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| 1 | WJD 5^(th) Anniversary Special Issues(3): Type 1 diabetes Distinct clinical and laboratory characteristics of latent autoimmune diabetes in adults in relation to type 1 and type 2 diabetes mellitus显示文摘Ever since its first appearance among the multiple forms of diabetes,latent autoimmune diabetes in adults(LADA),has been the focus of endless discussions concerning mainly its existence as a special type of diabetes.In this mini-review,through browsing important peer-reviewed publications,(original articles and reviews),we will attempt to refresh our knowledge regarding LADA hoping to enhance our understanding of this controversial diabetes entity.A unique combination of immunological,clinical and metabolic characteristics has been identified in this group of patients,namely persistent islet cell antibodies,high frequency of thyroid and gastric autoimmunity,DR3 and DR4 human leukocyte antigen haplotypes,progressive loss of beta cells,adult disease onset,normal weight,defective glycaemic control,and without tendency to ketoacidosis.Although anthropomorphic measurements are useful as a first line screening,the detection of C-peptide levels and the presence of glutamic acid decarboxylase(GAD)autoantibodies is undoubtedly the sine qua non condi-tion for a confirmatory LADA diagnosis.In point of fact,GAD autoantibodies are far from being solely a biomarker and the specific role of these autoantibodies in disease pathogenesis is still to be thoroughly studied.Nevertheless,the lack of diagnostic criteria and guidelines still puzzle the physicians,who struggle between early diagnosis and correct timing for insulin treatment. | Elena Pipi Marietta Marketou Alexandra Tsirogianni | 2014 | World Journal of Diabetes2014，5，4： | 11 |
| 2 | Germline MLH1 and MSH2 mutational spectrum including frequent large genomic aberrations in Hungarian hereditary non-polyposis colorectal cancer families:Implications for genetic testing显示文摘AIM: To analyze the prevalence of germline MLH1 and MSH2 gene mutations and evaluate the clinical characteristics of Hungarian hereditary non-polyposis colorectal cancer (HNPCC) families. METHODS: Thirty-six kindreds were tested for mutations using conformation sensitive gel electrophoreses, direct sequencing and also screening for genomic rearrangements applying multiplex ligation-dependent probe amplifi cation (MLPA). RESULTS: Eighteen germline mutations (50%) were identifi ed, 9 in MLH1 and 9 in MSH2. Sixteen of these sequence alterations were considered pathogenic, the remaining two were non-conservative missense alterations occurring at highly conserved functional motifs. The majority of the defi nite pathogenic mutations (81%, 13/16) were found in families fulfilling the stringent Amsterdam Ⅰ/Ⅱ criteria, including three rearrangements revealed by MLPA (two in MSH2 and one in MLH1). However, in three out of sixteen HNPCC-suspected families (19%), a disease-causing alteration could be revealed. Furthermore, nine mutations described here are novel, and none of the sequence changes were found in more than one family.CONCLUSION: Our study describes for the f irst time the prevalence and spectrum of germline mismatch repair gene mutations in Hungarian HNPCC and suspected-HNPCC families. The results presented here suggest that clinical selection criteria should be relaxed and detection of genomic rearrangements should be included in genetic screening in this population. | Janos Papp Marietta E Kovacs Edith Olah | 2007 | World Journal of Gastroenterology2007，13，19： | 9 |
| 3 | Characterization and Genetic Analysis of a Light-and Temperature-sensitive Spotted-leaf Mutant in Rice显示文摘A rice spotted-leaf mutant was isolated from an ethane methyl sulfonate (EMS)-induced IR64 mutant bank. The mutant, designated as spl30 (spotted-leaf30), displayed normal green leaf color under shade but exhibited red-brown lesions under natural summer field conditions. Initiation of the lesions was induced by light and the symptom was enhanced at 33 ° C relative to 26°C. Histochemical staining did not show cell death around the red-brown lesions. Chlorophyll contents in the mutant were significantly lower than those of the wild type while the ratio of chlorophyll a/b remained the same, indicating that spl30 was impaired in biosynthesis or degradation of chlorophyll. Disease reaction patterns of the mutant to Xanthomonas oryzae pv. oryzae were largely unchanged to most races tested except for a few strains. Genetic analysis showed that the mutation was controlled by a single recessive gene, tentatively named spl30(t), which co-segregated with RM15380 on chromosome 3, and was delimited to a 94 kb region between RM15380 and RM15383. Spl30(t) is likely a novel rice spotted-leaf gene since no other similar genes have been identified near the chromosomal region. The genetic data and recombination populations provided in this study will enable further fine-mapping and cloning of the gene. | Qi-Na Huang Yong-Feng shi Yang Yang Bao-Hua Feng Yan-Lin Wei Jie Chen Marietta Baraoidan Jian-Li Wu | 2011 | Journal of Integrative Plant Biology2011，53，8： | 8 |
| 4 | Enoxaparin Prevents Portal Vein Thrombosis and Liver Decompensation in Patients With Advanced Cirrhosis显示文摘 | Erica Villa Calogero Cammà Marco Marietta Monica Luongo Rosina Critelli Stefano Colopi Cristina Tata Ramona Zecchini Stefano Gitto Salvatore Petta Barbara Lei Veronica Bernabucci Ranka Vukotic Nicola De Maria Filippo Schepis Aimilia Karampatou Cristian Ca | 2012 | Gastroenterology2012，，5： | 5 |
| 5 | Inflammatory bowel disease-related colorectal cancer:Past,present and future perspectives显示文摘Inflammatory bowel disease-related colorectal cancer(IBD-CRC)is one of the most serious complications of IBD contributing to significant mortality in this cohort of patients.IBD is often associated with diet and lifestyle-related gut microbial dysbiosis,the interaction of genetic and environmental factors,leading to chronic gut inflammation.According to the“common ground hypothesis”,microbial dysbiosis and intestinal barrier impairment are at the core of the chronic inflammatory process associated with IBD-CRC.Among the many underlying factors known to increase the risk of IBD-CRC,perhaps the most important factor is chronic persistent inflammation.The persistent inflammation in the colon results in increased proliferation of cells necessary for repair but this also increases the risk of dysplastic changes due to chromosomal and microsatellite instability.Multiple pathways have been identified,regulated by many positive and negative factors involved in the development of cancer,which in this case follows the‘inflammation-dysplasia-carcinoma’sequence.Strategies to lower this risk are extremely important to reduce morbidity and mortality due to IBD-CRC,among which colonoscopic surveillance is the most widely accepted and implemented modality,forming part of many national and international guidelines.However,the effectiveness of surveillance in IBD has been a topic of much debate in recent years for multiple reasons—cost-benefit to health systems,resource requirements,and also because of studies showing conflicting long-term data.Our review provides a comprehensive overview of past,present,and future perspectives of IBD-CRC.We explore and analyse evidence from studies over decades and current best practices followed globally.In the future directions section,we cover emerging novel endoscopic techniques and artificial intelligence that could play an important role in managing the risk of IBD-CRC. | Snehali Majumder Uday Nagesh Shivaji Rangarajan Kasturi Alben Sigamani Subrata Ghosh Marietta Iacucci | 2022 | World Journal of Gastrointestinal Oncology2022，14，3： | 5 |
| 6 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 7 | Differences in inflammatory and thrombotic markers between unstable angina and acute myocardial infarction显示文摘 | Dimitris Tousoulis Charalambos Antoniades Erini Bosinakou Maria Kotsopoulou Costas Tsoufis Kyriakoula Marinou Marietta Charakida Elli Stefanadi Manolis Vavuranakis George Latsios Christodoulos Stefanadis | 2006 | International Journal of Cardiology2006，，2： | 2 |
| 8 | Tissue factor exposing microparticles in inflammatory bowel disease显示文摘 | Julia Palkovits Gottfried Novacek Marietta Kollars Gregor Hron Wolf Osterode Peter Quehenberger Paul Alexander Kyrle Harald Vogelsang Walter Reinisch Pavol Papay Ansgar Weltermann | 2012 | Journal of Crohn’s and Colitis2012，，： | 2 |
| 9 | A Controlled Trial of Gluten-Free Diet in Patients With Irritable Bowel Syndrome-Diarrhea: Effects on Bowel Frequency and Intestinal Function显示文摘 | Maria I. Vazquez–Roque Michael Camilleri Thomas Smyrk Joseph A. Murray Eric Marietta Jessica O’Neill Paula Carlson Jesse Lamsam Denise Janzow Deborah Eckert Duane Burton Alan R. Zinsmeister | 2013 | Gastroenterology2013，，5： | 2 |
| 10 | Screening for refractive errors in children: The plusoptiX S08 and the Retinomax K-plus2 performed by a lay screener compared to cycloplegic retinoscopy显示文摘 | Tamara Paff Anne Marie Oudesluys-Murphy Ron Wolterbeek Marietta Swart-van den Berg Johan M. de Nie Els Tijssen Nicoline E. Schalij-Delfos | 2010 | Journal of AAPOS2010，，6： | 1 |
| 11 | Knowledge,attitudes,and behaviors of college students regarding the 1990nutrition labeling education act food labels 显示文摘 | Marietta A B Welshimer K J Andereon S L | 1999 | J Am Diet Assoc1999，99，4： | 1 |
| 12 | Nitric oxide synthase assays显示文摘 | Hevel J M Marietta M A | 1994 | Meth Enzymol1994，23，： | 1 |
| 13 | AEGIS ORIT-the first and future ultimate integrated diagnosis system显示文摘 | Martin D B Martin Marietta | 1994 | IEEE AES System Maga- zine1994，19，2： | 1 |
| 14 | Goat milk with different αa2-casein content: Analysis of allergenic potency by REAST-inhibition assay 显示文摘 | Marietta D Bordonaro S Guastella A M | 2004 | Small Rumin ant Res2004，52，： | 1 |
| 15 | Characterisation of intact recombinant human erythropoietins applied in doping by means of planar gel electrophoretic techniques and matrix - assisted laser desorption/ionisation linear time - of - flight mass spectrometry显示文摘 | Gerald Sttibiger Martina Marchetti Marietta Nagano Christian Reichel ( tinter Gmeiner Gtinter Allmaier | 2005 | Rapid Communications in Mass Spectrometry2005，19，5： | 1 |
| 16 | In situ detection of global DNA hypomethylation in exfoliative urine cytology of patients with suspected bladder cancer显示文摘 | Hans-Helge Seifert Viola Schmiemann Mirko Mueller Marietta Kazimirek Fabiana Onofre Anne Neuhausen Andrea R. Florl Rolf Ackermann Alfred Boecking Wolfgang A. Schulz Hans Juergen Grote | 2006 | Experimental and Molecular Pathology2006，，： | 1 |
| 17 | Spectral and kinetic studies on the activation of soluble guanylate cyclase by nitric oxide 显示文摘 | Stone JR Marietta MA | 1996 | Biochemistry1996，35，4： | 1 |
| 18 | The Friedrichs extension of singular differential operators 显示文摘 | Marietta M Zettle A | 2000 | Journal of Differential Equation2000，160，： | 1 |
| 19 | Acetaldehydestimulates FANCD2 monoubiquitination, H2AXphosphorylation,and BRCA1 phosphorylation in human cells invitro :Implications for alcohol-related carcinogenesis显示文摘 | Marietta C Thompson LH Lamerdin JE | 2009 | MutatRes2009，664，1： | 1 |
| 20 | Thioredoxin catalyzes the S- nitrosation of the caspase-3 active site cysteine 显示文摘 | Mitchell DA Marietta MA | 2005 | Nat C hem Biol2005，1，3： | 1 |
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