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| 1 | The Chinese Society of Clinical Oncology(CSCO):Clinical guidelines for the diagnosis and treatment of gastric cancer,2021显示文摘There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the Eastern and Western countries.The Chinese Society of Clinical Oncology(CSCO)has organized a panel of senior experts specializing in all sub-specialties of gastric cancer to compile a clinical guideline for the diagnosis and treatment of gastric cancer since 2016 and renews it annually.Taking into account regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted expert consensus judgment on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes in China.The 2021 CSCO Clinical Practice Guidelines for Gastric Cancer covers the diagnosis,treatment,follow-up,and screening of gastric cancer.Based on the 2020 version of the CSCO Chinese Gastric Cancer guidelines,this updated guideline integrates the results ofmajor clinical studies from China and overseas for the past year,focused on the inclusion of research data from the Chinese population for more personalized and clinically relevant recommendations.For the comprehensive treatment of non-metastatic gastric cancer,attentions were paid to neoadjuvant treatment.The value of perioperative chemotherapy is gradually becoming clearer and its recommendation level has been updated.For the comprehensive treatment of metastatic gastric cancer,recommendations for immunotherapy were included,and immune checkpoint inhibitors fromthird-line to the first-line of treatment for different patient groups with detailed notes are provided. | Feng-Hua Wang Xiao-Tian Zhang Yuan-Fang Li Lei Tang Xiu-Juan Qu Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Hong Qiu Chang Wang Miao-Zhen Qiu Mu-Yan Cai QiWu Hao Liu Wen-Long Guan Ai-Ping Zhou Yu-Jing Zhang Tian-Shu Liu Feng Bi Xiang-Lin Yuan Sheng-Xiang Rao Yan Xin Wei-Qi Sheng Hui-Mian Xu Guo-Xin Li Jia-Fu Ji Zhi-Wei Zhou Han Liang Yan-Qiao Zhang Jing Jin Lin Shen Jin Li Rui-Hua Xu | 2021 | Cancer Communications2021，41，8： | 97 |
| 2 | Chemical composition and source apportionment of PM10 and PM2.5 in different functional areas of Lanzhou,China显示文摘To elucidate the air pollution characteristics of northern China, airborne PM_10(atmospheric dynamic equivalent diameter ≤ 10 μm) and PM_(2.5)(atmospheric dynamic equivalent diameter ≤ 2.5 μm) were sampled in three different functional areas(Yuzhong County,Xigu District and Chengguan District) of Lanzhou, and their chemical composition(elements, ions, carbonaceous species) was analyzed. The results demonstrated that the highest seasonal mean concentrations of PM_10(369.48 μg/m^3) and PM_(2.5)(295.42 μg/m^3) were detected in Xigu District in the winter, the lowest concentration of PM_(2.5)(53.15 μg/m^3) was observed in Yuzhong District in the fall and PM_10(89.60 μg/m^3) in Xigu District in the fall.The overall average OC/EC(organic carbon/elemental carbon) value was close to the representative OC/EC ratio for coal consumption, implying that the pollution of Lanzhou could be attributed to the burning of coal. The content of SNA(the sum of sulfate, nitrate,ammonium, SNA) in PM_(2.5)in Yuzhong County was generally lower than that at other sites in all seasons. The content of SNA in PM_(2.5)and PM_10 in Yuzhong County was generally lower than that at other sites in all seasons(0.24–0.38), indicating that the conversion ratios from precursors to secondary aerosols in the low concentration area was slower than in the area with high and intense pollutants. Six primary particulate matter sources were chosen based on positive matrix factorization(PMF) analysis, and emissions from dust, secondary aerosols, and coal burning were identified to be the primary sources responsible for the particle pollution in Lanzhou. | Xionghui Qiu Lei Duan Jian Gao Shulan Wang Fahe Chai Jun Hu Jingqiao Zhang Yaru Yun | 2016 | Journal of Environmental Sciences2016，28，2： | 33 |
| 3 | Clinical impact of plasma TGF-β1 and circulating TGF-β1 mRNA in diagnosis of hepatocellular carcinoma显示文摘BACKGROUND:Transforming growth factor-β(TGF-β) plays an important role in the regulation of cell growth and differentiation,angiogenesis,extracellular matrix formation,immunosuppression and cancer development. In this study,we investigated the levels of TGF-β1 and TGF-β1 mRNA expression,their relationship with HBV replication,and their diagnostic value for hepatocellular carcinoma(HCC). METHODS:Total RNAs were extracted from HCC samples and matched non-tumor tissues,and from peripheral blood mononuclear cells in HCC patients.TGF-β1 mRNA was amplified by RT-PCR and confirmed by DNA sequencing. The distribution of TGF-β1 expression was assessed by immunohistochemistry.The clinical characteristics were analyzed between TGF-β1 and HBV replication.The diagnostic value of circulating TGF-β1 and TGF-β1 mRNA levels were investigated in HCC patients. RESULTS:The incidence of hepatic TGF-β1 expression was 83.3%in HCC samples,43.3%in the surrounding tissues, 94.7%in the HBV DNA-positive group,and 63.6%in the HBV DNA-negative group.Liver TGF-β1 expression was associated with the degree of HCC differentiation and the status of HBV replication,but not with the size or number of tumors.Circulating TGF-β1 level and incidence of TGF-β1 mRNA were significantly higher in the HCC groupthan in any group of patients with benign liver disease, with a higher sensitivity of 89.5%and a specificity of 94.0% for HCC diagnosis when circulating TGF-β1 levels were >1.2μg/L.No significant correlation was found between TGF-β1 expression and AFP level or tumor size.Combining TGF-β1 level and serum AFP raised the detection rate to 97.4%. CONCLUSIONS:Abnormal expression of hepatic TGF-β1 is associated with the degree of HCC differentiation and HBV replication.Both circulating TGF-β1 and TGF-β1 mRNA can be used as sensitive biomarkers for the diagnosis and prognosis of HBV-induced HCC. | Zhi-Zhen Dong,Deng-Fu Yao,Min Yao,Li-Wei Qiu,Lei Zong,Wei Wu, Xin-Hua Wu,Deng-Bing Yao and Xian-Yong Meng Department of Diagnostics,Research Center of Clinical Molecular Biology,Department of Laboratory Science,and Department of GastroenterologyAffiliated Hospital and Institute of Neurosciences,Nantong University,Nantong 226001,China | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，3： | 27 |
| 4 | Sleep and Cognitive Abnormalities in Acute Minor Thalamic Infarction显示文摘In order to characterize sleep and the cognitive patterns in patients with acute minor thalamic infarction(AMTI), we enrolled 27 patients with AMTI and 12 matched healthy individuals. Questionnaires about sleep and cognition as well as polysomnography(PSG) were performed on days 14 and 90 post-stroke. Compared to healthy controls, in patients with AMTI, hyposomnia was more prevalent; sleep architecture was disrupted as indicated by decreased sleep efficiency, increased sleep latency, and decreased non-rapid eye movement sleep stages 2 and 3;more sleep-related breathing disorders occurred; and cognitive functions were worse, especially memory. While sleep apnea and long-delay memory recovered to a large extent in the patients, other sleep and cognitive function deficit often persisted. Patients with AMTI are at an increased risk for hyposomnia, sleep structure disturbance,sleep apnea, and memory deficits. Although these abnormalities improved over time, the slow and incomplete improvement suggest that early management should be considered in these patients. | Wei Wu Linyang Cui Ying Fu Qianqian Tian Lei Liu Xuan Zhang Ning Du Ying Chen Zhijun Qiu Yijun Song Fu-Dong Shi Rong Xue | 2016 | Neuroscience Bulletin2016，32，4： | 28 |
| 5 | Combined serum hepatoma-specific alpha-fetoprotein and circulating alpha-fetoprotein-mRNA in diagnosis of hepatocellular carcinoma显示文摘BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, its prognosis is poor, and early detection is of utmost importance. Although alpha-fetoprotein (AFP) is a useful marker for detecting and monitoring HCC development, the false-negative or false-positive rates with AFP alone may be as high as 30%-40% for patients with small HCCs. To enhance the specificity and accuracy of AFP measurements for HCC, we analyzed AFP expression states in livers, detected the hepatoma-specific AFP (HS-AFP) fraction and AFP-mRNA from peripheral blood mononuclear cells, and explored their clinical implications for HCC diagnosis. METHODS: AFP expression and hepatocyte distributions in liver specimens were investigated by an immunohistoche- mical assay. Total RNAs were extracted from circulating blood, synthesized to cDNA through random primers and reverse transcriptase, and fragments of the AFP gene were amplified by a nested-PCR assay. The HS-AFP fraction was separated by lectin-affinity chromatography and its level was detected by radioimmunoassay. RESULTS: The incidence of AFP was 73.3% in HCC tissues and its expression in HCCs with moderate or low differentiation was significantly stronger than that of HCCs with high differentiation (P<0.05). The incidence of AFP gene fragments was 100% in HCCs, and 60% in paracancerous tissues (P<0.01). In the HCC and liver cirrhosis groups, the incidence of HS-AFP was 91.7% and 18% (P<0.01), and of AFP-mRNA was 56.7% and 16% (P<0.01), respectively, and neither was found in controls.HS-AFP or AFP-mRNA was not significantly related to size or number of HCC, but to its differentiation, metastasis, and relapse (P<0.05). CONCLUSIONS: Different AFP expression is present in different parts of HCC tissues. HS-AFP and AFP-mRNA fragments improve sensitivity and specificity, and both are useful markers to diagnose HCC or monitor metastasis and relapse. | Wei Wu, Deng-Fu Yao, Yong-Mei Yuan, Ji-Wei Fan, Xiu-Feng Lu, Xiao-Hua Li, Li-Wei Qiu, Lei Zong and Xin-Hua Wu Research Center of Clinical Molecular Biology, Affiliated Hospital of Nantong University, Nantong 226001, China | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，4： | 26 |
| 6 | Design and Experiment of PZT Network-based Structural Health Monitoring Scanning System显示文摘基于主动Lamb波和压电传感器网络的结构健康监测技术是一种评估航空结构健康状态的有效方法。在实际应用中,监测大型结构需要使用压电传感器网络。扫查这些压电传感器网络中的压电激励-传感通道以达到在线的结构健康监测是非常重要的。基于PXI(PCI eXtensions for Instrumentation)平台,研发了一套基于主动Lamb波和压电传感器网络的集成多通道扫查系统,该系统结构紧凑、便于携带,能大规模自动扫查激励-传感通道并进行损伤评估。提出和讨论了该系统中:4通道PXI程控增益电荷放大器的实现、支持276个激励-传感通道的外部扫查模块和集成的结构健康监测软件的实现。最后,主要讨论了系统在某型无人机碳纤维复合材料机翼盒段上的功能验证实验,包括:压电贴层的设计、激励信号频率的选择方法、损伤成像的功能性测试、系统稳定性测试和载荷对信号的影响。实验结果验证了该系统的稳定性和损伤监测功能。 | Qiu Lei Yuan Shenfang Wang Qiang Sun Yajie Yang Weiwei | 2009 | Chinese Journal of Aeronautics2009，22，5： | 23 |
| 7 | The Reference Genome Sequence of Scutellaria baicalensis Provides Insights into the Evolution of Wogonin Biosynthesis显示文摘Scutellaria baicalensis Georgi is important in Chinese traditional medicine where preparations of dried roots,'Huang Qin,' are used for liver and lung complaints and as complementary cancer treatments. We report a high-quality reference genome sequence for S. baicalensis where 93% of the 408.14-Mb genome has been assembled into nine pseudochromosomes with a super-N50 of 33.2 Mb. Comparison of this sequence with those of closely related species in the order Lamiales, sesamum indicum and Salvia splendens,revealed that a specialized metabolic pathway for the synthesis of 4'-deoxyflavone bioactives evolved in the genus Scu-tellaria. We found that the gene encoding a specific cinnamate coenzyme A ligase likely obtained its newfunc- tion following recent mutations, and that four genes encoding enzymes in the 4'-deoxyflavone pathway are present as tandem repeats in the genome of S. baicalensis. Further analyses revealed that gene duplications, segmental duplication, gene amplification, and point mutations coupled to gene neo- and subfunctionaliza-tions were involved in the evolution of 4'-deoxyflavone synthesis in the genus Scutellaria. Our study not only provides significant insight into the evolution of specific flavone biosynthetic pathways in the mint family, Lamiaceae, but also will facilitate the development of tools for enhancing bioactive productivity by metabolic engineering in microbes or by molecular breeding in plants. The reference genome of S. baicalensis is also useful for improving the genome assemblies for other members of the mint family and offers an important foundation for decoding the synthetic pathways of bioactive compounds in medicinal plants. | Qing Zhao Jun Yang Meng-Ying Cui Jie Liu Yumin Fang Mengxiao Yan Wenqing Qiu Huiwen Shang Zhicheng Xu Reheman Yidiresi Jing-Ke Weng Tomas Pluskal Marielle Vigouroux Burkhard Steuernagel Yukun Wei Lei Yang Yonghong Hu Xiao-Ya Chen Cathie Martin | 2019 | Molecular Plant2019，12，7： | 23 |
| 8 | Early screening and diagnosis strategies of pancreatic cancer:a comprehensive review显示文摘Pancreatic cancer is a highly malignant digestive system tumor with a poor prognosis.Most pancreatic cancer patients are diagnosed at an advanced stage or even metastasis due to its highly aggressive characteristics and lack of typical early symptoms.Thus,an early diagnosis of pancreatic cancer is crucial for improving its prognosis.Currently,screening is often applied in high-risk individuals to achieve the early diagnosis of pancreatic cancer.Fully understanding the risk factors of pancreatic cancer and pathogenesis could help us identify the high-risk population and achieve early diagnosis and timely treatment of pancreatic cancer.Notably,accumulating studies have been undertaken to improve the detection rate of different imaging methods and the diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA)which is the golden standard for pancreatic cancer diagnosis.In addition,there are currently no biomarkers with sufficient sensitivity and specificity for the diagnosis ofpancreatic cancer to be applied in the clinic. As the only serum biomarkerapproved by the United States Food and Drug Administration, carbohydrateantigen 19-9 (CA19-9) is not recommended to be used in the early screeningof pancreatic cancer because of its limited specificity. Recently, increasingnumbers of studies focused on the discovering of novel serum biomarkersand exploring their combination with CA19-9 in the detection of pancreaticcancer. Besides, the application of liquid biopsy involving circulating tumor cells(CTCs), circulating tumor DNA (ctDNA), microRNAs (miRNAs), and exosomesin blood and biomarkers in urine, and saliva in pancreatic cancer diagnosis aredrawing more and more attention. Furthermore, many innovative technologiessuch as artificial intelligence, computer-aided diagnosis system, metabolomicstechnology, ion mobility spectrometry (IMS) associated technologies, and novelnanomaterials have been tested for the early diagnosis of pancreatic cancer andhave shown promising prospects. Hence, this review aims to summarize therecent progress in the development of early screening and diagnostic methods,including imaging, pathological examination, serological examination, liquidbiopsy, as well as other potential diagnostic strategies for pancreatic cancer. | Jinshou Yang Ruiyuan Xu Chengcheng Wang Jiangdong Qiu Bo Ren Lei You | 2021 | Cancer Communications2021，41，12： | 23 |
| 9 | Sevoflurane postconditioning protects against myocardial ischemia/reperfusion injury by restoring autophagic flux via an NO-dependent mechanism显示文摘Volatile anesthetics improve postischemic cardiac function and reduce infarction even when administered for only a brief-time at the onset of reperfusion.A recent study showed that sevoflurane postconditioning (SPC)attenuated myocardial reperfusion injury, but the underlying mechanisms remain unclear,in this study,we examined the effects of sevoflurane on nitric oxide (NO)release and autophagic flux during the myocardial ischemia/reperfusion (I/R)injury in rats in vivo and ex vivo.Male rats were subjected to 30 min ischemia and 2 h reperfusion in the presence or absence of sevoflurane (1.0 minimum alveolar concentration)during the first 15 min of reperfusion.We found that SPC significantly improved hemodynamic performance after reperfusion,alleviated postischemic myocardial infarction,reduced nicotinamide adenine dinucleotide content loss,and cytochrome c.release in heart tissues.Furthermore,SPC significantly increased the phosphorylation of endothelial nitric oxide synthase (NOS)and neuronal nitric oxide synthase,and elevated myocardial NOS activity and NO production.All these effects were abolished by treatment with an NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME,10 mg/kg,i.v.).We also observed myocardial I/R-induced accumulation of autophagosomes in heart tissues,as evidenced by increased ratios of microtubule:associated protein 1 light chain 3 Ⅱ/Ⅰ,upregulation of Beclin 1 and P62,and reduced lysosome-assciated membrane protein-2 expression.SPC significantly attenuated I/R- impaired autophagic flux,which were blocked by L-NAME.Moreover,pretreatment with the autophagic flUX blocker chloroquine (10 mg/kg,i.p.)increased autophagosome accumulation in SPC-treated heart following I/R and blocked SPC-induced cardioprotection.The same results were also observed in a rat model of myocardial I/R injury ex vivo,suggesting that SPC protects rat hearts against myocardial reperfusion injury by restoring I/R-impaired autophagic flux yia an NO-dependent mechanism. | Shi-gang Qiao Ying Sun Bo Sun An Wang Jia Qiu Lei Hong Jian-zhong An Chen Wang Hui-ling Zhang | 2019 | Acta Pharmacologica Sinica2019，40，1： | 21 |
| 10 | Clinicopathological features and prognosis assessment of extranodal follicular dendritic cell sarcoma显示文摘AIM: To establish a model for prognosis assessment of extranodal follicular dendritic cell (FDC) sarcoma.METHODS: Nine lesions were examined by routine and molecular approaches.Clinicopathological factors from the new cases and 97 reported cases were analyzed for their prognostic values.RESULTS: The current lesions were found in f ive male and four female patients,located mainly in the head and neck area and averaging 7.2 cm in size.Six patients had recurrence or metastasis and three remained free of disease.The 106 patients (male/female ratio,1.1:1) were aged from 9 to 82 years (median,44 years).The tumor sizes ranged from 1.5 to 21 cm (mean,7.4 cm).Abdominal/pelvic region was affected most frequently (43%).Surgical resection was performed in 100 patients,followed by radiation and/or chemotherapy in 35 of them.Follow-up data were available in 91 cases,covering a period of 3-324 mo (mean,27 mo;median,19 mo).Of the informative cases,38 (42%) had recurrence or metastasis,and 12 (13%) died of the disease.These tumors were classif ied histologically into lowand high-grade lesions.A size ≥ 5 cm (P = 0.003),highgrade histology (P = 0.046) and a mitotic count ≥ 5/10 HPF (P = 0.013) were associated with tumor recurrence.The lesions were def ined as low-,intermediateand high-risk tumors,and their recurrence rates were 16%,46% and 73%,and their mortality rates 0%,4% and 45%,respectively.CONCLUSION: Extranodal FDC tumors behave like soft tissue sarcomas.Their clinical outcomes are variable and can be evaluated according to their sizes and grades. | Li, Lan Shi, Yong-Hong Guo, Zhi-Juan Qiu, Tian Guo, Lei Yang, Hong-Ying Zhang, Xun Zhao, Xin-Ming Su, Qin | 2010 | World Journal of Gastroenterology2010，16，20： | 18 |
| 11 | Evaluation of soil fertility of the shelter-forest land along the Tarim Desert Highway显示文摘To study the changes of soil fertility of the shelter-forest land along the Tarim Desert Highway, soils from the forest land were collected at the layers of 0―10 cm, 10―20 cm, 20―30 cm. Different soil fertility parameters were measured, and quantitative evaluation of soil fertility was performed by the soil integrated fertility index (IFI). The main results show that the construction of the shelter forest along the Tarim Desert Highway improved the soil physical structure, increased soil porosity and enhanced wa- ter-holding capacity. With the increase of plantation time of the shelter forest, soil microbial biomass C, N, P and the activities of six types of enzyme were enhanced, which promoted the accumulation and transformation of soil nutrients of the forest land. Consequently, the soil nutrients in 12-year-old forest land were much higher than in the newer ones and drifting sand. However, soil salt content of the older forest land was higher owing to the drip-irrigation with salt water. Through the comprehensive evalua- tion, we found that soil fertility index in the forest land was enhanced with the forest age, and it had close correlations with the growth indices of the forest trees. In summary, construction of the shelterforest along the Tarim Desert Highway accelerated the improvement of aeolian soil in the forest land, and the soil fertility improved year by year. We conclude that the forest trees grow normally under the stress of the present drip-irrigation with salt water. | JIN ZhengZhong LEI JiaQiang XU XinWen LI ShengYu ZHAO SiFeng QIU YongZhi XU Bo | 2008 | Chinese Science Bulletin2008，53，S2： | 18 |
| 12 | Fetal central nervous system anomalies: comparison of magnetic resonance imaging and ultrasonography for diagnosis显示文摘胎儿的中央神经系统(CNS ) 的背景评估发育不全 byultrasonography (美国) 经常被限制,但是磁性的回声成像(MRI ) 有它的自己的优点并且在显示怀疑的胎儿的异例正在获得流行。这研究的目的是在检测胎儿的 CNS 发育不全探索 MRI 的价值。方法 34 个女人(从 22 ~ 35 年年老,一般水准 27 年) 与复杂怀孕(16- 39 星期怀孕期,一般水准 30 星期) 在 ultrasonography 以后在 24 个小时以内与 1.5 T 超导的先生单位被检验。Half-Fourier 获得单个射击的涡轮纺纱回响(匆忙) T_2-weightedimaging (T_2WI ) 顺序在所有病人,和快低角度射击(闪光) 被执行 T_1 加权的成像(T_1WI ) 顺序在他们中的七个顺序被使用。结果的比较在 MRI 和美国调查结果以及尸体或出生后的后续 MRIfindings 之间被做。胎儿的回转, sulcus,语料库 callosum,丘脑,小脑,大脑茎,和针的绳索比在 T_1 加权的先生图象上在 T_2 加权的先生图象上更清楚地被显示出的结果。MRIcorrected 在 10 种情况中的美国的诊断(10/34, 29.41%) 并且诊断仅仅在 1case 被错过(1/34, 2.94%) 。结论 MRI 在检测胎儿的 CNS 异例有优点到美国并且是对在复杂怀孕的美国的补充。 | WANG Guang-bin SHAN Rui-qin MA Yu-xiang SHI Hao CHEN Li-guang LIU Wen QIU Xiu-ling WEI Yu-long GUO Li QU Lei LI Hui-hua | 2006 | Chinese Medical Journal2006，，15： | 18 |
| 13 | Collagen type Ⅱ suppresses articular chondrocyte hypertrophy and osteoarthritis progression by promoting integrin β1-SMAD1 interaction显示文摘Hypertrophic differentiation is not only the terminal process of endochondral ossification in the growth plate but is also an important pathological change in osteoarthritic cartilage.Collagen type II(COL2A1)was previously considered to be only a structural component of the cartilage matrix,but recently,it has been revealed to be an extracellular signaling molecule that can significantly suppress chondrocyte hypertrophy.However,the mechanisms by which COL2A1 regulates hypertrophic differentiation remain unclear.In our study,a Col2a1 p.Gly1170Ser mutant mouse model was constructed,and Col2a1 loss was demonstrated in homozygotes.Loss of Col2a1 was found to accelerate chondrocyte hypertrophy through the bone morphogenetic protein(BMP)-SMAD1 pathway.Upon interacting with COL2A1,integrinβ1(ITGB1),the major receptor for COL2A1,competed with BMP receptors for binding to SMAD1 and then inhibited SMAD1 activation and nuclear import.COL2A1 could also activate ITGB1-induced ERK1/2 phosphorylation and,through ERK1/2-SMAD1 interaction,it further repressed SMAD1 activation,thus inhibiting BMP-SMAD1-mediated chondrocyte hypertrophy.Moreover,COL2A1 expression was downregulated,while chondrocyte hypertrophic markers and BMP-SMAD1 signaling activity were upregulated in degenerative human articular cartilage.Our study reveals novel mechanisms for the inhibition of chondrocyte hypertrophy by COL2A1 and suggests that the degradation and decrease in COL2A1 might initiate and promote osteoarthritis progression. | Chengjie Lian Xudong Wang Xianjian Qiu Zizhao Wu Bo Gao Lei Liu Guoyan Liang Hang Zhou Xiaoming Yang Yan Peng Anjing Liang Caixia Xu Dongsheng Huang Peiqiang Su | 2019 | Bone Research2019，7，1： | 17 |
| 14 | Renewed profile of the Mesozoic magmatism in Korean Peninsula: Regional correlation and broader implication for cratonic destruction in the North China Craton显示文摘Widespread Mesozoic magmatism occurs in the Korean Peninsula(KP). The status quo is poles apart between the northern and southern parts in characterizing its distribution and nature, with the nearly absence of any related information in North Korea. We have the opportunity to have conducted geological investigations in North Korea and South Korea during the past ten years through international cooperation programs. This led to the revelation of a number of granitoids and related volcanic rocks and thus facilitates the comparison with those in East China and Japan. Mesozoic granitoids in the KP can be divisible into three age groups: the Triassic group with a peak age of ~220 Ma, the Jurassic one of ~190–170 Ma and the late Early Cretaceous one of ~110 Ma. The Triassic intrusions include syenite, calc-alkaline to alkaline granite and minor kimberlite in the Pyeongnam Basin of North Korea. They have been considered to form in post-orogenic settings related to the Central Asian Orogenic Belt(CAOB) or the Dabie-Sulu Orogenic Belt(DSOB). The Jurassic granitoids constitute extensive occurrence in the KP and are termed as the Daebo-period magmatism. They correlate well with coeval counterparts in NE China encompassing the northeastern part of the North China Craton(NCC) and the eastern segment of the CAOB. They commonly consist of biotite or two-mica granites and granodiorites, with some containing small dark diorite enclaves. On one hand, Early Jurassic to early Middle Jurassic magmatic rocks are rare in most areas of the NCC, whilst Middle-Late Jurassic ones are not developed in the KP. On the other hand, both NCC and KP host abundant Cretaceous granites. However, the present data revealed contrasting age peaks, with ~130–125 Ma in the NCC and ~110–105 Ma in the KP. Cretaceous granites in the KP comprise the dominant biotite granites and a few amphibole granites. The former exhibit mildly fractionated REE patterns and zircon εHf(t) values from ?15 to ?25, whereas the latter feature strongly fractionated REE patterns and zircon εHf(t) values from ?10 to ?1. Both granites contain inherited zircons of ~1.8–1.9 or ~2.5 Ga. These geochemical characters testify to their derivation from re-melting distinct protoliths in ancient basement. Another Cretaceous magmatic sub-event has been entitled as the Gyeongsang volcanism, which is composed of bimodal calc-alkaline volcanic rocks of 94–55 Ma and granitic-hypabyssal granitic bodies of 72–70 Ma. Synthesizing the Mesozoic magmatic rocks across the KP, NCC and Japan can lead to the following highlights:(1) All Triassic granites in the NCC, KP and Japan have similar characteristics in petrology, chronology and geochemistry. Therefore, the NCC, KP and Japan tend to share the same tectonic setting during the Triassic, seemingly within the context of Indosinian orogensis.(2) Jurassic to earliest Cretaceous magmatic rocks in the NCC seem to define two episodes: episode A from 175 to 157 Ma and episode B from 157 to 135 Ma. Jurassic magmatic rocks in the KP span in age mainly from 190 to 170 Ma, whereas 160–135 Ma ones are rare. With the exception of ~197 Ma Funatsu granite, Jurassic magmatic rocks are absent in Japan.(3) Cretaceous granites in the KP have a peak age of ~110, ~20 Ma younger than those in the NCC, while Japan is exempt from ~130–100 Ma granites.(4) The spatial-temporal distribution and migratory characteristics of theJurassic-Cretaceous magmatic rocks in Japan, KP, and NE China-North China indicate that the subduction of the Paleo-Pacific plate might not be operative before Late Cretaceous(~130–120 Ma).(5) Late Cretaceous magmatic rocks(~90–60 Ma) occur in the southwestern corner of the KP and also in Japan, coinciding with the metamorphic age of ~90–70 Ma in the Sanbagawa metamorphic belt of Japan. The magmatic-metamorphic rock associations and their spatial distribution demonstrate the affinities of sequentially subduction zone, island arc and back-arc basin from Japan to Korea, arguing for the Pacific plate subduction during Late Cretaceous.(6) This study raises another possibility that the Mesozoic cratonic destruction in the NCC, which mainly occurred during ~150–120 Ma, might not only be due to the subduction of the Paleo-Pacific Plate, but also owe much to the intraplate geodynamic forces triggered by other adjacent continental plates like the Eurasian and Indian plates. | ZHAI MingGuo ZHANG YanBin ZHANG XiaoHui WU Fu Yuan PENG Peng LI Qiu Li HOU QuanLin LI TieSheng ZHAO Lei | 2016 | Science China(Information Sciences)2016，59，12： | 16 |
| 15 | Combined transjugular intrahepatic portosystemic shunt and other interventions for hepatocellular carcinoma with portal hypertension显示文摘AIM: To evaluate combination transjugular intrahepatic portosystemic shunt(TIPS) and other interventions for hepatocellular carcinoma(HCC) and portal hypertension.METHODS: Two hundred and sixty-one patients with HCC and portal hypertension underwent TIPS combined with other interventional treatments(transarterial chemoembolization/transarterial embolization,radiofrequency ablation,hepatic arterio-portal fistulas embolization,and splenic artery embolization) from January 1997 to January 2010 at Beijing Shijitan Hospital. Two hundred and nine patients(121 male and 88 female,aged 25-69 years,mean 48.3 ± 12.5 years) with complete clinical data were recruited. We evaluated the safety of the procedure(procedurerelated death and serious complications),change of portal vein pressure before and after TIPS,symptom relief [e.g.,ascites,hydrothorax,esophageal gastricfundus variceal bleeding(EGVB)],cumulative rates of survival,and distributary channel restenosis. The characteristics of the patients surviving ≥ 5 and < 5 years were also analyzed.RESULTS: The portosystemic pressure was decreased from 29.0 ± 4.1 mm Hg before TIPS to 18.1 ± 2.9 mm Hg after TIPS(t = 69.32,P < 0.05). Portosystemic pressure was decreased and portal hypertension symptoms were ameliorated. During the 5 year followup,the total recurrence rate of resistant ascites or hydrothorax was 7.2%(15/209); 36.8%(77/209) for EGVB; and 39.2%(82/209) for hepatic encephalopathy. The cumulative rates of distributary channel restenosis at 1,2,3,4,and 5 years were 17.2%(36/209),29.7%(62/209),36.8%(77/209),45.5%(95/209) and 58.4%(122/209),respectively. No procedure-related deaths and serious complications(e.g.,abdominal bleeding,hepatic failure,and distant metastasis) occurred. Moreover,Child-Pugh score,portal vein tumor thrombosis,lesion diameter,hepatic arterio-portal fistulas,HCC diagnosed before or after TIPS,stent type,hepatic encephalopathy,and type of other interventional treatments were related to 5 year survival after comparing patient characteristics.CONCLUSION: TIPS combined with other interventional treatments seems to be safe and efficacious in patients with HCC and portal hypertension. | Bin Qiu Meng-Fei Zhao Zhen-Dong Yue Hong-Wei Zhao Lei Wang Zhen-Hua Fan Fu-Liang He Shan Dai Jian-Nan Yao Fu-Quan Liu | 2015 | World Journal of Gastroenterology2015，21，43： | 16 |
| 16 | An HNF 1α-regulated feedback circuit modulates hepatic fibrogenesis via the crosstalk between hepatocytes and hepatic stellate cells显示文摘 | Hui Qian Xing Deng Zhao-Wei Huang Ji Wei Chen-Hong Ding Ren-Xin Feng Xin Zeng Yue-Xiang Chen Jin Ding Lei Qiu Zhen-Lin Hu Xin Zhang Hong-Yang Wang Jun-Ping Zhang Wei-Fen Xie | 2015 | Cell Research2015，25，8： | 15 |
| 17 | Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes:A Population-based Prospective Cohort Study of Inner Mongolians in China显示文摘This prospective study was designed to examine the combined influence of insulin resistance(IR)and inflammatory biomarker levels on type 2 diabetes mellitus(T2DM)among 1,903Inner Mongolians.During follow-up,205(10.77%)participants developed T2DM,and the incidence | QIU Qiao Yan ZHANG Bei Lei ZHANG Ming Zhi WU Jia Hui ZHOU Jing Wen LIANG Zhu ZHANG Yong Hong ZHANG Shao Yan | 2018 | Biomedical and Environmental Sciences2018，31，4： | 15 |
| 18 | Comprehensive eco-environmental effects of the shelter-forest ecological engineering along the Tarim Desert Highway显示文摘In this work, we report a comprehensive study about the eco-environmental effects of the shelter forest along the Tarim Desert Highway, including the effects on aeolian environment, soil, micro-climate, biodiversity, and groundwater. The results show that: (1) The movement of windblown sand near the ground surface was affected by the shelter forest. The wind speed and sediment transport rate in the shelter forest decreased by 64%―80% and 87.45%―99.02%, respectively. In addition, there were also significant changes in the sand flux structure, the sand grain size, and the deflation and deposition on the ground surface. (2) Compared to the natural mobile sand, the soil bulk density in the forest area decreased while the total salt content, the total porosity, and the water content increased. In addition, the soil fertility was significantly improved in the forest area, and showed the 'first rapid, then slow' variation pattern. (3) The shelter forest showed positive effects on the micro-climate. Within the 6 m height above the ground, the air temperature in the shelter forest at different heights was lower than that in the mobile sand, while the air humidity was higher, while, the soil temperature was also lower in the shelter forest than mobile sand. (4) The number of soil microbial species increased significantly with the improvement of habitat in the shelterbelt. However, the population of different species was not distributed evenly across the surveyed area. (5) Currently, no significant effects of groundwater-pumping and forest-irrigation water have been found on the groundwater level and its salinity. The variation amplitude of both groundwater level and salinity was at the level of centimeters and 1g/L, respectively. No obvious variation trend has been observed. | LEI JiaQiang LI ShengYu JIN ZhengZhong FAN JingLong WANG HaiFeng FAN DongDong ZHOU HongWei GU Feng QIU YongZhi XU Bo | 2008 | Chinese Science Bulletin2008，53，S2： | 14 |
| 19 | IL-10 Gene Modified Dendritic Cells Inhibit T Helper Type 1-Mediated Alloimmune Responses and Promote Immunological Tolerance in Diabetes显示文摘Dendritic cells (DCs) have the potency to regulate the outcome of autoimmunity through the modulation of immune responses. The induction of antigen specific tolerance is critical for prevention and treatment of allograft rejection. In the present study,we transfected IL-10 gene into DCs and investigated their effect on inhibition of lymphocyte activity in vitro and induction of immune tolerance on islet allograft in mice. An IDDM C57BL/6 mouse model was induced by streptozotocin. The islet cells isolated from the BALB/c mice were transplanted into the kidney capules of the model mice followed by injection of IL-10 modified DCs (mDCs). The results showed that mDCs could significantly inhibit T lymphocyte proliferation mediated by allotype cells and induce its apoptosis,whereas,unmodified DCs (umDCs) could promote the murine lymphocyte proliferation markedly. The injection of mDCs could prolong the survival of allotype islet transplanted IDDM mice. The average plasma glucose (PG) level in mDCs treated mice returned to normal within 3 days and lasted for about 2 weeks. The rejection response in control mice occurred for 5 days after transplantation. The level of IFN-γ was lower while IL-4 was higher in mDCs treated mice than that in umDCs treated mice,which indicated that Th1/Th2 deviation occurred. Our studies suggest that IL-10 gene modified DCs can induce the immune tolerance to islet graft and prolong survival of the recipients by the inhibiting of T cell proliferation in allotype mice. | Huifen Zhu Wenhong Qiu Ping Lei Wei Zhou Xue Wen Fengrong He Li Li Hong Dai Guanxin Shen Feili Gong | 2008 | Cellular & Molecular Immunology2008，5，1： | 14 |
| 20 | A novel matrine derivate inhibits differentiated human hepatoma cells and hepatic cancer stem-like cells by suppressing PI3K/AKT signaling pathways显示文摘Matrine 是从一个中国植物 Sophora flavescens 河中小岛提取的碱,它对各种各样的癌症显示出 chemopreventive 潜力。在这研究,我们评估了 matrine 的新奇衍生物的 anticancer 功效,(6aS, 10S, 11aR, 11bR, 11cS )-10-methylamino-dodecahydro- 3a,7a-diazabenzo (de )(MASM ) ,对人的 hepatocellular 在 vitro 并且在 vivo 的癌(HCC ) 房间和他们的相应范围房间。人的 HCC 房间线(Hep3B 和 Huh7 ) 与 MASM 被对待。房间增长用 CCK8 和殖民地试金被估计;房间 apoptosis 和房间周期分布与流动 cytometry 被检验。房间标记和发信号的分子的表示被检测使用西方的污点和 qRT-PCR 分析。一种范围文化技术被用来在 Hep3B 和 Huh7 房间充实癌症干细胞(CSC ) 。在里面 MASM 的 vivo antitumor 功效在 BALB/c 裸体老鼠在 Huh7 房间异种皮移植模型被评估,它被管理 MASM (10 | Ying LIU Yang QI Zhi-hui BAI Chen-xu NI Qi-hui REN Wei-heng XU Jing XU Hong-gang HU Lei QIU Jian-zhong LI Zhi-gao HE Jun-ping ZHANG | 2017 | Acta Pharmacologica Sinica2017，38，1： | 14 |
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