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| 1 | Origin and accumulation of high-maturity oil and gas in deep parts of the Baxian Depression, Bohai Bay Basin, China显示文摘Great quantities of light oil and gas are produced from deep buried hill reservoirs at depths of 5,641 m to 6,027 m and 190 °C to 201 °C in the Niudong-1 Well, representing the deepest and hottest commercial hydrocarbons discovered in the Bohai Bay Basin in eastern China. This discovery suggests favorable exploration prospects for the deep parts of the basin. However, the discovery raises questions regarding the genesis and accumulation of hydrocarbons in deep reservoirs. Based on the geochemical features of the hydrocarbons and characteristics of the source rocks as well as thermal simulation experiments of hydrocarbon generation, we conclude that the oil and gas were generated from the highly mature Sha-4 Member (Es4 ) source rocks instead of thermal cracking of crude oils in earlier accumulations. The source kitchen with abnormal pressures and karsted carbonate reservoirs control the formation of high-maturity hydrocarbon accumulations in the buried hills (i.e., Niudong-1) in conjunction with several structural-lithologic traps in the Es4 reservoirs since the deposition of the upper Minghuazhen Formation. This means the oil and gas exploration potential in the deep parts of the Baxian Depression is probably high. | Zhao Xianzheng Jin Qiang Jin Fengming Ma Peng Wang Quan Wang Jing Ren Chunling Xi Qiuling | 2013 | Petroleum Science2013，10，3： | 10 |
| 2 | Emerging Views on the Overall Process Treatment of Municipal Domestic Waste for the Sustainable Use of Landfills in China显示文摘1.Introduction With the continuous improvement of living standards and the rapid development of urbanization,the annual production of municipal domestic waste in China has reached over 2108 t and is expected to increase in the future.Landfill technology,which is the main method for the traditional treatment of domestic waste,accounts for more than 60%of the total treatment in China.However,current single-landfill technologies have a series of problems(Fig.1(a)).First,recyclable resources within the vast amount of domestic waste often cannot be recycled and utilized,thereby causing resources to be wasted and deviated from sustainable cycles.Second,the amount of domestic waste that is decomposed and disposed of by landfill technology is considerably less than the amount entering landfill sites each year.Accordingly,a large area of valuable land must be developed for the construction of new landfill sites. | Wenbing Tan Beidou Xi Xinyu Zhao Qiuling Dang | 2020 | Engineering2020，6，7： | 4 |
| 3 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 4 | GM130 regulates pulmonary surfactant protein secretion in alveolar typeⅡcells显示文摘Pulmonary surfactant is a lipid-protein complex secreted by alveolar typeⅡepithelial cells and is essential for the maintenance of the delicate structure of mammalian alveoli to promote efficient gas exchange across the air-liquid barrier.The Golgi apparatus plays an important role in pulmonary surfactant modification and secretory trafficking.However,the physiological function of the Golgi apparatus in the transport of pulmonary surfactants is unclear.In the present study,deletion of GM130,which encodes for a matrix protein of the cis-Golgi cisternae,was shown to induce the disruption of the Golgi structure leading to impaired secretion of lung surfactant proteins and lipids.Specifically,the results of in vitro and in vivo analysis indicated that the loss of GM130 resulted in trapping of Sftpa in the endoplasmic reticulum,Sftpb and Sftpc accumulation in the Golgi apparatus,and an increase in the compensatory secretion of Sftpd.Moreover,global and epithelial-specific GM130 knockout in mice resulted in an enlargement of alveolar airspace and an increase in alveolar epithelial autophagy;however,surfactant repletion partially rescued the enlarged airspace defects in GM130-deficient mice.Therefore,our results demonstrate that GM130 and the mammalian Golgi apparatus play a critical role in the control of surfactant protein secretion in pulmonary epithelial cells. | Qianqian Pang Chunyi Liu Yulong Qiao Jian Zhao Sin Man Lam Mei Mei Guanghou Shui Shilai Bao Qiuling Li | 2022 | Science China(Life Sciences)2022，65，1： | 2 |
| 5 | Refractive-diffractive visual system for micro-display of LCOS显示文摘One head-mounted display visual system for computer entertainment and three-dimensional display of virtual-reality was achieved, which consists of a hybrid re-fractive-diffractive eyepiece and a relay reflector. It can be used in micro-display of liquid crystal on silicon (LCOS) diagonal of 18 mm. The whole system has better performance, with 60° field of view, 10 mm exit pupil, 23 mm eye relief, and reduces weight and size. | ZHAO Qiuling WANG Zhaoqi MU Guoguang LU Zhenwu | 2002 | Chinese Science Bulletin2002，47，16： | 1 |
| 6 | Hydrogen selenide,a vital metabolite of sodium selenite,uncouples the sulfilimine bond and promotes the reversal of liver fibrosis显示文摘Sodium selenite has alleviating effects on liver fibrosis;however,its therapeutic molecular mechanism remains unclear.Herein,hydrogen selenide,a major metabolite of Na_(2)SeO_(3),was tested to uncouple the sulfilimine bond in collagen IV,the biomarker of liver fibrosis.A mouse model of liver fibrosis was constructed via a CCl_(4)-induced method,followed by the administration of 0.2 mg kg−1 Na_(2)SeO_(3)via gavage three times per week for 4 weeks.Changes in H2Se,NADPH,and H_(2)O_(2)levels were monitored in real time by using NIR-H2Se,DCI-MQ-NADPH,and H_(2)O_(2)probes in vivo,respectively.H_(2)Se continuously accumulated in the liver throughout the Na_(2)SeO_(3)treatment period,but the levels of NADPH and H_(2)O_(2)decreased.The expression of collagen IV was analyzed through Western blot and liquid chromatography-mass spectrometry.Results confirmed that the sulfilimine bond of collagen IV in the fibrotic mouse livers could be broken by H2Se with the Na_(2)SeO_(3)treatment.Therefore,the therapeutic effect of Na_(2)SeO_(3)on liver fibrosis could be mainly attributed to H_(2)Se that uncoupled the sulfilimine bond to induce collagen IV degradation.This study provided a reasonable explanation for the molecular mechanism of the in vivo function of Na_(2)SeO_(3)and the prevention of liver fibrosis by administering inorganic selenium. | Dongrui Luan Zengteng Zhao Dandan Xia Qiuling Zheng Xiaonan Gao Kehua Xu Bo Tang | 2021 | Science China(Life Sciences)2021，64，3： | 1 |
| 7 | The Protein Arginine Methylase 5(PRMT5/SKB1) Gene Is Required for the Maintenance of Root Stem Cells in Response to DNA Damage显示文摘Plant root stem cells and their surrounding microenvironment,namely the stem cell niche,are hypersensitive to DNA damage.However,the molecular mechanisms that help maintain the genome stability of root stem cells remain elusive.Here we show that the root stem cells in the skbl(Shk1 kinase binding protein 1) mutant undergoes DNA damage-induced cell death,which is enhanced when combined with a lesion of the Ataxia-telangiectasia mutated(ATM) or the ATM/RAD3-related(ATR) genes,suggesting that the SKBI plays a synergistically effect with ATM and ATR in DNA damage pathway.We also provide evidence that SKBI is required for the maintenance of quiescent center(QC),a root stem cell niche,under DNA damage treatments.Furthermore,we report decreased and ectopic expression of SHORTROOT(SHR) in response to DNA damage in the skbl root tips,while the expression of SCARECROW(SCR) remains unaffected.Our results uncover a new mechanism of plant root stem cell maintenance under DNA damage conditions that requires SKB1. | Qiuling Li Yan Zhao Minghui Yue Yongbiao Xue Shilai Bao | 2016 | Journal of Genetics and Genomics2016，43，4： | 1 |
| 8 | Individual eye model based on wavefront aberration显示文摘 | Zhaoqi Wang Qiuling Zhao Wei Quan Yan Wang | 2004 | Optik2004，116，2： | 1 |
| 9 | State of China’s Climate in 2020显示文摘2020年,全国平均气温10.25°C,较常年偏高0.7°C;全国平均降水量694.8毫米,比常年偏多10.3%.总体上涝重于旱,夏季南方地区发生1998年以来最严重汛情,暴雨洪涝灾害重;干旱呈区域性阶段性特征,灾害损失偏轻;春夏季节转换早,高温出现早,极端性强,夏季南方高温持续时间长;登陆台风偏少,影响时段和地域集中;冷空气影响范围广,局地降温幅度大.与近十年平均值相比,气象灾害造成的农作物受灾面积和死亡失踪人口明显偏少,直接经济损失略偏多. | Wei Li Shanshan Zhao Yu Chen Qiuling Wang Wanxiu Ai | 2021 | Atmospheric and Oceanic Science Letters2021，14，4： | 1 |
| 10 | Study on Storage and Bourgeoning of Spruce Pollen显示文摘The effects of sucrose concentration,pH value and storage conditions on germination and pollen tube growth of in vitro cultured spruce were studied and the ingredients of culture medium were optimized.The results showed that the effect of sucrose concentration and pH value on spruce pollen’s germination was significant,and a clear threshold effect existed.Low or high concentration of sucrose was not conducive to the pollen’s germination,it was found that 10%of which was more suitable to the in vitro culture of spruce pollen; different spruce species required different concentrations of sucrose medium,7.5%of sucrose concentration medium was better to pollen tube germination of Picea asperata,but 10%of which was the best medium to that of Picea abies.Both pH 4.5 and 6.5 had restrained action on pollen germinating rate of spruce,and the growth of pollen tubes.Under dark culture conditions,P.abies began to germinate in 6 h,but P.asperata germinated in 8 h,the mass germinating power of P.abies was higher than that of P.asperata;the growth process of P.abies was 20-22 h,and that of P.asperata was about 16 h;The pollen tubes of P.abies was over 10 ?m longer in length than that of P.asperata. There were significant differences of germinating power and length of pollen tubes between genotypes of two different individuals of both spruces.The storage methods had great influence on the viability of pollen.In the process of pollen preservation, temperature was the key factor.Cryopreservation was better than cold storage and room temperature preservation was unfavorable. | Ma Jianwei Wang Junhui Zha Shounggong Zhao Qiuling Han Yunhua Zhang Zengshun | 2012 | Chinese Forestry Science and Technology2012，11，3： | 0 |
| 11 | On the applicability of the‘humic acids’nomenclature from natural ecosystems to engineering sciences显示文摘‘Humic acids(HA)’are the major constituents of natural organic matter(NOM)derived from the plant or biological residues by decomposition and synthesis in natural ecosystems.They have been defined as relatively high molecular weight aggregates of macromolecules associations with series of highly reactive functional compounds,and considered to be as irreplaceable roles(such as the impact on global carbon and nitrogen dynamics,atmosphere,living plants,chemically reactive and NOM structure stabilization)in natural ecosystems[1]. | Xinyu Zhao Beidou Xi Wenbing Tan Xiang Li Qiuling Dang Renfei Li | 2021 | Environmental Science and Ecotechnology2021，，2： | 0 |
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