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| 1 | Involvement of carbon monoxide produced by heme oxygenase in ABA-induced stomatal closure in Vicia faba and its proposed signal transduction pathway显示文摘Carbon monoxide (CO) has recently proven to be an important bioactive or signaling molecule in mammalian cells. Its effects are mainly mediated by nitric oxide (NO) and cyclic GMP (cGMP). In Vicia faba leaves, CO production and heme oxygenase (HO) activity, an important CO synthetic enzyme, are first reported to increase in response to ABA treatment, which could result in stomatal closure. Inter- estingly, ABA-induced stomatal closure in V. faba guard cells is partially blocked when the synthetic CO inhibitor ZnPP, or the CO/NO scavenger Hb is added. Furthermore, we show that, exogenously applied CO donor, hematin, and CO aqueous solution not only result in the enhancement of CO release, but also time-dependently induce stomatal closure, and the latter is mimicked by the application of an NO donor SNP. The above-mentioned stomatal closure effects are differentially reversed by the addition of tungstate, a potent inhibitor of NO synthetic enzyme nitrate reductase (NR), the specific NO scavenger cPTIO, ZnPP, or Hb. During treatment for 4 h, SNP, 0.01% CO aqueous solution or hematin significantly triggers NO synthesis, whereas cPTIO, or tungstate approximately fully inhibits NO fluorescence. Ad- ditionally, application of the GC inhibitor ODQ blocks CO-induced stomatal closure. This inhibition could be reversed when 8-Br-cGMP is added. Thus, the above results suggest that CO produced by HO is involved in ABA-induced stomatal closure, and NO and cGMP may function as downstream interme- diates in the CO signaling responsible for stomatal closure. | CAO ZeYu HUANG BenKai WANG QingYa XUAN Wei LING TengFang ZHANG Bo CHEN Xi NIE Li SHEN WenBiaot | 2007 | Chinese Science Bulletin2007，52，17： | 16 |
| 2 | A-DA′D-A non-fullerene acceptors for high-performance organic solar cells显示文摘Since the world-record power conversion efficiency of 15.7%was achieved for organic solar cells(OSCs)in 2019,the newly developed non-fullerene acceptor(NFA)Y6 with an A-DA′D-A structure(A denotes an electron-accepting moiety,D denotes an electron-donating moiety)has attracted increasing attention.Subsequently,many new A-DA′D-A NFAs have been designed and synthesized,and the A-DA′D-A NFAs have played a significant role in the development of high-performance non-fullerene organic solar cells(NF-OSCs).Compared with the classical A-D-A-type acceptors,A-DA′D-A NFAs contain an electrondeficient core(such as benzothiadiazole(BT),benzotriazole(BTA),quinoxaline(Qx),or their derivatives)in the ladder-type fused rings to fine-tune the energy levels,broaden light absorption and achieve higher electron mobility of the NFAs.This review emphasizes the recent progress on these emerging A-DA′D-A(including Y-series)NFAs.The synthetic methods of DA′D-fused rings are introduced.The relationships between the chemical structure of the A-DA′D-A NFAs and the photovoltaic performance of the corresponding OSCs are summarized and discussed.Finally,issues and prospects for further improving photovoltaic performance of the OSCs are also proposed. | Qingya Wei Wei Liu Mario Leclerc Jun Yuan Honggang Chen Yingping Zou | 2020 | Science China Chemistry2020，63，10： | 7 |
| 3 | Reaction kinetics of CaC2 formation from powder and compressed feeds显示文摘 | Renxing Wang Zhenyu Liu Leiming Ji Xiaojin Guo Xi Lin Junfei Wu Qingya Liu | 2016 | Frontiers of Chemical Science and Engineering2016，10，4： | 6 |
| 4 | Recent progress in organic solar cells(PartⅠmaterial science)显示文摘During past several years,the photovoltaic performances of organic solar cells(OSCs)have achieved rapid progress with power conversion efficiencies(PCEs)over 18%,demonstrating a great practical application prospect.The development of material science including conjugated polymer donors,oligomer-like organic molecule donors,fused and nonfused ring acceptors,polymer acceptors,single-component organic solar cells and water/alcohol soluble interface materials are the key research topics in OSC field.Herein,the recent progress of these aspects is systematically summarized.Meanwhile,the current problems and future development are also discussed. | Yahui Liu Bowen Liu Chang-Qi Ma Fei Huang Guitao Feng Hongzheng Chen Jianhui Hou Lingpeng Yan Qingya Wei Qun Luo Qinye Bao Wei Ma Wei Liu Weiwei Li Xiangjian Wan Xiaotian Hu Yanchun Han Yaowen Li Yinhua Zhou Yingping Zou Yiwang Chen Yongfang Li Yongsheng Chen Zheng Tang Zhicheng Hu Zhi-Guo Zhang Zhishan Bo | 2022 | Science China Chemistry2022，65，2： | 5 |
| 5 | Prevalence of liver injury among patients with acquired immunodeficiency syndrome treated with highly active antiretroviral therapy in China显示文摘OBJECTIVE: To estimate the prevalence of liver injury among patients with acquired immunodeficiency syndrome(AIDS) who received highly active antiretroviral therapy(HAART) in rural Henan Province in China, and to explore whether Traditional Chinese Medicine(TCM) treatment based on HAART would increase this risk.METHODS: This was a retrospective cross-sectional study. We collected medical information on patients with AIDS from two treatment databases in2014. Criteria established by the AIDS Clinical Trials Group in 1996 were used for grading liver injury,classified based on the limit of normal(ULN) for alanine transaminase and aspartate aminotransferase:grade 1(1.25-2.5 × ULN); grade 2(2.6-5 × ULN);grade 3(5.1-10 × ULN); and grade 4(> 10 × ULN).Factors associated with liver injury were evaluated using a logistic regression model.RESULTS: A total 6953 patients with AIDS(3324 male and 3629 female patients) were enrolled into this study. The prevalence of liver injury was 22.0%(18.0% grade 1, 3.1% grade 2, 0.9% grade 3). In multivariate analysis, patients aged 34-45 years were more likely to have liver injury than patients in other age groups [adjusted odds ratio(AOR), 1.39; 95%CI, 1.01-1.91)]. Other factors associated with liver injury included male sex(AOR, 1.64; 95% CI,1.46-1.85), HIV infection via blood(AOR, 1.47; 95%CI, 1.19-1.82), hepatitis B virus antibody positive(AOR, 1.07; 95% CI, 0.85-1.36), and hepatitis C virus(HCV) antibody positive(AOR, 2.76; 95% CI,2.28-3.34).CONCLUSION: The prevalence of liver injury was relatively high among HAART-experienced patients. Several factors associated with liver injury included male sex, age 35-45 years old, HIV infection through blood, and concurrent HCV infection. TCM had no relationship with liver injury in patients receiving HAART. | Yuan Jun Xu Qianlei Chen Xiumin Meng Pengfei Li Qingya Xu Liran Meng Xiangle Jin Yantao Guo Huijun | 2019 | Journal of Traditional Chinese Medicine2019，39，2： | 5 |
| 6 | Recent progress in organic solar cells(PartⅡdevice engineering)显示文摘1 Introduction Organic solar cells(OSCs)belong to a multidisciplinary field composed of chemistry,materials science,physics,engineering,etc.For a better reviewing of this field,we briefly divide the research field of OSCs into two parts:material science and device engineering.In our previous review,the material science part of OSCs,including conjugated polymer donors and acceptors,small molecular donors and acceptors. | Yahui Liu Bowen Liu Chang-Qi Ma Fei Huang Guitao Feng Hongzheng Chen Jianhui Hou Lingpeng Yan Qingya Wei Qun Luo Qinye Bao Wei Ma Wei Liu Weiwei Li Xiangjian Wan Xiaotian Hu Yanchun Han Yaowen Li Yinhua Zhou Yingping Zou Yiwang Chen Yuqiang Liu Lei Meng Yongfang Li Yongsheng Chen Zheng Tang Zhicheng Hu Zhi-Guo Zhang Zhishan Bo | 2022 | Science China Chemistry2022，65，8： | 3 |
| 7 | Lifetime prediction of electrical connectors under multiple environment stresses of temperature and particulate contamination显示文摘Electrical connectors play a significant role in the electronic and communication systems.As they are often exposed in the atmosphere environment, it is extremely easy for them to cause electrical contact failure.It is essential to carry out the reliability modeling and predict the lifetime.In the present work, the accelerated lifetime testing method which is on account of the uniform design method was designed to obtain the degradation data under multiple environmental stresses of temperature and particulate contamination for electrical connectors.Based on the degradation data, the pseudo life can be acquired.Then the reliability model was established by analyzing the pseudo life.Accordingly, the reliability function and reliable lifetime function were set up, and the reliable lifetime of the connectors under the multiple environment stresses of temperature and particulate contamination could be predicted for electrical connectors. | Li Qingya Gao Jinchun Xie Gang Jin Qiuyan Ji Rui | 2016 | The Journal of China Universities of Posts and Telecommunications2016，23，5： | 3 |
| 8 | Cryo-EM structures of inactive and active GABAB receptor显示文摘Metabotropic GABAB G protein-coupled receptor functions as a mandatory heterodimer of GB1 and GB2 subunits and mediates inhibitory neurotransmission in the central nervous system.Each subunit is composed of the extracellular Venus flytrap(VFT)domain and transmembrane(TM)domain.Here we present cryo-EM structures of full-length human heterodimeric GABAB receptor in the antagonist-bound inactive state and in the active state complexed with an agonist and a positive allosteric modulator in the presence of Gi1 protein at a resolution range of 2.8–3.0Å.Our structures reveal that agonist binding stabilizes the closure of GB1 VFT,which in turn triggers a rearrangement of TM interfaces between the two subunits from TM3-TM5/TM3-TM5 in the inactive state to TM6/TM6 in the active state and finally induces the opening of intracellular loop 3 and synergistic shifting of TM3,4 and 5 helices in GB2 TM domain to accommodate theα5-helix of Gi1.We also observed that the positive allosteric modulator anchors at the dimeric interface of TM domains.These results provide a structural framework for understanding class C GPCR activation and a rational template for allosteric modulator design targeting the dimeric interface of GABAB receptor. | Chunyou Mao Cangsong Shen Chuntao Li Dan-Dan Shen Chanjuan Xu Shenglan Zhang Rui Zhou Qingya Shen Li-Nan Chen Jianfeng Liu Yan Zhang | 2020 | Cell Research2020，30，7： | 3 |
| 9 | Determinants of self-management behaviors among pulmonary tuberculosis patients: a path analysis显示文摘Background Tuberculosis(TB)is one of the top 10 causes of death in the world.Since Directly Observed Therapy(DOT)as a core strategy for the global TB control are not applicable to all types of TB patients,and self-management of TB patients(SMTP)as a patient-centered supervision type is a supplement to DOT and can improve TB case management.However,the factors related to SMTP are complex and need more study.This study aimed at identifying the determinants of SMTP and examining the direct/indirect effects of these determinants.Methods The purposive sampling technique was used to select study sites and participants were recruited from the study sites by the consecutive sampling method.The PRECEDE model was used as the framework to analyze the determinants of SMTP.The responses of TB patients were acquired via a questionnaire survey for data collection.A Pearson correlation analysis was used to define the relationship between the predisposing,enabling,reinforcing factors with SMTP behaviors.A regression-based path analysis was used to determine the action paths of the predisposing,enabling,and reinforcing factors on SMTP behaviors.Results The predisposing(TB knowledge),enabling[health education and healthcare workers(HCWs)support],reinforcing factors(family support)had significant positive correlations with SMTP behaviors(P<0.05).The predisposing,enabling,reinforcing factors were positively correlated with each other(r=0.123‒0.918,P<0.05),except for family support and HCWs support.The predisposing factors(TB knowledge,β=0.330)and the enabling factors(HCWs support,β=0.437)had direct effects on SMTP behaviors.The enabling factors(health education and HCWs support)and the reinforcing factors(family support)had indirect effects on SMTP behaviors.Conclusions This study revealed the effects and action path of TB knowledge,health education,HCWs support,and family support on SMTP behaviors via a path analysis.Assessing patient’s needs for SMTP along with promoting effective TB health education and providing firm support from HCWs and family members are potential strategies to promote SMTP behaviors. | Jin Li Jie Pu Jiaqing Liu Qingya Wang Rui Zhang Ting Zhang Jiani Zhou Wei Xing Shengxiang Liang Daiyu Hu Ying Li | 2021 | Infectious Diseases of Poverty2021，10，4： | 2 |
| 10 | Primary Intestinal Lymphangiectasia: Four Case Reports and a Review of the Literature显示文摘 | Jie Wen Qingya Tang Jiang Wu Ying Wang Wei Cai | 2010 | Digestive Diseases and Sciences2010，，12： | 2 |
| 11 | Cyclophosphamide loaded thermo-responsive hydrogel system synergize with a hydrogel cancer vaccine to amplify cancer immunotherapy in a prime-boost manner显示文摘Although neoantigen-based cancer vaccines show great potential in cancer immunotherapy due to their ability to induce effective and long-lasting anti-tumor immunity,their development is hindered by the limitations of neoantigens identification,low immunogenicity,and weak immune response.Cyclophosphamide(CTX)not only directly kills tumors but also causes immunogenic cell death,providing a promising source of antigens for cancer vaccines.Herein,a combined immunotherapy strategy based on temperature-sensitive PLEL hydrogel is designed.First,CTX-loaded hydrogel is injected intratumorally into CT26 bearing mice to prime anti-tumor immunity,and then 3 days later,PLEL hydrogels loaded with CpG and tumor lysates are subcutaneously injected into both groins to further promote anti-tumor immune responses.The results confirm that this combined strategy reduces the toxicity of CTX,and produces the cytotoxic T lymphocyte response to effectively inhibit tumor growth,prolong survival,and significantly improve the tumor cure rate.Moreover,a long-lasting immune memory response is observed in the mice.About 90%of the cured mice survive for at least 60 days after being re-inoculated with tumors,and the distant tumor growth is also well inhibited.Hence,this PLEL-based combination therapy may provide a promising reference for the clinical promotion of chemotherapy combined with cancer vaccines. | Fan Yang Kun Shi Ying Hao Yanpeng Jia Qingya Liu Yu Chen Meng Pan Liping Yuan Yongyang Yu Zhiyong Qian | 2021 | Bioactive Materials2021，6，10： | 2 |
| 12 | Intracellular aggregation of peptide-reprogrammed small molecule nanoassemblies enhances cancer chemotherapy and combinatorial immunotherapy显示文摘The intracellular retention of nanotherapeutics is essential for their therapeutic activity.The immobilization of nanotherapeutics inside target cell types can regulate various cell behaviors.However,strategies for the intracellular immobilization of nanoparticles are limited.Herein,a cisplatin prodrug was synthesized and utilized as a glutathione(GSH)-activated linker to induce aggregation of the cisplatin prodrug/IR820/docetaxel nanoassembly.The nanoassembly has been reprogrammed with peptidecontaining moieties for tumor-targeting and PD-1/PD-L1 blockade.The aggregation of the nanoassemblies is dependent on GSH concentration.Evaluations in vitro and in vivo revealed that GSH-induced intracellular aggregation of the nanoassemblies enhances therapeutic activity in primary tumors by enhancing the accumulation and prolonging the retention of the chemotherapeutics in the tumor site and inducing reactive oxygen species(ROS)generation and immunogenic cell death.Moreover,the nanoassemblies reinvigorate the immunocytes,especially the systemic immunocytes,and thereby alleviate pulmonary metastasis,even though the population of immunocytes in the primary tumor site is suppressed due to the enhanced accumulation of chemotherapeutics.This strategy provides a promising option for the intracellular immobilization of nanoparticles in vitro and in vivo. | Jinrong Peng Yao Xiao Qian Yang Qingya Liu Yu Chen Kun Shi Ying Hao Ruxia Han Zhiyong Qian | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 2 |
| 13 | How Reliable Can Two-Path Protection Be?显示文摘 | SHE Qingya HUANG Xiaodong JUE J | 2010 | IEEE/ACM Transactions on Networking2010，18，3： | 1 |
| 14 | SO2 removal from flue gas by activated semi-cokes(Ⅰ): The preparation of catalysts and determination of operating conditions 显示文摘 | Liu Qingya Li Chunhu Li Yanxu | 2003 | Carbon2003，41，： | 1 |
| 15 | The role of supercriticalwater in pyrolysis of carbonaceous compounds 显示文摘 | Xu Tao Liu Qingya Liu Zhenyu Wu Junfei | 2013 | Energ Fuel2013，27，31： | 1 |
| 16 | SO2 removal from flue gas by activated semi-cokes : effects of physical structures and chemical properties on SO2 removal activity显示文摘 | Liu Qingya Li Chunhu Li Yanxu | 2003 | Carbon2003，41，12： | 1 |
| 17 | Cytosolic TGM2 promotes malignant progression in gastric cancer by suppressing the TRIM21-mediated ubiquitination/degradation of STAT1 in a GTP binding-dependent modality显示文摘Background:Previous studies have revealed the critical role of transglutaminase 2(TGM2)as a potential therapeutic target in cancers,but the oncogenic roles and underlying mechanisms of TGM2 in gastric cancer(GC)are not fully understood.In this study,we examined the role and potential mechanism of TGM2 in GC.Methods:Western blotting,immunohistochemistry,CCK8,colony formation and transwell assays were used to measure TGM2 expression in the GC cells and tissues and to examine the in vitro role of TGM2 in GC.Xenograft and in vivo metastasis experiments were performed to examine the in vivo role of TGM2 in GC.Gene set enrichment analysis,quantitative PCR and western blotting were conducted to screen for potential TGM2 targets involved in GC.Gain/loss-offunction and rescue experiments were conducted to detect the biological roles of STAT1 in GC cells in the context of TGM2.Co-immunoprecipitation,mass spectrometry,quantitative PCR and western blotting were conducted to identify STAT1-interacting proteins and elucidate their regulatory mechanisms.Mutations in TGM2 and two molecules(ZM39923 and A23187)were used to identify the enzymatic activity of TGM2 involved in the malignant progression of GC and elucidate the underlying mechanism.Results:In this study,we demonstrated elevated TGM2 expression in the GC tissues,which closely related to pathological grade,and predicted poor survival in patients with GC.TGM2 overexpression or knockdown promoted(and inhibited)cell proliferation,migration,and invasion,which were reversed by STAT1 knockdown or overexpression.Further studies showed that TGM2 promoted GC progression by inhibiting STAT1 ubiquitination/degradation.Then,tripartite motif-containing protein 21(TRIM21)was identified as a ubiquitin E3 ligase of STAT1 in GC.TGM2 maintained STAT1 stability by facilitating the dissociation of TRIM21 and STAT1 with GTP-binding enzymatic activity.A23187 abolished the role of TGM2 in STAT1 and reversed the pro-tumor role of TGM2 in vitro and in vivo.Conclusions:This study revealed a critical role and regulatory mechanism of TGM2 on STAT1 in GC and highlighted the potential of TGM2 as a therapeutic target,which elucidates the development of medicine or strategies by regulating the GTP-binding activity of TGM2 in GC. | Lu Zhang Qingya Li Jing Yang Penghui Xu Zhe Xuan Jianghao Xu Zekuan Xu | 2023 | Cancer Communications2023，43，1： | 1 |
| 18 | Formation and reaction of ammonium sulfate salts on V2OJAC catalyst during selective eatalytic reduction of nitric oxide by ammonia at low temperatures 显示文摘 | Zhanggen Huang Zhenyu Liu Qingya Liu | 2003 | Journal of Catalysis2003，214，： | 1 |
| 19 | Y6 and its derivatives:molecular design and physical mechanism显示文摘Non-fullerene-acceptor(NFA) materials in the bulk heterojunction(BHJ) play an important role in high-performance organic solar cells(OSCs). Recently,Y-series acceptors with an A-DA D-A structure have been a research hotspot and advanced device efficiency to 15%–18%. This perspective will focus on the discovery of Y6 and its derivatives as well as the intrinsic physical mechanism of Y-series-based devices, which provides a guideline for future molecular design. | Qingya Wei Jun Yuan Yuanping Yi Chunfeng Zhang Yingping Zou | 2021 | National Science Review2021，8，8： | 1 |
| 20 | SOzremoval from flue gas by activated semi-cokes:the preparation of catalysts and determination of operating conditions显示文摘 | Liu Qingya Li Chunhu Li Yanxu | 2003 | Carbon2003，41，12： | 1 |
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