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| 1 | Trace metals in atmospheric fine particles in one industrial urban city: Spatial variations, sources, and health implications显示文摘Trace metals in PM2.5were measured at one industrial site and one urban site during September, 2010 in Ji'nan, eastern China. Individual aerosol particles and PM2.5samples were collected concurrently at both sites. Mass concentrations of eleven trace metals(i.e., Al, Ti, Cr, Mn, Fe, Ni, Cu, Zn, Sr, Ba, and Pb) and one metalloid(i.e., As) were measured by inductively coupled plasma atomic emission spectroscopy(ICP-AES). The result shows that mass concentrations of PM2.5(130 μg/m3) and trace metals(4.03 μg/m3) at the industrial site were 1.3 times and 1.7 times higher than those at the urban site, respectively, indicating that industrial activities nearby the city can emit trace metals into the surrounding atmosphere. Fe concentrations were the highest among all the measured trace metals at both sites, with concentrations of 1.04 μg/m3at the urban site and 2.41 μg/m3at the industrial site, respectively. In addition, Pb showed the highest enrichment factors at both sites, suggesting the emissions from anthropogenic activities existed around the city. Correlation coefcient analysis and principal component analysis revealed that Cu, Fe, Mn, Pb, and Zn were originated from vehicular trafc and industrial emissions at both sites; As, Cr, and part of Pb from coal-fired power plant; Ba and Ti from natural soil. Based on the transmission electron microscopy analysis, we found that most of the trace metals were internally mixed with secondary sulfate/organic particles. These internally mixed trace metals in the urban air may have diferent toxic abilities compared with externally mixed trace metals. | Shengzhen Zhou Qi Yuan Weijun Li Yaling Lu Yangmei Zhang Wenxing Wang | 2014 | Journal of Environmental Sciences2014，26，1： | 23 |
| 2 | Research progress in electrospinning engineering for all-solid-state electrolytes of lithium metal batteries显示文摘Owing to safety issue and low energy density of liquid lithium-ion batteries(LIBs),all-solid-state lithium metal batteries(ASLMBs)with unique all-solid-state electrolytes(SEs)have attracted wide attentions.This arises mainly from the advantages of the SEs in the suppression of lithium dendrite growth,long cycle life,and broad working temperature range,showing huge potential applications in electronic devices,electric vehicles,smart grids,and biomedical devices.However,SEs suffer from low lithiumion conductivity and low mechanical integrity,slowing down the development of practical ASLMBs.Nanostructure engineering is of great efficiency in tuning the structure and composition of the SEs with improved lithium-ion conductivity and mechanical integrity.Among various available technologies for nanostructure engineering,electrospinning is a promising technique because of its simple operation,cost-effectiveness,and efficient integration with different components.In this review,we will first give a simple description of the electrospinning process.Then,the use of electrospinning technique in the synthesis of various SEs is summarized,for example,organic nanofibrous matrix,organic/inorganic nanofibrous matrix,and inorganic nanofibrous matrix combined with other components.The current development of the advanced architectures of SEs through electrospinning technology is also presented to provide references and ideas for designing high-performance ASLMBs.Finally,an outlook and further challenges in the preparation of advanced SEs for ASLMBs through electrospinning engineering are given. | Manxi Wang Yaling Wu Min Qiu Xuan Li Chuanping Li Ruiling Li Jiabo He Ganggang Lin Qingrong Qian Zhenhai Wen Xiaoyan Li Ziqiang Wang Qi Chen Qinghua Chen Jinhyuk Lee Yiu-Wing Mai Yuming Chen | 2021 | Journal of Energy Chemistry2021，30，10： | 4 |
| 3 | Correlation of genomic and expression alterations of AS3 with esophageal squamous cell carcinoma显示文摘Androgen-induced proliferation shutoff gene AS3, also known as APRIN, is a growth inhibitory gene that is initially implicated in prostate cancer. This gene is required for androgen-dependent growth arrest and is a primary target for 1,25(OH)2D3 and androgens. Alle- lic loss at AS3 locus has been linked to a variety of cancers. However, the correlation of genomic and expression alterations of AS3 with esophageal squamous cell carcinoma (ESCC) is not well established. In this study, the genomic and expression alterations of AS3 in ESCC and their clinical significance are evaluated. Loss of heterozygosity (LOH) analysis using an AS3 intragenic microsatellite marker D13S171 revealed 72% allelic loss at AS3 locus in ESCC, which is significantly correlated with higher pathological grade (P=0.042). RT-PCR examination showed that AS3 mRNA obviously decreased in 44% tumors and its down-regulation was correlated with the sex of patients (P=0.03). Furthermore, the correlation between genomic and expression alterations of AS3 gene was analyzed in 18 ESCC specimens, which indicated that the consistency between allelic loss and decreased mRNA expression of AS3 was relatively poor. The results of this study indicate that the aberrant expression of AS3 may be involved in the tumorigenesis of esophagus and is responsible for the male predominance of ESCC. | Yu Zhang Xiaoping Huang Jun Qi Cai Yan Xin Xu Yaling Han Mingrong Wang | 2008 | Journal of Genetics and Genomics2008，35，5： | 1 |
| 4 | Electrosynthsis of large polypyrrole films by multi-potential steps method显示文摘Polypyrrole (PPy) films were prepared by multi-potential steps polymerization in an aqueous pyrrole solution, with lithium perchlorate and oxalic acid as supporting electrolytes. Morphology and structure of PPy films were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD). Electrochemical behaviors of PPy films were studied by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The results show that multi-potential steps polymerization improves the conductivity of PPy films and large polymer films can be peeled off easily from the electrode without cracking. Lithium perchlorate and oxalic acid provide appropriate dopants for PPy polymerization. It was observed that the polymerization time and the current density have a crucial influence on the surface morphology of PPy films. Smooth and compact PPy films could be generated under long polymerization time and low current density. Multi-potential steps polymerization decreases the occurrence of peroxidation, which improves the conductivity of PPy films. The parameters for multi-potential steps polymerization have been optimized. | LI BaoSong QI HongXu ZHAI WenTao ZHANG YaLing ZHANG Xiang LI ShuXi WEI Yan | 2011 | Science China(Technological Sciences)2011，54，7： | 1 |
| 5 | Effect of tumor suppressor PTEN gene on apoptosis and cell cycle of human airway smooth muscle cells显示文摘 | Liang Luo Yuan Qi Gong XieFei Qi WenYan Lai Haibing Lan Yaling Luo | 2013 | Molecular and Cellular Biochemistry2013，，1： | 1 |
| 6 | Rare tumors: a blue ocean of investigation显示文摘Advances in novel drugs,therapies,and genetic techniques have revolutionized the diagnosis and treatment of cancers,substantially improving cancer patients’prognosis.Although rare tumors account for a non-negligible number,the practice of precision medicine and development of novel therapies are largely hampered by many obstacles.Their low incidence and drastic regional disparities result in the difficulty of informative evidence-based diagnosis and subtyping.Sample exhaustion due to difficulty in diagnosis also leads to a lack of recommended therapeutic strategies in clinical guidelines,insufficient biomarkers for prognosis/efficacy,and inability to identify potential novel therapies in clinical trials.Herein,by reviewing the epidemiological data of Chinese solid tumors and publications defining rare tumors in other areas,we proposed a definition of rare tumor in China,including 515 tumor types with incidences of less than 2.5/100000 per year.We also summarized the current diagnosis process,treatment recommendations,and global developmental progress of targeted drugs and immunotherapy agents on the status quo.Lastly,we pinpointed the current recommendation chance for patients with rare tumors to be involved in a clinical trial by NCCN.With this informative report,we aimed to raise awareness on the importance of rare tumor investigations and guarantee a bright future for rare tumor patients. | Shuhang Wang Peiwen Ma Ning Jiang Yale Jiang Yue Yu Yuan Fang Huilei Miao Huiyao Huang Qiyu Tang Dandan Cui Hong Fang Huishan Zhang Qi Fan Yuning Wang Gang Liu Zicheng Yu Qi Lei Ning Li | 2023 | Frontiers of Medicine2023，17，2： | 0 |
| 7 | Reduced Sp1 expression inhibits the proliferation and migration of HepG2 cells显示文摘Specificity protein 1(Sp1)is a ubiquitously expressed transcription factor involved in the regulation of a large number of genes including housekeeping genes as well as actively regulated genes.Increasing evidences have indicated that Sp1 is closely correlated with the occurrence and progression of many tumors.The plasmid expression vector of short hairpin RNA(shRNA)targeting Sp1 was constructed and transfected into HepG2 cells by Lipo2000 transfection reagent.Immunocytochemistry,Western blot and quantitative real-time PCR were applied to determine Sp1 expression,and MTT and Transwell assay were used to analyze the cell proliferation and migration,respectively.The expressions of Sp1 protein and mRNA decreased significantly in HepG2 cell after transfection with Sp1 shRNA,and reduced Sp1 expression inhibited proliferation and migration of HepG2 cells. | Lan Yonghong Rao Langyu Cui Zhigang Niu Haiyan Qi Yaling Yang Zhi | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 8 | Designing cancer nanodrugs that are highly loaded,pH-responsive,photothermal, and possess a favored morphology:A hierarchical assembly of DOX and layer-by-layer modified rGO显示文摘An effective cancer nanodrug not only needs to load a large fraction of pharmaceutical molecules and release them in responsive ways, to function as imaging and photothermal agents, but also needs to possess the favorable morphologies that are favored by the EPR effect of cancer tissues. In this study, we designed a spherical nanodrug by forming clusters using DOX and a polymer-engineered rGO. These spherical nanodrugs had a diameter of around 750 nm and assumed both functionalities of chemical therapy and the photothermal effect. In addition, this nanodrug featured a high-loading capability of DOX, a pH-responsive release profile, a self-fluorescent capability, and an effective accumulation in cancer cells. The layer-by-layer assembly of three cycles of polyethylene glycol (PEG) and polyacrylic acid (PAA) around the rGO core was indispensable in achieving a chemically-modified rGO precursor that assembled with DOX to produce the spherical nanodrug. The spherical nanodrug effectively decreased cell viability upon NIR irradiations. | Xiangming Li Yihe Zhang Zequn Ma Chengjun He Yaling Wu Qi An | 2019 | Chinese Chemical Letters2019，30，2： | 0 |
| 9 | Heterostructure of Ta_(3)N_(5) nanorods and CaTaO_(2)N nanosheets fabricated using a precursor template to boost water splitting under visible light显示文摘Fabrication of heterostructure composed of one-dimensional(1D)and 2D semiconductors has inspired extensive interest in promoting photogenerated charge separation as well as performances of solar fuel production,but it is still challenging for(oxy)nitride photocatalysts due to their uncontrollable ammonia thermal preparative process.In this work,we report a synthesis on heterostructure of Ta_(3)N_(5)nanorods and CaTaO_(2)N(CTON)nanosheets(denoted as Ta_(3)N_(5)/CTON)by directly nitriding a 2D Dion-Jacobson(DJ)type of perovskite KCa_(2)Ta_(3)O_(10)(KCTO)precursor under the assistance of K_(2)CO_(3)flux.It is demonstrated that the 2D morphology of KCTO can be well inherited to get 2D CTON,and the Ta-rich(nonstoichiometric ratio of Ca:Ta compared to CTON)feature of the KCTO as well as the easy evaporation of K species results in the formation of 1D Ta_(3)N_(5)nanorods.Meanwhile,the formation of intermediate species K_(2)Ca_(2)Ta_(3)O_(9)N owning similar crystal lattice as Ta_(3)N_(5)was detected and deduced to be responsible for the generation of Ta_(3)N_(5)nanorods and observation of intimate interface between CTON and Ta_(3)N_(5).Benefitting from the formation of special 1D/2D type-II heterostructure,obviously promoted charge separation as well as photocatalytic water splitting performance can be obtained.Extended discussion demonstrates the generality of the hard-template preparative strategy developed here.To our knowledge,this should be the first fabrication of 1D/2D heterostructure for the(oxy)nitride semiconductors,and the developed hard-template strategy may provide an alternative way of fabricating heterostructures of other semiconductors prepared at high temperature. | Yanpei Luo Hao Li Yaling Luo Zheng Li Yu Qi Fuxiang Zhang Can Li | 2022 | Journal of Energy Chemistry2022，31，4： | 0 |
| 10 | Modularly designed peptide-based nanomedicine inhibits angiogenesis to enhance chemotherapy for post-surgical recurrence of esophageal squamous cell carcinomas显示文摘Traditional surgical treatment is difficult to thoroughly remove esophageal squamous cell carcinomas(ESCC),postoperative recurrence caused by residual tumor cells is a critical factor in the poor prognosis.Since surgical resection promotes the local angiogenesis at the tumor site,further exacerbating the proliferation and invasion of residual tumor cells,it is urgent to inhibit angiogenesis after surgery.Here,a functional peptide-based nanomedicine was obtained from peptide–drug conjugates,which are composed of a hydrophilic targeting motif(vascular endothelial growth factor family and their receptors(VEGFR)targeting peptide for anti-angiogenesis),an ester-linked hydrophobic oridonin(ORI).The nanomedicine exhibits esterase-catalyzed disassembly and drug release,significantly enhanced the anti-tumor efficacy of chemotherapeutics in a postoperative tumor recurrence model through synergistic anti-angiogenic strategies.This study provides an integrated solution for anti-angiogenesisaugmented chemotherapy and demonstrates the encouraging potential for postoperative treatment. | Yingqiu Qi Jinxiu Shen Chen Liu Anni Du Mengdie Chen Xiaocao Meng Hui Wang Saiyang Zhang Lirong Zhang Zhongjun Li Yike Li Yale Yue Huan Min | 2023 | Nano Research2023，16，5： | 0 |
| 11 | Mechanism of Scalp Acupuncture Combined with Distal Acupoint Selection in the Treatment of Vascular Headache Caused by Hyperactivity of Liver-Yang显示文摘The clinical effect of acupuncture on vascular headache caused by hyperactivity of liver-yang has been shown, but the specific mechanism is not yet clear. This paper is intended to discuss the etiology and pathogenesis of vascular headache caused by hyperactivity of liver-yang and the mechanism of acupuncture, so as to provide a certain reference for clinical diagnosis and treatment of scalp acupuncture treatment of vascular headache caused by hyperactivity of liver-yang. | Rongrong QI Hui LI Wenting LIU Tinghui LIU Huitao SU Jie YUAN Xinghua MA Yuting ZHANG Yaling LEI | 2023 | Medicinal Plant2023，14，4： | 0 |
| 12 | Immunogenic cell death effects induced by doxorubicin improved chemo-immunotherapy via restoration of granzyme B activity显示文摘Chemotherapy remains one of the irreplaceable treatments for cancer therapy.The use of immunogenic cell death(ICD)-inducing chemotherapeutic drugs offers a practical strategy for killing cancer cells,simultaneously eliciting an antitumor immune response by promoting the recruitment of cytotoxic immune cells and production of granzyme B(GrB).However,numerous malignant cancers adaptively acquired the capacity of secreting serpinb9(Sb9),a physiological inhibitor of GrB,which can reversibly inhibit the biological activity of GrB.To circumvent this dilemma,in this study,an integrated tailor-made nanomedicine composed of tumor-targeting peptide(Arg-Gly-Asp,RGD)decorated liposome,doxorubicin(DOX,an effective ICD inducer),and the compound 3034(an inhibitor of Sb9),is developed(termed as D3RL)for breast cancer chemo-immunotherapy.In vitro and in vivo studies show that D3RL can directly kill tumor cells and trigger the host immune response by inducing ICD.Meanwhile,D3RL can competitively relieve the inhibition of Sb9 to GrB.The restored GrB can not only effectively induce tumor immunotherapy,but also degrade matrix components in the tumor microenvironment,consequently improving the infiltration of immune cells and the penetration of nanomedicines,which in return enhance the combined antitumor effect.Taken together,this work develops an integrated therapeutic solution for targeted production and restoration of GrB to achieve a combined chemo-immunotherapy for breast cancer. | Tao Huang Xiaofan Sun Yingqiu Qi Xi Yang Linyao Fan Mengdie Chen Yale Yue Hong Ge Yiye Li Guangjun Nie Huan Min Xianfu Sun | 2023 | Nano Research2023，16，12： | 0 |
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