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20篇 您的检索式:作者名="Haofei Zhou"
    题名 作者 年代 出处 被引量
1Full-colour nanoprint-hologram synchronous metasurface with arbitrary hue-saturationbrightness control显示文摘The colour gamut,a two-dimensional(2D)colour space primarily comprising hue and saturation(HS),lays the most important foundation for the colour display and printing industries.Recently,the metasurface has been considered a promising paradigm for nanoprinting and holographic imaging,demonstrating a subwavelength image resolution,a flat profile,high durability,and multi-functionalities.Much effort has been devoted to broaden the 2D HS plane,also known as the CIE map.However,the brightness(B),as the carrier of chiaroscuro information,has long been neglected in metasurface-based nanoprinting or holograms due to the challenge in realising arbitrary and simultaneous control of full-colour HSB tuning in a passive device.Here,we report a dielectric metasurface made of crystal silicon nanoblocks,which achieves not only tailorable coverage of the primary colours red,green and blue(RGB)but also intensity control of the individual colours.The colour gamut is hence extruded from the 2D CIE to a complete 3D HSB space.Moreover,thanks to the independent control of the RGB intensity and phase,we further show that a singlelayer silicon metasurface could simultaneously exhibit arbitrary HSB colour nanoprinting and a full-colour hologram image.Our findings open up possibilities for high-resolution and high-fidelity optical security devices as well as advanced cryptographic approaches.Yanjun Bao Ying Yu Haofei Xu Chao Guo Juntao Li Shang Sun Zhang-Kai Zhou Cheng-Wei Qiu Xue-Hua Wang 2019Light(Science & Applications)2019,8,1:25
2miR-125a-3p targets MTA1 to suppress NSCLC cell proliferation, migration, and invasion显示文摘联系转移的基因(MTA1 ) 1 在 non-small-cell 肺癌症(NSCLC ) 与房间生长,转移,和幸存被联系。几份以前的报告证明了 microRNAs 通过在他们的种子区域和目标 mRNA 的 3-untranslated 区域之间的相互作用影响基因表示,导致 post-transcriptional 规定。这研究的目的是识别 miRNAs 由指向 MTA1 在 NSCLC 房间压制恶意。在有 MTA1 的 transfection 模仿以后,二根人的 NSCLC 房间线被量的 RT-PCR 并且西方的弄污为 MTA1 的表示分析。酶记者试金被建立测试在 MTA1 和它的在上游的 miRNAs 之间的直接连接。房间增长被 3-(4,5-dimethylthiazol-2-yl ) 估计 -2,5-diphenyltetrazolium 溴化物试金, 5-ethynyl-2-deoxyuridine 分析,和殖民地形成试金。房间移植和侵略能力被愈合创伤的试金和 transwell 试金评估。miRNA/MTA1 轴被量的 RT-PCR 并且从八个 NSCLC 病人的在样品的西方的弄污也探查。在候选人 miRNAs 之中, miR-125a-3p 被显示 post-transcriptionally 在 NSCLC 房间调整 MTA1。这些数据被酶记者试金增强,除了 MTA1 相反地与在 NSCLC 纸巾的 miR-125a-3p 被相关的示范。而且, miR-125a-3p 被发现禁止 NSCLC 房间增长,移植,和侵略,通过下面调整的 MTA1 的一样的机制。我们的报告证明 miR-125a-3p 通过 MTA1 的下面规定禁止 NSCLC 房间的增长,迁居,和侵略,显示在 NSCLC 的 miR-125a-3p/MTA1 轴的角色,并且可以提供新奇卓见进分子的机制 underpinning 疾病和潜在的治疗学的目标。Hong Zhang Xiaoxia Zhu Na Li Dianhe Li Zhou Sha Xiaokang Zheng Haofei Wang 2015Acta Biochimica et Biophysica Sinica2015,47,7:9
3Direct observation of epitaxial alignment of Au on M0S2 at atomic resolution显示文摘The morphology and structural stability of metal/2D semic on ductor interfaces strongly affect the performa nee of 2D electronic devices and synergistic catalysis. However, the structural evolution at the interfaces has not been well explored particularly at atomic resolution. In this work, we study the structural evoluti on of Au nan oparticles (NPs) on few-layer MoS2 by high resol utio n transmissi on electro n microscopy (HRTEM) an d quan titative high-angle annular dark field seanning TEM. It is found that in the transition of Au from nan oparticles to den drites, a dynamically epitaxial align ment betwee n Au and MoS2 lattices is formed, and Moirc patter ns can be directly observed in HRTEM images due to the mismatch between Au and M0S2 lattices. This epitaxial alignment can occur in ambient conditions, and can also be accelerated by the irradiation of high-energy electron beam. In situ observation clearly reveals the rotation of Au NPs, the atom migration inside Au NPs, and the transfer of Au atoms between neighboring Au NPs, finally leading to the formation of epitaxially aligned Au dendrites on M0S2. The structural evoluti on of metal/2D semico nductor in terfaces at atomic scale can provide valuable information for the design and fabricatio n of the metal/2D semicon ductorn ano-devices with desired physical and chemical performa nces.Yinghui Sun Haofei Zhao Dan Zhou Yuchen Zhu Huanyu Ye Yan Aung Moe 2019Nano Research2019,12,4:4
4Disulfide-Containing Molecular Sticker Assists Cellular Delivery of DNA Nanoassemblies by Bypassing Endocytosis显示文摘The delivery efficiency of DNA nanoassemblies to the cytosol remains unsatisfactory due to endoand lysosomal entrapment and degradation,which restricts their bioanalytical and biomedical applications.Herein,the authors developed a disulfide-containing molecular sticker(DSMS)assisted approach to achieve efficient cytosolic delivery of DNA nanoassemblies.DSMS is designed to consist of a disulfide unit for thiol-mediated uptake and a guanidinium cation unit for strongly adhering to DNA nanoassemblies.After attaching with DSMS,a set of DNA nanoassemblies maintained their original three-dimensional features but had a different cellular internalization pathway.These results demonstrated that DSMS-DNA nanoassemblies complex did not enter the cells via endocytosis but instead entered through thiol-mediated direct uptake.Taking advantages of this facile assembly,universal applicability,and direct cytosolic delivery,DSMS might serve as a potent agent to facilitate the applications of DNA nanoassemblies in a variety of fields,such as bioimaging,drug delivery,and gene therapy.Wen Yang Xiaochen Liu Haofei Li Jie Zhou Shan Chen Pengfei Wang Juan Li Huanghao Yang 2021CCS Chemistry2021,3,3:2
5Transition from source-to stress-controlled plasticity in nanotwinned materials below a softening temperature显示文摘Nanotwinned materials have been widely studied as a promising class of nanostructured materials that exhibit an exceptional combination of high strength,good ductility,large fracture toughness,remarkable fatigue resistance,and creep stability.Recently,an apparent controversy has emerged with respect to how the strength of nanotwinned materials varies as the twin thickness is reduced.While a transition from hardening to softening was observed in nanotwinned Cu when the twin thickness is reduced below a critical value,continuous hardening was reported in nanotwinned ceramics and nanotwinned diamond.Here,by conducting atomistic simulations and developing a theoretical modeling of nanotwinned Pd and Cu systems,we discovered that there exists a softening temperature,below which the material hardens continuously as the twin thickness is reduced(as in nanotwinned ceramics and diamond),while above which the strength first increases and then decreases,exhibiting a maximum strength and a hardening to softening transition at a critical twin thickness(as in nanotwinned Cu).This important phenomenon has been attributed to a transition from source-to stress-controlled plasticity below the softening temperature,and suggests that different hardening behaviors may exist even in the same nanotwinned material depending on the temperature and that at a given temperature,different materials could exhibit different hardening behaviors depending on their softening temperature.Seyedeh Mohadeseh Taheri Mousavi Haofei Zhou Guijin Zou Huajian Gao 2019npj Computational Materials2019,,1:2
6Atomistic dynamics of disconnection-mediated grain boundary plasticity:A case study of gold nanocrystals显示文摘Grain boundary(GB)mediated deformation is a vital contributor to the plasticity of polycrystalline materials,where the disconnection model has become a widely recognized approach to depict the GB dynamics.However,experimental understanding of the atomistic disconnection dynamics remains scarce.In this case study of gold nanocrystals,atomistic disconnection dynamics governing the shear-coupled migration of flat GBs have been systematically investigated via in situ transmission electron microscopy nanomechanical testing supported by molecular dynamics simulations.Specifically,the site-dependent nucleation,shear-driven propagation,and diverse interactions associated with distinct GB disconnections are systematically elucidated and quantitatively compared.Moreover,the disconnection-mediated GB plasticity proves to prevail among different tilt and mixed GBs in gold.Eventually,a conceptual map of disconnection-mediated GB dynamics is established,which would furnish a unified understanding of GB plasticity in metallic materials.Qi Zhu Haofei Zhou Yingbin Chen Guang Cao Chuang Deng Ze Zhang Jiangwei Wang 2022Journal of Materials Science & Technology2022,,30:1
7Giant enhancements of high-order upconversion luminescence enabled by multiresonant hyperbolic metamaterials显示文摘Photonic nanostructures with resonant modes that can generate large electric field(EF) enhancements are applied to enhance light-matter interactions in nanoscale, bringing about great advances in both fundamental and applied science. However, a small hot spot(i.e., the regions with strong EF enhancements) and highly inhomogeneous EF distribution of the resonant modes usually hinder the enhancements of light-matter interactions in a large spatial scale. Additionally, it is a severe challenge to simultaneously generate multiple resonant modes with strong EF enhancements in a broadband spectral range, which greatly limits the capacity of a photonic nanostructure in boosting optical responses including nonlinear conversion, photoluminescence, etc. In order to overcome these challenges, we presented an arrayed hyperbolic metamaterial(AHMM). This AHMM structure is applied to simultaneously enhance the three-photon and four-photon luminescence of upconversion nanoparticles. Excitingly, the enhancement of the three-photon process is 1 order of magnitude larger than previous records, and for the enhancing four-photon process, we achieve an enhancement of 3350 times, greatly beneficial for overcoming the crucial problem of low efficiency in near infrared light upconversion. Our results demonstrated a promising platform for realizing giant enhancements of light-matter interactions, holding potential in constructing various photonics applications such as the nonlinear light sources.Haofei Xu Zhimin Zhu Jiancai Xue Qiuqiang Zhan Zhangkai Zhou Xuehua Wang 2021Photonics Research2021,9,3:1
8Coordinated grain boundary deformation governed nanograin annihilation in shear cycling显示文摘Grain growth and shrinkage are essential to the thermal and mechanical stability of nanocrystalline metals,which are assumed to be governed by the coordinated deformation between neighboring grain boundaries(GBs)in the nanosized grains.However,the dynamics of such coordination has rarely been reported,especially in experiments.In this work,we systematically investigate the atomistic mechanism of coordinated GB deformation during grain shrinkage in an Au nanocrystal film through combined stateof-the-art in situ shear testing and atomistic simulations.We demonstrate that an embedded nanograin experiences shrinkage and eventually annihilation during a typical shear loading cycle.The continuous grain shrinkage is accommodated by the coordinated evolution of the surrounding GB network via dislocation-mediated migration,while the final grain annihilation proceeds through the sequential dislocation-annihilation-induced grain rotation and merging of opposite GBs.Both experiments and simulations show that stress distribution and GB structure play important roles in the coordinated deformation of different GBs and control the grain shrinkage/annihilation under shear loading.Our findings establish a mechanistic relation between coordinated GB deformation and grain shrinkage,which reveals a general deformation phenomenon in nanocrystalline metals and enriches our understanding on the atomistic origin of structural stability in nanocrystalline metals under mechanical loading.Yingbin Chen Qishan Huang Qi Zhu Kexing Song Yanjun Zhou Haofei Zhou Jiangwei Wang 2021Journal of Materials Science & Technology2021,,27:1
9MSVM Recognition Model for Dynamic Process Abnormal Pattern Based on Multi-kernel Functions显示文摘Liu Yumin Zhou Haofei 2014Journal of Systems Science and Information2014,2,5:1
10择优取向纳米孪晶金属中的“链式”关联位错显示文摘本文综述了择优取向纳米孪晶金属中'链式'关联位错(CNDs)的研究进展。当拉伸方向与孪晶界方向水平,且孪晶厚度(λ)为1 nm左右时,关联位错会大量开动,引起材料持续强化。在较宽的孪晶片层中,裂纹等初始缺陷可引起应力集中,诱发关联位错形核。此外,循环变形也会促进关联位错在纳米孪晶结构中的形成,使后者具有与历史无关、稳定和拉压对称的循环响应。最后,本文提出了择优取向纳米孪晶金属中与'链式'关联位错相关的潜在研究方向。Haofei ZHOU Pan-pan ZHU 2020Journal of Zhejiang University-Science A(Applied Physics & Engineering)2020,21,4:0
11Publisher Correction:Transition from source-to stresscontrolled plasticity in nanotwinned materials below a softening temperature显示文摘The original version of this Article was incorrectly labelled as a‘Review Article’.This has now been corrected to‘Article’in both the HTML and PDF versions.Seyedeh Mohadeseh Taheri Mousavi Haofei Zhou Guijin Zou Huajian Gao 2019npj Computational Materials2019,,1:0
12Isobaric Vapor–Liquid Equilibrium for tert-Butyl Alcohol + Water + Propane-1,3-Diol + 1-Ethyl-3-Methylimidazolium Chloride at 101.3 kPa显示文摘In this study, we used a mixture of organic liquid propane-1,3-diol and ionic liquid 1-ethyl-3-methylimidazolium chloride([emim]Cl) as the entrainer to separate tert-butyl alcohol(TBA) + water. We measured the isobaric vapor–liquid equilibrium(VLE) for the quaternary system TBA + water + propane-1,3-diol + [emim]Cl at 101.3 kPa, and found the VLE data to be well correlated with the nonrandom two-liquid model. These results show that the mixed solvent of propane-1,3-diol + [emim]Cl can increase the relative volatility of TBA to water and break the azeotropic point. We found no notable synergetic effect between them, and observed that the liquid mixed solvent of propane-1,3-diol and [emim]Cl had lower viscosity than [emim]Cl, which makes it a promising entrainer for separating the TBA + water azeotrope in industrial applications.Xianbao Cui Qinglong Cheng Haofei Liu Lexing Xue Jinbo Zhou Ying Zhang Tianyang Feng Kai Zhang 2018Transactions of Tianjin University2018,24,5:0
13Supramolecular complex glycoconjugate vaccine generates self-enhancement effects for carbohydrate antigen delivery显示文摘Targeting delivery of tumor-associated carbohydrate antigen(TACA)-based vaccine to antigen-presenting cells(APCs)mediated by endogenous antibodies can improve the immunogenicity of TACA.However,an essential requirement of this approach is to generate high titers of endogenous antibodies in vivo through pre-immunization,which complicates the immunization procedure and may cause side effects.Herein,we report a new generation of APC-targeting TACA-based supramolecular complex vaccine,assembled by sialyl Thomsen-nouveau-bovine serum albumin-adamantine(sTn-BSA-Ada)and heptavalent rhamnose(Rha)-modifiedβ-cyclodextrin(β-CD)via host-guest interaction.The complex vaccine retained anti-Rha antibodies recruiting capability and facilitated the APCs uptake of the vaccine via the interaction of the Fc-domain with the Fc receptors on APCs.We demonstrate that direct immunization of complex vaccine elicited anti-Rha and anti-sTn specific immune response synchronously,generating a novel self-enhancement effect that can improve the antigen delivery to APCs in high efficacy.The structure-activity relationship(SAR)study proved that complex vaccine 4 with polyethylene glycol 6(PEG 6)linker in host molecule provoked a robust and specific sTn immune response comparable to the pre-immunization approach.The antisera induced by complex vaccine,either through direct immunization or pre-immunization,exhibited equal potency of cytotoxicity against the sTn expression cancer cells.This study provides a general platform for TACA-based vaccines with self-enhancement effects without the need for pre-immunization.Han Lin Yanchun Li Kun Zhou Dan Li Hangyan Yu Jie Zhao Haofei Hong Zhifang Zhou Zhimeng Wu 2024Chinese Chemical Letters2024,35,2:0
14Synthesis of DNP-modified GM3-based anticancer vaccine and evaluation of its immunological activities for cancer immunotherapy显示文摘Tumor-associated carbohydrate antigens(TACAs) are attractive targets for vaccine development. In this context, we described a strategy combining artificial TACA and glycoengineering for cancer vaccine development. A 2,4-ditrophenyl(DNP)-modified GM3 intermediate was synthesized chemoenzymatically and conjugated to keyhole limpet hemocyanin(KLH), and the resulting bioconjugate was tested for its potential as a vaccine candidate. Mice immunological studies revealed that the DNP-modified GM3(GM3-NHDNP) analog elicited strong and rapid immune responses by recruiting anti-DNP antibodies to facilitate the targeted delivery of the vaccine construct to antigen processing cells(APCs). Moreover, the endogenously produced anti-DNP antibodies, together with the elicited antibodies against GM3-NHDNP, may synergistically promote tumor binding and cancer cell death when the cancer cell surfaces are glycoengineered to express the GM3-NHDNP antigen.Han Lin Haofei Hong Lipeng Feng Jie Shi Zhifang Zhou Zhimeng Wu 2021Chinese Chemical Letters2021,32,12:0
15Effects of Sc on the vacancy and solute behaviours in aluminium显示文摘Element Sc is a promising candidate for optimizing the high-temperature mechanical properties of Al alloys.In this study,the Sc-solute,Al_(3) Sc-vacancy and Al_(3) Sc-solute interactions in aluminium are inves-tigated extensively by using first-principles calculations.The correlation between the various interaction energies and the solute atomic size,and the Sc-solute compound formation energy has been evaluated.A negative correlation between the first nearest neighbour Sc-solute binding energies and the lowest Sc-solute compound formation energies has been identified,while the second nearest neighbour Sc-solute binding energies increase monotonically with the solute atomic size.Al_(3) Sc precipitates can bind vacancy strongly at the specific atomic site,but their relatively low number density limits their influence on va-cancy behaviours during the ageing period shortly after quenching.Compared to the atomic size,the trend for solute segregating at the interface between Al_(3) Sc precipitate and Al bulk is more strongly re-lated to the Sc-solute binding energy.The calculated results can clarify the available experimental obser-vations for Al-Sc,Al-Cu,Al-Mg-Si and Al-Zn-Mg-Cu alloys,and it is hoped to guide the design of high-performance Al alloys.Xingpu Zhang Liangliang Xu Wenxin Hu Haofei Zhou Jiangwei Wang 2023Journal of Materials Science & Technology2023,,17:0
16Evolution of precipitate and precipitate/matrix interface in Al-Zn-Mg-Cu(-Ag)alloys显示文摘Evolution of precipitate and precipitate/matrix interface in artificially aged Al-Zn-Mg-Cu(-Ag)alloys has been systematically studied.In the early stage of ageing,Ag,as a fast diffuser,can promote the formation of solute pairs and small clusters.Solute clusters are further demonstrated to be able to act as precursors forη’precipitates by in-situ STEM heating.With prolonged ageing time,the precipitate/matrix interface evolves from the Zn-dominated interface between early-stageη’and Al matrix to the Zn and Mg co-segregatedη’/Al andη_(2)/Al interfaces.Theη’/Al interfacial layers are shown to precede the formation ofη’,while theη_(2)/Al interfaces are found to be closely related to the thickening process ofη_(2)and the involved particular atomic movements are specified.Experimental observations and DFT calculations re-veal that forη’andη_(2),Ag can dissolve into the precipitate as well as locate at the precipitate/matrix interface without showing preference.For Cu,its dissolution in the precipitate and segregation on the interface mainly occur forη_(2)rather thanη’.The incorporation of Ag and Cu does not change the defined precipitate structure.Xingpu Zhang Zhongkang Han Liangliang Xu Haohan Ni Xiaojuan Hu Haofei Zhou Yu Zou Jiangwei Wang 2023Journal of Materials Science & Technology2023,,7:0
17Hydrogen-bonded organic framework for red light-mediated photocatalysis显示文摘The development of heterogeneous molecule-based catalysts for red light-mediated photocatalysis is still challenging due to the improper light absorption for most materials and the photoactivity deactivation for solid assembly.Herein,red light photocatalysis with a hydrogen-bonded organic framework(HOF)is established.This HOF,named HOF-66,is formed from the self-assembly of guanine-decorated naphthalenediimide(NDI)molecule through hydrogen-bonded guanine-quadruplex nodes,showing square grid supramolecular layers confirmed by powder X-ray diffraction analysis.In contrast to unsubstituted NDI HOF,introduction of ethylamino groups to NDI core in HOF-66 tunes strong electronic maximum absorption peak to 619 nm,allowing red light photocatalysis of singlet oxygen evolution proved by 1,3-diphenylisobenzofuran degradation and electron spin resonance determination.Particularly,under the same conditions,the sulfide oxidation rate in the presence of HOF-66 was 28 times higher compared to its unsubstituted analogue.This work integrates the molecular design and aggregation effect towards the application of HOFs,opening a new gate for red light photocatalysts.Haofei Zhao Ziwen Zhou Xuenan Feng Chao Liu Hui Wu Wei Zhou Hailong Wang 2023Nano Research2023,16,7:0
18Atomic-scale study on the precipitation behavior of an Al-Zn-Mg-Cu alloy during isochronal aging显示文摘The precipitation behavior of a 7075 Al alloy during isochronal heat treatments at three different heating rates has been studied using differential scanning calorimetry,high-angle-annular-dark-field scanningtransmission-electron microscope and density functional theory calculation.In the early stage of aging,GPI and GPII zones form sequentially and cause two characteristic DSC peaks.Subsequently,the formation ofη_(1) precipitates takes place concurrently withη’.A novel type of metastable phaseη_(1)’is identified as the precursor ofη_(1),which can lower the lattice misfit betweenη_(1) and Al matrix along the direction of[1010]_(η_(1))//[001]_(Al).Accordingly,a pathway for the formation ofη_(1) viaη_(1)’is demonstrated.Precipitatesη’together withη_(1) andη_(1)’contribute to the third DSC peak.With the further increase of temperature,ηprecipitates become prevailing.Based on the quantitative analyses,the influence of the heating rate and ending temperature on the cross section and number density of phases formed is discussed.Xingpu Zhang Xiaotong Deng Haofei Zhou Jiangwei Wang 2022Journal of Materials Science & Technology2022,,13:0
19MUC1 vaccines usingβ-cyclodextrin grafted chitosan(CS-g-CD)as carrier via host-guest interaction elicit robust immune responses显示文摘We construct MUC1 vaccines usingβ-cyclodextrin grafted chitosan(CS-g-CD)as carrier via host-guest interaction.These vaccines based on non-covalent assembling can provoke robust immune responses,including high level of specific antibodies and cytokines.The induced antibodies can specifically recognize tumor cells and mediate cytotoxicity against tumor cells.These results indicate that CS-g-CD with strong immunostimulatory activities can be a straightforward platform for peptide-based vaccine construction.Hangyan Yu Han Lin Yuntian Xie Mengyuan Qu Min Jiang Jie Shi Haofei Hong Hongrui Xu Ling Li Guochao Liao Zhimeng Wu Zhifang Zhou 2022Chinese Chemical Letters2022,33,11:0
20Microscopic pump-probe optical technique to characterize the defect of monolayer transition metal dichalcogenides显示文摘Monolayer transition metal dichalcogenides(TMDs)are ideal materials for atomically thin,flexible optoelec.tronic and catalytic devices.However,their optoelectrical performance such as quantum yield and carrier mobility often shows below theoretical expectations due to the existence of defects.For monolayer TMD-based devices,finding a low-cost,time-efficient, and nondestructive technique to visualize the change of defect distribution in the space domain and the defect-induced change of the carrier's lifetime is vital for optimizing their optoelectronic properties.Here, we propose a microscopic pump-probe technique to map the defect distribution of monolayer TMDs.It is found that there is a linear relationship between transient differential reflection intensity and defect density,suggesting that this technique not only realizes the visualization of the defect distribution but also achieves the quantitative estimation of defect density.Moreover,the carrier lifetime at each point can also be obtained by the technique. The technique used here provides a new route to characterize the defect of monolayer TMDs on the micro-zone, which will hopefiilly guide the fabrication of high-quality two-dimensional (2D) materials and the promotion of optoelectrical performance.Ying Yu Xiankun Zhang Zhangkai Zhou Zheng Zhang Yanjun Bao Haofei Xu Limin Lin Yue Zhang Xuehua Wang 2019Photonics Research2019,7,7:0
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