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| 1 | The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer显示文摘Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous cells1 that play crucial negative regulatory roles in immune-associated diseases,including infections,2 cancer,3 transplantation4,and autoimmunity.5 We and others have shown that mTOR signaling and its downstream metabolic pathways regulate MDSC recruitment and function in inflammation and autoimmunity. | Anna Jia Yuexin Wang Yufei Wang Yan Li Qiuli Yang Yejin Cao Ying He Lin Dong Yingjie Dong Yueru Hou Ruoning Wang Yujing Bi Guangwei Liu | 2021 | Cellular & Molecular Immunology2021，18，4： | 7 |
| 2 | Distribution,fractionation,and contamination assessment of heavy metals in offshore surface sediments from western Xiamen Bay,China显示文摘Surface sediment samples were collected at 21 offshore sites in western Xiamen Bay, Southeast China.Total concentrations of Li, V, Cr, Co, Ni, Cu, Zn, Sr, Mn,Pb, Ba, Fe, and Ti were determined by inductively coupled plasma-optical emission spectrometry; Hg was determined by atomic fluorescence spectrometry. A modified BCR sequential extraction procedure was used to extract fractions of the above elements. Concentrations of Pb, Cr, and Hg at most sites met the primary standard criteria of Marine Sediment Quality except site S12 for Pb and S7 for Cr, while concentrations of Zn at 17 sites and Cu at seven sites exceeded the criteria. The mean concentration of Hg was three times higher than the background, with a possible source being the Jiulong River. Fe, Ti, Ba, Co, V, and Li dominated the residual phase, mainly from terrestrial input.Ni, Cr, Pb, and Hg in the non-residual phase varied largely between sites. Sr, Mn, Cu, and Zn were mainly in the nonresidual fraction. Most sites showed considerable ecological risk; exceptions were site S7(very high) and sites S10,S11, and S14(moderate). Cu showed moderate-to-high pollution and Pb exhibited no-to-low pollution, while other metals had a non-pollution status according to their ratios of secondary phase to primary phase(RSP). Results of two assessment methods showed moderate pollution and a veryhigh ecological risk for Cu, Zn, Ni, and Cr at site S7, which might be due to the local sewage treatment plant. | Qiuli Yang Gongren Hu Ruilian Yu Haixing He Chengqi Lin | 2016 | Acta Geochimica2016，35，4： | 2 |
| 3 | Association of oxidative stress with the formation of reproductive toxicity from mercury exposure on hermaphrodite nematode Caenorhabditis elegans 显示文摘 | WU Qiuli HE Kewen LIU Peidang | 2011 | Environmental Toxicology and Pharmacology2011，32，2： | 1 |
| 4 | New agedetermination of the Cenozoic Lunpola basin, central Tibet 显示文摘 | He Huaiyu Sun Jimin Li Qiuli Zhu Rixiang | 2012 | Geol Mag2012，149，14： | 1 |
| 5 | On boundedness of the difference equation with period-k coefficients 显示文摘 | Taixiang Sun Hongjian Xi Qiuli He | 2011 | Applied Mathematics and Computation2011，217，1215： | 1 |
| 6 | On boundedness of the difference equation with period-k coefficients 显示文摘 | Sun Taixiang Xi Hongjian He Qiuli | 2011 | Xn--s+l Applied Mathematics and Computation2011，217，1215： | 1 |
| 7 | On boundedness of the difference equation with period-k coefficients显示文摘 | SUN Taixiang XI Hongjian HE Qiuli | | 0，，1215： | 1 |
| 8 | Crucial role of histone deacetylase SIRT1 in myeloid-derived suppressor cell-mediated reprogramming of CD4^(+) T-cell differentiation显示文摘Myeloid-derived suppressor cells(MDSCs)are heterogeneous,immature myeloid cells that inhibit the immune responses of T cells.1–5 MDSCs play a crucial role in infection,6,7 transplantation,8,9 autoimmune diseases10,11,and tumors12,13 by driving the differentiation of specific T-cell subsets,but the precise regulatory mechanism is still unclear.Recently,our results showed that SIRT1,a histone deacetylase,suppresses the functions of proinflammatory MDSCs and promotes tumor growth.14 However,it remains unclear whether SIRT1 regulates the MDSC-induced differentiation of T cells.Here,we identified the regulatory effects of SIRT1 in CD11b+Gr1+MDSCs on T-cell differentiation. | Lin Dong Yujing Bi Anna Jia Qing Yu Yuexin Wang Yufei Wang Qiuli Yang Yejin Cao Ying He Ruichen Liu Yan Li Guangwei Liu | 2020 | Cellular & Molecular Immunology2020，17，7： | 0 |
| 9 | Effect of TrκB-PLC/IP3 pathway on intestinal inflammatory factors and enterocyte apoptosis in mice with colitis显示文摘In this study,we aimed to explore the effect of TrκB-PLC/IP3 pathway on intestinal inflammatory factors and enterocyte apoptosis in mice with colitis.The mouse model of ulcerative colitis was established by medication,and 40 SPF C57BL/6J mice(8 weeks old)were randomly divided into normal group(healthy mice,n=10),control group(sham-operated mice,n=10),model group(model mice without any treatment,n=10),and K252a group(model mice treated with 100 pmol/kg TrκB-PLC/IP3 pathway inhibitor for 5 days before clysis,n=10).The results showed that mice in the model and K252a groups,as compared with normal and control groups,had no significant ch a nges in the levels and protein expressi ons of serum tumor necrosis factor-α(TNF-α)and TNF-γin the colo n tissues(P>0.05),and had a significant in crease in disease activity index,colon mucosa damage index,tissue damage index scores,and levels and protein expressions of serum interleukin-4(IL-4)and IL8,but had a significant decrease in the level and protein expression of serum lb10(P<0.05).Mice in the model and K252a groups showed blocked enterocyte cycle progression,elevated apoptosis ratio,and significantly in creased mRNA and protein expressi ons of Caspase3,Bax,FasL,and Fas,but significantly reduced mRNA and protein expressions of p-TrκB,PLC-γ1,IP3,and Bcl-2(P<0.05).Moreover,intestinal inflammation and apoptosis induced by colitis in the K252a group became more aggravated by inhibiting the activity of TrκB-PLC/IP3 pathway.In conclusi on,inhibiti on of TrκB-PLC/IP3 pathway can in crease the expressi on of in testinal inflammatory factors and promote enterocyte apoptosis in mice with colitis. | Guangmeng Xu Yajuan Sun Huaiqiang He Qiuli Xue Yajie Liu Lihua Dong | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 0 |
| 10 | Carbon–sulfur bond formation via photochemical strategies: An efficient method for the synthesis of sulfur-containing compounds显示文摘The development of green and convenient methods for C–S bond formation has received significant attention because C–S bond widely occurs in many important pharmaceutical and biological compounds.Recently, visible-light photoredox catalysis has been established as an efficient and general tool for the construction of C–C and C-heteroatom bonds. In this review, we have focused on the research on recent advances in C–S bond formation via visible-light photoredox catalysis, and the growing opportunities they present to the construction of complex chemical scaffolds for applications encompassing bioactive molecules synthesis, synthetic methodology development, and sulfur-containing drugs. We hope that this review will provide chemists with a synthetic tool that will open the door to further development of organsulfur chemistry. | Daoshan Yang Qiuli Yan Enjie Zhu Jian Lv Wei-Min He | 2022 | Chinese Chemical Letters2022，33，4： | 0 |
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