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| 1 | Ectopic expression of BdCIPK31 confers enhanced low-temperature tolerance in transgenic tobacco plants显示文摘Calcineurin 象 B 一样蛋白质(CBL ) , Ca 2+ 传感器,和它的交往的蛋白质 kinases (CIPK ) 在植物反应起必要作用强调。然而,很少研究在低温度的反应集中了于 CIPK 的功能。在现在的学习, BdCIPK31,在 Brachypodium distachyon 的寒冷应答的 CIPK,被发现参予低温度的反应。BdCIPK31 的宫外的表示在转基因的烟草授与冷忍耐。进一步的分析显示 BdCIPK31 的那个表达式在低温度的处理下面在转基因的植物改进了 ROS 解毒和 omsoprotectant 生合成,建议 BdCIPK31 在到导致寒冷的氧化、渗透的压力的植物改编断然工作。而且, BdCIPK31 能 upregulate 在寒冷下面的一些代表性的压力相关的基因的表情强调。在结论,这些调查结果建议 BdCIPK31 在植物寒冷反应断然工作。 | Qingchen Luo Qiuhui Wei Ruibin Wang Yang Zhang Fan Zhang Yuan He Guangxiao Yang Guangyuan He | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 3 |
| 2 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 3 | Identification of cross-reactive CD8^(+)T cell receptors with high functional avidity to a SARS-CoV-2 immunodominant epitope and its natural mutant variants显示文摘Despite the growing knowledge of T cell responses in COVID-19 patients,there is a lack of detailed characterizations for T cell-antigen interactions and T cell functions.Here,with a predicted peptide library from SARS-CoV-2 S and N proteins,we found that specific CD8+T cell responses were identified in over 75%of COVID-19 convalescent patients(15/20)and an epitope from the N protein,N361-369(KTFPPTEPK),was the most dominant epitope from our selected peptide library.Importantly,we discovered 2 N361-369-specific T cell receptors(TCRs)with high functional avidity that were independent of the CD8 co-receptor.These TCRs exhibited complementary cross-reactivity to several presently reported N361-369 mutant variants,as to the wild-type epitope.Further,the natural functions of these TCRs in the cytotoxic immunity against SARS-CoV-2 were determined with dendritic cells(DCs)and the lung organoid model.We found that the N361-369 epitope could be normally processed and endogenously presented by these different types of antigen presenting cells,to elicit successful activation and effective cytotoxicity of CD8+T cells ex vivo.Our study evidenced potential mechanisms of cellular immunity to SARS-CoV-2,and illuminated potential ways of viral clearance in COVID-19 patients.These results indicate that utilizing CD8-independent TCRs against SARS-CoV-2-associated antigens may provide functional superiority that is beneficial for the adoptive cell immunotherapies based on natural or genetically engineered T cells.Additionally,this information is highly relevant for the development of the next-generation vaccines with protections against continuously emerged SARS-CoV-2 mutant strains. | Chao Hu Meiying Shen Xiaojian Han Qian Chen Luo Li Siyin Chen Jing Zhang Fengxia Gao Wang Wang Yingming Wang Tingting Li Shenglong Li Jingjing Huang Jianwei Wang Ju Zhu Dan Chen Qingchen Wu Kun Tao Da Pang Aishun Jin | 2022 | Genes & Diseases2022，9，1： | 0 |
| 4 | A Brachypodium distachyon calcineurin B-like protein-interacting protein kinase,BdCIPK26,enhances plant adaption to drought and high salinity stress显示文摘As sessile organisms,plants possess a complex system to cope with environmental changes.Ca^(2+)functions as a vital second messenger in the stress signaling of plants,and the CBL-interacting protein kinases(CIPKs)serve as essential elements in the plant Ca^(2+)signaling pathway.In this study,calcineurin B-like protein-interacting protein kinase 26(BdCIPK26)from Brachypodium distachyon was characterized.Overexpression of BdCIPK26 enhanced tolerance to drought and salt stress of transgenic plants.Further investigations revealed that BdCIPK26 participated in abscisic acid(ABA)signaling,conferred hypersensitivity to exogenous ABA in transgenic plants,and promoted endogenous ABA biosynthesis.Moreover,BdCIPK26 was found to maintain ROS homeostasis in plants under stress conditions.Therefore,this study indicates that BdCIPK26 functions as a positive regulator in drought and salt stress response. | QINGCHEN LUO JIALU FENG XIUQI DENG | 2023 | BIOCELL2023，47，5： | 0 |
| 5 | Maximizing the linear and nonlinear optical responses of alkaline tricyanomelaminate显示文摘High-performance bi-functional materials are in urgent demand for the next-generation integrated optical devices.In this work,we successfully synthesized the first tricyanomelaminate with bi-functional optical responses,namely Cs_(3)C_(6)N_(9)•H_(2)O(I),from its analogue Na_(3)C_(6)N_(9)•3H_(2)O by a facile ion exchange method.In contrast to Na_(3)C_(6)N_(9)•3H_(2)O,I realizes an optimal arrangement of��π-conjugated(C_(6)N_(9))3−anion groups in its crystal structure.As a result,the second-order nonlinear optical(NLO)response is greatly enhanced from nearly zero of Na_(3)C_(6)N_(9)•3H_(2)O to∼9.8×KH_(2)PO_(4)of I.Furthermore,I exhibits a giant linear optical anisotropic response(i.e.birefringence)of 0.52 at the wavelength of 550 nm.Both responses are almost the largest among the inorganic compounds ofπ-conjugated rings,which indicates that I has great potential as a bi-functional optical crystal.Structural and theoretical analyses reveal the microscopic origin of excellent optical properties.This work would attract a lot of interest to the persistently neglected potential of tricyanomelaminates as linear optical and NLO crystals. | Yanqiang Li Qingchen Wu Zheshuai Lin Youchao Liu Yang Zhou Xin Chen Minjuan Li Maochun Hong Junhua Luo Sangen Zhao | 2023 | Fundamental Research2023，3，6： | 0 |
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