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| 1 | Microfossils and molecular records in oil shales of the Songliao Basin and implications for paleo-depositional environment显示文摘Several oil shale beds, over 10 m thick, occur at the base of the first member of the Upper Cretaceous Qingshankou Formation (K2qn1) in the Songliao Basin. They act both as excellent source rocks for conventional oil and as potential oil deposit for shale oil production. Here we combine micropaleon-tology with organic geochemistry to investigate the paleo-depositional environment and organic source characteristics of the oil shales and black shales. Our results indicate that algal remains are dominant microfossils in K2qn1 oil shales, and their relatively high abundance suggests a major algal thriving event during the oil shale deposition. The presence of fresh water and brackish water species, Sentusidinium, Vesperopsis and Nyktericysta, and marine or brackish water deltaic and lagoonal species such as Kiokansium and Dinogymniopsis demonstrate that this paleo-continental lake was influenced by marine transgressions at the time of K2qn1 oil shale formation. The extremely low pristine/phytane ratios, relatively high abundance of gammacerane and 4-methyl steranes, and low δ 13C values of C14-C37 n-alkanes in the oil shale organic extracts indicate the deposition of oil shales in anoxic and highly stratified water columns and the significant contribution of lacustrine algae to sedimentary organic matter. High molecular-weight paraffinic hydrocarbons with unusually high abundance of nC43, nC45, and nC47 may be related to special algal species associated with marine transgression events. The giant water body of Songliao paleo-lake and the change in the organic and chemical environment (such as nutrition source and water column salinity) associated with seawater transgression into the lake are among the most important reasons for oil shales in the Songliao Basin being different from mudstone and oil shale in other rifted basins. | FENG ZiHui FANG Wei WANG Xue HUANG ChunYan HUO QiuLi ZHANG JuHe HUANG QingHua ZHANG Lei | 2009 | Science China Earth Sciences2009，52，10： | 12 |
| 2 | Distribution and significance of C~_(40) alkanes in the extracts of Cretaceous source rocks from the Songliao Basin显示文摘Source rock extracts and crude oils from the Songliao Basin were analyzed by high-temperature gas chromatography (HTGC), gas chromatography-mass spectrometry (HTGC-MS) and gas chromatography-isotope ratio-mass spectrometry (GC-IRMS), for high molecular-weight alkanes. The distributions of n-alkanes in the Nenjiang Formation extracts are in the C14―C63 range; a bimodal distribution occurs in the C-21 and C21―40 regions. The C30―C37 n-alkanes are accompanied by C29―C35 hopanes, whereas the high molecular-weight C45―C47 n-alkanes co-occur with abundant isoalkanes, alkylcyclohexanes and alkylcyclopentanes. The high δ 13C values of the n-alkanes and the microscopic maceral compositions indicate a highly diversified organic source input for the Nenjiang Formation source rocks, ranging from aquatic plants, blue alge-bacteria, to land plant material. In contrast, n-alkanes in the rock extracts of the Qingshankou Formation are characterized by a single modal distribution, with relatively low abundances of C29―C35 hopanes, but high molecular-weight isoalkanes, alkylcyclohexanes and alkylcyclopentanes. The relatively low δ 13C values of C22―C44 n-alkanes and organic material compositions indicate that the source rocks in the Qingshankou Formation contain dominantly type I algal organic matter. The relative abundance of C+40 compounds in source rocks changes little at low maturity stage, but decreases drastically at higher maturity levels, with a concurrent reduction in the odd/even carbon predominance. In crude oils, in contrast, the relative abundance of C+40 compounds appears to relate closely with the oil source and oil viscosity. | FENG ZiHui FANG Wei ZHANG JuHe LI ZhenGuang HUANG ChunYan WANG Xue ZHAO QinLing HUO QiuLi | 2007 | Science China Earth Sciences2007，50，10： | 10 |
| 3 | Depositional environment of terrestrial petroleum source rocks and geochemical indicators in the Songliao Basin显示文摘To determine geochemical indicators for depositional environment favored by terrestrial petroleum source rocks, we selected 40 source rock samples from the Late Cretaceous Qingshankou Formation (K2qn) and the first member of Nenjiang Formation (K2n1) in the Songliao Basin to qualify saturate fraction and aromatic fraction using GC-HRT (gas chromatography high reso lution time-of-flight mass spectrometry) and quantify important biomarkers using GC-MS. The results reveal that source rocks from the 1st member of Qingshankou Formation (K2qn1) are characterized by not only high contents of terpanes, regular ster anes and 4-methylsteranes but also high contents of dinosteranes, C31 steranes and aryl isoprenoids. Presence of specific bi omarkers like elementary sulfur and lanostanes indicates a depositional environment of lagoon characterized by water stratifi cation and high salinity. In the 2nd-3rd members of Qingshankou Formation (K2qn2+3), source rocks contain lower contents of biomarkers, indicating a depositional environment of shallow fresh-water lake delta. Source rocks in the K2n1 contain high contents of terpanes, regular steranes and 4-methylsteranes but lower contents of dinosteranes, C31 steranes and aryl isopre noids, indicating a depositional environment of fresh-brackish open lake characterized by low salinity and poor water stratifi cation, where organic matter is seriously altered by bacteria. Overall analysis shows that primary geochemical indicators for terrestrial petroleum source rocks are as follows: 1) C30 hopanes > 1500 ppm; 2) gammacerane >190 ppm; 3) C27 steranes >200 ppm; 4) 4-methylsteranes >100 ppm; 5) aryl isoprenoids > 3 ppm; 6) dehydroxyl-vitamin E >10 ppm. | FENG ZiHui FANG Wei LI ZhenGuang WANG Xue HUO QiuLi HUANG ChunYan ZHANG JuHe ZENG HuaSen | 2011 | Science China Earth Sciences2011，54，9： | 6 |
| 4 | A Study of the Migration and Accumulation Efficiency and the Genesis of Hydrocarbon Natural Gas in the Xujiaweizi Fault Depression显示文摘摘要:为了在 Xujiaweizi 调查迁居和烃天然气的累积效率,并且为它的开始的分类提供新证据,指责消沉,在一个封闭系统的一个来源岩石热分解实验被设计并且执行了。基于这,为描述从有机物的产生和碳同位素分别在这期间处理的气体的运动模型被建立,校准然后外推到由联合 Xushen-1 的热历史数据很好的地质的条件。结果显示在 Xujiaweizi 差错消沉的煤措施是典型高效率的煤气的来源,从他们产生的天然气有高迁居和累积效率,并且因而,大规模天然气累积发生在区域。在 Xujiaweizi 差错消沉的高度 / 过去成熟的煤措施与高 13C1 价值产生 coaliferous 气体(>?20%) 在迟了的阶段,使碳成为器官的链烷气体的同位素作文反常地重。另外,通过天然气的 caprock 混合和驱散能导致否定的碳同位素顺序(13C1 > 13C2 > 13C3 > 13C4 ) 器官的链烷,气体,和驱散罐头也导致器官的链烷气体的反常地重的碳同位素作文。至于无机的 nonhydrocarbon 气体水库的发现,它能是仅仅服务一补助证据而非烃气体是无机的一条直接证据。作为结果,作为无机的气体在 Xujiaweizi 差错消沉分类烃天然气需要更充分的证据。 | LI Jijun LU Shuangfang XUE Haitao HUO Qiuli XU Qingxia | 2008 | Acta Geologica Sinica(English Edition)2008，82，3： | 5 |
| 5 | Challenges of Sustaining Malaria Community Case Management in 81 Township Hospitals along the China-Myanmar Border Region—Yunnan Province,China,2020显示文摘Summary What is already known on this topic?The health workforce at township hospitals in the China-Myanmar border region has played a key role in sustaining Community case management of malaria(CCMm),while few studies have investigated their performance and challenges.What is added by this report?Sustaining CCMm in the region was subject to the following major challenges. | Wei Ding Shenning Lu Qiuli Xu Xuejiao Ma Bei Wang Jingbo Xue Xiaodong Sun Jianwei Xu Chris Cotter Duoquan Wang Yayi Guan Ning Xiao | 2021 | China CDC weekly2021，3，17： | 0 |
| 6 | Effect of TrκB-PLC/IP3 pathway on intestinal inflammatory factors and enterocyte apoptosis in mice with colitis显示文摘In this study,we aimed to explore the effect of TrκB-PLC/IP3 pathway on intestinal inflammatory factors and enterocyte apoptosis in mice with colitis.The mouse model of ulcerative colitis was established by medication,and 40 SPF C57BL/6J mice(8 weeks old)were randomly divided into normal group(healthy mice,n=10),control group(sham-operated mice,n=10),model group(model mice without any treatment,n=10),and K252a group(model mice treated with 100 pmol/kg TrκB-PLC/IP3 pathway inhibitor for 5 days before clysis,n=10).The results showed that mice in the model and K252a groups,as compared with normal and control groups,had no significant ch a nges in the levels and protein expressi ons of serum tumor necrosis factor-α(TNF-α)and TNF-γin the colo n tissues(P>0.05),and had a significant in crease in disease activity index,colon mucosa damage index,tissue damage index scores,and levels and protein expressions of serum interleukin-4(IL-4)and IL8,but had a significant decrease in the level and protein expression of serum lb10(P<0.05).Mice in the model and K252a groups showed blocked enterocyte cycle progression,elevated apoptosis ratio,and significantly in creased mRNA and protein expressi ons of Caspase3,Bax,FasL,and Fas,but significantly reduced mRNA and protein expressions of p-TrκB,PLC-γ1,IP3,and Bcl-2(P<0.05).Moreover,intestinal inflammation and apoptosis induced by colitis in the K252a group became more aggravated by inhibiting the activity of TrκB-PLC/IP3 pathway.In conclusi on,inhibiti on of TrκB-PLC/IP3 pathway can in crease the expressi on of in testinal inflammatory factors and promote enterocyte apoptosis in mice with colitis. | Guangmeng Xu Yajuan Sun Huaiqiang He Qiuli Xue Yajie Liu Lihua Dong | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 0 |
| 7 | Brain-targeted polymersome codelivery of siRNA and temozolomide for effective glioblastoma chemo-RNAi synergistic therapy显示文摘Temozolomide (TMZ) is a clinically approved drug for glioblastoma (GBM) therapy. However, as a result of methylguanine-DNA-methyltransferase (MGMT), which is able to repair damaged DNA-damage repairing, TMZ usually yields unsatisfactory therapeutic effects. Small interfering RNA (siRNA) is a potential alteration tool for sensitivity of TMZ by targeting DNA repair enzymes. However, a suitable TMZ and siRNA codelivery system that can effectively and actively co-deliver siRNA/TMZ into the brain tumor is lacking. In this study, we constructed an angiopep-2 decorated polymersomal delivery system to co-deliver TMZ/siRNA for synergistic GBM therapy. This targeted polymersomal nanomedicine not only enhanced the circulation time of siRNA/TMZ in blood but also improved their blood-brain barrier (BBB) crossing and GBM targeting ability. Moreover, when we co-administered siRNAs specific to retinoblastoma binding protein 4 (RBBP4) together with TMZ in GBM cells, these RBBP4- specific siRNA (siRBBP4) modulated the sensitivity of TMZ by regulating MGMT, and thus showed a powerful synergistic anti-tumor effect. We demonstrated that angiopep-2 decorated polymersomal siRBBP4/TMZ co-loaded nanomedicines are capable of inhibiting tumor growth and significantly improved life expectancy of orthotropic GBM bearing mice. Overall, our study suggests that such a polymersomal TMZ/siRNA codelivery system provides a robust and potent nanoplatform for targeted GBM chemo-RNAi therapy. | Meng Zheng Chengnan Yan Qingshan Yang Feiyan Zhu Qiuli Du Xue Xia Marco Morsch Albert Lee Jinglong Yin Yan Zou Bingyang Shi | 2022 | ChemPhysMater2022，1，3： | 0 |
| 8 | China Ready for New Houses | Xue Qiuli Shanghai Jiaotong University | 1993 | China City Planning Review1993，10，1： | 0 |
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