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| 1 | Multifractal Analysis of Element Distribution in Skarn-type Deposits in the Shizishan Orefield,Tongling Area,Anhui Province,China显示文摘与进不同 skarn 类型的大约 1000 m 扔的长度从四个练习核心取样的一系列元素集中从 Shizishan orefield 被选择,中央 Tongling,安徽的东南的部分省。用 multifractal 方法,专业和踪迹元素的分发和迁居特征被分析。而踪迹元素的光谱是扭曲权利的,主要元素的 multifractal 光谱是扭曲左的,它证明在 skarn 形成的过程,踪迹元素仅仅局部地被充实,并且主要元素在一个大得多的范围以内搬运。 multifractal 参数的关联系数一( multifractal 光谱的宽度)四项练习,核心是相对低的,但是 multifractal 参数 R (光谱对称参数)的关联系数和 f 相对更高,显示尽管元素的分发的非同类的紧张是不一致的,他们的空间累积模式是几乎一样在形成矿石的过程期间。在不同地点的各种各样的元素的 multifractal 参数的统计证明在 Shizishan orefield 的形成矿石的进程和元素移植模式是一致的,并且踪迹元素的迁居和主要元素展出一些差别。 | WANG Qingfei DENG Jun WAN Li ZHAO Jie GONG Qingjie YANG Liqiang ZHOU Lei ZHANG Zhijun | 2008 | Acta Geologica Sinica(English Edition)2008，82，4： | 8 |
| 2 | Influence of the Chuxiong Yao'an Earthquake on the Mineralization of Hot Springs in the Tengchong Geothermal Area,Southwestern China显示文摘Tengchong 地热的区域,有经常的地震的一个活跃构造区域,位于西南的中国的云南省。这个区域包含丰富的活跃温泉,它经常显示高金属集中和明显的矿化作用现象。在 19:19 在 2009 年 7 月 9 日,地震发生在 Yao'an, Chuxiong,云南省,它是到 Tengchong 地热的区域的东北的 300 km。我们从 7 月 4 日在 Tengchong 区域在温泉取样了水到 2009 年 7 月 9 日并且从 7 月 10 日到 2009 年 7 月 15 日在地震前后学习元素的集中的变化并且在温泉的矿化作用上讨论地震的影响。大多数踪迹元素的集中稍微增加了,但是 REE (稀土元素元素) 的集中在一个趋势 NS 差错附近在温泉在地震以后在 50% 减少了。元素的集中在 Longtan 和 Suanshuigou 仍然保持未改变,它与一个不活跃的坑有关。在表面、小规模的差错控制的另外的弹簧的元素的集中在地震以后减少了。地震能刺激深差错和岩浆房间的活动,作为为沿着趋势 NS 深差错的温泉的金属集中的增加负责;而它能减少可渗透的岩石的孔,在与表面的差错有关的温泉导致忍受矿石的液体和相应矿化作用的流动的衰落。 | DENG Jun XIAO Changhao WANG Qingfei ZHOU Xingzhi YANG Liqiang ZHANG Jing ZHAO Yan | 2010 | Acta Geologica Sinica(English Edition)2010，84，6： | 6 |
| 3 | Late Mesozoic magmatism in the Jiaodong Peninsula,East China:Implications for crust-mantle interactions and lithospheric thinning of the eastern North China Craton显示文摘A section from the Linglong gold deposit on the northwestern Jiaodong Peninsula,East China,containing Late Mesozoic magmatic rocks from mafic and intermediate dikes and felsic intrusions,was chosen to investigate the lithospheric evolution of the eastern North China Craton(NCC).Zircon U-Pb data showed that low-Mg adakitic monzogranites and granodiorite intrusions were emplaced during the Late Jurassic(~145 Ma) and late Early Cretaceous(112-107 Ma),respectively;high-Mg adakitic diorite and mafic dikes were also emplaced during the Early Cretaceous at^139 Ma and ~118 Ma,and 125-145 Ma and 115-120 Ma,respectively.The geochemical data,including whole-rock major and trace element compositions and Sr-Nd-Pb isotopes,imply that the mafic dikes originated from the partial melting of a lithospheric mantle metasomatised through hydrous fluids from a subducted oceanic slab.Low-Mg adakitic monzogranites and granodiorite intrusions originated from the partial melting of the thickened lower crust of the NCC,while high-Mg adakitic diorite dikes originated from the mixing of mafic and felsic melts.Late Mesozoic magmatism showed that lithosphere-derived melts showed a similar source depth and that crust-derived felsic melts originated from the continuously thickened lower crust of the Jiaodong Peninsula from the Late Jurassic to Early Cretaceous.We infer that the lower crust of the eastern NCC was thickened through compression and subduction of the Palaeo-Pacific plate beneath the NCC during the Middle Jurassic.Slab rollback of the plate from ~160 Ma resulted in lithospheric thinning and accompanied Late Mesozoic magmatism. | Yayun Liang Xuefei Liu Qingfei Wang Rui Zhao Yao Ma | 2020 | Geoscience Frontiers2020，11，3： | 5 |
| 4 | GPP(composition of Ganoderma lucidum polysaccharides and Polyporus umbellatus polysaccharides) protects against DSS-induced murine colitis by enhancing immune function and regulating intestinal flora显示文摘Previous study have demonstrated that a compound composed of water-soluable Ganoderma lucidum polysaccharides(GLP)and Polyporus umbellatus polysaccharides(PUP)in a ratio of 3:1 named GPP enhances innate immune function in mice through enhancing the function of macrophage cells and activity of natural killer(NK)cells.Here in our research,we further investigated the effect of GPP on the diversity and composition of intestinal flora,and explored its effect on colitis model mice.The immunoregulatory verification experiments of GPP were conducted in both normal and DSS-induced mice model.Our research showed that GPP increased the diversity of intestinal microorganisms in mice with the extension of administration time.Daily GPP intake attenuated DSS-induced colon injury,protected the splenic lymphocyte proliferation ability,enhanced the serum hemolysin synthesis,and increased peripheral phagocytes and NK cell activity in model mice.Comparisons of the predominant gene pathways of the bacterial microbiota showed that DNA repair and recombination,base mismatch repair pathways was stronger in GPP-treatment group than in control group,indicating the possible molecular mechanisms of immune function regulation.Our study showed that GPP regulated immune function in both health and colitis model,and had a positive effect on maintaining intestinal flora homeostasis. | Liyuan Li Yannan Guo Qing Huang Xiaojin Shi Qingqing Liu Fang Wang Qingfei Liu Kang Yu Zhao Wang | 2022 | Food Science and Human Wellness2022，11，4： | 2 |
| 5 | Co-B Amor- phous Alloy Nanochains with Enhanced Magnetization and Elec- trochemical Activity Prepared in a Biphasic System 显示文摘 | Li Hui Wang Chengzuo Zhao Qingfei | 2008 | Appl SurfSci2008，254，22： | 1 |
| 6 | Ordered meso- porous Pd/Silica-Carbon as a highly active heterogeneous catalyst for coupling reaction of chlorobenzene in aqueous media显示文摘 | Ying Wan Haiyan Wang Qingfei Zhao | 2009 | J Am Chem Soc2009，131，12： | 1 |
| 7 | Selective hydrogenation of p-chloronitrobenzene over Ni P B amorphous catalyst and synergistic promoting effects of B and P显示文摘 | Li Hui Zhao Qingfei Li Hexing | 2008 | Journal of Molecular Catalysis A2008，285，12： | 1 |
| 8 | UV-assisted photoca- talytic synthesis of ZnO-reduced graphene oxide composites with enhanced photocatalytic activity in reduction of Cr( VI ) 显示文摘 | Liu Xinjuan Pan Likun Zhao Qingfei | 2012 | Che- mical Engineering Journal2012，183，4： | 1 |
| 9 | Ample dietary fat reduced the risk of primary vesical calculi by inducing macrophages to engulf budding crystals in mice显示文摘Although primary vesical calculi is an ancient disease,the mechanism of calculi formation remains unclear.In this study,we established a novel primary vesical calculi model with D,L-choline tartrate in mice.Compared with commonly used melamine and ethylene glycol models,our model was the only approach that induced vesical calculi without causing kidney injury.Previous studies suggest that proteins in the daily diet are the main contributors to the prevention of vesical calculi,yet the effect of fat is overlooked.To assay the relationship of dietary fat with the formation of primary vesical calculi,D,L-choline tartrate-treated mice were fed a high-fat,low-fat,or normal-fat diet.Genetic changes in the mouse bladder were detected with transcriptome analysis.A high-fat diet remarkably reduced the morbidity of primary vesical calculi.Higher fatty acid levels in serum and urine were observed in the high-fat diet group,and more intact epithelia in bladder were observed in the same group compared with the normal-and low-fat diet groups,suggesting the protective effect of fatty acids on bladder epithelia to maintain its normal histological structure.Transcriptome analysis revealed that the macrophage differentiation-related gene C-X-C motif chemokine ligand 14(Cxcl14)was upregulated in the bladders of high-fat diet-fed mice compared with those of normal-or low-fat diet-fed mice,which was consistent with histological observations.The expression of CXCL14 significantly increased in the bladder in the high-fat diet group.CXCL14 enhanced the recruitment of macrophages to the crystal nucleus and induced the transformation of M2 macrophages,which led to phagocytosis of budding crystals and prevented accumulation of calculi.In human bladder epithelia(HCV-29)cells,high fatty acid supplementation significantly increased the expression of CXCL14.Dietary fat is essential for the maintenance of physiological functions of the bladder and for the prevention of primary vesical calculi,which provides new ideas for the reduction of morbidity of primary vesical calculi. | Huiling Chen Kaiqiang Hu Yaru Liang Yuqi Gao Chenye Zeng Kang Xu Xiaojin Shi Liyuan Li Yuemiao Yin Yi Qiao Ying Qiu Qingfei Liu Zhao Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 1 |
| 10 | Evaluation of the physiochemical and metabolite of different region coffee beans by using UHPLC-QE-MS untargeted-metabonomics approaches显示文摘Coffee is one of the most important agricultural commodities and has the unique organoleptic characteristics such as strong but not bitter taste,fragrant,oily,and fruity.In this study,an untargeted metabolomics approach based on UHPLC-QE-MS was used to investigate the differences in terms of components of precursor metabolites in coffee beans from 18 producing regions worldwide.Fingerprint analysis,principal component analysis and hierarchical clustering analysis revealed a neat separation among coffee beans.Compounds with high relevance to variance in the projection values in supervised multivariate analysis were selected as important metabolites for the discrimination of coffee samples.In total,10 different families of compounds were considered as potential markers of the coffee beans:3-hydroxycoumarin,4,5-di-O-caffeoylquinic,cryptochlorogenic acid,palmitic amide,linoleamide,arachidic acid,petroselinic acid,trehalose,L-glutamic acid,L-malic acid.The findings presented herein serve as a suitable framework for the design of novel discrimination strategies in food origin tracing. | Yue Miao Qingfei Zou Qiuping Wang Jiashun Gong Chao Tan Chunxiu Peng Chunyan Zhao Zelin Li | 2022 | Food Bioscience2022，46，2： | 1 |
| 11 | Selective hydrogenation of p-chloronitrobenzene over Ni-P-B amorphous catalyst and synergistic promoting effects of B and P显示文摘 | Li Hui Zhao Qingfei Li Hexing | 2008 | J Mol Catal A:Chem2008，285，： | 1 |
| 12 | Self-Assembly of Mesoporous Ni-B Amorphous Alloy Catalysts显示文摘 | Li Hexing Zhao Qingfei Wan Ying | 2006 | J Catal2006，244，2： | 1 |
| 13 | The fractal rela- tionship between orebody tonnage and thickness显示文摘 | Wang Qingfei Deng J un Zhao Juncai | 2012 | Journal of Geochemical Exploration2012，122，： | 1 |
| 14 | Ellagic acid ameliorates cisplatin-induced acute kidney injury by regulating inflammation and SIRT6/TNF-α signaling显示文摘De spite cisplatin has been widely used in the treatment of various cancers,the noteworthy nephrotoxicity greatly constrained its clinical value.For this reason,finding novel targeted therapies to attenuate the nephrotoxicity of cisplatin should be pretty significant.Our previous study found that histone deacetylase sirtuin 6(SIRT6)could be an ideal target for the treatment of cisplatin-induced acute kidney injury.In this study,we explored the protective effects of ellagic acid,a natural polyphenol compound that activates SIRT6,on cisplatin-induced nephrotoxicity.Pre-treatment of ellagic acid attenuated cytotoxicity of cisplatin in primary renal cells and TCMK-1 cells.Moreover,ellagic acid ameliorated renal dysfunction,apoptosis and fibrosis induced by cisplatin in mice.Furthermore,ellagic acid reduced nephrotoxicity-associated inflammatory factor interleukin(IL)-1βand IL-6 expression both in vitro and in vivo.Mechanistically,ellagic acid reversed cisplatin-reduced SIRT6 expression and diminished cisplatin-induced tumor necrosis factor(TNF)-αexpression.And SIRT6 knockdown abrogated the protective effects of ellagic acid on cisplatin-induced cell apoptosis,indicating the renal-protective effects of ellagic acid are mainly dependent on ellagic acid-mediated SIRT6 activation.Our results provide preclinical rationale for using ellagic acid as a feasible and promising agent to ameliorate cisplatin-induced acute kidney injury,and support ellagic acid as a potential adjunctive therapy for future cancer treatment. | Yuqi Gao Kezheng Peng Yida Wang Yannan Guo Chenye Zeng Rui Hua Qingfei Liu Xue Li Ying Qiu Zhao Wang | 2023 | Food Science and Human Wellness2023，12，6： | 1 |
| 15 | Self-Assembly of Mesoporous Ni-B Amorphous Alloy Catalysts 显示文摘 | Li Hexing Zhao Qingfei Wan Ying | 2006 | J Catal2006，244，2： | 1 |
| 16 | Studies on tissue distribution of scutellarin and methyl polyethylene glycol (mPEG)-scutellarin prodrug in mice显示文摘This study was to determine tissue distribution and pharmacokinetics of mPEG-scutellarin prodrug(7e),a chemical entity previously shown to have a beneficial effect in cerebral ischemia/reperfusion(I/R)injury.After injecting scutellarin or prodrug 7e,the concentrations of scutellarin and 7e in tissues were determined and the pharmacokinetic parameters were calculated.The results showed that the distribution of scutellarin in tissues was enhanced by PEGylation.The distribution of 7e in brain was approximately 2.1-fold higher than that of scutellarin,indicating that PEGylation increased the brain penetration of scutellarin.We conclude that 7e could exert more effective protection on cerebral I/R injury in mice.This study also provided a simple and convenient strategy to identify novel drugs with potential protective function for I/R injury in mice. | Juan Lu Xia Zhan Qingfei Liu Xi Chen Xinge Zhao Yiming Wang Guoan Luo | 2012 | Acta Pharmaceutica Sinica B2012，2，3： | 0 |
| 17 | Sinopec Promotes Effective Development of Proven Undeveloped Reserves显示文摘Proven undeveloped reserves (PUDs) refers to discovered proven reserves that are difficult to develop, require high costs for production, have low commercial value or are temporarily not put into commercial development under the existing technological and economic conditions. Sinopec’s PUDs are dominated by deep-and ultra-deep reservoirs with ultra-low permeability, high-density, low-pressure coefficient and low abundance. These oil reservoirs have narrow storage space and complex storage status, leading to difficulties in predicting effective reservoirs, low single-well production, high production cost and difficulties in benefit generation. Since the “13th Five-year Plan” period, Sinopec’s upstream sector in China has taken the effective development of PUDs as an important measure to ensure national energy security. It has made every effort to promote innovation, cost reduction and reform to generate benefits, made a series of new technological progress and management achievements, and effectively revitalized a batch of resources. | Hou Zhen Qu Jie Fan Yumei Hou Mingyang Zhao Qingfei | 2022 | China Oil & Gas2022，29，5： | 0 |
| 18 | Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy显示文摘Gene therapy provides a promising approach in treating cancers with high efficacy and selectivity and few adverse effects.Currently,the development of functional vectors with safety and effectiveness is the intense focus for improving the delivery of nucleic acid drugs for gene therapy.For this purpose,stimuli-responsive nanocarriers displayed strong potential in improving the overall efficiencies of gene therapy and reducing adverse effects via effective protection,prolonged blood circulation,specific tumor accumulation,and controlled release profile of nucleic acid drugs.Besides,synergistic therapy could be achieved when combined with other therapeutic regimens.This review summarizes recent advances in various stimuliresponsive nanocarriers for gene delivery.Particularly,the nanocarriers responding to endogenous stimuli including pH,reactive oxygen species,glutathione,and enzyme,etc.,and exogenous stimuli including light,thermo,ultrasound,magnetic field,etc.,are introduced.Finally,the future challenges and prospects of stimuli-responsive gene delivery nanocarriers toward potential clinical translation are well discussed.The major objective of this review is to present the biomedical potential of stimuli-responsive gene delivery nanocarriers for cancer therapy and provide guidance for developing novel nanoplatforms that are clinically applicable. | Qingfei Zhang Gaizhen Kuang Wenzhao Li Jinglin Wang Haozhen Ren Yuanjin Zhao | 2023 | Nano-Micro Letters2023，15，3： | 0 |
| 19 | Tuning the structures of two-dimensional cuprous oxid econfined on Au(111)显示文摘Two-dimensional (2D) cuprous oxide (Cu20) nanostructures (NSs) of monolayerthickness were synthesized on Au(111) and characterized using atomic-resolutionscanning tunneling microscopy, X-ray photoelectron spectroscopy, and densityfunctional theory (DFT) calculations. The surface and edge structures of 2DCu20 were resolved at the atomic level and found to exhibit a graphene-like latticestructure. Cu20 NSs grew preferentially at the face centered cubic (fcc) domains ofAu(111). Depending on the annealing temperature, the shapes and structuresof Cu20 NSs were found to vary from elongated islands with a defectivehexagonal lattice (mostly topological 5-7 defects) to triangular NSs with analmost-perfect hexagonal lattice. The edge structures of Cu20 NSs also variedwith the annealing temperature, from predominantly the arm-chair 56 structureat 400 K to almost exclusively the zig-zag structure at 600 K. DFT calculationssuggested that the herringbone ridges of Au(111) confined the growth andstructure of Cu20 NSs on Au(111). As such, the arm-chair edges of Cu20 NSs,which are less stable than the zig-zag edges, could be exposed preferentially at400 K. Cu20 NSs developed into the thermodynamically-favored triangular formand exposed zig-zag edges at 600 K, when the Au(111) substrate became mobile.The confined growth of 2D cuprous oxide on Au(111) demonstrated the importanceof metal-oxide interactions in tuning the structures of supported 2D oxide NSs. | Qingfei Liu Nannan Han Shengbai Zhang Jijun Zhao Fan Yang Xinhe Bao | 2018 | Nano Research2018，11，11： | 0 |
| 20 | Photopolymerized 3D Printing Scaffolds with Pt(IV) Prodrug Initiator for Postsurgical Tumor Treatment显示文摘Biomedical scaffolds have shown great success in postsurgical tumor treatment;their current efforts are focusing on eradicating residual tumor cells and circulating tumor cells and simultaneously repairing postoperative tissue defects. | Qingfei Zhang Xiaocheng Wang Gaizhen Kuang Yunru Yu Yuanjin Zhao | 2023 | Research2023，，2： | 0 |
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