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| 1 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 2 | PDK1 plays a critical role in regulating cardiac function in mice and human显示文摘背景 PDK1 是在哺乳动物的开发起一个关键作用的必要蛋白质 kinase。老鼠缺乏 PDK1 在 E9.5 导致多重畸形和胚胎的致命性。阐明在心的 PDK1 的角色,我们调查了在不同生长时期和在我们采用了的人的失败的 heart.Methods 发信号的 PDK1 的改变在心缺乏 PDK1 的鼠标的心脏的显型产生 PDK1flox/flox 的 Cre/loxP 系统:-MHC-Cre 老鼠,明确地在出生在心肌删除了 PDK1,和 tamoxifen 可诱导的心特定的 PDK1 猛烈老鼠(PDK1flox/flox : MerCreMer 老鼠) ,在哪个 PDK1 与 tamoxifen 响应处理在心肌层被删除。从人的失败的心和正常的心的 Transmural 心肌的纸巾从左室的顶被取样分析由西方的 blotting.Results PDK1flox/flox 表明小径的 PDK1/Akt 的活动:-MHC-Cre 老鼠在 5 和 10 个星期死于心失败旧。PDK1flox/flox-MerCreMer 老鼠在 8 个星期在 tamoxifen 处理的开始以后从 5 ~ 21 个星期死于心失败旧。我们在人的失败的心纸巾发现那个表达式 PDK1 的层次显著地与我们的结果建议的控制 hearts.Conclusion 相比被减少发信号的那 PDK1 网络参加在鼠标调整心脏的生存能力和功能,并且可以也涉及人的心失败疾病。 | DI Ruo-min FENG Qiu-ting CHANG Zai LUAN Qing ZHANG Yang-yang HUANG Jun LI Xin-li YANG Zhong-zhou | 2010 | Chinese Medical Journal2010，，17： | 7 |
| 3 | Mouse knockout models reveal largely dispensable but context-dependent functions of IncRNAs during development显示文摘 | Xue Han Sai Luo Guangdun Peng Yuyang Lu Guizhong Cui Lichao Liu Pixi Yan Yafei Yin Wei Liu Ran Wang Jiejie Zhang Shanshan Ai Zai Chang Jie Na Aibin He Naihe Jing Xiaohua Shen | 2018 | Journal of Molecular Cell Biology2018，10，2： | 3 |
| 4 | Changing Grains for the Prevention and Treatment of Kashin-Beck Disease in Children: a Meta-analysis显示文摘To evaluate the efficacy of changing grains on the prevention and treatment of Kashin-Beck Disease(KBD)in children,community-based trials were acquired from seven electronic databases(up to July 2014).As a result,the methodological quality of the six trials that have been included into our analysis was low.The pooled ORs favoring the prevention and treatment effects of changing grains were 0.15(95%CI:0.03-0.70)and 2.13(95% | HAN Jing YU Fang Fang CHANG Zai Ping YANG Bo QU Cheng Juan ZHOU Tian Tian LIU Rui Yu GUO Xiong | 2015 | Biomedical and Environmental Sciences2015，28，4： | 2 |
| 5 | Life-cycle cost based maintenance plan for steel bridge protection systems显示文摘 | ZAYED T M CHANG Luh-Maan FRICKER J D | 2002 | Journal of Performance of Constructed Facilities2002，16，2： | 1 |
| 6 | Prototype model for build- operate-transfer risk assessment显示文摘 | ZAYED T M CHANG L M | 2002 | Journal of Management in Engineering2002，18，1： | 1 |
| 7 | Preparation and Properties of Water-based Conducting Polyaniline显示文摘IntroductionInthepastdecade,conjugatedconductingpolymerslikepolyaniline,polythiopheneandpolypyrolehavereceivedconsiderableate... | WANG Xian hong, GENG Yan hou, YU Lei, SUN Zai cheng Li Ji, JING Xia bin ** and WANG Fo song (Polymer Chemistry Lab, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022) LEE Chang jin and RHEE Suh bo | 1998 | Chemical Research in Chinese Universities1998，14，3： | 1 |
| 8 | Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome显示文摘Organization of the genome into euchromatin and heterochromatin appears to be evolutionarily conserved and relatively stable during lineage differentiation.In an effort to unravel the basic principle underlying genome folding,here we focus on the genome itself and report a fundamental role for L1(LINE1 or LINE-1)and B1/Alu retrotransposons,the most abundant subclasses of repetitive sequences,in chromatin compartmentalization.We find that homotypic clustering of L1 and B1/Alu demarcates the genome into grossly exclusive domains,and characterizes and predicts Hi-C compartments.Spatial segregation of L1-rich sequences in the nuclear and nucleolar peripheries and B1/Alu-rich sequences in the nuclear interior is conserved in mouse and human cells and occurs dynamically during the cell cycle.In addition,de novo establishment of L1 and B1 nuclear segregation is coincident with the formation of higher-order chromatin structures during early embryogenesis and appears to be critically regulated by L1 and B1 transcripts.Importantly,depletion of L1 transcripts in embryonic stem cells drastically weakens homotypic repeat contacts and compartmental strength,and disrupts the nuclear segregation of L1-or B1-rich chromosomal sequences at genome-wide and individual sites.Mechanistically,nuclear co-localization and liquid droplet formation of L1 repeat DNA and RNA with heterochromatin protein HP1αsuggest a phase-separation mechanism by which L1 promotes heterochromatin compartmentalization.Taken together,we propose a genetically encoded model in which L1 and B1/Alu repeats blueprint chromatin macrostructure.Our model explains the robustness of genome folding into a common conserved core,on which dynamic gene regulation is overlaid across cells. | J.Yuyang Lu Lei Chang Tong Li Ting Wang Yafei Yin Ge Zhan Xue Han Ke Zhang Yibing Tao Michelle Percharde Liang Wang Qi Peng Pixi Yan Hui Zhang Xianju Bi Wen Shao Yantao Hong Zhongyang Wu Runze Ma Peizhe Wang Wenzhi Li Jing Zhang Zai Chang Yingping Hou Bing Zhu Miguel Ramalho-Santos Pilong Li Wei Xie Jie Na Yujie Sun Xiaohua Shen | 2021 | Cell Research2021，31，6： | 1 |
| 9 | Prototype model for Build-Operate-Transfer risk assessment 显示文摘 | Zayed T M Chang L M | 2002 | Journal of Management in Engineering2002，18，1： | 1 |
| 10 | Prototype model for build-operate-transfer risk assessment显示文摘 | Zayed T M Chang L | 2002 | Journal of Management in Engineering2002，，1： | 1 |
| 11 | Granularmechanical analysis of the strength and dilatancy ofsands显示文摘 | CHANG Zai YANG Jun CHENG Xiao-hui | 2003 | Engineering Mechanics2003，43，3： | 1 |
| 12 | Prototype model for build-operate-transfer risk assessment显示文摘 | Tarek M Zayed S Chang L M | 2002 | Journal of Management in Engineering2002，18，1： | 1 |
| 13 | Prototype model for build-operate-transfer risk assessment显示文摘 | ZAYED T CHANG L | 2002 | Journal of Management in Engineering2002，18，1： | 1 |
| 14 | Prototype Model for Build-Operate- Transfer Risk Assessment 显示文摘 | Zayed T M Luh-Maan Chang | 2002 | Journal of Management in Engineering2002，，1： | 1 |
| 15 | Prototype model for build-operate-transfer risk assessment 显示文摘 | Tarek M Zayed S Chang L M | 2002 | Journal of Management in Engineering2002，18，1： | 1 |
| 16 | SYNTHESIS OF N-GLUCURONIDES OF 5-FLUOROURACIL AND THEIR ANTITUMOR ACTIVITIES显示文摘SYNTHESISOFN-GLUCURONIDESOF5-FLUOROURACILANDTHEIRANTITUMORACTIVITIES￥ChangJunSUN;YiGuiWANG;ZaiChengCHEN;PengXUE;WeiFengHU(Dep... | Chang Jun SUN Yi Gui WANG Zai Cheng CHEN Peng XUE Wei Feng HU (Department of chemistry, Shandong University,Jinan 250100)Bet Li XU Yao Ran ZHAO Mei Ling WANG (Shandong Academy of Medical Sciences,Jinan 250014) | 1994 | Chinese Chemical Letters1994，5，5： | 0 |
| 17 | TET1蛋白亚型转换调控DNA去甲基化和小鼠发育显示文摘文章简介DNA甲基化氧化酶TET蛋白在介导DNA去甲基化和调控个体发育中均起着非常重要的作用。但是,TET蛋白如何识别基因组中的催化位点仍然有待研究。本研究通过细致地观测转录组学数据,意外发现了TET蛋白家族成员TET1在小鼠不同发育时期中存在两个亚型。其中全长TET1亚型(TET1e)仅在小鼠早期胚胎、小鼠胚胎干细胞和原始生殖细胞中表达; | Wenhao Zhang Weikun Xia Qiujun Wang Aaron J Towers Jiayu Chen Rui Gao Yu Zhang Chia-an Yen Ah Young Lee Yuanyuan Li Chen Zhou Kaili Liu Jing Zhang Tian-Peng Gu Xiuqi Chen Zai Chang Danny Leung Shaorong Gao Yong-hui Jiang 颉伟 | 2017 | 科学新闻2017，19，4： | 0 |
| 18 | STUDIES ON THE SYNTHESIS OF D-GLUCURONIC ACID DERIVATIVES OF 2-BUTOXY-5-FLUORO-3H-4-PYRIMIDONE AND THEIR ANTICANCER ACTIVITIES显示文摘2-Butoxy-5-fluoro-3H-4-pyrimidone derivatives of D-glucuronic acid having0-glycosidic linkage or N-glycosidic linkage were synthesized and their anticanceractivity tested.Their structures were confirmed by elementary analysis,IR spectraand ~1HNMR. | Chang Jun SUN Zai Cheng CHEN Yi Gui WANG Peng XUE Department of Chemistry,Shandong University,Jinan,250100Feng Yao LIU Department of Chemistry,Zaozhuang Teachers College,Zaozhuang,Shandong,277000 | 1993 | Chinese Chemical Letters1993，4，3： | 0 |
| 19 | 3dCAP-Wheat: An Open-Source Comprehensive Computational Framework Precisely Quantifies Wheat Foliar, Nonfoliar, and Canopy Photosynthesis显示文摘Canopy photosynthesis is the sum of photosynthesis of all above-ground photosynthetic tissues.Quantitative roles of nonfoliar tissues in canopy photosynthesis remain elusive due to methodology limitations.Here,we develop the first complete canopy photosynthesis model incorporating all above-ground photosynthetic tissues and validate this model on wheat with state-of-the-art gas exchange measurement facilities. | Tian-Gen Chang Zai Shi Honglong Zhao Qingfeng Song Zhonghu He Jeroen Van Rie Bart Den Boer Alexander Galle Xin-Guang Zhu | 2022 | Plant Phenomics2022，4，1： | 0 |
| 20 | AN IMPROVED METHOD FOR PREPARING 2—ALKOXY—5—FLUORO—3H—4—PYRIMIDONE~△显示文摘In this paper, we report an improved method for preparing 2--alkoxy 5 fluoro--3H--4--pyrimidone from 2--chloro--5--fluoro--3H--4--pyrimidone and sodium alkoxide under normalpressure at reflux temperature. Some new compounds were synthesized in higher yield by this method. | Chang Jun SUN Zai Cheng CHEN Yi MENG Yi Gui WANG Peng XUE Jian Guo ZHANG Gui Xiang CUI Department of Chemistry, Shandong University, Jinan 250100 | 1993 | Chinese Chemical Letters1993，4，7： | 0 |
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