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| 1 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 2 | Chip-scale broadband spectroscopic chemical sensing using an integrated supercontinuum source in a chalcogenide glass waveguide显示文摘On-chip spectroscopic sensors have attracted increasing attention for portable and field-deployable chemical detection applications. So far, these sensors largely rely on benchtop tunable lasers for spectroscopic interrogation. Large footprint and mechanical fragility of the sources, however, preclude compact sensing system integration. In this paper, we address the challenge through demonstrating, for the first time to our knowledge, a supercontinuum source integrated on-chip spectroscopic sensor, where we leverage nonlinear Ge_(22)Sb_(18)Se_(60) chalcogenide glass waveguides as a unified platform for both broadband supercontinuum generation and chemical detection. A home-built, palm-sized femtosecond laser centering at 1560 nm wavelength was used as the pumping source. Sensing capability of the system was validated through quantifying the optical absorption of chloroform solutions at 1695 nm. This work represents an important step towards realizing a miniaturized spectroscopic sensing system based on photonic chips. | QINGYANG DU ZHENGQIAN LUO HUIKAI ZHONG YIFEI ZHANG YIZHONG HUANG TUANJIE DU WEI ZHANG TIAN GU JUEJUN HU | 2018 | Photonics Research2018，6，6： | 9 |
| 3 | A multiregional model of China and its application显示文摘 | Qingyang Gu Kang Chen | 2005 | Economic Modelling2005，，22： | 1 |
| 4 | Nanocage structure derived from sulfonated beta-cyclodextrin intercalated layered double hydroxides and selective adsorption for phenol compounds显示文摘 | Xue Xiangyu Gu Qingyang Pan Guohua | 2014 | Inorg Chem2014，53，3： | 1 |
| 5 | A multiregional model of China and its application显示文摘 | Qingyang Gu Kang Chen | 2005 | Economic Modeling2005，，22： | 1 |
| 6 | Real-time,in situ probing of gamma radiation damage with packaged integrated photonic chips显示文摘Integrated photonics is poised to become a mainstream solution for high-speed data communications and sensing in harsh radiation environments,such as outer space,high-energy physics facilities,nuclear power plants,and test fusion reactors.Understanding the impact of radiation damage in optical materials and devices is thus a prerequisite to building radiation-hard photonic systems for these applications.In this paper,we report real-time,in situ analysis of radiation damage in integrated photonic devices.The devices,integrated with an optical fiber array package and a baseline-correction temperature sensor,can be remotely interrogated while exposed to ionizing radiation over a long period without compromising their structural and optical integrity.We also introduce a method to deconvolve the radiation damage responses from different constituent materials in a device.The approach was implemented to quantify gamma radiation damage and post-radiation relaxation behavior of SiO2-cladded SiC photonic devices.Our findings suggest that densification induced by Compton scattering displacement defects is the primary mechanism for the observed index change in SiC.Additionally,post-radiation relaxation in amorphous SiC does not restore the original pre-irradiated structural state of the material.Our results further point to the potential of realizing radiation-hard photonic device designs taking advantage of the opposite signs of radiation-induced index changes in SiC and SiO2. | QINGYANG DU JEROME MICHON BINGZHAO LI DEREK KITA DANHAO MA HAIJIE ZUO SHAOLIANG YU TIAN GU ANURADHA AGARWAL MO LI JUEJUN HU | 2020 | Photonics Research2020，8，2： | 1 |
| 7 | Fabrication of novel bifunctional nanohybrid based on layered rare-earth hydroxide with magnetic and fluorescent properties显示文摘We demonstrate the fabrication of a novel magnetic nanohybrid involving the drug molecule 5 aminolevulinic acid(5-ALA)intercalated Gd-Eu layered rare-earth hydroxide(LRH)coated on magnesium ferrite particles(MgFe2O4).The structure,thermostability,morphology,luminescence properties,cytotoxic effect and magnetism are investigated.The 5-ALA intercalated composite may correspond to a monolayered vertical arrangement,and the thermal stability of organics is enhanced after intercalation.The LRH precursor shows red emission of Eu^3+and the maximum emission peak of the composite is at 451 nm,corresponding to the blue emission.The detection of drug molecules can be realized through the change of luminescence.The magnetic nanohybrid shows strong magnetic sensitivity,which provides an easy and efficient way to separate 5-ALA-MgFe2O4@LGd0.95H:Eu0.05 particles from a sol or a suspension system and to carry drugs to targeted locations under an external magnetic field.The cytotoxic effect of MgFe2O4@LRH is observed with a sulforhodamine B(SRB)colorimetric assay,which has low cytotoxic effects on selected cells.The fabrication of novel bifunctional drug carriers based on LRH with magnetic and fluorescent properties has potential applications in drug detection and drug delivery. | Qingyang GU jinyan LI Liangshuo JI Ruijun JU Haibo JIN Rongyue ZHANG | 2020 | Frontiers of Materials Science2020，14，4： | 0 |
| 8 | CIADS燃料棒在束流瞬态下的安全特性显示文摘China Initiative Accelerator Driven System(CiADS)is a major science and technology infrastructure that is prioritized for construction in the“Twelfth Five-Year Plan”.CiADS is the first accelerator-driven transmutation research device in China.The frequency of beam trip and stable operation are the hot spots and difficulties in the research of high-power continuous-wave accelerators.It can be predicted that during the future CiADS operation,frequent high beam accelerators will also experience frequent beam transients. | Zhang Qingyang Gu Long Peng Tianji | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
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