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| 1 | SHRIMP zircon U-Pb dating for volcanic rocks of the Dasi Formation in southeast Hubei Province,middle-lower reaches of the Yangtze River and its implications显示文摘The Jinniu Basin in southeast Hubei,located at the westernmost part of middle-lower val-ley of the Yangtze River,is one of the important vol-canic basins in East China. Volcanic rocks in the Jin-niu Basin are distributed mainly in the Majiashan Formation,the Lingxiang Formation and the Dasi Formation,consisting of rhyolite,basalt and basaltic andesite,(trachy)-basalt and basaltic trachy-andesite and (trachy)-andesite and (trachy)-dacite and rhyolite respectively,in which the Dasi volcanism is volumet-rically dominant and widespread. The Dasi volcanic rocks were selected for SHRIMP zircon U-Pb dating to confirm the timing of volcanism. The results indi-cate that there exist a large amount of magmatic zir-cons characterized by high U and Th contents in the volcanic rocks. The concordia ages for 13 points are 128 ± 1Ma (MSWD = 3.0). On account of the shape of zircons and Th/U ratios,this age is considered to represent the crystallization time of the Dasi volcan-ism. The volcanic rocks in the Dasi,Majiashan and Lingxiang Formations share similar trace elementand REE partition patterns as well as Sr-Nd isotopic compositions. In combination with the regional geol-ogy,it is proposed that the southeast Hubei volcanic rocks were formed mainly during the Early Creta-ceous,just like other volcanic basins in middle-lower Yangtze valley. A lithospheric extension is also sug-gested for tectonic regime in this region in the Cre-taceous Period. | XIE Guiqing MAO Jingwen LI Ruiling ZHOU Shaodong YE Huishou YAN Quanren ZHANG Zusong | 2006 | Chinese Science Bulletin2006，51，24： | 38 |
| 2 | SHRIMP U-Pb zircon age of tuff from the Kunyang Group in central Yunnan:Evidence for Grenvillian orogeny in South China显示文摘Whether or not Grenvillian orogeny occurred in South China still remains highly controversial because high-quality,discriminating data are lacking,and therefore,the key to resolve this matter is to find datable volcanic and/or sedimentary rocks related to Grenvillian orogeny. Such rocks are apparently present in the Fuliangpeng Member from the lower-middle part of Kunyang Group in central Yunnan; here the unit is more than 100 m thick and consists of andesitic ignimbrite,tuffite,terrigeous clastic rocks and carbonates. These volcanic rocks,developed south of the Sibao fold-thrust belts,represent the earliest calc-alkaline volcanic activity in late Precambrian time from central Yunnan and are coeval with both a change in sedimentary facies from detritus to carbonates and the beginning of seismite development elsewhere. Two samples for SHRIMP analysis were collected from this volcanic unit. Sample G3-29-2,from the bottom of Fuliangpeng Member,is an ignimbrite,and about 100 zircon crys-tals recovered from it have euhedral shapes and display relatively simple sector zonation under cathodoluminescent (CL) imaging,suggesting a magmatogenic origin. Twenty-five of the zircons were analyzed and a weighed-mean U-Pb age of 1032±9 Ma was obtained. Sample G3-29-3 from uppermost part of Fuliangpeng Member is a tuffite,and many rounded,evidently detrital zircons were recovered. Nine of these zircons were analyzed,and the oldest single-grain U-Pb zircon age is 1938±26 Ma,im-plying that Paleoproterozoic basement developed in Cathaysia. The dating result,combined with the geotectonic research on the Fuliangpeng Member,leads us to conclude that late Mesoproterozoic orogenic volcanic activity occurred in the western part of South China,and that the related collision of Yangtze and Cathaysian cratons was an integral part of the assembly of Rodinia. | ZHANG ChuanHeng GAO LinZhi WU ZhenJie SHI XiaoYing YAN QuanRen LI DaJian | 2007 | Chinese Science Bulletin2007，52，11： | 35 |
| 3 | Re-Os and U-Pb Geochronology of the Erlihe Pb-Zn Deposit,Qinling Orogenic Belt,Central China,and Constraints on Its Deposit Genesis显示文摘The Erlihe Pb-Zn deposit is an important mine of the Pb-Zn metallogenic zone in the South Qinling Orogen.It has been considered a sedimentary exhalative deposit in previous investigations because the ore body occurs concordantly at the transitional location of an upright fold.Re and Os isotopic analyses for paragenetic pyrites with sphalerite and galena from the ore body have been used to determine the timing of mineralization and to trace the source of metallogenic materials.The Re-Os isotopic data of four pyrite samples construct an isochron,yielding a weighted average age of 226±17 Ma(mean square weighted deviation=1.7),which is considered the main mineralization age.A dioritic porphyrite vein sample,showing weaker mineralization,was also dated using the SHRIMP zircon UPb isotopic method to constrain the youngest metallogenic age of the ore deposit,because it distributes along a group of tensional joints cutting not only the upright fold in the deposit field,but also the main ore bodies.The dioritic porphyrite sample yields a weighted mean ^(206)Pb/^(238)U age of 221±3 Ma,which is slightly younger than the Re-Os isotopic isochron age of the pyrites,considered as the upper age limit of the mineralization,namely the ending age of the mineralization.The Os isotopic compositions of sulfide minerals distribute within a range between Os isotopic compositions of the crust and the mantle, indicating that the ore deposit can be derived from magma-related fluid,and the metallogenic materials are most likely derived from the mixing source of the crust and the mantle.The Erlihe Pb-Zn deposit and associated dioritic porphyrite vein,important records of Qinling tectonic-magmatism-mineralization activities,were formed during the Triassic collisional orogeny processes. | ZHANG Fan LIU Shuwen LI Qiugen SUN Yali WANG Zongqi YAN Quanren YAN Zhen | 2011 | Acta Geologica Sinica(English Edition)2011，85，3： | 30 |
| 4 | Ages of the Laocheng Granitoids and Crustal Growth in the South Qinling Tectonic Domain,Central China:Zircon U-Pb and Lu-Hf Isotopic Constraints显示文摘Laocheng granitoid pluton 位于 Qinling erogenic 带的南方 Qinling 构造领域,南部的 Shaanxi 省,并且由石英闪长岩, granodiorite 和 monzogranite 主要组成。LA-ICP-MS 锆石 U-Pb 与阴极射线发光图象一起,同位素的标明日期表明石英闪长岩和 granodiorite 是从 220 妈的 emplaced 到 216 妈,当 monzogranite 是在 210 妈的 emplaced 时。在原处,锆石 Hf 同位素的分析证明从 8.1 的石英闪长岩和到 +1.3 的 granodiorite 范围的 Hf (t)价值,和单个阶段的 Hf 从 809 妈为年龄建模到 1171 妈,当 monzogranite 的 Hf (t)价值是 14.5 到 +16.7 和单个阶段的 Hf 时,从 189 妈为年龄建模到 1424 妈。这些 Hf 同位素的特征表明石英闪长岩, granodiorite 和 monzogranite 从混合从弄空的披风和更低的大陆的部分融化导出的岩浆被形成外壳的材料,并且在 Neoproterozoic ( 800 妈)和 Indosinian ( 210 妈)期间有大陆人外壳生长的二个阶段分别地,时代在 Qinling orogrnic 的南方 Qinling 构造领域系上带子,华中。 | YANG Pengtao LIU Shuwen LI Qiugen ZHANG Fan WANG Zongqi WANG Dongsheng WANG Ruiting YAN Quanren YAN Zhen | 2011 | Acta Geologica Sinica(English Edition)2011，85，4： | 15 |
| 5 | Zircon U-Pb and geochemical analyses for leucocratic intrusive rocks in pillow lavas in the Danfeng Group,north Qinling Mountains,China显示文摘Field observation showed that there are many irregular leucocratic intrusive rocks in pillow lavas in the Danfeng Group in the Xiaowangjian area, north Qinling orogenic belt. Photomicrographs indicated that the protoliths of those altered leucocratic intrusive rocks are dioritic rocks. Geochemical analyses showed that pillow lavas have a range of SiO2 from 47.35% to 51.20%, low abundance of TiO2 from 0.97% to 1.72%, and percentages of MgO (MgO#=41―49). Chondrite-normalized REE patterns of pillow lavas are even, indicative of a weak differentiation between LREE and HREE (La/YbN=1.52―0.99). N-MORB-normalized trace element abundances showed that pillow lavas are enriched in incompatible elements (e.g., K, Rb, and Ba). Leucocratic intrusive rocks in pillow lavas have a wide range of SiO2 from 53.85%―67.20%, low abundances of TiO2 from 0.51%―1.10%, and MgO (MgO#=40―51), and higher percentages of Al2O3 (13.32%―16.62%) and concentration of Sr (342-539 μg/g), ratios of Na2O/K2O (2―7) and Sr/Y (17―28). Chondrite-normalized REE patterns of leucocratic intrusive rocks showed highly differentiation between LREE and HREE (La/YbN=12.26―19.41). N-MORB-normalized trace element abundances showed that leucocratic intrusive rocks are enriched in incompatible elements (e.g., K, Rb, and Ba), and significantly depleted in HFSE (e.g., Nb, Ta, Zr and Ti), indicative of a relationship to subduction. Isotopically, leucocratic intrusive rocks have a similar εNd(t) (+7.45―+13.14) to that of MORB (+8.8―+9.7), which indicates that those leucocratic intrusive rocks sourced from depleted mantle most likely. SHRIMP U-Pb analyses for zircon showed that those leucocratic intrusive rocks were formed at 442±7 Ma, yielding an age of subduction in the early Paleozoic in the north Qinling orogenic belt. | Yan QuanRen Chen JunLu Wang ZongQi Yan Zhen Wang Tao Li QiuGen Zhang ZongQing Jiang ChunFa | 2008 | Science China Earth Sciences2008，51，2： | 14 |
| 6 | Efficacy of platinum in advanced triple-negative breast cancer with germline BRCA mutation determined by next generation sequencing显示文摘Objective:To compare the efficacy of platinum-and non-platinum-based regimens as first-line treatment for advanced triple-negative breast cancer(TNBC)and analyze the relationship between their efficacy and BRCA gene status.Methods:Retrospectively analyze clinical data of 220 patients diagnosed pathologically with advanced TNBC and treated at the Department of Breast Oncology,Peking University Cancer Hospital from 2013 to 2018 and evaluate the efficacy of chemotherapy.A total of 114 patients had BRCA1/2 gene tested by next generation sequencing(NGS)using peripheral blood,and we analyzed the correlation between their efficacy and BRCA1/2 gene status.Results:Non-platinum-based chemotherapy(NPCT)was administered to 129 and platinum-based chemotherapy(PBCT)to 91 study patients.The clinical benefit rate(CBR)and median progression-free survival(PFS)were not statistically different between NPCT and PBCT groups.The median overall survival(OS)was 30.0 and 22.5 months for PBCT and NPCT group,respectively[P=0.090,hazard ratios(HR)=0.703].BRCA status was assessed in 114 patients,14 of whom had deleterious germline BRCA1/2(g BRCA)mutations(seven in each group).In PBCT group,the CBR was 85.7%and 35.1%for patients with and without deleterious g BRCA mutations,respectively(P=0.039).The median PFS were 14.9 and 5.3 months and median OS were 26.5 and 15.5 months for patients with and without deleterious g BRCA mutations,respectively(P=0.001,P=0.161,respectively).Patients in PBCT group had significantly greater rates of grade 3-4 anemia(5.5%vs.0%)and thrombocytopenia(8.8%vs.0%),whereas palmar-plantar erythrodysesthesia(12.4%vs.0%)and peripheral neuropathy(8.6%vs.1.1%)occurred more frequently in NPCT group.Conclusions:Platinum-based regimens are more effective in patients with deleterious g BRCA mutations,but no difference in patients without BRCA gene mutations,so non-platinum is an option in patients without BRCA gene mutations considering the toxicity and side effect.And we recommend that patients with advanced TNBC should have BRCA gene test. | Nan Wang Kun Li Wenfa Huang Weiyao Kong Xiaoran Liu Weijie Shi Feng Xie Hanfang Jiang Guohong Song Lijun Di Quanren Wang Jianjun Yu Huiping Li | 2020 | Chinese Journal of Cancer Research2020，32，2： | 7 |
| 7 | SHRIMP Zircon U-Pb and Molybdenite Re-Os Datings of the Superlarge Donggou Porphyry Molybdenum Deposit in the East Qinling,China,and Its Geological Implications显示文摘摘要:在东方 Qinling 铝带的东方部分定位了, Donggou 存款是在最近的年里发现的 superlarge 斑岩铝存款。作者执行了在 Donggou 铝存款的使矿物化的斑岩和矿石的高度精确的标明日期。Donggou 铝土的 A 类型花岗石斑岩标明日期的虾 U-Pb 锆石给了 112 楬瑡摥 ? 的形成岩石的年龄 ??????? | YE Huishou MAO Jingwen LI Yongfeng GUO Baojian ZHANG Changqing LIU Jun YAN Quanren LIU Guoyin | 2008 | Acta Geologica Sinica(English Edition)2008，82，1： | 6 |
| 8 | Indosinian Tectonic Setting of the Southern Yidun Arc: Constraints from SHRIMP Zircon Chronology and Geochemistry of Dioritic Porphyries and Granites显示文摘granitoid 和 dioritic 侵入的一个团在 southernYidun 弧,代表性的 Indosinian 侵入在 Daocheng 县和忧郁在之中包括 Dongco 和 Maxionggougranitoid 侵入被散布深渊侵入进弧火山岩的侵入接近 Xiangcheng 镇。Dongco 和 Maxionggou granitoid 侵入主要在于 ofporphyraceous monzogranites, megacryst monzogranites 和细晶岩花岗石。Xiangcheng hypabyssalintrusions 由 dioritic 斑岩主导地组成。224+-3 妈 and222+-3 妈的虾锆石年龄分别地为 Dongco granitoid 侵入和 Xiangcheng dioriticporphyries 被获得了。Xiongcheng dioritic 斑岩显示出计算碱的 geochemicalfeature,并且被更高的 Sr/Y 描绘比率,使干涸的 Nb, Ta, P 和 Ti,充实的 LILE,和更低的 epsilon_Nd (t)( 建议他们可能从显然是的披风来源岩浆被导出的 =-3.27), 由大陆污染了外壳的材料。然而, Dongco 和 Maxionggougranitoids 与一个 per-metaluminous 特征属于高钾的计算碱的系列,并且被更高的CaO/(西格马 FeO+MgO )和Al_2O_3/(西格马FeO+ MgO )描绘比率,更低( La/Yb ) _n andSr/Y 比率,使干涸的 Nb , Ta , Sr , P 和 Ti ,充实的 LILE ,和很低的 epsilon_Nd (t)( granitoids 可能从主要硬砂岩的大陆地壳材料的部分融化被导出的= -8.10),indicating 。Dongco 和 Maxionggou granitoids 的岩石成因论暗示在 Zongza 大陆块(ZCB ) 和 Yangtze 古地台(WMYZC ) 的西方的边缘之间有一个海洋的外壳。并且海洋的外壳平板在 Indosinian 时代期间向西代替 ducted,生产 anAndes 类型大陆在 WMSCC 的边缘的弧和背弧盆。然后,关上的海洋盆地和左首地侧面的碰撞发生在 ca。在 ZCB 和 WMYZC 之间的 224 马马,引起产生 theDongco 和 Maxionggou 侵入的 granitoid 岩浆的在背弧盆的沉积的部分融化。 | LIU Shuwen WANG Zongqi YAN Quanren LI Qiugen ZHANG Dehui | 2006 | Acta Geologica Sinica(English Edition)2006，80，3： | 6 |
| 9 | PhaseⅠdose-escalation and expansion study of PARP inhibitor,fluzoparib(SHR3162),in patients with advanced solid tumors显示文摘Objective:Fluzoparib(SHR3162)is a novel,potent poly(ADP-ribose)polymerases(PARP)1,2 inhibitor that showed anti-tumor activity in xenograft models.We conducted a phaseⅠ,first-in-human,dose-escalation and expansion(D-Esc and D-Ex)trial in patients with advanced solid cancer.Methods:This was a 3+3 phaseⅠD-Esc trial with a 3-level D-Ex at 5 hospitals in China.Eligible patients for DEsc had advanced solid tumors refractory to standard therapies,and D-Ex enrolled patients with ovarian cancer(OC).Fluzoparib was administered orally once or twice daily(bid)at 11 dose levels from 10 to 400 mg/d.Endpoints included dose-finding,safety,pharmacokinetics,and antitumor activity.Results:Seventy-nine patients were enrolled from March,2015 to January,2018[OC(47,59.5%);breast cancer(BC)(16,20.3%);colorectal cancer(8,10.1%),other tumors(8,10.1%)];48 patients were treated in the D-Esc arm and 31 in the D-Ex arm.The maximum tolerated dose(MTD)was 150 mg bid,with a half-life of 9.14 h.Grade 3/4 adverse events included anemia(7.6%)and neutropenia(5.1%).The objective response rate(ORR)was 30%(3/10)in patients with platinum-sensitive OC and 7.7%(1/13)in patients with BC.Among patients treated with fluzoparib≥120 mg/d,median progression-free survival(m PFS)was 7.2[95%confidence interval(95%CI),1.8-9.3]months in OC,9.3(95%CI,7.2-9.3)months in platinum-sensitive OC,and 3.5(range,2.0-28.0)months in BC.In patients with germline BC susceptibility gene mutation(g BRCAMut)(11/43 OC;2/16 BC),m PFS was 8.9 months for OC(range,1.0-23.2;95%CI,1.0-16.8)and 14 and 28 months for BC(those two patients both also had somatic BRCAMut).Conclusions:The MTD of fluzoparib was 150 mg bid in advanced solid malignancies.Fluzoparib demonstrated single-agent antitumor activity in BC and OC,particularly in BRCAMut and platinum-sensitive OC. | Huiping Li Rongrui Liu Bin Shao Ran Ran Guohong Song Ke Wang Yehui Shi Jihong Liu Wenjing Hu Fu Chen Xiaoran Liu Gairong Zhang Chuanhua Zhao Ru Jia Quanren Wang Hope S.Rugo Yifan Zhang Guangze Li Jianming Xu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 4 |
| 10 | Equilibrium between Clinopyroxene and Host Rocks:Implication for the Magmatic Source and Evolution of Alkali Basalts of the Taohekou Formation in the Northern Daba Mountains,China显示文摘Taohekou 形成是在北 Daba 山在早志留纪形成的一个暴烈沉积的岩层,中国。与主导的碱暗岩和次要的披风捕虏体,暴烈的岩石在 clinopyroxene 斑晶被充实。Geochemical 分析证明从不同岩相的 clinopyroxenes 的作文有一种靠近的亲密关系。从到 amygdaloidal 暗岩的粗糙的斑状的暗岩,枕头或好斑状的暗岩有在 clinopyroxenes (包括的斑晶, microcrystal 和 xenocryst ) 的作文在场的班机关联。所有 clinopyroxenes 除了在披风捕虏体的 clinopyroxenes,显示出踪迹元素和 REE 的一个类似的模式,它显示他们是从血缘的岩浆的连续部分结晶化的可能的产品。然而,在披风捕虏体的 Clinopyroxenes 是披风 xenocrysts。clinopyroxenes 的结晶化压力逐渐地从披风捕虏体,深层的 xenocryst,粗糙的 porphritic 暗岩,枕头或好 porphritic 暗岩减少,到 amygdaloidal 暗岩,它分别地是 1.924.41 GPa, 1.182.36 GPa, 1.132.05 GPa, 0.440.62 GPa 和 0.140.28 GPa。计算结果建议主要岩浆比 68 km 深从一个披风区域发源并且在 3768 km, 1520 km 和 59 km 的间隔停滞在期间它的上升。碱暗岩被增加 Si 的集中描绘并且与 magmatic 进化碱。同时,他们显著地在 LREE 被充实,并且踪迹元素和 REE 的模式类似于海洋的岛暗岩的那些。 | XIANG Zhongjin YAN Quanren YAN Zhen WANG Zongqi WANG Tao ZHANG Yingli QIN Xiaofeng | 2011 | Acta Geologica Sinica(English Edition)2011，85，1： | 3 |
| 11 | Discovery of late Paleozoic fossils in tectonic blocks of the Dabao Formation in the South Qinling Orogenic Belt and their significance显示文摘The Dabao Formation in the South Qinling Orogenic Belt was previously regarded as Ordovician in age and consists of clastic matrix and blocks of siltstone,limestone,chert,and volcanic rocks.However,some Middle Devonian corals,conodonts,and other fossil fragments within the limestone blocks were discovered in recent field investigations,indicating that the Dabao Formation was formed during late Paleozoic.Combined with other regional geological data,the Dabao Formation in the Southern Qinling Orogenic Belt is considered to be a late Paleozoic or early Mesozoic accretionary complex. | WANG Tao WANG ZongQi YAN Zhen YAN QuanRen ZHANG YingLi XIANG ZhongJin | 2011 | Science China Earth Sciences2011，54，7： | 3 |
| 12 | Devonian Sedimentary Environments and Provenance of the Qinling Orogen: Constraints on Late Paleozoic Southward Accretionary Tectonics of the North China Craton显示文摘 | Zhen Yan Zongqi Wang Quanren Yan Tao Wang Wenjiao Xiao Jiliang Li Fanglin Han Junlu Chen Yongcheng Yang | 2006 | International Geology Review2006，，7： | 1 |
| 13 | Polymorphisms of the maternal Slug gene in fetal neural tube defects in a Chinese population显示文摘Several studies have demonstrated that Slug, which encodes a zinc finger of the Snail family of transcription factors, is a potential risk factor for neural tube defects. Neural tube defects tend to occur with a high rate in Shanxi province, China. The present case-control study investigated genotypic distributions and allele frequencies of Slug C1548A polymorphisms in DNA samples from 59 women with a history of neural tube defect pregnancies and 73 controls during the same period from Shanxi Province, China. Results demonstrated that women with a history of neural tube defect pregnancies had significantly greater genotypic distributions of Slug AA genotypes and A allele frequencies compared with controls, and A allele Slug C1548A was a risk factor for neural tube defects (odds ratio = 3.444; 95% confidence interval: 2.021-5.868, P < 0.05). Three-dimensional structure prediction revealed that Slug C1548A resulted in transition of aspartic acid into glutamate at position 119. This indicated that these mutations could lead to damaged protein structure and function. These findings suggest that Slug C1548A gene polymorphism is closely related to neural tube defects in a population of Han Chinese origin from Shanxi Province, | Li Guo Hong Zhao Yuheng Pei Quanren He Wan-I Li Ting Zhang Xiaoying Zheng Ran Zhou Jun Xie | 2010 | Neural Regeneration Research2010，5，17： | 1 |
| 14 | Synthesis of Nafion^(■)-stabilized Pt nanoparticles to improve the durability of proton exchange membrane fuel cell显示文摘Nafion-stabilized Pt nanoparticle colloidal solution is synthesized through ethylene glycol reduction.Pt/Nafion added with carbon black as electric conduction material(labeled Pt/Nafion-XC72) shows excellent electrochemical property compared with Pt/C.After a 300-cycle discharging durability test,the cell performance of membrane electrode assembly(MEA) with the Pt/Nafion-XC72 and Pt/C catalysts indicates a 29.9% and 92.2% decrease,respectively.The charge transfer resistances of Pt/Nafion-XC72 and Pt/C increase by 27.2% and 101.9%,respectively.The remaining electrochemically active surface area of Pt is about 61.7% in Pt/Nafion-XC72 and about 38.1% in Pt/C after the durability test.The particle size of Pt/C increases from about 5.1 nm to about 10.8 nm but only from 3.6 nm to 5.8 nm in the case of Pt/Nafion-XC72.These data suggest that Pt/Nafion-XC72 as a catalyst can enhance the durability of PEMFCs compared with Pt/C. | Xin Sun Hongfeng Xu Quanren Zhu Lu Lu Hong Zhao | 2015 | Journal of Energy Chemistry2015，24，3： | 1 |
| 15 | ANALYSIS ON THERMAL ELASTO-PLASTIC ASPERITY CONTACTS OF LAYERED MEDIA显示文摘A thermal elasto-plastic asperity contact model is investigated,which takes into account the steady-state heat transfer and the asperity distortion due to thermal elasto-plastic deformations.A hard coating and a soft coating are applied to study the correlations between contact area and contact pressure,average gap and contact pressure,coating thickness and contours of the contact stress distribution,etc.The effects of material properties,coating thickness,frictional coefficient,and the heat input combinations on the stress distribution are investigated and discussed.The frictional heat input increases the maximum value of von Mises stress.Finally,the appropriate thickness of the hard coating is also discussed.To protect the substrate,one can choose hard coating and the thickness of that is suggested that can be h_c=70 R_m. | TONG Ruiting LIU Geng ZENG Quanren LIU Tianxiang | 2008 | Chinese Journal of Mechanical Engineering2008，21，2： | 1 |
| 16 | Brain stem global gene expression profiles in human spina bifida embryos显示文摘Environmental and genetic factors influence the occurrence of neural tube defects, such as spina bifida. Specific disease expression patterns will help to elucidate the pathogenesis of disease. However, results obtained from animal models, which often exhibit organism specificity, do not fully explain the mechanisms of human spina bifida onset. In the present study, three embryos with a gestational age of approximately 17 weeks and a confirmed diagnosis of spina bifida, as well as 3 age-matched normal embryos, were obtained from abortions. Fetal brain stem tissues were dissected for RNA isolation, and microarray analyses were conducted to examine profiles of gene expression in brain stems of spina bifida and normal embryos using Affymetrix HG-U133A 2.0 GeneChip arrays. Of the 14 500 gene transcripts examined, a total of 182 genes exhibited at least 2.5-fold change in expression, including 140 upregulated and 42 downregulated genes. These genes were placed into 19 main functional categories according to the Gene Ontology Consortium database for biological functions. Of the 182 altered genes, approximately 50% were involved in cellular apoptosis, growth, adhesion, cell cycle, stress, DNA replication and repair, signal transduction, nervous system development, oxidoreduction, immune responses, and regulation of gene transcription. Gene expression in multiple biological pathways was altered in the brain stem of human spina bifida embryos. | Hong Zhao Xiang Li Wan-I Li Quanren He Ting Zhang Xiaoying Zheng Ran Zhou JunXie | 2011 | Neural Regeneration Research2011，6，5： | 0 |
| 17 | ROLLING MILL SYSTEM DYNAMIC DESIGN显示文摘It is studied how the aluminum foil chatter mark is produced and controlled The stableness of hydraulic AGC system,fluid vibration of capsule system,and electromechanical coupling of AC/AC VVVF system and de coupling are also studied It is shown that rolling mill design should go to system dynamic design from traditional design The framed drawing of system dynamic design program is presented. | Li Mouwei, Liu Hongfei, Zhang Yang, Zhao Yongzhong (College of Mechanical Engineering,University of Science and Technology Beijing) Wany Yide, Li Aiqun, Pei Quanren (Taiyuan Iron and Steel(Group)Ltd.) Zhao Liangmo, Zou Lihe, Zhou Binsheng (Northeast Light | 2001 | Chinese Journal of Mechanical Engineering2001，14，4： | 0 |
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