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| 1 | A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir显示文摘oseltamivir 的使用,广泛地是的 stockpiled 为在可能的鸟的流行性感冒的使用的药之一流行,被报导了与 neuropsychiatricdisorders 和严重皮肤反应被联系,首先在日本。这里,我们在 dbSNP 数据库识别了非同义的 SNP (单个核苷酸多型性) , R41Q 在 humancytosolic sialidase 的酶的活跃地点附近,是 oseltamivir 的目标的病毒 neuraminidase 的一个相当或相同事物。在欧洲、非洲的美国人口的 9.29% 亚洲人口和没有的这 SNPoccurred。Ourstructural 分析和 Ki 大小使用试管内 sialidase 试金显示这 SNPcould 增加人的 sialidase 的非计划中的有约束力的亲密关系到 oseltamivir 羧化物, oseltamivir 的活跃形式,因此减少 sialidase 活动。另外,这 SNP 自己与一项内在地更低的 sialidase 活动导致酶,由它的增加的 Km 证明 Vmax 珍视并且减少。理论上,到有这 SNP 的人的 oseltamivir 的管理可能进一步减少他们的 sialidase 活动。我们注意 oseltamivir 的 reportedneuropsychiatric 副酌和人的 sialidase-relateddisorders 的已知的症状的类似。我们建议这个充实亚洲人的 sialidase 变化由 SNP 引起了,在同型结合的形式可能,可以与对 oseltamivir 的某些严重不利反应被联系。 | Chuan-Yun Li Quan Yu Zhi-Qiang Ye Ying Sun Quanyuan He Xiao-Mo Li Wuxue Zhang Jingchu Luo Xiaocheng Gu Xiaofeng Zheng Liping Wei | 2007 | Cell Research2007，17，4： | 5 |
| 2 | Dataset of the plasma membrane proteome of nasopharyngeal carcinoma cell line HNE1 for uncovering protein function显示文摘鼻咽的癌(NPC ) 是在南部的中国和东南亚洲的一个通常发生的肿瘤。当前的学习集中了于为 NPC 房间线 HNE1 的外部、不可分的蛋白质开发一个广泛的分析方法。外部膜蛋白质被 biotinylated 丰富提取, 0.1 M Na 2 公司 3, 和 H 2 O。不可分或全部的血浆膜部分用 30% Percoll 密度等级 centrifugation 被准备与或没有 0.1 M Na 2 公司 3 处理并且由西方的污点分析评估了。蛋白质受到与双人脚踏车团 spectrometry,与双人脚踏车团 spectrometry 相结合的钠 dodecyl sulfate-polyacrylamide 胶化电气泳动,和猎枪分析相结合的二维的电气泳动。我们分别地从外部、不可分、全部的血浆膜部分识别了 371, 180,和 702 蛋白质。总共, 848 非冗余的蛋白质(534 个组) 被识别。有约束力、催化、结构的分子是主要的班。除了 NPC 房间的已知的房间表面标记,分析在癌症房间是特征的疾病小径揭示了涉及多重发信号房间的小径的 311 蛋白质和 25 蛋白质。由寻找,差别表示了蛋白质数据库(http://gffzze0f623e48f094866hxxuoqpukbxvo6kx9.ffgz.tsg.suse.edu.cn/depd/index.jsp ) , 199 蛋白质被发现是在以前的癌症 proteome 研究表示的差别。671 蛋白质蛋白质相互作用网络被获得,包括在这个工作的 178 识别蛋白质。五蛋白质的血浆膜本地化被免疫学的技术证实,验证这 proteomic 策略。我们的学习能为理解 NPC 的分子的机制提供一些帮助。 | Lijun Zhang Xiaofang Jia Xiaohui Liu Tingting Sheng Rui Cao Quanyuan He Zhen Liu Xia Peng JixianXiong Pengfei Zhang Ni Shi Songping Liang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，1： | 5 |
| 3 | An Overview of Mineral Processing in China显示文摘The latest progress in mineral processing in China is described. It is also pointed out that the existing techno- logy can not meet the needs of economic development. The combined challenges of poor resources, economical benefits and environmental pollution issues require further research to upgrade the separation efficiency economically. The methods of mineral processing should play a more important pod in waste treatment such as wastewater treatment, the re- mediation of contaminated soil and the recycling of wastes. Biomineral technology will be utilised in the near future. | Quanyuan Chen, Jingshen Zhang, Dianzuo Whng (Changsha Research Institute of Mining and Metallurgy, Changsha 410012, China General Research Institute for Nonferrous Metals, Beijing 100088, China) | 2001 | Rare Metals2001，20，2： | 2 |
| 4 | Synthesis and properties of soluble polyimides based on isomeric ditrifluoromethyl substituted 1,4-bis (4-aminophenoxy) benzene显示文摘 | Qiu Zhiming Wang Junhua Zhang Quanyuan | 2006 | Polymer2006，47，26： | 1 |
| 5 | al: Synthesis and properties of soluble polyimides based on isomeric ditriflu- oromethyl substituted 1,4-bis (4-aminophenoxy) benzene 显示文摘 | Zhiming Qiu Junhua Wang Quanyuan Zhang et | 2006 | Polymer2006，47，26： | 1 |
| 6 | Development and characterization of co‐polyimide/attapulgite nanocomposites with highly enhanced thermal and mechanical properties显示文摘 | Ying Zhang Jie Shen Qing Li Zushun Xu Kelvin W. K. Yeung Changfeng Yi Quanyuan Zhang | 2014 | Compos2014，，1： | 1 |
| 7 | Synthesis and Properties of Novel Organosoluble Polyimides Derived from 1,4 - Bis triptycene Dianhydride and Various Aromatic Diamines显示文摘 | Quanyuan Zhang Shenghai Li Wenmu Li | 2007 | Polymer2007，48，： | 1 |
| 8 | LinuxDirector: A Connection Director for Sealable Internet Services显示文摘 | Zhang Wensong Jin Shiyao Wu Quanyuan | 2000 | Journal of Computer Science and Technology2000，15，56： | 1 |
| 9 | Linux virtual server:Server clustering for scalable network services显示文摘 | Zhang W Jin S Wu Quanyuan | 2000 | Beijing:Proceeding of World Congress Conference2000，9，7： | 1 |
| 10 | Synthesis and properties of novel organosoluble polyimides derived from 1, 4-bis 1-4-(3,4-dicarboxylphenoxy)] triptycene dianhydride and various aromatic diamines 显示文摘 | Zhang Quanyuan Li Shenghai Zhang Suobo | 2007 | Polymer2007，48，： | 1 |
| 11 | Genomic sequence comparison, promoter activity, SNP detection of RIG-I gene and association with resistance/susceptibility to grass carp reovirus in grass carp ( Ctenopharyngodon idella )显示文摘 | Quanyuan Wan Jianguo Su Xiaohui Chen Chunrong Yang Lijun Chen Nana Yan Yixuan Zhang | 2012 | Developmental and Comparative Immunology2012，，： | 1 |
| 12 | Synthesis and Gas Transport Property of Polyimide from 2 2'-Disubstituted Biphenyltetraearboxylic Dianhydrides (BPDA) 显示文摘 | Zhiming Qiu Guang Chen Quanyuan Zhang | 2007 | European Polymer Journal2007，43，： | 1 |
| 13 | Application of accelerated carbonation with a combination of Na2CO3 and CO2 in cement-based solidification/stabilization of heavy metal-bearing sediment 显示文摘 | Chen Quanyuan Ke Yujuan Zhang Lina | 2009 | Journal of Hazardous Materials2009，166，： | 1 |
| 14 | 显示文摘 | Zhang Quanyuan Li Shenghai Li Wenmu | 2007 | Polymer2007，48，： | 1 |
| 15 | Bend family proteins mark chromatin boundaries and synergistically promote early germ cell differentiation显示文摘Understanding the regulatory networks for germ cell fate specification is necessary to developing strategies for improving the efficiency of germ cell production in vitro.In this study,we developed a coupled screening strategy that took advantage of an arrayed bi-molecular fluorescence complementation(BiFC)platform for protein-protein interaction screens and epiblast-like cell(EpiLC)-induction assays using reporter mouse embryonic stem cells(mESCs).Investigation of candidate interaction partners of core human pluripotent factors OCT4,NANOG,KLF4 and SOX2 in EpiLC differentiation assays identified novel primordial germ cell(PGC)-inducing factors including BEN-domain(BEND/Bend)family members.Through RNA-seq,ChIP-seq,and ATAC-seq analyses,we showed that Bend5 worked together with Bend4 and helped mark chromatin boundaries to promote EpiLC induction in vitro.Our findings suggest that BEND/Bend proteins represent a new family of transcriptional modulators and chromatin boundary factors that participate in gene expression regulation during early germline development. | Guang Shi Yaofu Bai Xiya Zhang Junfeng Su Junjie Pang Quanyuan He Pengguihang Zeng Junjun Ding Yuanyan Xiong Jingran Zhang Jingwen Wang Dan Liu Wenbin Ma Junjiu Huang Zhou Songyang | 2022 | Protein & Cell2022，13，10： | 1 |
| 16 | Synthesis and properties of novel organosoluble polyimides derived from 1,4-bistriptycene dianhy- dride and various aromatic diamines显示文摘 | Zhang Quanyuan Li Shenghai Li Wenmu | 2007 | Polymer2007，48，21： | 1 |
| 17 | Linux Virtual Server: Server Clustering for Scalable Network Services显示文摘 | Zhang W Jin S Wu Quanyuan | 2000 | Beijing: Proceeding of World Congress Conference 20002000，9，7： | 1 |
| 18 | Synthesis and properties of novel organosoluble polyimides derived from 1,4- bis14-93,4-diearboxylphenoxy:triptycene dianhydride and va- rious aromatic diamines显示文摘 | Zhang Quanyuan I i Shenghai Li Wenmu | 2007 | Polymer2007，48，21： | 1 |
| 19 | Synthesis and properties of soluble polyimides based on isomeric ditriflu- oromethylsubstitutedl, 4-bis(4-aminophenoxy) benzene显示文摘 | Qiu Zhiming Wang Junhua Zhang Quanyuan | 2006 | Pol- ymer2006，47，26： | 1 |
| 20 | LinuxDirector:A connection director for scalable Internet services显示文摘 | ZHANG Wensong JIN Shiyao WU Quanyuan | | 0，，06： | 1 |
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