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146篇 您的检索式：作者名="Quehenberger"

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	题名	作者	年代	出处	被引量
1	Tissue factor exposing microparticles in inflammatory bowel disease显示文摘	Julia Palkovits Gottfried Novacek Marietta Kollars Gregor Hron Wolf Osterode Peter Quehenberger Paul Alexander Kyrle Harald Vogelsang Walter Reinisch Pavol Papay Ansgar Weltermann	2012	Journal of Crohn’s and Colitis2012，，：	2
2	AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer.	Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger	2019	Cell Research2019，29，7：	2
3	Hemodynamic and oxygenation profiles in the early period after hyperbaric oxygen therapy:an observational study of intensivecare patients显示文摘	Ratzenhofer-Komenda B Offner A Quehenberger F	2003	Acta Anaesthesiol Scand2003，47，5：	1
4	Leptin induces endothelin-1 in endothelial ceils in vitro 显示文摘	Quehenberger P Exner M Sunder-Plassmann R et at	2002	Circ Res2002，90，6：	1
5	Validation of a novel tissue factor assay in experimental human endotoxemia显示文摘	QUEHENBERGER P MACKMAN N	2003	Thromb Res2003，111，45：	1
6	Endothelin 1 tran-scription is controlled by nuclear factor-kB in AGE-stimulated cul-tured endothelial cells 显示文摘	P Quehenberger Bierhaus A Fasching P	2000	Diabetes2000，49，9：	1
7	Evaluation of formalin-free tissue fixation for RNA and microRNA studies 显示文摘	Arzt L Kothmaier H Quehenberger FH	2011	Exp Mol Pathol2011，91，2：	1
8	Hemodynamic and oxygenation profiles in the early period after hyperbaric oxygen therapy: an observational study of intensive-care patients显示文摘	Ratzenhofer-Komenda B Offner A Quehenberger F	2003	Acta Anaesthesiol Scand2003，47，5：	1
9	Long-term results of nephron-sprig surgery for renal cell carcinoma in 114 patients:risk factors for progressive disease显示文摘	Zigeuner R Quehenberger F Pummer K	2003	BJU Int2003，92，6：	1
10	Endothelin 1 transcription is controlled by nuclear factor-kappaB in AGE- stimulated cultured endothelial cells显示文摘	Quehenberger P Bierhaus A Fasching P	2000	Diabetes2000，49，：	1
11	Leptin induces endothelin-1 in endothelial cells in vitro显示文摘	Quehenberger P Exner M Sunder P R	2002	Cire Res2002，90，：	1
12	Lipidomics analysis of essential fatty acids in macrophages显示文摘	Quehenberger O Armando A Dumlao D	2008	Prostaglandins Leukot Essent Fatty Acids2008，79，35：	1
13	Minimally oxidized LDL offsets the apoptotic effects of extensively oxidized LDL and flee cholesterol in macrophages 显示文摘	Boullier A Li Y Quehenberger O	2006	Arterioscler Thromb Vasc Biol2006，26，5：	1
14	Long-term results of nepphron-sparing surgery for renal carcinoma in 114 patients:risk factors for progressive disease显示文摘	Zigetmer R Quehenberger F Pummer K	2003	BJU Int2003，92，6：	1
15	Whole body hyperthermia treatment increases interleukin 10 and toU-like receptor 4 expression in patients with ankylosing spondylitis: a pilot study显示文摘	Zauner D Quehenberger F Hermann J	2014	Int J Hyperthermia2014，30，6：	1
16	Dis tal ureterectomy is a safe surgical option in patients with urothe- lial carcinoma of the distal ureter显示文摘	DALPIAZ O EHRLICH G QUEHENBERGER F	2014	Urol Oncol2014，32，：	1
17	Evaluation of formalin-free tissue fixation for RNA and microRNA studies显示文摘	Arzt L Kothmaier H Quehenberger F	2011	Exp Mol Pathol2011，91，2：	1
18	Adjuvant radiotherapy in male breast cancer显示文摘	STRANZL H MAYER R QUEHENBERGER F	1999	Radiother Oncol1999，53，1：	1
19	Endothelin 1 transcription is controlled by nuclear factor-kappa B in AGE-stimulated cultured endothelial cells显示文摘	Quehenberger P Bierhaus A Fasching P	2000	Diabetes2000，49，：	1
20	Endothelin 1 transcription is controlled by nuclear factor-kappaB in AGE-stimulated cultured endothelial cells显示文摘	Quehenberger P Bierhaus A Fasching P		0，，：	1

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