;95%confidence interval(95%CI):0.003−0.483;P=0.012].Furthermore,patients with a high enhancement pattern experienced an improvement in the objective response ratio[31.3%vs.14.7%,odds ratio(OR)=3.488;95%CI:1.024−11.875;P=0.046],and well-defined tumor margins were associated with a higher disease control rate(DCR)(89.3%vs.68.2%,OR=4.535;95%CI:1.285−16.011;P=0.019)compared to poorlydefined margins.Conclusions:These pre-treatment radiological features,namely high ASER-peri,high enhancement pattern,and well-defined tumor margins,have the potential to serve as predictive markers of efficacy in patients with PNELM receiving surufatinib. | Jianwei Zhang Haibin Zhu Lin Shen Jie Li Xiaoyan Zhang Chunmei Bai Zhiwei Zhou Xianrui Yu Zhiping Li Enxiao Li Xianglin Yuan Wenhui Lou Yihebali Chi Nong Xu Yongmei Yin Yuxian Bai Tao Zhang Dianrong Xiu Jia Chen Shukui Qin Xiuwen Wang Yujie Yang Haoyun Shi Xian Luo Songhua Fan Weiguo Su Ming Lu Jianming Xu | 2023 | Chinese Journal of Cancer Research2023，35，5： | 0 |
| 20 | Field Surveys Suggest Biennial Reproduction Cycle and Competition-triggered Dispersal of the Endangered Chinese Crocodile Lizard显示文摘The endangered Chinese crocodile lizard(Shinisaurus crocodilurus)is a habitat specialist living in streams of mountain forests in southern China and northern Vietnam.Conservation efforts are increasing for recovering its wild populations.However,the growth,reproduction,and dispersal ability of crocodile lizards in the wild are largely unknown.We conducted field surveys of the crocodile lizard population in Daguishan National Nature Reserve,one of the largest extant wild populations of crocodile lizards,for three consecutive years in Guangxi,China.We found that crocodile lizards generally reach sexual maturity at the age of 2.5 years in the wild.Unlike most viviparous lizards,which reproduce annually,the crocodile lizard shows a biennial reproductive cycle.The number of observed juveniles and subadults fluctuated between years,whereas that of adults remained relatively stable.Non-adults had longer three-year dispersal distance than adults.Crocodile lizards showed preference for backwater pools in the stream.Competition for better resources may be the main trigger for dispersal. | Shuyi LUO Yujie YANG Chunsheng YANG Jun GUO Xudong QIN Haiyao CEN Hongxin XIE Zhengjun WU | 2022 | Asian Herpetological Research2022，13，3： | 0 |
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